MicroRNA-22 is downregulated in clear cell renal cell carcinoma, and inhibits cell growth, migration and invasion by targeting PTEN

Molecular Medicine Reports

Volumn 13, Issue 6, 2016, Pages 4800-4806

  Fan, Wenxing ^a   Huang, Jie ^a   Xiao, Hua ^a   Liang, Zhang ^a  

^a KUNMING MEDICAL UNIVERSITY   (China)

Author keywords

MicroRNA 22; Phosphatase and tensin homolog; Renal cell carcinoma

Indexed keywords

MICRORNA 22; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; MICRORNA; MIRN22 MICRORNA, HUMAN; PTEN PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER TISSUE; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG TARGETING; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY CARCINOMA; LUCIFERASE ASSAY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS INHIBITION; MIDDLE AGED; MTT ASSAY; SIGNAL TRANSDUCTION; TUMOR INVASION; WESTERN BLOTTING; CELL MOTION; GENE EXPRESSION REGULATION; GENETICS; KIDNEY; KIDNEY TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY; KIDNEY NEOPLASMS; MALE; MICRORNAS; MIDDLE AGED; PTEN PHOSPHOHYDROLASE;

EID: 84966588505     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2016.5101     Document Type: Article

References (28)

1. White NM and Yousef GM: MicroRNAs: Exploring a new dimension in the pathogenesis of kidney cancer. BMC Med 8: 65, 2010.
2. Saini S, Yamamura S, Majid S, Shahryari V, Hirata H, Tanaka Y and Dahiya R: MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. Cancer Res 71: 6208-6219, 2011.
3. Lian JH, Wang WH, Wang JQ, Zhang YH and Li Y: MicroRNA-122 promotes proliferation, invasion and migration of renal cell carcinoma cells through the PI3K/Akt signaling pathway. Asian Pac J Cancer Prev 14: 5017-5021, 2013.
4. Yu ZH, Zhang Q, Wang YD, Chen J, Jiang ZM, Shi M, Guo X, Qin J, Cui GH, Cai ZM, et al: Overexpression of cyclooxygenase-1 correlates with poor prognosis in renal cell carcinoma. Asian Pac J Cancer Prev 14: 3729-3734, 2013.
5. Jiang Z, Chu PG, Woda BA, Liu Q, Balaji KC, Rock KL and Wu CL: Combination of quantitative IMP3 and tumor stage: A new system to predict metastasis for patients with localized renal cell carcinomas. Clin Cancer Res 14: 5579-5584, 2008.
6. Wu D, Li M, Wang L, Zhou Y, Zhou J, Pan H and Qu P: MicroRNA-145 inhibits cell proliferation, migration and invasion by targeting matrix metallopeptidase-11 in renal cell carcinoma. Mol Med Rep 10: 393-398, 2014.
7. Li M, Wang Y, Song Y, Bu R, Yin B, Fei X, Guo Q and Wu B: MicroRNAs in renal cell carcinoma: A systematic review of clinical implications (Review). Oncol Rep 33: 1571-1578, 2015.
8. Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 116: 281-297, 2004.
9. Dang Y, Zhao S, Qin Y, Han T, Li W and Chen ZJ: MicroRNA-22-3p is down-regulated in the plasma of Han Chinese patients with premature ovarian failure. Fertil Steril 103: 802-807, 2015.
10. Huang ZP and Wang DZ: MIR-22 in cardiac remodeling and disease. Trends Cardiovasc Med 24: 267-272, 2014.
11. Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell 136: 215-233, 2009.
12. Friedman RC, Farh KK, Burge CB and Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19: 92-105, 2009.
13. Kwak PB, Iwasaki S and Tomari Y: The microRNA pathway and cancer. Cancer Sci 101: 2309-2315, 2010.
14. Chen X, Bo L, Zhao X and Chen Q: MicroRNA-133a inhibits cell proliferation, colony formation ability, migration and invasion by targeting matrix metallopeptidase 9 in hepatocellular carcinoma. Mol Med Rep 11: 3900-3907, 2015.
15. Eacker SM, Dawson TM and Dawson VL: Understanding microRNAs in neurodegeneration. Nat Rev Neurosci 10: 837-841, 2009.
16. Li B, Song Y, Liu TJ, Cui YB, Jiang Y, Xie ZS and Xie SL: MiRNA-22 suppresses colon cancer cell migration and invasion by inhibiting the expression of T-cell lymphoma invasion and metastasis 1 and matrix metalloproteinases 2 and9. Oncol Rep 29: 1932-1938, 2013.
17. Guo MM, Hu LH, Wang YQ, Chen P, Huang JG, Lu N, He JH and Liao CG: MIR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1. Med Oncol 30: 542, 2013.
18. Li J, Liang S, Yu H, Zhang J, Ma D and Lu X: An inhibitory effect of MIR-22 on cell migration and invasion in ovarian cancer. Gynecol Oncol 119: 543-548, 2010.
19. Zhang J, Yang Y, Yang T, Liu Y, Li A, Fu S, Wu M, Pan Z and Zhou W: MicroRNA-22, downregulated in hepatocellular carcinoma and correlated with prognosis, suppresses cell proliferation and tumourigenicity. Br J Cancer 103: 1215-1220, 2010.
20. Ling B, Wang GX, Long G, Qiu JH and Hu ZL: Tumor suppressor MIR-22 suppresses lung cancer cell progression through post-transcriptional regulation of ErbB3. J Cancer Res Clin Oncol 138: 1355-1361, 2012.
21. Tao J, Lu Q, Wu D, Li P, Xu B, Qing W, Wang M, Zhang Z and Zhang W: microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells. Oncol Rep 25: 1721-1729, 2011.
22. Wang X, Yu H, Lu X, Zhang P, Wang M and Hu Y: MIR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151. Biochem Biophys Res Commun 445: 175-179, 2014.
23. Rizvi MM, Alam MS, Mehdi SJ, Ali A and Batra S: Allelic loss of 10q23.3, the PTEN gene locus in cervical carcinoma from northern indian population. Pathol Oncol Res 18: 309-313, 2012.
24. Cheng T, Zhang JG, Cheng YH, Gao ZW and Ren XQ: Relationship between PTEN and Livin expression and malignancy of renal cell carcinomas. Asian Pac J Cancer Prev 13: 2681-2685, 2012.
25. Gu J, Tamura M and Yamada KM: Tumor suppressor PTEN inhibits integrin-and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways. J Cell Biol 143: 1375-1383, 1998.
26. Brenner W, Färber G, Herget T, Lehr HA, Hengstler JG and Thüroff JW: Loss of tumor suppressor protein PTEN during renal carcinogenesis. Int J Cancer 99: 53-57, 2002.
27. Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X and Wu H: PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci USA 96: 6199-6204, 1999.
28. Hager M, Haufe H, Kemmerling R, Mikuz G, Kolbitsch C and Moser PL: PTEN expression in renal cell carcinoma and oncocytoma and prognosis. Pathology 39: 482-485, 2007.