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Volumn 40, Issue , 2016, Pages 35-40

Clostridium difficile ribotype 176 - A predictor for high mortality and risk of nosocomial spread?

Author keywords

ATLAS score; Clostridium difficile; MLVA; PCR Ribotype 176; Ribotyping; Thr82Ile

Indexed keywords

ARGININE; ASPARAGINE; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; FIDAXOMICIN; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; HISTIDINE; ISOLEUCINE; LINCOSAMIDE; LYSINE; MACROLIDE; METRONIDAZOLE; MIKAMYCIN B; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; RNA POLYMERASE BETA SUBUNIT; THREONINE; VANCOMYCIN; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN;

EID: 84966430231     PISSN: 10759964     EISSN: 10958274     Source Type: Journal    
DOI: 10.1016/j.anaerobe.2016.05.002     Document Type: Article
Times cited : (25)

References (38)
  • 3
    • 84922693344 scopus 로고    scopus 로고
    • Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual,point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID)
    • Davies K.A., Longshaw C.M., Davis G.L., Bouza E., Barbut F., Barna Z., et al. Underdiagnosis of Clostridium difficile across Europe: the European, multicentre, prospective, biannual,point-prevalence study of Clostridium difficile infection in hospitalised patients with diarrhoea (EUCLID). Lancet Infect. Dis. 2014, 14(12):1208-1219.
    • (2014) Lancet Infect. Dis. , vol.14 , Issue.12 , pp. 1208-1219
    • Davies, K.A.1    Longshaw, C.M.2    Davis, G.L.3    Bouza, E.4    Barbut, F.5    Barna, Z.6
  • 4
    • 84933506535 scopus 로고    scopus 로고
    • Pan-European longitudinal surveillance of antibiotic resistance among prevalent Clostridium difficile ribotypes
    • e9-248.e16
    • Freeman J., Vernon J., Morris K., Nicholson S., Todhunter S., Longshaw C., et al. Pan-European longitudinal surveillance of antibiotic resistance among prevalent Clostridium difficile ribotypes. Clin. Microbiol. Infect. 2015, 21(3):248. e9-248.e16.
    • (2015) Clin. Microbiol. Infect. , vol.21 , Issue.3 , pp. 248
    • Freeman, J.1    Vernon, J.2    Morris, K.3    Nicholson, S.4    Todhunter, S.5    Longshaw, C.6
  • 5
    • 84907966303 scopus 로고    scopus 로고
    • A case of imported Clostridium difficile PCR-ribotype 027 infection within the Czech Republic which has a high prevalence of C. difficile ribotype 176
    • Krutova M., Nyc O., Kuijper E.J., Geigerova L., Matejkova J., Bergerova T., et al. A case of imported Clostridium difficile PCR-ribotype 027 infection within the Czech Republic which has a high prevalence of C. difficile ribotype 176. Anaerobe 2014, 30:153-155.
    • (2014) Anaerobe , vol.30 , pp. 153-155
    • Krutova, M.1    Nyc, O.2    Kuijper, E.J.3    Geigerova, L.4    Matejkova, J.5    Bergerova, T.6
  • 6
    • 83755172954 scopus 로고    scopus 로고
    • Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage
    • Valiente E., Dawson L.F., Cairns M.D., Stabler R.A., Wren B.W. Emergence of new PCR ribotypes from the hypervirulent Clostridium difficile 027 lineage. J. Med. Microbiol. 2012, 61(Pt 1):49-56.
    • (2012) J. Med. Microbiol. , vol.61 , pp. 49-56
    • Valiente, E.1    Dawson, L.F.2    Cairns, M.D.3    Stabler, R.A.4    Wren, B.W.5
  • 7
    • 33748563622 scopus 로고    scopus 로고
    • Emergence of Clostridium difficile-associated disease in North America and Europe
    • Review
    • Kuijper E.J., Coignard B., Tüll P., ESCMID Study Group for Clostridium difficile, EU Member States, European Centre for Disease Prevention and Control Emergence of Clostridium difficile-associated disease in North America and Europe. Clin. Microbiol. Infect. 2006, 12(6):2-18. Review.
