Automatic Control of Gene Expression in Mammalian Cells

ACS Synthetic Biology

Volumn 5, Issue 4, 2016, Pages 296-302

  Fracassi, Chiara ^a   Postiglione, Lorena ^a,b   Fiore, Gianfranco ^a   Di Bernardo, Diego ^a,b  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

control engineering; gene expression; mammalian cell; microfluidics; synthetic biology

Indexed keywords

DOXYCYCLINE; TETRACYCLINE; TRANSACTIVATOR PROTEIN; YELLOW FLUORESCENT PROTEIN; BACTERIAL PROTEIN; PHOTOPROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ANIMAL CELL; ARTICLE; CHO CELL LINE; COMPUTER MODEL; CONTROLLED STUDY; FEEDBACK SYSTEM; FLUORESCENCE MICROSCOPY; GENE DOSAGE; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; MAMMAL CELL; MICROFLUIDICS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SYNTHETIC BIOLOGY; ALGORITHM; ANIMAL; CRICETULUS; CYTOMEGALOVIRUS; GENE EXPRESSION; GENETICS; HAMSTER; METABOLISM; REPORTER GENE; TIME LAPSE IMAGING;

ALGORITHMS; ANIMALS; BACTERIAL PROTEINS; CHO CELLS; CRICETINAE; CRICETULUS; CYTOMEGALOVIRUS; GENE EXPRESSION; GENES, REPORTER; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; PROMOTER REGIONS, GENETIC; TIME-LAPSE IMAGING; TRANS-ACTIVATORS;

EID: 84966351263     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.5b00141     Document Type: Article

References (15)

1. Grodins, F. S., Gray, J. S., Schroeder, K. R., Norins, A. L., and Jones, R. W. (1954) Respiratory responses to CO2 inhalation. A theoretical study of a nonlinear biological regulator J. Appl. Physiol. 7, 283-308
2. Milias-Argeitis, A., Summers, S., Stewart-Ornstein, J., Zuleta, I., Pincus, D., El-Samad, H., Khammash, M., and Lygeros, J. (2011) In silico feedback for in vivo regulation of a gene expression circuit Nat. Biotechnol. 29, 1114-6 10.1038/nbt.2018
3. Ulhendorf, J., Miermont, A., Delaveau, T., Chavrin, G., Fages, F., Bottani, S., Batt, G., and Hersen, P. (2012) Long-term model predictive control of gene expression at the population and single-cell levels Proc. Natl. Acad. Sci. U. S. A. 109, 14271-6 10.1073/pnas.1206810109
4. Menolascina, F., Fiore, G., Orabona, E., De Stefano, L., Ferry, M., Hasty, J., di Bernardo, M., and di Bernardo, D. (2014) In-vivo real-time control of protein expression from endogenous and synthetic gene networks PLoS Comput. Biol. 10, e1003625 10.1371/journal.pcbi.1003625
5. Toettcher, J. E., Gong, D., Lim, W. a., and Weiner, O. D. (2011) Light-based feedback for controlling intracellular signaling dynamics Nat. Methods 8, 837-9 10.1038/nmeth.1700
6. Darzacq, X., Shav-Tal, Y., de Turris, V., Brody, Y., Shenoy, S. M., Phair, R. D., and Singer, R. H. (2007) In vivo dynamics of RNA polymerase II transcription Nat. Struct. Mol. Biol. 14, 796-806 10.1038/nsmb1280
7. Kolnik, M., Tsimring, L. S., and Hasty, J. (2012) Vacuum-assisted cell loading enables shear-free mammalian microfluidic culture Lab Chip 12, 4732-7 10.1039/c2lc40569e
8. Siciliano, V., Menolascina, F., Marucci, L., Fracassi, C., Garzilli, I., Moretti, M. N., and di Bernardo, D. (2011) Construction and Modelling of an Inducible Positive Feedback Loop Stably Integrated in a Mammalian Cell-Line PLoS Comput. Biol. 7, e1002074 10.1371/journal.pcbi.1002074
9. Tigges, M., Marquez-Lago, T. T., Stelling, J., and Fussenegger, M. (2009) A tunable synthetic mammalian oscillator Nature 457, 309-12 10.1038/nature07616
10. Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters Proc. Natl. Acad. Sci. U. S. A. 89, 5547-51 10.1073/pnas.89.12.5547
11. Gossen, M., Bonin, a. L., Freundlieb, S., and Bujard, H. (1994) Inducible gene expression systems for higher eukaryotic cells Curr. Opin. Biotechnol. 5, 516-520 10.1016/0958-1669(94)90067-1
12. Åström, K. J. and Murray, R. M. (2010) Feedback Systems: An Introduction for Scientists and Engineers, Princeton University Press, Princeton, NJ.
13. Tsypkin, I. Z. (1984) Relay Control Systems, Cambridge University Press, Cambridge, U.K.
14. Hirata, Y., di Bernardo, M., Bruchovsky, N., and Aihara, K. (2010) Hybrid optimal scheduling for intermittent androgen suppression of prostate cancer Chaos 20, 045125 10.1063/1.3526968
15. Siciliano, V., Garzilli, I., Fracassi, C., Criscuolo, S., Ventre, S., and di Bernardo, D. (2013) MiRNAs confer phenotypic robustness to gene networks by suppressing biological noise Nat. Commun. 4, 2364 10.1038/ncomms3364