Aqueous-based coaxial electrospinning of genetically engineered silk elastin core-shell nanofibers

Materials

Volumn 9, Issue 4, 2016, Pages

  Zhu, Jingxin ^a,b   Huang, Wenwen ^b   Zhang, Qiang ^b,c   Ling, Shengjie ^b,d   Chen, Ying ^b   Kaplan, David L ^b  

^a TAIYUAN UNIVERSITY OF TECHNOLOGY   (China)

^b Tufts University   (United States)

^c WUHAN TEXTILE UNIVERSITY   (China)

^d Massachusetts Institute of Technology   (United States)

Author keywords

Coaxial electrospinning; Core shell structure; Silk fibroin; Silk elastin like protein polymer

Indexed keywords

CROSSLINKING; ELASTIN; ELECTROSPINNING; GLYCOPROTEINS; METHANOL; NANOFIBERS; PROTEINS; SOLUTIONS; SPINNING (FIBERS); TENSILE TESTING;

COAXIAL ELECTROSPINNING; CORE SHELL STRUCTURE; CORE-SHELL NANOFIBERS; ELASTIN-LIKE PROTEINS; NANO-FABRICATION METHODS; PROCESSING PARAMETERS; SECONDARY STRUCTURES; SILK FIBROIN;

SHELLS (STRUCTURES);

EID: 84965071453     PISSN: None     EISSN: 19961944     Source Type: Journal    
DOI: 10.3390/ma9040221     Document Type: Article

References (47)

