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Volumn 28, Issue 4, 2016, Pages 269-277

Immune-mediated respiratory adverse events of checkpoint inhibitors

Author keywords

anti CTLA 4; anti PD 1; anti PD L1; checkpoint inhibitors; immune mediated pneumonitis; immunotherapy; toxicity

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNE CHECKPOINT INHIBITOR; RESPIRATORY TRACT AGENT; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY; NIVOLUMAB; PEMBROLIZUMAB;

EID: 84965045436     PISSN: 10408746     EISSN: 1531703X     Source Type: Journal    
DOI: 10.1097/CCO.0000000000000291     Document Type: Review
Times cited : (44)

References (44)
  • 1
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: Back to Virchow
    • London, England
    • Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet (London, England) 2001; 357:539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1    Mantovani, A.2
  • 2
    • 84944472689 scopus 로고    scopus 로고
    • Releasing the brakes on cancer immunotherapy
    • Ribas A. Releasing the brakes on cancer immunotherapy. New Engl J Med 2015; 373:1490-1492.
    • (2015) New Engl J Med , vol.373 , pp. 1490-1492
    • Ribas, A.1
  • 4
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. New Engl J Med 2010; 363:711-723.
    • (2010) New Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 5
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. New Engl J Med 2011; 364:2517-2526.
    • (2011) New Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 6
    • 84943143291 scopus 로고    scopus 로고
    • Current status and future directions of the immune checkpoint inhibitors ipilimumab, pembrolizumab, and nivolumab in oncology
    • Barbee MS, Ogunniyi A, Horvat TZ, Dang TO. Current status and future directions of the immune checkpoint inhibitors ipilimumab, pembrolizumab, and nivolumab in oncology. Annals Pharmacotherapy 2015; 49:907-937.
    • (2015) Annals Pharmacotherapy , vol.49 , pp. 907-937
    • Barbee, M.S.1    Ogunniyi, A.2    Horvat, T.Z.3    Dang, T.O.4
  • 7
    • 84922004360 scopus 로고    scopus 로고
    • Clinical impact of checkpoint inhibitors as novel cancer therapies
    • Shih K, Arkenau HT, Infante JR. Clinical impact of checkpoint inhibitors as novel cancer therapies. Drugs 2014; 74:1993-2013.
    • (2014) Drugs , vol.74 , pp. 1993-2013
    • Shih, K.1    Arkenau, H.T.2    Infante, J.R.3
  • 8
    • 84946221495 scopus 로고    scopus 로고
    • Exploring novel immune-related toxicities and endpoints with immune-checkpoint inhibitors in nonsmall cell lung cancer
    • Chow LQ. Exploring novel immune-related toxicities and endpoints with immune-checkpoint inhibitors in nonsmall cell lung cancer. Am Soc Clin Oncol 2013.
    • (2013) Am Soc Clin Oncol
    • Chow, L.Q.1
  • 9
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012; 12:252-264.
    • (2012) Nat Rev Cancer , vol.12 , pp. 252-264
    • Pardoll, D.M.1
  • 10
    • 84863938356 scopus 로고    scopus 로고
    • Pulmonary sarcoid-like granulomatosis induced by ipilimumab
    • Berthod G, Lazor R, Letovanec I, et al. Pulmonary sarcoid-like granulomatosis induced by ipilimumab. J Clin Oncol 2012; 30:e156-e159.
    • (2012) J Clin Oncol , vol.30 , pp. e156-e159
    • Berthod, G.1    Lazor, R.2    Letovanec, I.3
  • 11
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y, Wood CR, Chernova T, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol 2001; 2:261-268.
    • (2001) Nat Immunol , vol.2 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3
  • 12
    • 84899758346 scopus 로고    scopus 로고
    • RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance
    • Xiao Y, Yu S, Zhu B, et al. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med 2014; 211:943-959.
    • (2014) J Exp Med , vol.211 , pp. 943-959
    • Xiao, Y.1    Yu, S.2    Zhu, B.3
  • 13
    • 84925545111 scopus 로고    scopus 로고
    • Clinical blockade of PD1 and LAG3-potential mechanisms of action
    • Nguyen LT, Ohashi PS. Clinical blockade of PD1 and LAG3-potential mechanisms of action. Nat Rev Immunol 2015; 15:45-56.
    • (2015) Nat Rev Immunol , vol.15 , pp. 45-56
    • Nguyen, L.T.1    Ohashi, P.S.2
  • 15
    • 84937053577 scopus 로고    scopus 로고
    • Anti-PD-1-related pneumonitis during cancer immunotherapy
    • Nishino M, Sholl LM, Hatabu H, et al. Anti-PD-1-related pneumonitis during cancer immunotherapy. New Engl J Med 2015; 373:288-290.
    • (2015) New Engl J Med , vol.373 , pp. 288-290
    • Nishino, M.1    Sholl, L.M.2    Hatabu, H.3
  • 16
    • 84962476269 scopus 로고    scopus 로고
    • Radiographic profiling of immunerelated adverse events in advanced melanoma patients treated with ipilimumab
    • Tirumani SH, Ramaiya NH, Keraliya A, et al. Radiographic profiling of immunerelated adverse events in advanced melanoma patients treated with ipilimumab. Cancer Immunol Res 2015; 3:1185-1192.
