Interleukin-2/Anti-Interleukin-2 Immune Complex Attenuates Cardiac Remodeling after Myocardial Infarction through Expansion of Regulatory T Cells

Journal of Immunology Research

Volumn 2016, Issue , 2016, Pages

  Zeng, Zhipeng ^a,b   Yu, Kunwu ^a   Chen, Long ^a   Li, Weihua ^b   Xiao, Hong ^c   Huang, Zhengrong ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^c Dept of Hand Surgery   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; CD4 ANTIGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; MESSENGER RNA; MULTIPROTEIN COMPLEX; RECOMBINANT INTERLEUKIN 1 JES 6 1 COMPLEX; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; ANTIBODY; ANTIGEN ANTIBODY COMPLEX; AUTACOID; BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIAC MUSCLE CELL; CD4+ T LYMPHOCYTE; CELL EXPANSION; CONTROLLED STUDY; GENE EXPRESSION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHENOTYPE; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; TRANSTHORACIC ECHOCARDIOGRAPHY; TUNEL ASSAY; WOUND HEALING; ANIMAL; ANTIGEN ANTIBODY COMPLEX; CARDIAC MUSCLE; DISEASE MODEL; ECHOCARDIOGRAPHY; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; PATHOPHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; APOPTOSIS; BIOMARKERS; CYTOKINES; DISEASE MODELS, ANIMAL; ECHOCARDIOGRAPHY; GENE EXPRESSION; IMMUNOPHENOTYPING; INFLAMMATION MEDIATORS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MALE; MICE; MYOCARDIAL INFARCTION; MYOCARDIUM; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84965130961     PISSN: 23148861     EISSN: 23147156     Source Type: Journal    
DOI: 10.1155/2016/8493767     Document Type: Article

References (33)