1. Bhardwaj, N.; Kundu, S.C. Electrospinning: A fascinating fiber fabrication technique. Biotechnol. Adv. 2010, 28, 325-347.
2. Li, H.; Xu, Y.; Xu, H.; Chang, J. Electrospun membranes: Control of the structure and structure related applications in tissue regeneration and drug delivery. J. Mater. Chem. B 2014, 2, 5492-5510.
3. Alessandrino, A.; Marelli, B.; Arosio, C.; Fare, S.; Tanzi, M.C.; Freddi, G. Electrospun silk fibroin mats for tissue engineering. Eng. Life Sci. 2008, 8, 219-225.
4. Li, C.M.; Vepari, C.; Jin, H.J.; Kim, H.J.; Kaplan, D.L. Electrospun silk-BMP-2 scaffolds for bone tissue engineering. Biomaterials 2006, 27, 3115-3124.
5. Vepari, C.; Kaplan, D.L. Silk as a biomaterial. Prog. Polym. Sci. 2007, 32, 991-1007.
6. Hu, X.; Tang-Schomer, M.D.; Huang, W.; Xia, X.-X.; Weiss, A.S.; Kaplan, D.L. Charge-tunable autoclaved silk-tropoelastin protein alloys that control neuron cell responses. Adv. Funct. Mater. 2013, 23, 3875-3884.
7. Jin, H.J.; Fridrikh, S.V.; Rutledge, G.C.; Kaplan, D.L. Electrospinning bombyx mori silk with poly(ethylene oxide). Biomacromolecules 2002, 3, 1233-1239.
8. Zhu, J.; Zhang, Y.; Shao, H.; Hu, X. Electrospinning and rheology of regenerated bombyx mori silk fibroin aqueous solutions: The effects of ph and concentration. Polymer 2008, 49, 2880-2885.
9. Huang, W.; Tarakanova, A.; Dinjaski, N.; Wang, Q.; Xia, X.; Chen, Y.; Wong, J.; Buehler, M.J.; Kaplan, D.L. Design of multi-stimuli responsive hydrogels using integrated modeling and genetically engineered silk-elastin-like-proteins. Adv. Funct. Mater. 2016.
10. Wang, Q.; Xia, X.; Huang, W.; Lin, Y.; Xu, Q.; Kaplan, D.L. High throughput screening of dynamic silk-elastin-like protein biomaterials. Adv. Funct. Mater. 2014, 24, 4303-4310.
11. Xia, X.X.; Xu, Q.B.; Hu, X.; Qin, G.K.; Kaplan, D.L. Tunable self-assembly of genetically engineered silk-elastin-like protein polymers. Biomacromolecules 2011, 12, 3844-3850.
12. Nagarsekar, A.; Crissman, J.; Crissman, M.; Ferrari, F.; Cappello, J.; Ghandehari, H. Genetic engineering of stimuli-sensitive silkelastin-like protein block copolymers. Biomacromolecules 2003, 4, 602-607.
13. Huang, W.; Rollett, A.; Kaplan, D.L. Silk-elastin-like protein biomaterials for the controlled delivery of therapeutics. Expert Opin. Drug Deliv. 2015, 12, 779-791.
14. Xia, X.-X.; Wang, M.; Lin, Y.; Xu, Q.; Kaplan, D.L. Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery. Biomacromolecules 2014, 15, 908-914.
15. Dinerman, A.A.; Cappello, J.; Ghandehari, H.; Hoag, S.W. Swelling behavior of a genetically engineered silk-elastinlike protein polymer hydrogel. Biomaterials 2002, 23, 4203-4210.
16. Teng, W.; Cappello, J.; Wu, X. Recombinant silk-elastinlike protein polymer displays elasticity comparable to elastin. Biomacromolecules 2009, 10, 3028-3036.
17. Golinska, M.D.; Pham, T.T.H.; Werten, M.W.T.; de Wolf, F.A.; Stuart, M.A.C.; van der Gucht, J. Fibril formation by pH and temperature responsive silk-elastin block copolymers. Biomacromolecules 2013, 14, 48-55.
18. Nagarajan, R.; Drew, C.; Mello, C.M. Polymer-micelle complex as an aid to electrospinning nanofibers from aqueous solutions. J. Phys. Chem. C 2007, 111, 16105-16108.
19. Ner, Y.; Stuart, J.A.; Whited, G.; Sotzing, G.A. Electrospinning nanoribbons of a bioengineered silk-elastin-like protein (SELP) from water. Polymer 2009, 50, 5828-5836.
20. Qiu, W.; Huang, Y.; Teng, W.; Cohn, C.M.; Cappello, J.; Wu, X. Complete recombinant silk-elastinlike protein-based tissue scaffold. Biomacromolecules 2010, 11, 3219-3227.
21. Machado, R.; da Costa, A.; Sencadas, V.; Garcia-Arevalo, C.; Costa, C.M.; Padrao, J.; Gomes, A.; Lanceros-Mendez, S.; Carlos Rodriguez-Cabello, J.; Casal, M. Electrospun silk-elastin-like fibre mats for tissue engineering applications. Biomed. Mater. 2013, 8, 1-13.
22. Li, D.; Xia, Y.N. Direct fabrication of composite and ceramic hollow nanofibers by electrospinning. Nano Lett. 2004, 4, 933-938.
23. Li, D.; Babel, A.; Jenekhe, S.A.; Xia, Y.N. Nanofibers of conjugated polymers prepared by electrospinning with a two-capillary spinneret. Adv. Mater. 2004, 16, 2062-2066.
24. Loscertales, I.G.; Barrero, A.; Guerrero, I.; Cortijo, R.; Marquez, M.; Ganan-Calvo, A.M. Micro/nano encapsutation via electrified coaxial liquid jets. Science 2002, 295, 1695-1698.
