OPA-15406, a novel, topical, nonsteroidal, selective phosphodiesterase-4 (PDE4) inhibitor, in the treatment of adult and adolescent patients with mild to moderate atopic dermatitis (AD): A phase-II randomized, double-blind, placebo-controlled study

Journal of the American Academy of Dermatology

Volumn 75, Issue 2, 2016, Pages 297-305

  Hanifin, Jon M ^a   Ellis, Charles N ^b   Frieden, Ilona J ^c   Fölster Holst, Regina ^d   Stein Gold, Linda F ^e   Secci, Angelo ^f   Smith, Angela J ^f   Zhao, Cathy ^f   Kornyeyeva, Elena ^f   Eichenfield, Lawrence F ^g  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e HENRY FORD HEALTH SYSTEM   (United States)

^f OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

atopic dermatitis; atopic eczema; OPA 15406; phosphodiesterase type 4 inhibitor; topical agents; topical calcineurin inhibitor

Indexed keywords

COCODAMOL; DERMATOLOGICAL AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPA 15406; PHOSPHODIESTERASE IV INHIBITOR; PLACEBO; UNCLASSIFIED DRUG; ANISOLE DERIVATIVE; MM 36; NITRILE;

ADOLESCENT; ADULT; AGED; APPLICATION SITE EXCORIATION; APPLICATION SITE PAIN; AREA UNDER THE CURVE; ARTICLE; ATOPIC DERMATITIS; CHILD; CONTROLLED STUDY; DEPRESSION; DERMATOMYCOSIS; DIARRHEA; DISEASE EXACERBATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; ECZEMA AREA AND SEVERITY INDEX SCORE; ERYTHEMA; FEMALE; GIARDIASIS; HEADACHE; HUMAN; IMPETIGO; INVESTIGATOR GLOBAL ASSESSMENT OF DISEASE SEVERITY SCORE; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MULTIPLE DRUG DOSE; MULTIPLE SCLEROSIS; PARALLEL DESIGN; PHASE 2 CLINICAL TRIAL; PREGNANCY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SCORING SYSTEM; SIDE EFFECT; SKIN DISEASE ASSESSMENT; SPLEEN RUPTURE; TIME TO MAXIMUM PLASMA CONCENTRATION; TOOTH PAIN; TREATMENT DURATION; UPPER RESPIRATORY TRACT INFECTION; VOMITING; VULVOVAGINAL DISEASE; BLOOD; CLINICAL TRIAL; COMPLICATION; CUTANEOUS DRUG ADMINISTRATION; DERMATITIS, ATOPIC; MIDDLE AGED; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADMINISTRATION, CUTANEOUS; ADOLESCENT; ADULT; ANISOLES; CHILD; DERMATITIS, ATOPIC; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRILES; PHOSPHODIESTERASE 4 INHIBITORS; PRURITUS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84967166963     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2016.04.001     Document Type: Article

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