Effect of Topical and Intravenously Applied Tranexamic Acid Compared to Control Group on Bleeding in Primary Unilateral Total Knee Arthroplasty

Journal of Knee Surgery

Volumn 30, Issue 2, 2017, Pages 152-157

  Uǧurlu, Mahmut ^a   Aksekili, Mehmet Atlf Erol ^a   Çaǧlar, Ceyhun ^a   Yüksel, Kaǧan ^a   Şahin, Ercan ^b   Akyol, Mesut ^a  

^a Ylldlrlm Beyazlt University   (Turkey)

^b ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

Author keywords

hemoglobin; intravenous; topical; total knee arthroplasty; tranexamic acid

Indexed keywords

HEMOGLOBIN; TRANEXAMIC ACID; ANTIFIBRINOLYTIC AGENT;

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; CELLULITIS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; FEMALE; HEART ARRHYTHMIA; HEMOGLOBIN BLOOD LEVEL; HUMAN; LENGTH OF STAY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE HEMORRHAGE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RANDOMIZED CONTROLLED TRIAL; RELIABILITY; SINGLE DRUG DOSE; SURGICAL DRAINAGE; TOTAL KNEE ARTHROPLASTY; TREATMENT OUTCOME; UNILATERAL PRIMARY TOTAL KNEE ARTHROPLASTY; BLOOD LOSS, SURGICAL; COMPARATIVE STUDY; INTRAVENOUS DRUG ADMINISTRATION; KNEE REPLACEMENT; MIDDLE AGED; OSTEOARTHRITIS, KNEE; REPRODUCIBILITY; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, TOPICAL; AGED; ANTIFIBRINOLYTIC AGENTS; ARTHROPLASTY, REPLACEMENT, KNEE; BLOOD LOSS, SURGICAL; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; POSTOPERATIVE HEMORRHAGE; REPRODUCIBILITY OF RESULTS; TRANEXAMIC ACID;

EID: 84965002817     PISSN: 15388506     EISSN: 19382480     Source Type: Journal    
DOI: 10.1055/s-0036-1583270     Document Type: Article

References (26)

1. Hiippala S. T., Strid L. J., Wennerstrand M. I., et al. Tranexamic acid radically decreases blood loss and transfusions associated with total knee arthroplasty. Anesth Analg: 1997; 84 4 839 844
2. Bong M. R., Patel V., Chang E., Issack P. S., Hebert R., Di Cesare P. E. Risks associated with blood transfusion after total knee arthroplasty. J Arthroplasty: 2004; 19 3 281 287
3. Goodnough L. T., Verbrugge D., Marcus R. E. The relationship between hematocrit, blood lost, and blood transfused in total knee replacement. Implications for postoperative blood salvage and reinfusion. Am J Knee Surg: 1995; 8 3 83 87
4. Bower W. F., Jin L., Underwood M. J., Lam Y. H., Lai P. B. Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients. Hong Kong Med J: 2010; 16 2 116 120
5. Rajesparan K., Biant L. C., Ahmad M., Field R. E. The effect of an intravenous bolus of tranexamic acid on blood loss in total hip replacement. J Bone Joint Surg Br: 2009; 91 6 776 783
6. Zohar E., Ellis M., Ifrach N., Stern A., Sapir O., Fredman B. The postoperative blood-sparing efficacy of oral versus intravenous tranexamic acid after total knee replacement. Anesth Analg: 2004; 99 6 1679 1683
7. Hoylaerts M., Lijnen H. R., Collen D. Studies on the mechanism of the antifibrinolytic action of tranexamic acid. Biochim Biophys Acta: 1981; 673 1 75 85
8. Tengborn L., Blombäck M., Berntorp E. Tranexamic acid-an old drug still going strong and making a revival. Thromb Res: 2015; 135 2 231 242
9. Ipema H. J., Tanzi M. G. Use of topical tranexamic acid or aminocaproic acid to prevent bleeding after major surgical procedures. Ann Pharmacother: 2012; 46 1 97 107
10. Panteli M., Papakostidis C., Dahabreh Z., Giannoudis P. V. Topical tranexamic acid in total knee replacement: a systematic review and meta-analysis. Knee: 2013; 20 5 300 309
11. Kim T. K., Chang C. B., Koh I. J. Practical issues for the use of tranexamic acid in total knee arthroplasty: a systematic review. Knee Surg Sports Traumatol Arthrosc: 2014; 22 8 1849 1858
12. Wang H., Shen B., Zeng Y. Comparison of topical versus intravenous tranexamic acid in primary total knee arthroplasty: a meta-analysis of randomized controlled and prospective cohort trials. Knee: 2014; 21 6 987 993
13. Gybel M., Kristensen K., Roseva-Nielsen N. Cardiac arrest caused by massive pulmonary embolism during treatment with tranexamic acid [in Danish]. Ugeskr Laeger: 2013; 175 20 1426 1427
14. Taparia M., Cordingley F. T., Leahy M. F. Pulmonary embolism associated with tranexamic acid in severe acquired haemophilia. Eur J Haematol: 2002; 68 5 307 309
15. Krivokuca I., Lammers J. W. Recurrent pulmonary embolism associated with a hemostatic drug: tranexamic acid. Clin Appl Thromb Hemost: 2011; 17 1 106 107
16. Wong J., Abrishami A., El Beheiry H., et al. Topical application of tranexamic acid reduces postoperative blood loss in total knee arthroplasty: a randomized, controlled trial. J Bone Joint Surg Am: 2010; 92 15 2503 2513
17. Vaněk T., Straka Z. Topical use of tranexamic acid in cardiac surgery- A review and meta-analysis of four randomized controlled trials. Thrombosis: 2013; 55 e184 e189
18. Yue C., Pei F., Yang P., Xie J., Kang P. Effect of topical tranexamic acid in reducing bleeding and transfusions in TKA. Orthopedics: 2015; 38 5 315 324
19. Sano M., Hakusui H., Kojima C., Akimoto T. Absorption and excretion of tranexamic acid following intravenous, intramuscular and oral administrations in healthy volunteers. Jpn J Clin Pharmacol Ther: 1976; 7 375 382
20. Eriksson O., Kjellman H., Pilbrant A., Schannong M. Pharmacokinetics of tranexamic acid after intravenous administration to normal volunteers. Eur J Clin Pharmacol: 1974; 7 5 375 380
21. Sharma V., Katznelson R., Jerath A., et al. The association between tranexamic acid and convulsive seizures after cardiac surgery: a multivariate analysis in 11 529 patients. Anaesthesia: 2014; 69 2 124 130
22. Maniar R. N., Kumar G., Singhi T., Nayak R. M., Maniar P. R. Most effective regimen of tranexamic acid in knee arthroplasty: a prospective randomized controlled study in 240 patients. Clin Orthop Relat Res: 2012; 470 9 2605 2612
23. Soni A., Saini R., Gulati A., Paul R., Bhatty S., Rajoli S. R. Comparison between intravenous and intra-articular regimens of tranexamic acid in reducing blood loss during total knee arthroplasty. J Arthroplasty: 2014; 29 8 1525 1527
24. Petäjä J., Myllynen P., Myllylä G., Vahtera E. Fibrinolysis after application of a pneumatic tourniquet. Acta Chir Scand: 1987; 153 (11-12): 647 651
25. Shakur H., Roberts I., Bautista R., et al. CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet: 2010; 376 (9734): 23 32
26. Zhang Y., Fu X., Liu W. X., Li Y. M., Ma X. L., Li Z. J. Safety and efficacy of intra-articular injection of tranexamic acid in total knee arthroplasty. Orthopedics: 2014; 37 9 e775 e782