Stability of Monodisperse Phospholipid-Coated Microbubbles Formed by Flow-Focusing at High Production Rates

Langmuir

Volumn 32, Issue 16, 2016, Pages 3937-3944

  Segers, Tim ^a   De Rond, Leonie ^a   De Jong, Nico ^b   Borden, Mark ^c   Versluis, Michel ^a  

^a UNIVERSITY OF TWENTE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UCB 450   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFACE STATES; MOLECULES; MONOLAYERS; NOZZLES; PHASE INTERFACES; PHOSPHOLIPIDS; THROUGHPUT; ULTRASONIC IMAGING;

ACOUSTIC CHARACTERIZATION; GAS-LIQUID INTERFACE; HIGH PRODUCTION RATE; LAPLACE PRESSURE; MICROFLUIDIC FLOW-FOCUSING DEVICES; PHOSPHOLIPID MONOLAYERS; ULTRASOUND CONTRAST AGENT; ULTRASOUND IMAGING;

MICROFLUIDICS;

EID: 84967152794     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/acs.langmuir.6b00616     Document Type: Article

References (51)

1. Overvelde, M.; Garbin, V.; Sijl, J.; Dollet, B.; de Jong, N.; Lohse, D.; Versluis, M. Nonlinear shell behavior of phospholipid-coated microbubbles Ultrasound Med. Biol. 2010, 36, 2080-2092 10.1016/j.ultrasmedbio.2010.08.015
2. Lindner, J. R. Microbubbles in medical imaging: current applications and future directions Nat. Rev. Drug Discovery 2004, 3, 527-533 10.1038/nrd1417
3. Minnaert, M. On musical air-bubbles and the sound of running water Philos. Mag. 1933, 16, 235-248 10.1080/14786443309462277
4. Klibanov, A. L. Microbubble Contrast Agents: Targeted ultrasound imaging and ultrasound-assisted drug-delivery applications Invest. Radiol. 2006, 41, 354-362 10.1097/01.rli.0000199292.88189.0f
5. Carson, A. R.; McTiernan, C. F.; Lavery, L.; Grata, M.; Leng, X.; Wang, J.; Chen, X.; Villanueva, F. S. Ultrasound-targeted microbubble destruction to deliver siRNA cancer therapy Cancer Res. 2012, 72, 6191-6199 10.1158/0008-5472.CAN-11-4079
6. Hernot, S.; Klibanov, A. L. Microbubbles in ultrasound-triggered drug and gene delivery Adv. Drug Delivery Rev. 2008, 60, 1153-1166 10.1016/j.addr.2008.03.005
7. Tsutsui, J. M.; Xie, F.; Porter, R. T. The use of microbubbles to target drug delivery Cardiovasc. Ultrasound 2004, 2, 23 10.1186/1476-7120-2-23
8. Deelman, L. E.; Decléves, A. E.; Rychak, J. J.; Sharma, K. Targeted renal therapies through microbubbles and ultrasound Adv. Drug Delivery Rev. 2010, 62, 1369-1377 10.1016/j.addr.2010.10.002
9. Dewitte, H.; Vanderperren, K.; Haers, H.; Stock, E.; Duchateau, L.; Hesta, M.; Saunders, J. H.; De Smedt, S. C.; Lentacker, I. Theranostic mRNA-loaded Microbubbles in the Lymphatics of Dogs: Implications for Drug Delivery Theranostics 2015, 5, 97-109 10.7150/thno.10298
10. Emmer, M.; Vos, H. J.; Goertz, D. E.; van Wamel, A.; Versluis, M.; de Jong, N. Pressure-dependent attenuation and scattering of phospholipid-coated microbubbles at low acoustic pressures Ultrasound Med. Biol. 2009, 35, 102-111 10.1016/j.ultrasmedbio.2008.07.005
11. Goertz, D. E.; de Jong, N.; van der Steen, A. F. W. Attenuation and size distribution measurements of definity and manipulated definity populations Ultrasound Med. Biol. 2007, 33, 1376-1388 10.1016/j.ultrasmedbio.2007.03.009
12. Feshitan, J. A.; Chen, C. C.; Kwan, J. J.; Borden, M. A. Microbubble size isolation by differential centrifugation J. Colloid Interface Sci. 2009, 329, 316-324 10.1016/j.jcis.2008.09.066
13. Kok, M. P.; Segers, T.; Versluis, M. Bubble sorting in pinched microchannels for ultrasound contrast agent enrichment Lab Chip 2015, 15, 3716-3722 10.1039/C5LC00370A
14. Leighton, T. G. The Acoustic Bubble; Academic Press: London, 1994.
15. Segers, T.; Versluis, M. Acoustic bubble sorting for ultrasound contrast agent enrichment Lab Chip 2014, 14, 1705-1714 10.1039/c3lc51296g
