Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats

International Journal of Endocrinology

Volumn 2016, Issue , 2016, Pages

  Demir, Şule ^a   Ünübol, Mustafa ^a   Aypak, Serap Ünübol ^a   Ipek, Emrah ^a   Aktaş, Serdar ^a   Ekren, Gamze Sevri ^a   Yilmaz, Murat ^a   Tunca, Recai ^a   Güney, Engin ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUCOSE; HEMATOXYLIN; HIGH DENSITY LIPOPROTEIN; INSULIN; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; THIAMAZOLE; THYROTROPIN; THYROXINE; TRIACYLGLYCEROL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BIOCHEMICAL ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; HYPOTHYROIDISM; LIOTHYRONINE BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER BIOPSY; MALE; NONALCOHOLIC FATTY LIVER; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84965139151     PISSN: 16878337     EISSN: 16878345     Source Type: Journal    
DOI: 10.1155/2016/5083746     Document Type: Article

References (57)

1. M. A. Michalaki, A. G. Vagenakis, A. S. Leonardou et al., "Thyroid function in humans with morbid obesity, " Thyroid, vol. 16, no. 1, pp. 73-78, 2006.
2. Y. Raftopoulos, D. J. Gagné, P. Papasavas et al., "Improvement of hypothyroidism after laparoscopic Roux-en-Y gastric bypass for morbid obesity, " Obesity Surgery, vol. 14, no. 4, pp. 509-513, 2004.
3. T. Tzotzas, G. E. Krassas, T. Konstantinidis, and M. Bougoulia, "Changes in lipoprotein(a) levels in overt and subclinical hypothyroidism before and during treatment, " Thyroid, vol. 10, no. 9, pp. 803-808, 2000.
4. Z. Efstathiadou, S. Bitsis, H. J. Milionis et al., "Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?" European Journal of Endocrinology, vol. 145, no. 6, pp. 705-710, 2001.
5. K. Te Sligte, I. Bourass, J. P. Sels, A. Driessen, R. W. Stockbrugger, and G. H. Koek, "Non-alcoholic steatohepatitis: review of a growing medical problem, " European Journal of Internal Medicine, vol. 15, no. 1, pp. 10-21, 2004.
6. S. K. Erickson, "Nonalcoholic fatty liver disease, " Journal of Lipid Research, vol. 50, supplement, pp. 412-416, 2009.
7. G. Pagano, G. Pacini, G. Musso et al., "Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association, " Hepatology, vol. 35, no. 2, pp. 367-372, 2002.
8. A. Eshraghian and A. H. Jahromi, "Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic review, " World Journal of Gastroenterology, vol. 20, no. 25, pp. 8102-8109, 2014.
9. J. Zhang, H. Sun, L. Chen et al., "Relationship between serum TSH level with obesity and NAFLD in euthyroid subjects, " Journal of Huazhong University of Science and Technology: Medical Science, vol. 32, no. 1, pp. 47-52, 2012.
10. L. Carulli, S. Ballestri, A. Lonardo et al., "Is nonalcoholic steatohepatitis associated with a high-though-normal thyroid stimulating hormone level and lower cholesterol levels?" Internal and Emergency Medicine, vol. 8, no. 4, pp. 297-305, 2013.
11. A. Eshraghian, M. H. Dabbaghmanesh, H. Eshraghian, M. R. Fattahi, and G. R. Omrani, "Nonalcoholic fatty liver disease in a cluster of Iranian population: thyroid status and metabolic risk factors, " Archives of Iranian Medicine, vol. 16, no. 10, pp. 584-589, 2013.
12. T. Ittermann, R. Haring, H. Wallaschofski et al., "Inverse association between serumfree thyroxine levels and hepatic steatosis: results from the study of health in pomerania, " Thyroid, vol. 22, no. 6, pp. 568-574, 2012.
13. G. E. Chung, D. Kim, W. Kim et al., "Non-alcoholic fatty liver disease across the spectrum of hypothyroidism, " Journal of Hepatology, vol. 57, no. 1, pp. 150-156, 2012.
14. C. MacNabb, E. O'Hare, J. Cleary, and A. P. Georgopoulos, "Varied duration of congenital hypothyroidism potentiates perseveration in a response alternation discrimination task, " Neuroscience Research, vol. 36, no. 2, pp. 121-127, 2000.
15. L. L. Bernardis and B. D. Patterson, "Correlation between "Lee index" and carcass fat content in weanling and adult female rats with hypothalamic lesions, " Journal of Endocrinology, vol. 40, no. 4, pp. 527-528, 1968.
16. C. Ruehl-Fehlert, B. Kittel, G. Morawietz et al., "Revised guides for organ sampling and trimming in rats and mice-part 1: A joint publication of the RITA and NACAD groups, " Experimental and Toxicologic Pathology, vol. 55, no. 2-3, pp. 91-106, 2003.
