Functional analysis of the p.(Leu15Pro) and p.(Gly20Arg) sequence changes in the signal sequence of LDL receptor

Atherosclerosis

Volumn 250, Issue , 2016, Pages 9-14

  Pavloušková, Jana ^a,b   Réblová, Kamila ^b   Tichý, Lukáš ^a   Freiberger, Tomáš ^b,c   Fajkusová, Lenka ^a,b  

^a UNIVERSITY HOSPITAL BRNO   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c CENTRE FOR CARDIOVASCULAR SURGERY AND TRANSPLANTATION   (Czech Republic)

Author keywords

Endoplasmic reticulum; Familial hypercholesterolemia; Fluorescence microscopy; LDL; Modeling; Mutations; Signal sequence

Indexed keywords

ARGININE; GLYCINE; LEUCINE; LOW DENSITY LIPOPROTEIN RECEPTOR; PROLINE; SIGNAL PEPTIDE; LDLR PROTEIN, HUMAN;

ALPHA HELIX; ANIMAL CELL; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; CHO CELL LINE; CONFOCAL MICROSCOPY; CRICETULUS; FAMILIAL HYPERCHOLESTEROLEMIA; GENETICS; HAMSTER; HETEROZYGOTE; HUMAN; METABOLISM; MUTATION; PEDIGREE; PROTEIN SECONDARY STRUCTURE;

ANIMALS; ARGININE; CHO CELLS; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM; GLYCINE; HETEROZYGOTE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; LEUCINE; MICROSCOPY, CONFOCAL; MUTATION; PEDIGREE; PROLINE; PROTEIN FOLDING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, LDL;

EID: 84965126087     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2016.04.022     Document Type: Article

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