16. Gañán-Calvo, A. M.; Gordillo, J. M. Perfectly monodisperse microbubbling by capillary flow focusing Phys. Rev. Lett. 2001, 87, 274501 10.1103/PhysRevLett.87.274501
17. Anna, S. L.; Bontoux, N.; Stone, H. A. Formation of dispersions using "flow focusing" in microchannels Appl. Phys. Lett. 2003, 82, 364-366 10.1063/1.1537519
18. Garstecki, P.; Stone, H. A.; Whitesides, G. M. Mechanism for Flow-Rate Controlled Breakup in Confined Geometries: A Route to Monodisperse Emulsions Phys. Rev. Lett. 2005, 94, 164501 10.1103/PhysRevLett.94.164501
19. Hettiarachchi, K.; Talu, E.; Longo, M. L.; Dayton, P. A.; Lee, A. P. On-chip generation of microbubbles as a practical technology for manufacturing contrast agents for ultrasonic imaging Lab Chip 2007, 7, 463-468 10.1039/b701481n
20. Talu, E.; Hettiarachchi, K.; Powell, R. J.; Lee, A. P.; Dayton, P. A.; Longo, M. L. Maintaining monodispersity in a microbubble population formed by flow-focusing Langmuir 2008, 24, 1745-1749 10.1021/la703065v
21. Wang, K.; Lu, Y. C.; Xu, J. H.; Luo, G. S. Determination of Dynamic Interfacial Tension and Its Effect on Droplet Formation in the T-Shaped Microdispersion Process Langmuir 2009, 25, 2153-2158 10.1021/la803049s
22. Kwan, J. J.; Borden, M. A. Lipid monolayer collapse and microbubble stability Adv. Colloid Interface Sci. 2012, 183-184, 82-99 10.1016/j.cis.2012.08.005
23. Shih, R.; Bardin, D.; Martz, D. T.; Sheeran, P. S.; Dayton, P. A.; Lee, A. P. Flow-focusing regimes for accelerated production of monodisperse drug-loadable microbubbles toward clinical-scale applications Lab Chip 2013, 13, 4816-4826 10.1039/c3lc51016f
24. Shih, R.; Lee, A. P. Post-formation shrinkage and stabilization of microfluidic bubbles in lipid solution Langmuir 2016, 32, 1939 10.1021/acs.langmuir.5b03948
25. Wheatley, M. A.; Singhal, S. Structural studies on stabilized microbubbles: development of a novel contrast agent for diagnostic ultrasound React. Polym. 1995, 25, 157-166 10.1016/0923-1137(94)00039-8
26. Borden, M. A.; Longo, M. L. Oxygen permeability of fully condensed lipid monolayers J. Phys. Chem. B 2004, 108, 6009-1344 10.1021/jp037815p
27. Marmottant, P.; Van Der Meer, S.; Emmer, M.; Versluis, M.; De Jong, N.; Hilgenfeldt, S.; Lohse, D. A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture J. Acoust. Soc. Am. 2005, 118, 3499-3505 10.1121/1.2109427
28. Sarkar, K.; Shi, W. T.; Chatterjee, D.; Forsberg, F. Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic interface models for encapsulation J. Acoust. Soc. Am. 2005, 118, 539-550 10.1121/1.1923367
29. Church, C. C. The effect of an elastic solid surface layer on the radial pulsation of gas bubbles J. Acoust. Soc. Am. 1995, 97, 1510-1521 10.1121/1.412091
30. Van Der Meer, S.; Dollet, B.; Voormolen, M.; Chin, C. T.; Bouakaz, A.; De Jong, N.; Versluis, M.; Lohse, D. Microbubble spectroscopy of ultrasound contrast agents J. Acoust. Soc. Am. 2007, 121, 648-656 10.1121/1.2390673
31. Segers, T.; de Jong, N.; Lohse, D.; Versluis, M. Microbubbles for medical applications. Microfluidics for Medical Applications; RSC Nanoscience and Nanotechnology, Vol. 36; Royal Society of Chemistry: London, 2015; DOI: 10.1039/9781849737593.
32. Talu, E.; Powell, R. L.; Longo, M. L.; Dayton, P. A. Needle size and injection rate impact on microbubble contrast agent population Ultrasound Med. Biol. 2008, 34, 1182-1185 10.1016/j.ultrasmedbio.2007.12.018
33. de Rond, L. Characterization of phospholipid-coated monodisperse microbubbles for medical imaging, Master's thesis, University of Twente, The Netherlands, 2014.
34. Segers, T.; van Rooij, T.; de Rond, L.; Kooiman, K.; Dewitte, H.; Lentacker, I.; de Jong, N.; Versluis, M. Phospholipid formulation dependent bubble formation in microfluidic flow-focusing 2016, manuscript in preparation.