17. C. L. Scudamore, "Acquiring, recording, and analyzing pathology data from experimental mice: An overview, " Current Protocols in Mouse Biology, vol. 4, no. 1, pp. 1-10, 2014.
18. S. Liangpunsakul and N. Chalasani, "Is hypothyroidism a risk factor for non-alcoholic steatohepatitis?" Journal of Clinical Gastroenterology, vol. 37, no. 4, pp. 340-343, 2003.
19. M. G. Silveira, F. D. Mendes, N. N. Diehl, F. T. Enders, and K. D. Lindor, "Thyroid dysfunction in primary biliary cirrhosis, primary sclerosing cholangitis and non-alcoholic fatty liver disease, " Liver International, vol. 29, no. 7, pp. 1094-1100, 2009.
20. M. R. Pagadala, C. O. Zein, S. Dasarathy, L. M. Yerian, R. Lopez, and A. J. McCullough, "Prevalence of hypothyroidism in nonalcoholic fatty liver disease, " Digestive Diseases and Sciences, vol. 57, no. 2, pp. 528-534, 2012.
21. P. Parikh, A. Phadke, and P. Sawant, "Prevalence of hypothyroidism in nonalcoholic fatty liver disease in patients attending a tertiary hospital in western India, " Indian Journal of Gastroenterology, vol. 34, no. 2, pp. 169-173, 2015.
22. D. F. D. C. Mazo, V. M. R. de Lima, J. T. Stefano, F. Rabelo, J. Faintuch, and C. P. de Oliveira, "Gluco-lipidic indices in treated hypothyroidism associated with nonalcoholic fatty liver disease, " Arquivos de Gastroenterologia, vol. 48, no. 3, pp. 186-189, 2011.
23. L. Xu, H. Ma, M. Miao, and Y. Li, "Impact of subclinical hypothyroidism on the development of non-alcoholic fatty liver disease: A prospective case-control study, " Journal ofHepatology, vol. 57, no. 5, pp. 1153-1154, 2012.
24. J.-W. Park, G. Jeong, S. J. Kim, M. K. Kim, and S. M. Park, "Predictors reflecting the pathological severity of non-alcoholic fatty liver disease: comprehensive study of clinical andimmunohistochemical findings in younger Asian patients, " Journal of Gastroenterology and Hepatology, vol. 22, no. 4, pp. 491-497, 2007.
25. M. Moretto, C. Kupski, C. C. Mottin et al., "Hepatic steatosis in patients undergoing bariatric surgery and its relationship to body mass index and co-morbidities, " Obesity Surgery, vol. 13, no. 4, pp. 622-624, 2003.
26. P.-J. Hsiao, K.-K. Kuo, S.-J. Shin et al., "Significant correlations between severe fatty liver and risk factors for metabolic syndrome, " Journal of Gastroenterology and Hepatology, vol. 22, no. 12, pp. 2118-2123, 2007.
27. M. Machado, P. Marques-Vidal, and H. Cortez-Pinto, "Hepatic histology in obese patients undergoing bariatric surgery, " Journal of Hepatology, vol. 45, no. 4, pp. 600-606, 2006.
28. N. Knudsen, P. Laurberg, L. B. Rasmussen et al., "Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population, " Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 7, pp. 4019-4024, 2005.
29. A. Nyrnes, R. Jorde, and J. Sundsfjord, "Serum TSHis positively associated with BMI, " International Journal of Obesity, vol. 30, no. 1, pp. 100-110, 2006.
30. A. J. Hulbert, "Thyroid hormones and their effects: A new perspective, " Biological Reviews of the Cambridge Philosophical Society, vol. 75, no. 4, pp. 519-631, 2000.
31. L. H. Duntas, "Thyroid disease and lipids, " Thyroid, vol. 12, no. 4, pp. 287-293, 2002.
32. L. Tian, C. Gao, J. Liu, and X. Zhang, "Increased carotid arterial stiffness in subclinical hypothyroidism, " European Journal of Internal Medicine, vol. 21, no. 6, pp. 560-563, 2010.
33. M. Unubol, U. Eryilmaz, E. Guney, C. Akgullu, and I. K. Omurlu, "Epicardial adipose tissue in patients with subclinical hypothyroidism, " Minerva Endocrinologica, vol. 39, no. 2, pp. 135-140, 2014.
34. E. E. Türemen, B. ç etinarslan, T. Şahin, Z. Cantürk, and I. Tarkun, "Endothelial dysfunction and low grade chronic inflammation in subclinical hypothyroidism due to autoimmune thyroiditis, " Endocrine Journal, vol. 58, no. 5, pp. 349-354, 2011.
35. E. Fabbrini, F. Magkos, B. W. Patterson, B. Mittendorfer, and S. Klein, "Subclinical hypothyroidism and hyperthyroidism have opposite effects on hepatic very low density lipoprotein triglyceride kinetics, " The Journal of Clinical Endocrinology & Metabolism, vol. 97, no. 3, pp. 414-418, 2012.
36. S.-Y. Lin, Y.-Y. Wang, P.-H. Liu, W.-A. Lai, and W. H.-H. Sheu, "Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population, " Metabolism: Clinical and Experimental, vol. 54, no. 11, pp. 1524-1528, 2005.
