Demonstration that the radical s-adenosylmethionine (SAM) Enzyme PqqE catalyzes de novo carbon-carbon cross-linking within a peptide substrate PqqA in the presence of the peptide chaperone PqqD

Journal of Biological Chemistry

Volumn 291, Issue 17, 2016, Pages 8877-8884

  Barr, Ian ^a,b   Latham, John A ^a,b   Iavarone, Anthony T ^a,b   Chantarojsiri, Teera ^a   Hwang, Jennifer D ^a   Klinman, Judith P ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; CHAINS; COVALENT BONDS; ENZYME ACTIVITY; PROTEINS;

BIOSYNTHETIC PATHWAY; CARBON CARBONS; CARBON-CARBON BOND; CARBON-CARBON BOND FORMATION; PEPTIDE SUBSTRATES; PYRROLOQUINOLINE QUINONE; REDUCTION SYSTEMS; S-ADENOSYLMETHIONINE;

PEPTIDES;

CARBON; CHAPERONE; ENZYME; FLAVODOXIN; FLAVODOXIN REDUCTASE; GLUTAMIC ACID; IRON SULFUR PROTEIN; OXIDOREDUCTASE; PQQA PROTEIN; PQQD PROTEIN; PQQE PROTEIN; PYRROLOQUINOLINEQUINONE; S ADENOSYLMETHIONINE; TYROSINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; PQQA PROTEIN, METHYLOBACTERIUM EXTORQUENS; PQQD PROTEIN, METHYLOBACTERIUM EXTORQUENS; PQQE PROTEIN, METHYLOBACTERIUM EXTORQUENS; PROTEINASE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CHEMICAL BOND; CONJUGATION; CONTROLLED STUDY; CROSS LINKING; ENZYME SUBSTRATE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN MODIFICATION; CHEMISTRY; GENETICS; METABOLISM; MYCOBACTERIUM;

BACTERIAL PROTEINS; CATALYSIS; ENDOPEPTIDASES; MYCOBACTERIUM;

EID: 84965043992     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C115.699918     Document Type: Article

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