Performing Survival Analyses in the Presence of Competing Risks: A Clinical Example in Older Breast Cancer Patients

Journal of the National Cancer Institute

Volumn 108, Issue 5, 2016, Pages

  De Glas, Nienke A ^a   Kiderlen, Mandy ^a   Vandenbroucke, Jan P ^a   De Craen, Anton J M ^a   Portielje, Johanneke E A ^b   Van De Velde, Cornelis J H ^a   Liefers, Gerrit Jan ^a   Bastiaannet, Esther ^a   Le Cessie, Saskia ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HAGA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER; CANCER INCIDENCE; CANCER PATIENT; CANCER PROGNOSIS; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CARDIOVASCULAR DISEASE; CAUSE SPECIFIC SURVIVAL; CONCEPTUAL FRAMEWORK; DEMENTIA; DISTANT METASTASIS; GROUPS BY AGE; HEART INFARCTION; HUMAN; KAPLAN MEIER METHOD; LYMPH NODE METASTASIS; MENTAL DISEASE; NOTE; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; RISK ASSESSMENT; STATISTICAL ANALYSIS; SURVIVAL TIME; AGED; BREAST NEOPLASMS; CANCER GRADING; COMORBIDITY; DISEASE FREE SURVIVAL; FEMALE; INCIDENCE; MIDDLE AGED; MORTALITY; PATHOLOGY; PREDICTIVE VALUE; RISK FACTOR; STATISTICAL MODEL; TUMOR RECURRENCE;

AGED; BREAST NEOPLASMS; COMORBIDITY; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INCIDENCE; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; MODELS, STATISTICAL; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; PROPORTIONAL HAZARDS MODELS; RISK ASSESSMENT; RISK FACTORS;

EID: 84965088727     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djv366     Document Type: Note

References (20)

1. de Glas NA, Hamaker ME, Kiderlen M, et al. Choosing relevant endpoints for older breast cancer patients in clinical trials: an overview of all current clinical trials on breast cancer treatment. Breast Cancer Res Treat. 2014;146(3):591-597.
2. Andersen PK, Geskus RB, de WT, Putter H. Competing risks in epidemiology: possibilities and pitfalls. Int J Epidemiol. 2012;41:861-870.
3. Putter H, Fiocco M, Geskus RB. Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 2007;26:2389-2430.
4. Berry SD, Ngo L, Samelson EJ, Kiel DP. Competing risk of death: an important consideration in studies of older adults. J Am Geriatr Soc. 2010;58:783-787.
5. Pallis AG, Ring A, Fortpied C, et al. EORTC workshop on clinical trial methodology in older individuals with a diagnosis of solid tumors. Ann Oncol. 2011;22:1922-1926.
6. van de Water W, Markopoulos C, van de Velde CJ, et al. Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer. JAMA. 2012;307(6):579-597.
7. Bland JM, Altman DG. Survival probabilities (the Kaplan-Meier method). BMJ. 1998;317:1572.
8. Verduijn M, Grootendorst DC, Dekker FW, Jager KJ, le Cessie S. The analysis of competing events like cause-specific mortality - beware of the Kaplan-Meier method. Nephrol Dial Transplant. 2011;26:56-61.
9. Fine JP, Gray RJ. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999;94:496-509.
10. World Health Organisation. The ICD-10 Classification of Mental and Behavioural Disorders. 1992;10(5):1-267.
11. Kiderlen M, de Glas NA, Bastiaannet E, et al. Impact of comorbidity on outcome of older breast cancer patients: a FOCUS cohort study. Breast Cancer Res Treat. 2014;145(1):185-192.
12. Patnaik JL, Byers T, Diguiseppi C, Denberg TD, Dabelea D. The influence of comorbidities on overall survival among older women diagnosed with breast cancer. J Natl Cancer Inst. 2011;103:1101-1111.
13. Engelhardt EG, Garvelink MM, de Haes JH, et al. Predicting and Communicating the Risk of Recurrence and Death in Women With Early-Stage Breast Cancer: A Systematic Review of Risk Prediction Models. J Clin Oncol. 2014;32:238-250.
14. de Glas NA, van de Water W, Engelhardt EG, et al. Validity of Adjuvant! Online program in older patients with breast cancer: a population-based study. Lancet Oncol. 2014;15:722-729.
15. Fleming ID, Cooper JS, Henson DE, et al. AJCC Cancer Staging Manual, fifth edition. 5th ed. Philadelphia, PA: Lippincott-Raven, 1997.
16. de Glas NA, Jonker JM, Bastiaannet E, et al. Impact of omission of surgery on survival of older patients with breast cancer. Br J Surg. 2014;101(11):1397-1404.
17. de Wreede LC, Fiocco M, Putter H. The mstate package for estimation and prediction in non- and semi-parametric multi-state and competing risks models. Comput Methods Programs Biomed. 2010;99:261-274.
18. Therneau. A Package for Survival analysis in R version 2.38; 2015.
19. Grambauer N, Schumacher M, Beyersmann J. Proportional subdistribution hazards modeling offers a summary analysis, even if misspecified. Stat Med. 2010;29:875-884.
20. Beyersmann J, Allignol A, Schumacher M. Competing Risks and Multistate Models with R. Springer Science+Business Media, LLC; 2012