37. H. S. Shon, E. D. Jung, S. H. Kim, and J. H. Lee, "Free T4 is negatively correlated with body mass index in euthyroid women, " Korean Journal of Internal Medicine, vol. 23, no. 2, pp. 53-57, 2008.
38. I. J. Goldberg and H. N. Ginsberg, "Ins and outs modulating hepatic triglyceride and development of nonalcoholic fatty liver disease, " Gastroenterology, vol. 130, no. 4, pp. 1343-1346, 2006.
39. P. Puri, R. A. Baillie, M. M. Wiest et al., "A lipidomic analysis of nonalcoholic fatty liver disease, " Hepatology, vol. 46, no. 4, pp. 1081-1090, 2007.
40. G. Musso, R. Gambino, and M. Cassader, "Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD), " Progress in Lipid Research, vol. 48, no. 1, pp. 1-26, 2009.
41. E. E. Cable, P. D. Finn, J. W. Stebbins et al., "Reduction of hepatic steatosis in rats and mice after treatment with a liver-targeted thyroid hormone receptor agonist, " Hepatology, vol. 49, no. 2, pp. 407-417, 2009.
42. L. L. Stein, M. H. Dong, and R. Loomba, "Insulin sensitizers in nonalcoholic fatty liver disease and steatohepatitis: current status, " Advances inTherapy, vol. 26, no. 10, pp. 893-907, 2009.
43. I. Kowalska, J. Borawski, A. Nikoajuk et al., "Insulin sensitivity, plasma adiponectin and sICAM-1 concentrations in patients with subclinical hypothyroidism: response to levothyroxine therapy, " Endocrine, vol. 40, no. 1, pp. 95-101, 2011.
44. M. J. Smithson, "Screening for thyroid dysfunction in a community population of diabetic patients, " Diabetic Medicine, vol. 15, no. 2, pp. 148-150, 1998.
45. N. Gronich, S. N. Deftereos, I. Lavi, A. S. Persidis, D. R. Abernethy, and G. Rennert, "Hypothyroidismis a risk factor fornewonset diabetes: A cohort study, " Diabetes Care, vol. 38, no. 9, pp. 1657-1664, 2015.
46. G. Musso, R. Gambino, M. Durazzo et al., "Adipokines in NASH: postprandial lipid metabolism as a link between adiponectin and liver disease, " Hepatology, vol. 42, no. 5, pp. 1175-1183, 2005.
47. M. H. Jarrar, A. Baranova, R. Collantes et al., "Adipokines and cytokines in non-alcoholic fatty liver disease, " Alimentary Pharmacology andTherapeutics, vol. 27, no. 5, pp. 412-421, 2008.
48. D. G. Haider, G. Schaller, S. Kapiotis, C. Maier, A. Luger, and M. Wolzt, "The release of the adipocytokine visfatin is regulated by glucose and insulin, " Diabetologia, vol. 49, no. 8, pp. 1909-1914, 2006.
49. M.-P. Chen, F.-M. Chung, D.-M. Chang et al., "Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus, " Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 1, pp. 295-299, 2006.
50. D. G. Haider, K. Schindler, G. Schaller, G. Prager, M. Wolzt, and B. Ludvik, "Increased plasma visfatin concentrations in morbidly obese subjects are reduced after gastric banding, " Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 4, pp. 1578-1581, 2006.
51. R. Aller, D. A. de Luis, O. Izaola et al., "Influence of visfatin on histopathological changes of non-alcoholic fatty liver disease, " Digestive Diseases and Sciences, vol. 54, no. 8, pp. 1772-1777, 2009.
52. A. E. Altinova, F. B. TÖrüner, M. Aktürk et al., "Adiponectin levels and cardiovascular risk factors in hypothyroidism and hyperthyroidism, " Clinical Endocrinology, vol. 65, no. 4, pp. 530-535, 2006.
53. C. N. Aragão, L. L. Souza, A. Cabanelas, K. J. Oliveira, and C. C. Pazos-Moura, "Effect of experimental hypo-and hyperthyroidism on serum adiponectin, " Metabolism, vol. 56, no. 1, pp. 6-11, 2007.
54. M. Ozkaya, M. Sahin, E. Cakal et al., "Visfatin plasma concentrations in patients with hyperthyroidism and hypothyroidism before and after control of thyroid function, " Journal of Endocrinological Investigation, vol. 32, no. 5, pp. 435-439, 2009.
55. A. Caixàs, R. Tirado, J. Vendrell et al., "Plasma visfatin concentrations increase in both hyper and hypothyroid subjects after normalization of thyroid function and are not related to insulin resistance, anthropometric or inflammatory parameters, " Clinical Endocrinology, vol. 71, no. 5, pp. 733-738, 2009.
56. M. Tanaka, M. Nozaki, A. Fukuhara et al., "Visfatin is released from 3T3-L1 adipocytes via a non-classical pathway, " Biochemical and Biophysical Research Communications, vol. 359, no. 2, pp. 194-201, 2007.
57. R. MacLaren, W. Cui, and K. Cianflone, "Visfatin expression is hormonally regulated by metabolic and sex hormones in 3T3-L1 pre-adipocytes and adipocytes, " Diabetes, Obesity & Metabolism, vol. 9, no. 4, pp. 490-497, 2007.