    • (2006) Clin. Microbiol. Infect. , vol.12 , Issue.6 , pp. 2-18
    • Kuijper, E.J.1    Coignard, B.2    Tüll, P.3
  • 8
    • 0032901542 scopus 로고    scopus 로고
    • PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes
    • Stubbs S.L., Brazier J.S., O'Neill G.L., Duerden B.I. PCR targeted to the 16S-23S rRNA gene intergenic spacer region of Clostridium difficile and construction of a library consisting of 116 different PCR ribotypes. J. Clin. Microbiol. 1999, 37(2):461-463.
    • (1999) J. Clin. Microbiol. , vol.37 , Issue.2 , pp. 461-463
    • Stubbs, S.L.1    Brazier, J.S.2    O'Neill, G.L.3    Duerden, B.I.4
  • 9
    • 55549147163 scopus 로고    scopus 로고
    • Characterization of Clostridium difficile isolates using capillary gel electrophoresis-based PCR ribotyping
    • Indra A., Huhulescu S., Schneeweis M., Hasenberger P., Kernbichler S., Fiedler A., et al. Characterization of Clostridium difficile isolates using capillary gel electrophoresis-based PCR ribotyping. J. Med. Microbiol. 2008, 57(Pt 11):1377-1382.
    • (2008) J. Med. Microbiol. , vol.57 , pp. 1377-1382
    • Indra, A.1    Huhulescu, S.2    Schneeweis, M.3    Hasenberger, P.4    Kernbichler, S.5    Fiedler, A.6
  • 10
    • 56849092302 scopus 로고    scopus 로고
    • New multiplex PCR method for the detection of Clostridium difficile toxin A (tcdA) and toxin B (tcdB) and the binary toxin (cdtA/cdtB) genes applied to a Danish strain collection
    • Erratum in: Clin Microbiol Infect. 2009; 15 (3); 296
    • Persson S., Torpdahl M., Olsen K.E. New multiplex PCR method for the detection of Clostridium difficile toxin A (tcdA) and toxin B (tcdB) and the binary toxin (cdtA/cdtB) genes applied to a Danish strain collection. Clin. Microbiol. Infect. 2008, 14(11):1057-1064. Erratum in: Clin Microbiol Infect. 2009; 15 (3); 296.
    • (2008) Clin. Microbiol. Infect. , vol.14 , Issue.11 , pp. 1057-1064
    • Persson, S.1    Torpdahl, M.2    Olsen, K.E.3
  • 11
    • 0036840972 scopus 로고    scopus 로고
    • GyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile
    • Dridi L., Tankovic J., Burghoffer B., Barbut F., Petit J.C. gyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile. Antimicrob. Agents Chemother. 2002, 46(11):3418-3421.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , Issue.11 , pp. 3418-3421
    • Dridi, L.1    Tankovic, J.2    Burghoffer, B.3    Barbut, F.4    Petit, J.C.5
  • 12
    • 58849098153 scopus 로고    scopus 로고
    • High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    • Curry S.R., Marsh J.W., Shutt K.A., Muto C.A., O'Leary M.M., Saul M.I., et al. High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital. Clin. Infect. Dis. 2009, 48(4):425-429.
    • (2009) Clin. Infect. Dis. , vol.48 , Issue.4 , pp. 425-429
    • Curry, S.R.1    Marsh, J.W.2    Shutt, K.A.3    Muto, C.A.4    O'Leary, M.M.5    Saul, M.I.6
  • 13
    • 11144220934 scopus 로고    scopus 로고
    • Comparative analysis of Clostridium difficile clinical isolates belonging to different genetic lineages and time periods
    • Spigaglia P., Mastrantonio P. Comparative analysis of Clostridium difficile clinical isolates belonging to different genetic lineages and time periods. J. Med. Microbiol. 2004, 53(Pt 11):1129-1136.
    • (2004) J. Med. Microbiol. , vol.53 , pp. 1129-1136
    • Spigaglia, P.1    Mastrantonio, P.2
  • 14
    • 33947195010 scopus 로고    scopus 로고
    • Typing and subtyping of Clostridium difficile isolates by using multiple-locus variable-number tandem-repeat analysis
    • van den Berg R.J., Schaap I., Templeton K.E., Klaassen C.H., Kuijper E.J. Typing and subtyping of Clostridium difficile isolates by using multiple-locus variable-number tandem-repeat analysis. J. Clin. Microbiol. 2007, 45(3):1024-1028.