    • (2015) Cancer Immunol Res , vol.3 , pp. 1185-1192
    • Tirumani, S.H.1    Ramaiya, N.H.2    Keraliya, A.3
  • 17
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • Ribas A, Kefford R, Marshall MA, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol 2013; 31:616-622.
    • (2013) J Clin Oncol , vol.31 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3
  • 18
    • 84901641673 scopus 로고    scopus 로고
    • Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): A multicentre, randomised, double-blind, phase 3 trial
    • Kwon ED, Drake CG, Scher HI, et al. Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial. Lancet Oncol 2014; 15:700-712.
    • (2014) Lancet Oncol , vol.15 , pp. 700-712
    • Kwon, E.D.1    Drake, C.G.2    Scher, H.I.3
  • 19
    • 61849165013 scopus 로고    scopus 로고
    • CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation
    • Bashey A, Medina B, Corringham S, et al. CTLA4 blockade with ipilimumab to treat relapse of malignancy after allogeneic hematopoietic cell transplantation. Blood 2009; 113:1581-1588.
    • (2009) Blood , vol.113 , pp. 1581-1588
    • Bashey, A.1    Medina, B.2    Corringham, S.3
  • 20
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. New Engl J Med 2015; 373:23-34.
    • (2015) New Engl J Med , vol.373 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 21
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • Postow MA, Chesney J, Pavlick AC, et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. New Engl J Med 2015; 372:2006-2017.
    • (2015) New Engl J Med , vol.372 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 22
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. New Engl J Med 2012; 366:2443-2454.
    • (2012) New Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 23
    • 84912130561 scopus 로고    scopus 로고
    • Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced nonsmall-cell lung cancer (NSCLC): Survival and clinical activity by subgroup analysis
    • Brahmer JR, Horn L, Gandhi L, et al. Nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients (pts) with advanced nonsmall-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis. ASCO Meeting Abstracts 2014; 32 (15-suppl):8112.
    • (2014) ASCO Meeting Abstracts , vol.32 , Issue.15 , pp. 8112
    • Brahmer, J.R.1    Horn, L.2    Gandhi, L.3
  • 24
    • 84907614647 scopus 로고    scopus 로고
    • Safety and clinical activity of MK-3475 in previously treated patients (pts) with nonsmall cell lung cancer (NSCLC)
    • Garon EB, Leighl NB, Rizvi NA, et al. Safety and clinical activity of MK-3475 in previously treated patients (pts) with nonsmall cell lung cancer (NSCLC). ASCO Meeting Abstracts 2014; 32 (15-suppl):8020.
    • (2014) ASCO Meeting Abstracts , vol.32 , Issue.15 , pp. 8020
    • Garon, E.B.1    Leighl, N.B.2    Rizvi, N.A.3
  • 25
    • 84907543029 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts)
    • Ribas A, Hodi FS, Kefford R, et al. Efficacy and safety of the anti-PD-1 monoclonal antibody MK-3475 in 411 patients (pts) with melanoma (MEL). ASCO Meeting Abstracts 2014; 32 (18-suppl):LBA9000.
    • (2014) With Melanoma (MEL). ASCO Meeting Abstracts , vol.32 , Issue.18 , pp. LBA9000
    • Ribas, A.1    Hodi, F.S.2    Kefford, R.3
  • 26
    • 84898973055 scopus 로고    scopus 로고
    • Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab
    • Topalian SL, Sznol M, McDermott DF, et al. Survival, durable tumor remission, and long-term safety in patients with advanced melanoma receiving nivolumab. J Clin Oncol 2014; 32:1020-1030.
    • (2014) J Clin Oncol , vol.32 , pp. 1020-1030
    • Topalian, S.L.1    Sznol, M.2    McDermott, D.F.3
  • 27
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of nonsmall-cell lung cancer
    • Garon EB, Rizvi NA, Hui R, et al. Pembrolizumab for the treatment of nonsmall-cell lung cancer. New Engl J Med 2015; 372:2018-2028.
    • (2015) New Engl J Med , vol.372 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 28
    • 84946607195 scopus 로고    scopus 로고
    • Nivolumab versus everolimus in advanced renal-cell carcinoma
    • Motzer RJ, Escudier B, McDermott DF, et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. New Engl J Med 2015; 373:1803-1813.
    • (2015) New Engl J Med , vol.373 , pp. 1803-1813
    • Motzer, R.J.1    Escudier, B.2    McDermott, D.F.3
  • 29
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigatorchoice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): A randomised, controlled, phase 2 trial
    • Ribas A, Puzanov I, Dummer R, et al. Pembrolizumab versus investigatorchoice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol 2015; 16:908-918.
    • (2015) Lancet Oncol , vol.16 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3
  • 30
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. New Engl J Med 2013; 369: 134-144.
    • (2013) New Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 31