25. Sun, Z.C.; Zussman, E.; Yarin, A.L.; Wendorff, J.H.; Greiner, A. Compound core-shell polymer nanofibers by co-electrospinning. Adv. Mater. 2003, 15, 1929-1932.
26. Ojha, S.S.; Stevens, D.R.; Hoffman, T.J.; Stano, K.; Klossner, R.; Scott, M.C.; Krause, W.; Clarke, L.I.; Gorga, R.E. Fabrication and characterization of electrospun chitosan nanofibers formed via templating with polyethylene oxide. Biomacromolecules 2008, 9, 2523-2529.
27. Wang, M.; Yu, J.H.; Kaplan, D.L.; Rutledge, G.C. Production of submicron diameter silk fibers under benign processing conditions by two-fluid electrospinning. Macromolecules 2006, 39, 1102-1107.
28. Rockwood, D.N.; Preda, R.C.; Yucel, T.; Wang, X.; Lovett, M.L.; Kaplan, D.L. Materials fabrication from bombyx mori silk fibroin. Nat. Protoc. 2011, 6, 1612-1631.
29. Vaidya, P.; Grove, T.; Edgar, K.J.; Goldstein, A.S. Surface grafting of chitosan shell, polycaprolactone core fiber meshes to confer bioactivity. J. Bioact. Compat. Polym. 2015, 30, 258-274.
30. Huang, Z.M.; Zhang, Y.Z.; Ramakrishna, S.; Lim, C.T. Electrospinning and mechanical characterization of gelatin nanofibers. Polymer 2004, 45, 5361-5368.
31. Wong, S.-C.; Baji, A.; Leng, S. Effect of fiber diameter on tensile properties of electrospun poly(epsilon-caprolactone). Polymer 2008, 49, 4713-4722.
32. Huang, W.W.; Edenzon, K.; Fernandez, L.; Razmpour, S.; Woodburn, J.; Cebe, P. Nanocomposites of poly(vinylidene fluoride) with multiwalled carbon nanotubes. J. Appl. Polym. Sci. 2010, 115, 3238-3248.
33. Wray, L.S.; Hu, X.; Gallego, J.; Georgakoudi, I.; Omenetto, F.G.; Schmidt, D.; Kaplan, D.L. Effect of processing on silk-based biomaterials: Reproducibility and biocompatibility. J. Biomed. Mater. Res. B Appl. Biomater. 2011, 99B, 89-101.
34. Wang, Q.; Yang, Y.; Chen, X.; Shao, Z. Investigation of rheological properties and conformation of silk fibroin in the solution of amimcl. Biomacromolecules 2012, 13, 1875-1881.
35. Hodgkinson, T.; Chen, Y.; Bayat, A.; Yuan, X.-F. Rheology and electrospinning of regenerated bombyx mori silk fibroin aqueous solutions. Biomacromolecules 2014, 15, 1288-1298.
36. Tam, K.C.; Tiu, C. Steady and dynamic shear properties of aqueous polymer-solutions. J. Rheol. 1989, 33, 257-280.
37. Huang, Z.M.; Zhang, Y.Z.; Ramakrishna, S. Double-layered composite nanofibers and their mechanical performance. J. Polym. Sci. B Polym. Phys. 2005, 43, 2852-2861.
38. Yu, J.H.; Fridrikh, S.V.; Rutledge, G.C. Production of submicrometer diameter fibers by two-fluid electrospinning. Adv. Mater. 2004, 16, 1562-1566.
39. Yu, D.-G.; Branford-White, C.J.; Chatterton, N.P.; White, K.; Zhu, L.-M.; Shen, X.-X.; Nie, W. Electrospinning of concentrated polymer solutions. Macromolecules 2010, 43, 10743-10746.
40. Luo, C.J.; Edirisinghe, M. Core-liquid-induced transition from coaxial electrospray to electrospinning of low-viscosity poly(lactide-co-glycolide) sheath solution. Macromolecules 2014, 47, 7930-7938.
41. Zhang, Y.Z.; Huang, Z.M.; Xu, X.J.; Lim, C.T.; Ramakrishna, S. Preparation of core-shell structured PCL-r-gelatin bi-component nanofibers by coaxial electrospinning. Chem. Mater. 2004, 16, 3406-3409.
42. Yu, D.-G.; Branford-White, C.; Bligh, S.W.A.; White, K.; Chatterton, N.P.; Zhu, L.-M. Improving polymer nanofiber quality using a modified co-axial electrospinning process. Macromol. Rapid Commun. 2011, 32, 744-750.
43. Jorgensen, L.; Qvortrup, K.; Chronakis, I.S. Phospholipid electrospun nanofibers: Effect of solvents and co-axial processing on morphology and fiber diameter. RSC Adv. 2015, 5, 53644-53652.
44. Pakravan, M.; Heuzey, M.-C.; Ajji, A. Core-shell structured peo-chitosan nanofibers by coaxial electrospinning. Biomacromolecules 2012, 13, 412-421.
45. Hu, X.; Kaplan, D.; Cebe, P. Determining beta-sheet crystallinity in fibrous proteins by thermal analysis and infrared spectroscopy. Macromolecules 2006, 39, 6161-6170.
46. Huang, W.W.; Krishnaji, S.; Hu, X.; Kaplan, D.; Cebe, P. Heat capacity of spider silk-like block copolymers. Macromolecules 2011, 44, 5299-5309.
47. Huang, W.; Krishnaji, S.; Kaplan, D.; Cebe, P. Thermal analysis of spider silk inspired di-block copolymers in the glass transition region by tmdsc. J. Therm. Anal. Calorim. 2012, 109, 1193-1201.