    • (2007) J. Clin. Microbiol. , vol.45 , Issue.3 , pp. 1024-1028
    • van den Berg, R.J.1    Schaap, I.2    Templeton, K.E.3    Klaassen, C.H.4    Kuijper, E.J.5
  • 15
    • 33746191690 scopus 로고    scopus 로고
    • Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    • Marsh J.W., O'Leary M.M., Shutt K.A., Pasculle A.W., Johnson S., Gerding D.N., et al. Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals. J. Clin. Microbiol. 2006, 44(7):2558-2566.
    • (2006) J. Clin. Microbiol. , vol.44 , Issue.7 , pp. 2558-2566
    • Marsh, J.W.1    O'Leary, M.M.2    Shutt, K.A.3    Pasculle, A.W.4    Johnson, S.5    Gerding, D.N.6
  • 16
    • 70749150720 scopus 로고    scopus 로고
    • Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina
    • Goorhuis A., Legaria M.C., van den Berg R.J., Harmanus C., Klaassen C.H., Brazier J.S., et al. Application of multiple-locus variable-number tandem-repeat analysis to determine clonal spread of toxin A-negative Clostridium difficile in a general hospital in Buenos Aires, Argentina. Clin. Microbiol. Infect. 2009, 15(12):1080-1086.
    • (2009) Clin. Microbiol. Infect. , vol.15 , Issue.12 , pp. 1080-1086
    • Goorhuis, A.1    Legaria, M.C.2    van den Berg, R.J.3    Harmanus, C.4    Klaassen, C.H.5    Brazier, J.S.6
  • 18
    • 70649107673 scopus 로고    scopus 로고
    • European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI)
    • Bauer M.P., Kuijper E.J., van Dissel J.T., European Society of Clinical Microbiology and Infectious Diseases European Society of Clinical Microbiology and Infectious Diseases (ESCMID): treatment guidance document for Clostridium difficile infection (CDI). Clin. Microbiol. Infect. 2009, 15(12):1067-1079.
    • (2009) Clin. Microbiol. Infect. , vol.15 , Issue.12 , pp. 1067-1079
    • Bauer, M.P.1    Kuijper, E.J.2    van Dissel, J.T.3
  • 19
    • 84875301622 scopus 로고    scopus 로고
    • Derivation and validation of a simple clinical bedside score (ATLAS) for Clostridium difficile infection which predicts response to therapy
    • Miller M.A., Louie T., Mullane K., Weiss K., Lentnek A., Golan Y., et al. Derivation and validation of a simple clinical bedside score (ATLAS) for Clostridium difficile infection which predicts response to therapy. BMC Infect. Dis. 2013, 13:148.
    • (2013) BMC Infect. Dis. , vol.13 , pp. 148
    • Miller, M.A.1    Louie, T.2    Mullane, K.3    Weiss, K.4    Lentnek, A.5    Golan, Y.6
  • 20
    • 84887259304 scopus 로고    scopus 로고
    • European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection
    • Debast S.B., Bauer M.P., Kuijper E.J., European Society of Clinical Microbiology and Infectious Diseases European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection. Clin. Microbiol. Infect. 2014, 20(2):1-26.
    • (2014) Clin. Microbiol. Infect. , vol.20 , Issue.2 , pp. 1-26
    • Debast, S.B.1    Bauer, M.P.2    Kuijper, E.J.3
  • 21
    • 77951026738 scopus 로고    scopus 로고
    • Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA)
    • Cohen S.H., Gerding D.N., Johnson S., Kelly C.P., Loo V.G., McDonald L.C., et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect. Control Hosp. Epidemiol. 2010, 31(5):431-455.
    • (2010) Infect. Control Hosp. Epidemiol. , vol.31 , Issue.5 , pp. 431-455
    • Cohen, S.H.1    Gerding, D.N.2    Johnson, S.3    Kelly, C.P.4    Loo, V.G.5    McDonald, L.C.6
  • 22
    • 70349644969 scopus 로고    scopus 로고
    • Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for C. difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods
    • Eastwood K., Else P., Charlett A., Wilcox M. Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for C. difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods. J. Clin. Microbiol. 2009, 47(10):3211-3217.
    • (2009) J. Clin. Microbiol. , vol.47 , Issue.10 , pp. 3211-3217
    • Eastwood, K.1    Else, P.2    Charlett, A.3    Wilcox, M.4
  • 23
    • 79955674549 scopus 로고    scopus 로고
    • Clostridium difficile PCR ribotype 176 in the Czech Republic and Poland
    • Nyč O., Pituch H., Matějková J., Obuch-Woszczatynski P., Kuijper E.J. Clostridium difficile PCR ribotype 176 in the Czech Republic and Poland. Lancet 2011, 377(9775):1407.
