Airway surfactant protein D deficiency in adults with severe asthma

Chest

Volumn 149, Issue 5, 2016, Pages 1165-1172

  Mackay, Rose Marie A ^a   Grainge, Christopher L ^b   Lau, Laurie C ^a   Barber, C ^a,c   Clark, Howard W ^a,c   Howarth, Peter H ^a,c  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b JOHN HUNTER HOSPITAL   (Australia)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Asthma; Biomarkers; Bronchoalveolar lavage; Eosinophilic inflammation; Immunology (lung); Immunology asthma; Neutrophilic inflammation; Severe asthma; Surfactant protein D

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; INTERLEUKIN 8; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; SURFACTANT PROTEIN D; PEROXIDASE; RNASE3 PROTEIN, HUMAN;

ADULT; AGED; AIRWAY; ARTICLE; ASTHMA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; LUNG LAVAGE; MACROPHAGE; MALE; NEUTROPHIL COUNT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; WESTERN BLOTTING; ADOLESCENT; BRONCHOALVEOLAR LAVAGE FLUID; CASE CONTROL STUDY; CHEMISTRY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGY; INNATE IMMUNITY; LEUKOCYTE COUNT; METABOLISM; MIDDLE AGED; NEUTROPHIL; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ASTHMA; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHIL CATIONIC PROTEIN; FEMALE; HUMANS; IMMUNITY, INNATE; LEUKOCYTE COUNT; LEUKOCYTE ELASTASE; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; NEUTROPHILS; PEROXIDASE; PULMONARY SURFACTANT-ASSOCIATED PROTEIN D; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84966679980     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1016/j.chest.2015.11.012     Document Type: Article

References (31)

1. Schuijs MJ, Willart MA, Hammad H, Lambrecht BN. Cytokine targets in airway inflammation. Curr Opin Pharmacol. 2013;3(3):351-361.
2. Niimi A, Matsumoto H, Amitani R, et al. Airway wall thickness in asthma assessed by computed tomography. Relation to clinical indices. Am J Respir Crit Care Med. 2000;162(4 pt 1):1518-1523.
3. Moore WC, Hastie AT, Li X, et al. Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol. 2014;133(6):1557-1563.e5.
4. Green BJ, Wiriyachaiporn S, Grainge C, et al. Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma. PloS One. 2014;9(6):e100645.
5. Reid KB. Interactions of surfactant protein D with pathogens, allergens and phagocytes. Biochim Biophys Acta. 1998;1408(2-3):290-295.
6. Kishore U, Greenhough TJ, Waters P, et al. Surfactant proteins SP-A and SP-D: structure, function and receptors. Mol Immunol. 2006;43(9):1293-1315.
7. Singh M, Madan T, Waters P, et al. Protective effects of a recombinant fragment of human surfactant protein D in a murine model of pulmonary hypersensitivity induced by dust mite allergens. Immunol Lett. 2003;86(3): 299-307.
8. Deb R, Shakib F, Reid K, et al. Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D. J Biol Chem. 2007;282(51):36808-36819.
9. Qaseem AS, Sonar S, Mahajan L, et al. Linking surfactant protein SP-D and IL-13: implications in asthma and allergy. Mol Immunol. 2013;54(1):98-107.
10. Ogawa H, Ledford JG, Mukherjee S, et al. Surfactant protein D attenuates subepithelial fibrosis in allergic airways disease through TGF-beta. Respir Res. 2014;15:143.
11. Takeda K, Miyahara N, Rha YH, et al. Surfactant protein D regulates airway function and allergic inflammation through modulation of macrophage function. Am J Respir Crit Care Med. 2003;168(7):783-789.
12. Strong P, Townsend P, Mackay R, Reid KB, Clark HW. A recombinant fragment of human SP-D reduces allergic responses in mice sensitized to house dust mite allergens. Clin Exp Immunol. 2003;134(2):181-187.
13. Borron PJ, Crouch EC, Lewis JF, et al. Recombinant rat surfactant-Associated protein D inhibits human T lymphocyte proliferation and IL-2 production. J Immunol. 1998;161(9):4599-4603.
14. Hohlfeld JM, Erpenbeck VJ, Krug N. Surfactant proteins SP-A and SP-D as modulators of the allergic inflammation in asthma. Pathobiology. 2002;70(5):287-292.
15. Haczku A, Cao Y, Vass G, et al. IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response. J Immunol. 2006;176(6): 3557-3565.
16. Reddy AP, Gupta MR. Management of asthma: the current US and European guidelines. Adv Exp Med Biol. 2014;795: 81-103.
17. Guidelines for fiberoptic bronchoscopy in adults. American Thoracic Society. Medical Section of the American Lung Association. Am Rev of Respir Dis. 1987;136(4):1066.
18. Duvoix A, Mackay RM, Henderson N, et al. Physiological concentration of calcium inhibits elastase-induced cleavage of a functional recombinant fragment of surfactant protein D. Immunobiology. 2011;216(1-2):72-79.
19. Cooley J, McDonald B, Accurso FJ, Crouch EC, Remold-O'Donnell E. Patterns of neutrophil serine proteasedependent cleavage of surfactant protein D in inflammatory lung disease. J Leukoc Biol. 2008;83(4):946-955.
20. Alcorn JF, Wright JR. Degradation of pulmonary surfactant protein D by Pseudomonas aeruginosa elastase abrogates innate immune function. J Biol Chem. 2004;279(29):30871-30879.
21. Winkler C, Atochina-Vasserman EN, Holz O, et al. Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD. Respiratory Res. 2011;12:29.
22. Sin DD, Pahlavan PS, Man SF. Surfactant protein D: a lung specific biomarker in COPD? Ther Adv Respir Dis. 2008;2(2): 65-74.
23. Gaunsbaek MQ, Rasmussen KJ, Beers MF, Atochina-Vasserman EN, Hansen S. Lung surfactant protein D (SP-D) response and regulation during acute and chronic lung injury. Lung. 2013;191(3):295-303.
24. Lomas DA, Silverman EK, Edwards LD, et al. Serum surfactant protein D is steroid sensitive and associated with exacerbations of COPD. Eur Respir J. 2009;34(1):95-102.
25. Sims MW, Tal-Singer RM, Kierstein S, et al. Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study. Respir Res. 2008;9:13.
26. von Bredow C, Hartl D, Schmid K, et al. Surfactant protein D regulates chemotaxis and degranulation of human eosinophils. Clin Exp Allergy. 2006;36(12):1566-1574.
27. Hartshorn KL. Role of surfactant protein A and D (SP-A and SP-D) in human antiviral host defense. Front Biosci (Schol Ed). 2010;2:527-546.
28. Lahti M, Lofgren J, Marttila R, et al. Surfactant protein D gene polymorphism associated with severe respiratory syncytial virus infection. Pediatr Res. 2002;51(6):696-699.
29. Hawgood S, Brown C, Edmondson J, et al. Pulmonary collectins modulate strainspecific influenza a virus infection and host responses. J Virol. 2004;78(16): 8565-8572.
30. LeVine AM, Elliott J, Whitsett JA, et al. Surfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus. Am J Respir Cell Mol Biol. 2004;31(2):193-199.
31. Kishore U, Bernal AL, Kamran MF, et al. Surfactant proteins SP-A and SP-D in human health and disease. Arch Immunol Ther Exp (Warsz). 2005;53(5): 399-417.