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • Borghaei H, Paz-Ares L, Horn L, et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. New Engl J Med 2015; 373:1627-1639.
    • (2015) New Engl J Med , vol.373 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 32
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • Brahmer J, Reckamp KL, Baas P, et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. New Engl J Med 2015; 373:123-135.
    • (2015) New Engl J Med , vol.373 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 33
    • 84950117835 scopus 로고    scopus 로고
    • Pembrolizumab versus docetaxel for previously treated PD-L1-positive advanced nonsmall-cell lung cancer (KEYNOTE-010): A randomised controlled trial
    • Herbst RS, Baas P, Kim DW, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced nonsmall-cell lung cancer (KEYNOTE-010): a randomised controlled trial. Lancet (London, England) 2015.
    • (2015) Lancet (London England)
    • Herbst, R.S.1    Baas, P.2    Kim, D.W.3
  • 34
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. New Engl J Med 2015; 372:320-330.
    • (2015) New Engl J Med , vol.372 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 35
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • Robert C, Schachter J, Long GV, et al. Pembrolizumab versus ipilimumab in advanced melanoma. New Engl J Med 2015; 372:2521-2532.
    • (2015) New Engl J Med , vol.372 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3
  • 36
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): A randomised, controlled, open-label, phase 3 trial
    • Weber JS, D'Angelo SP, Minor D, et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol 2015; 16:375-384.
    • (2015) Lancet Oncol , vol.16 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3
  • 37
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. New Engl J Med 2012; 366:2455-2465.
    • (2012) New Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 38
    • 84905698694 scopus 로고    scopus 로고
    • Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC)
    • Powles T, Vogelzang N, Fine G, et al. Inhibition of PD-L1 by MPDL3280A and clinical activity in pts with metastatic urothelial bladder cancer (UBC). J Clin Oncology 2014; 32 (15 Suppl):128960-129144.
    • (2014) J Clin Oncology , vol.32 , Issue.15 , pp. 128960-129144
    • Powles, T.1    Vogelzang, N.2    Fine, G.3
  • 39
    • 84907521154 scopus 로고    scopus 로고
    • Preliminary data from a multiarm expansion study ofMEDI4736, an anti-PD-L1 antibody
    • Segal NH, Antonia SJ, Brahmer JR, et al. Preliminary data from a multiarm expansion study ofMEDI4736, an anti-PD-L1 antibody. J Clin Oncol 2014; 32 (15 Suppl):134136-134144.
    • (2014) J Clin Oncol , vol.32 , Issue.15 , pp. 134136-134144
    • Segal, N.H.1    Antonia, S.J.2    Brahmer, J.R.3
  • 40
    • 84944734156 scopus 로고    scopus 로고
    • Safety and clinical activity of MEDI4736 an antiprogrammed cell death-ligand 1 (PD-L1) antibody in patients with nonsmall cell lung cancer (NSCLC)
    • Rizvi NA, Brahmer JR, Ou S-HI, et al., editors. Safety and clinical activity of MEDI4736, an antiprogrammed cell death-ligand 1 (PD-L1) antibody, in patients with nonsmall cell lung cancer (NSCLC). ASCO Annual Meeting Proceedings; 2015.
    • (2015) ASCO Annual Meeting Proceedings
    • Rizvi, N.A.1    Brahmer, J.R.2    S-Hi, O.3
  • 41
    • 85009840975 scopus 로고    scopus 로고
    • Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected nonsmall cell lung cancer (NSCLC)
    • Besse B, Johnson M, Jaenne P, et al. Phase II, single-arm trial (BIRCH) of atezolizumab as first-line or subsequent therapy for locally advanced or metastatic PD-L1-selected nonsmall cell lung cancer (NSCLC). Eur J Cancer 2015.
    • (2015) Eur J Cancer
    • Besse, B.1    Johnson, M.2    Jaenne, P.3
  • 42
    • 84969542128 scopus 로고    scopus 로고
    • Atezolizumab monotherapy vs docetaxel in 2L/3L nonsmall cell lung cancer: Primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR)
    • Vansteenkiste J, Fehrenbacher L, Spira A, et al. Atezolizumab monotherapy vs docetaxel in 2L/3L nonsmall cell lung cancer: Primary analyses for efficacy, safety and predictive biomarkers from a randomized phase II study (POPLAR). Eur J Cancer 2015.
    • (2015) Eur J Cancer
    • Vansteenkiste, J.1    Fehrenbacher, L.2    Spira, A.3
  • 44
    • 78650794568 scopus 로고    scopus 로고
    • An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients
    • Limper AH, Knox KS, Sarosi GA, et al. An official American Thoracic Society statement: treatment of fungal infections in adult pulmonary and critical care patients. Am J Respir Crit Care Med 2011; 183:96-128.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 96-128
    • Limper, A.H.1    Knox, K.S.2    Sarosi, G.A.3


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