    • (2011) Lancet , vol.377 , Issue.9775 , pp. 1407
    • Nyč, O.1    Pituch, H.2    Matějková, J.3    Obuch-Woszczatynski, P.4    Kuijper, E.J.5
  • 24
    • 84900337483 scopus 로고    scopus 로고
    • Occurrence of Clostridium difficile PCR-ribotype 027 and it's closely related PCR-ribotype 176 in hospitals in Poland in 2008-2010
    • Obuch-Woszczatyński P., Lachowicz D., Schneider A., Mól A., Pawłowska J., Ozdzeńska-Milke E., et al. Occurrence of Clostridium difficile PCR-ribotype 027 and it's closely related PCR-ribotype 176 in hospitals in Poland in 2008-2010. Anaerobe 2014, 28:13-17.
    • (2014) Anaerobe , vol.28 , pp. 13-17
    • Obuch-Woszczatyński, P.1    Lachowicz, D.2    Schneider, A.3    Mól, A.4    Pawłowska, J.5    Ozdzeńska-Milke, E.6
  • 25
    • 84922691786 scopus 로고    scopus 로고
    • Antimicrobial susceptibility patterns of Clostridium difficile strains belonging to different polymerase chain reaction ribotypes isolated in Poland in 2012
    • Lachowicz D., Pituch H., Obuch-Woszczatyński P. Antimicrobial susceptibility patterns of Clostridium difficile strains belonging to different polymerase chain reaction ribotypes isolated in Poland in 2012. Anaerobe 2015, 31:37-41.
    • (2015) Anaerobe , vol.31 , pp. 37-41
    • Lachowicz, D.1    Pituch, H.2    Obuch-Woszczatyński, P.3
  • 26
    • 84966315802 scopus 로고    scopus 로고
    • Antibiotic profiling of Clostridium difficile ribotype 176-A multidrug resistant relative to C. difficile ribotype 027
    • Aug 6
    • Krutova M., Matejkova J., Tkadlec J., Nyc O. Antibiotic profiling of Clostridium difficile ribotype 176-A multidrug resistant relative to C. difficile ribotype 027. Anaerobe 2015, S1075-9964(15):30045-30047. Aug 6.
    • (2015) Anaerobe , vol.SUPPL. 10759964 , Issue.15 , pp. 30045-30047
    • Krutova, M.1    Matejkova, J.2    Tkadlec, J.3    Nyc, O.4
  • 27
    • 80052882560 scopus 로고    scopus 로고
    • European Study Group on Clostridium difficile (ESGCD). Multidrug resistance in European Clostridium difficile clinical isolates
    • Spigaglia P., Barbanti F., Mastrantonio P. European Study Group on Clostridium difficile (ESGCD). Multidrug resistance in European Clostridium difficile clinical isolates. J. Antimicrob. Chemother. 2011, 66(10):2227-2234.
    • (2011) J. Antimicrob. Chemother. , vol.66 , Issue.10 , pp. 2227-2234
    • Spigaglia, P.1    Barbanti, F.2    Mastrantonio, P.3
  • 28
    • 0034924147 scopus 로고    scopus 로고
    • Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA
    • Ackermann G., Tang Y.J., Kueper R., Heisig P., Rodloff A.C., Silva J., et al. Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA. Antimicrob. Agents Chemother. 2001, 45(8):2348-2353.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , Issue.8 , pp. 2348-2353
    • Ackermann, G.1    Tang, Y.J.2    Kueper, R.3    Heisig, P.4    Rodloff, A.C.5    Silva, J.6
  • 29
    • 0036840972 scopus 로고    scopus 로고
    • GyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile
    • Dridi L., Tankovic J., Burghoffer B., Barbut F., Petit J.C. gyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile. Antimicrob. Agents Chemother. 2002, 46(11):3418-3421.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , Issue.11 , pp. 3418-3421
    • Dridi, L.1    Tankovic, J.2    Burghoffer, B.3    Barbut, F.4    Petit, J.C.5
  • 30
    • 45249087419 scopus 로고    scopus 로고
    • Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe
    • Spigaglia P., Barbanti F., Mastrantonio P., Brazier J.S., Barbut F., Delmée M., et al. Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe. J. Med. Microbiol. 2008, 57(6):784-789.