1. A. L. Bui, T. B. Horwich, and G. C. Fonarow, "Epidemiology and risk profile of heart failure, " Nature Reviews Cardiology, vol. 8, no. 1, pp. 30-41, 2011.
2. M. G. Sutton and N. Sharpe, "Left ventricular remodeling after myocardial infarction: pathophysiology and therapy, " Circulation, vol. 101, no. 25, pp. 2981-2988, 2000.
3. J. Weirather, U. D. W. Hofmann, N. Beyersdorf et al., "Foxp3+ CD4+ T cells improve healing after myocardial infarction by modulating monocyte/macrophage differentiation, " Circulation Research, vol. 115, no. 1, pp. 55-67, 2014.
4. T.-T. Tang, J. Yuan, Z.-F. Zhu et al., "Regulatory T cells ameliorate cardiac remodeling after myocardial infarction, " Basic Research in Cardiology, vol. 107, no. 1, p. 232, 2012.
5. N. Xia, J. Jiao, T.-T. Tang et al., "Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism, " Clinical Science, vol. 128, no. 10, pp. 679-693, 2015.
6. K. Matsumoto, M. Ogawa, J.-I. Suzuki, Y. Hirata, R. Nagai, and M. Isobe, "Regulatory T lymphocytes attenuatemyocardial infarction-induced ventricular remodeling in mice, " International Heart Journal, vol. 52, no. 6, pp. 382-387, 2011.
7. P. Trzonkowski, R. Bacchetta, M. Battaglia et al., "Hurdles in therapy with regulatory T cells, " Science TranslationalMedicine, vol. 7, no. 304, Article ID 304ps18, 2015.
8. T. Hünig, "The storm has cleared: lessons from the CD28 superagonist TGN1412 trial, " Nature Reviews Immunology, vol. 12, no. 5, pp. 317-318, 2012.
9. P. Tabares, S. Berr, P. S. Römer et al., "Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08, " European Journal of Immunology, vol. 44, no. 4, pp. 1225-1236, 2014.
10. T. N. Dinh, T. S. Kyaw, P. Kanellakis et al., "Cytokine therapy with interleukin-2/anti-interleukin-2monoclonal antibody complexes expands CD4+CD25+Foxp3+ regulatory T cells and attenuates development and progression of atherosclerosis, " Circulation, vol. 126, no. 10, pp. 1256-1266, 2012.
11. K. E. Webster, S. Walters, R. E. Kohler et al., "In vivo expansion of t reg cells with il-2-mab complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression, " Journal of Experimental Medicine, vol. 206, no. 4, pp. 751-760, 2009.
12. M.-G. Kim, T. Y. Koo, J.-J. Yan et al., "IL-2/anti-IL-2 complex attenuates renal ischemia-reperfusion injury through expansion of regulatory T cells, " Journal of the American Society of Nephrology, vol. 24, no. 10, pp. 1529-1536, 2013.
13. K. Yodoi, T. Yamashita, N. Sasaki et al., "Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice, " Hypertension, vol. 65, no. 4, pp. 889-895, 2015.
14. J. B. Spangler, J. Tomala, V. C. Luca et al., "Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms, " Immunity, vol. 42, no. 5, pp. 815-825, 2015.
15. U. Hofmann, N. Beyersdorf, J. Weirather et al., "Activation of CD4 + T lymphocytes improves wound healing and survival after experimental myocardial infarction in mice, " Circulation, vol. 125, no. 13, pp. 1652-1663, 2012.
16. A. V. Finsen, G. Christensen, and I. Sjaastad, "Echocardiographic parameters discriminating myocardial infarction with pulmonary congestion from myocardial infarction without congestion in the mouse, " Journal of Applied Physiology, vol. 98, no. 2, pp. 680-689, 2005.
17. C. Wu, S. He, Y. Peng et al., "TSLPR deficiency attenuates atherosclerotic lesion development associated with the inhibition of TH17 cells and the promotion of regulator T cells in ApoE-deficient mice, " Journal of Molecular and Cellular Cardiology, vol. 76, pp. 33-45, 2014.
18. K. J. Livak and T. D. Schmittgen, "Analysis of relative gene expression data using real-time quantitative PCRand the 2 ?T method, " Methods, vol. 25, no. 4, pp. 402-408, 2001.
19. H. Methe, S. Brunner, D. Wiegand, M. Nabauer, J. Koglin, and E. R. Edelman, "Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes, " Journal of the American College of Cardiology, vol. 45, no. 12, pp. 1939-1945, 2005.
20. X. Cheng, X. Yu, Y. J. Ding et al., "The Th17/Treg imbalance in patients with acute coronary syndrome, " Clinical Immunology, vol. 127, no. 1, pp. 89-97, 2008.
21. S. K. Biswas, M. Chittezhath, I. N. Shalova, and J.-Y. Lim, "Macrophage polarization and plasticity in health and disease, " Immunologic Research, vol. 53, no. 1-3, pp. 11-24, 2012.
22. E. M. Shevach, "Application of IL-2 therapy to target T regulatory cell function, " Trends in Immunology, vol. 33, no. 12, pp. 626-632, 2012.
23. J. Koreth, K.-I. Matsuoka, H. T. Kim et al., "Interleukin-2 and regulatoryTcells in graft-versus-host disease, "TheNewEngland Journal of Medicine, vol. 365, no. 22, pp. 2055-2066, 2011.
24. D. Saadoun, M. Rosenzwajg, F. Joly et al., "Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis, " The New England Journal of Medicine, vol. 365, no. 22, pp. 2067-2077, 2011.
25. O. Boyman, M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent, "Selective stimulation of T cell subsets with antibodycytokine immune complexes, " Science, vol. 311, no. 5769, pp. 1924-1927, 2006.
26. T. Barhoumi, D. A. Kasal, M. W. Li et al., "T Regulatory lymphocytes prevent angiotensin II-induced hypertension and vascular injury, " Hypertension, vol. 57, no. 3, pp. 469-476, 2011.
27. U. Hofmann and S. Frantz, "Role of lymphocytes in myocardial injury, healing, and remodeling after myocardial infarction, " Circulation Research, vol. 116, no. 2, pp. 354-367, 2015.
28. T. Weinberger and C. Schulz, "Myocardial infarction: A critical role of macrophages in cardiac remodeling, " Frontiers in Physiology, vol. 6, article 107, 2015.
29. G. Courties, T. Heidt, M. Sebas et al., "In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing, " Journal of the American College of Cardiology, vol. 63, no. 15, pp. 1556-1566, 2014.
30. T. Harel-Adar, T. B. Mordechai, Y. Amsalem, M. S. Feinberg, J. Leor, and S. Cohen, "Modulation of cardiac macrophages by phosphatidylserine-presenting liposomes improves infarct repair, " Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 5, pp. 1827-1832, 2011.
31. Z. Yang, Y.-J. Day, M.-C. Toufektsian et al., "Myocardial infarctsparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes, " Circulation, vol. 114, no. 19, pp. 2056-2064, 2006.
32. X. Yan, T. Shichita, Y. Katsumata et al., "Deleterious effect of the IL-23/IL-17A axis and T cells on left ventricular remodeling after myocardial infarction, " Journal of the American Heart Association, vol. 1, no. 5, Article ID e004408, 2012.
33. S.-F. Zhou, J. Yuan, M.-Y. Liao et al., "IL-17A promotes ventricular remodeling after myocardial infarction, " Journal of Molecular Medicine, vol. 92, no. 10, pp. 1105-1116, 2014.