Evaluation of the anticonvulsant activity of the essential oil of Myrothamnus moschatus in convulsion induced by pentylenetetrazole and picrotoxin

Asian Pacific Journal of Tropical Biomedicine

Volumn 6, Issue 6, 2016, Pages 501-505

  Randrianarivo, Emmanuel ^a   Maggi, Filippo ^b   Nicoletti, Marcello ^c   Rasoanaivo, Philippe ^a  

^a Avarabohitra Itaosy   (Madagascar)

^b UNIVERSITY OF CAMERINO   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Convulsions; Essential oil; Myrothamnus moschatus; Pentylenetetrazole; Picrotoxin

Indexed keywords

ANTICONVULSIVE AGENT; DIAZEPAM; ESSENTIAL OIL; MYROTHAMNUS MOSCHATUS EXTRACT; PENTETRAZOLE; PICROTOXIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG DOSE ESCALATION; FEMALE; GABAERGIC SYSTEM; MALE; MEDICINAL PLANT; MORTALITY; MOUSE; MYROTHAMNUS MOSCHATUS; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; TREATMENT OUTCOME; TREATMENT RESPONSE;

EID: 84965071700     PISSN: 22211691     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apjtb.2016.01.017     Document Type: Article

References (23)

1. Ngugi A.K., Bottomley C., Kleinschmidt I., Sande J.W., Newton C.R. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia 2010, 51(5):883-890.
2. Newton C.R., Garcia H.H. Epilepsy in poor regions of the world. Lancet 2012, 380(9848):1193-1201.
3. World Health Organization Epilepsy in the WHO African region: bridging the gap. The global campaign against epilepsy "out of the shadows" 2004, World Health Organization, Geneva, [Online] Available from:, [Accessed on 15th October, 2015]. http://www.who.int/mental_health/management/epilepsy_in_African-region.pdf.
4. Andriantseheno L.M., Ralaizandriny D. Community prevalence of epilepsy in Madagascar. Epilepsies 2004, 16(2):83-86.
5. Carter J.A., Neville B.G.R., White S., Ross A.J., Otieno G., Mturi N., et al. Increased prevalence of epilepsy associated with severe falciparum malaria in children. Epilepsia 2004, 45(8):978-981.
6. Quet F., Guerchet M., Pion S.D.S., Ngoungou E.B., Nicoletti A., Preux P.M. Meta-analysis of the association between cysticercosis and epilepsy in Africa. Epilepsia 2010, 51(5):830-837.
7. Meyer A.C., Dua T., Ma J., Saxena S., Birbeck G. Global disparities in the epilepsy treatment gap: a systematic review. Bull World Health Organ 2010, 88(4):260-266.
8. Ratsimbazafy V., Rakotovao T., Marin B., Javerliat M., Preux P.M. The dangers of inadequate understanding of epilepsy in Madagascar. Lancet Neurol 2012, 11(9):748-749.
9. Rasoanaivo P., Ralaibia E., Maggi F., Papa F., Vittori S., Nicoletti M. Phytochemical investigation of the essential oil from the 'resurrection plant' Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar. J Essent Oil Res 2012, 24(3):299-304.
10. Becker A., Grecksch G., Brosz M. Antiepileptic drugs-their effects on kindled seizures and kindling-induced learning impairments. Pharmacol Biochem Behav 1995, 52(3):453-459.
11. Baskind R., Birbeck G.L. Epilepsy-associated stigma in sub-Saharan Africa: the social landscape of a disease. Epilepsy Behav 2005, 7(1):68-73.
12. Jaseja H. Scientific basis behind traditional practice of application of "shoe-smell" in controlling epileptic seizures in the eastern countries. Clin Neurol Neurosurg 2008, 110(6):535-538.
13. Koutroumanidou E., Kimbaris A., Kortsaris A., Bezirtzoglou E., Polissiou M., Charalabopoulos K., et al. Increased seizure latency and decreased severity of pentylenetetrazol-induced seizures in mice after essential oil administration. Epilepsy Res Treat 2013, 2013.
14. A receptor ligands in pentylenetetrazole-kindled mice. Prog Neuropsychopharmacol Biol Psychiatry 2004, 28(1):105-113.
15. Kaila K., Ruusuvuori E., Seja P., Voipio J., Puskarjov M. GABA actions and ionic plasticity in epilepsy. Curr Opin Neurobiol 2014, 26:34-41.
16. Lasoń W., Chlebicka M., Rejdak K. Research advances in basic mechanisms of seizures and antiepileptic drug action. Pharmacol Rep 2013, 65(4):787-801.
17. Randrianarivo E., Rasoanaivo P., Nicoletti M., Razafimahefa S., Lefebvre M., Papa F., et al. Essential-oil polymorphism in the 'resurrection plant' Myrothamnus moschatus and associated ethnobotanical knowledge. Chem Biodivers 2013, 10(11):1987-1998.
18. A) receptor. Chem Res Toxicol 2013, 26(10):1444-1454.
19. Efron R. The effect of olfactory stimuli in arresting uncinate fits. Brain 1956, 79(2):267-281.
20. Betts T., Fox S., MacCallum R. Using olfactory stimuli to abort or prevent seizures: countermeasure or cue-controlled arousal manipulation? Is there something special about smell?. Epilepsia 1995, 36(Suppl 3):S25.
21. Dailey J.W., Mishra P.K., Ko K.H., Penny J.E., Jobe P.C. Noradrenergic abnormalities in the central nervous system of seizure-naive genetically epilepsy-prone rats. Epilepsia 1991, 32(2):168-173.
22. Ebert U., Löscher W. Strong olfactory stimulation reduces seizure susceptibility in amygdala-kindled rats. Neurosci Lett 2000, 287(3):199-202.
23. Han C.L., Hu W., Stead M., Zhang T., Zhang J.G., Worrell G.A., et al. Electrical stimulation of hippocampus for the treatment of refractory temporal lobe epilepsy. Brain Res Bull 2014, 109:13-21.