    • (2008) J. Med. Microbiol. , vol.57 , Issue.6 , pp. 784-789
    • Spigaglia, P.1    Barbanti, F.2    Mastrantonio, P.3    Brazier, J.S.4    Barbut, F.5    Delmée, M.6
  • 31
    • 33847416012 scopus 로고    scopus 로고
    • GyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027
    • Drudy D., Kyne L., O'Mahony R., Fanning S. gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027. Emerg. Infect. Dis. 2007, 13(3):504-505.
    • (2007) Emerg. Infect. Dis. , vol.13 , Issue.3 , pp. 504-505
    • Drudy, D.1    Kyne, L.2    O'Mahony, R.3    Fanning, S.4
  • 32
    • 84871990888 scopus 로고    scopus 로고
    • Emergence and global spread of epidemic healthcare-associated Clostridium difficile
    • He M., Miyajima F., Roberts P., Ellison L., Pickard D.J., Martin M.J., et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nat. Genet. 2013, 45(1):109-113.
    • (2013) Nat. Genet. , vol.45 , Issue.1 , pp. 109-113
    • He, M.1    Miyajima, F.2    Roberts, P.3    Ellison, L.4    Pickard, D.J.5    Martin, M.J.6
  • 34
    • 58849098153 scopus 로고    scopus 로고
    • High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    • Curry S.R., Marsh J.W., Shutt K.A., Muto C.A., O'Leary M.M., Saul M.I., et al. High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital. Clin. Infect. Dis. 2009, 48(4):425-429.
    • (2009) Clin. Infect. Dis. , vol.48 , Issue.4 , pp. 425-429
    • Curry, S.R.1    Marsh, J.W.2    Shutt, K.A.3    Muto, C.A.4    O'Leary, M.M.5    Saul, M.I.6
  • 35
    • 84930790137 scopus 로고    scopus 로고
    • Burden of Clostridium difficile infection between 2010 and 2013: trends and outcomes from an academic center in Eastern Europe
    • Kurti Z., Lovasz B.D., Mandel M.D., Csima Z., Golovics P.A., Csako B.D., et al. Burden of Clostridium difficile infection between 2010 and 2013: trends and outcomes from an academic center in Eastern Europe. World J. Gastroenterol. 2015, 21(21):6728-6735.
    • (2015) World J. Gastroenterol. , vol.21 , Issue.21 , pp. 6728-6735
    • Kurti, Z.1    Lovasz, B.D.2    Mandel, M.D.3    Csima, Z.4    Golovics, P.A.5    Csako, B.D.6
  • 36
    • 84904044730 scopus 로고    scopus 로고
    • Clostridium difficile infection in hospitalized patients at a Czech tertiary center: analysis of epidemiology, clinical features, and risk factors of fulminant course
    • Balihar K., Kozak F., Kozeluhova J., Hejda V., Fremundova L., Krcma M., et al. Clostridium difficile infection in hospitalized patients at a Czech tertiary center: analysis of epidemiology, clinical features, and risk factors of fulminant course. Eur. J. Gastroenterol. Hepatol. 2014, 26(8):880-887.
    • (2014) Eur. J. Gastroenterol. Hepatol. , vol.26 , Issue.8 , pp. 880-887
    • Balihar, K.1    Kozak, F.2    Kozeluhova, J.3    Hejda, V.4    Fremundova, L.5    Krcma, M.6
  • 37
    • 84905698905 scopus 로고    scopus 로고
    • First clinical and microbiological characterization of Clostridium difficile infection in a Croatian University Hospital
    • Novak A., Spigaglia P., Barbanti F., Goic-Barisic I., Tonkic M. First clinical and microbiological characterization of Clostridium difficile infection in a Croatian University Hospital. Anaerobe 2014, 30:18-23.
    • (2014) Anaerobe , vol.30 , pp. 18-23
    • Novak, A.1    Spigaglia, P.2    Barbanti, F.3    Goic-Barisic, I.4    Tonkic, M.5
  • 38
    • 84936751435 scopus 로고    scopus 로고
    • Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality
    • Rao K., Micic D., Natarajan M., Winters S., Kiel M.J., Walk S.T., et al. Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Clin. Infect. Dis. 2015, 61(2):233-241.
    • (2015) Clin. Infect. Dis. , vol.61 , Issue.2 , pp. 233-241
    • Rao, K.1    Micic, D.2    Natarajan, M.3    Winters, S.4    Kiel, M.J.5    Walk, S.T.6


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