35. Duffy, D. C.; McDonald, J. C.; Schueller, O. J. A.; Whitesides, G. M. Rapid prototyping of microfluidic systems in poly(dimethylsiloxane) Anal. Chem. 1998, 70, 4974-4984 10.1021/ac980656z
36. Tan, Y. C.; Cristini, V.; Lee, A. P. Monodispersed microfluidic droplet generation by shear focusing microfluidic device Sens. Actuators, B 2006, 114, 350-356 10.1016/j.snb.2005.06.008
37. Chen, Q.; Zagzebski, J.; Wilson, T.; Stiles, T. Pressure-dependent attenuation in ultrasound contrast agents Ultrasound Med. Biol. 2002, 28, 1041-1051 10.1016/S0301-5629(02)00546-X
38. Israelachvili, J. N. Intermolecular and Surface Forces, Vol. 2; Academic Press: Waltham, MA, USA, 1992.
39. Postema, M.; Marmottant, P.; Lancee, C. T.; Hilgenfeldt, S.; de Jong, N. Ultrasound-induced microbubble coalescence Ultrasound Med. Biol. 2004, 30, 1337-1344 10.1016/j.ultrasmedbio.2004.08.008
40. Szijjarto, C.; Rossi, S.; Waton, G.; Krafft, M. P. Effects of perfluorocarbon gases on the size and stability characteristics of phospholipid-coated microbubbles: Osmotic effect versus interfacial film stabilization Langmuir 2012, 28, 1182-1189 10.1021/la2043944
41. Nguyen, P. N.; Trinh Dang, T.; Waton, G.; Vandamme, T.; Krafft, M. A nonpolar, nonamphiphilic molecule can accelerate adsorption of phospholipids and lower their surface tension at the air/water interface ChemPhysChem 2011, 12, 2646-2652 10.1002/cphc.201100425
42. Utada, A. S.; Fernandez-Nieves, A.; Stone, H. A.; Weitz, D. A. Dripping to jetting transitions in coflowing liquid streams Phys. Rev. Lett. 2007, 99, 094502 10.1103/PhysRevLett.99.094502
43. van Steijn, V.; Kreutzer, M. T.; Kleijn, C. R. μpiv study of the formation of segmented flow in microfluidic T-junctions Chem. Eng. Sci. 2007, 62, 7505-7514 10.1016/j.ces.2007.08.068
44. Nino, M. R. R.; Lucero, A.; Patino, J. M. R. Relaxation phenomena in phospholipid monolayers at the air-water interface Colloids Surf., A 2008, 320, 260-270 10.1016/j.colsurfa.2008.02.008
45. Ma, G.; Allen, H. C. DPPC Langmuir Monolayer at the Air-Water Interface: Probing the Tail and Head Groups by Vibrational Sum Frequency Generation Spectroscopy Langmuir 2006, 22, 5341-5349 10.1021/la0535227
46. Lee, S.; Kim, D. H.; Needham, D. Equilibrium and dynamic interfacial tension measurements at microscopic interfaces using a micropipet technique. 2. dynamics of phospholipid monolayer formation and equilibrium tensions at the water-air inteface Langmuir 2001, 17, 5544-5550 10.1021/la0103261
47. Lozano, M. M.; Longo, M. L. Complex formation and other phase transformations mapped in saturated phosphatidylcholine/DSPE-PEG2000 monolayers Soft Matter 2009, 5, 1822-1834 10.1039/b820070j
48. Segers, T.; de Jong, N.; Versluis, M. Uniform scattering and attenuation of acoustically sorted ultrasound contrast agents: modelling and experiments. Submitted for publication, 2015.
49. O'Brien, J.-P.; Ovenden, N.; Stride, E. Accounting for the stability of microbubbles to multi-pulse excitation using a lipid-shedding model J. Acoust. Soc. Am. 2011, 130, 180-185 10.1121/1.3630219
50. Luan, Y.; Lajoinie, G.; Gelderblom, E.; Skachkov, I.; van der Steen, A. F. W.; Vos, H. J.; Versluis, M.; de Jong, N. Lipid shedding from single oscillating microbubbles Ultrasound Med. Biol. 2014, 40, 1834-1846 10.1016/j.ultrasmedbio.2014.02.031
51. Dicker, S.; Mleczko, M.; Siepmann, M.; Wallace, N.; Sunny, Y.; Bawiec, C. R.; Schmitz, G.; Lewin, P.; Wrenn, S. P. Influence of shell composition on the resonance frequency of microbubble contrast agents Ultrasound Med. Biol. 2013, 39, 1292-1302 10.1016/j.ultrasmedbio.2013.02.462