Bacosides and neuroprotection

Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes

Volumn , Issue , 2013, Pages 3639-3660

  Majumdar, Sukanya ^a   Basu, Amrita ^a   Paul, Pijush ^a   Halder, Mihir ^a   Jha, Sumita ^a  

^a UNIVERSITY OF CALCUTTA   (India)

Author keywords

Antidepressant; Antioxidant; Bacopa monnieri; Bacosides; Memory enhancer; Neuroprotection

Indexed keywords

EID: 84964972747     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-22144-6_157     Document Type: Chapter

References (57)

1. Singh HK, Dhawan BN (1997) Neuropsychopharmacological effects of the Ayurvedic nootropic Bacopa monniera Linn. (Brahmi). Ind J Pharmacol 29:S359-S365
2. Mukherjee DG, Dey CD (1966) Clinical trial on Brahmi. I. J Exp Med Sci 10:5-11
3. Bhattacharya SK, Bhattacharya A, Kumar A, Ghosal S (2000) Antioxidant activity of Bacopa monniera in rat frontal cortex, striatum and hippocampus. Phytother Res 14:174-179
4. Sairam K, Dorababu M, Goel RK, Bhattacharya SK (2002) Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine 9:207-211
5. Rao CV, Sairam K, Goel RK (2000) Experimental evaluation of Bacopa monniera on rat gastric ulceration and secretion. Indian J Physiol Pharmacol 44:435-441
6. Elangovan V, Govindasamy S, Ramamoorthy N, Balasubramanian K (1995) In vitro studies on the anticancer activity of Bacopa monniera. Fitoterapia 66:211-215
7. Dar A, Channa S (1997) Relaxant effect of ethanol extract of Bacopa monniera on trachea, pulmonary artery and aorta from rabbit and guinea-pig. Phytother Res 11:323-325
8. Channa S, Dar A, Yaqoob M, Anjum S, Sultani Z, Rahman A (2003) Broncho-vasodilatatory activity of fractions and pure constituents isolated from Bacopa monniera. J Ethnopharmacol 86:27-35
9. Samiulla DS, Prashanth D, Amit A (2001) Mast cell stabilising activity of Bacopa monnieri. Fitoterapia 72:284-285
10. Levi MS, Brimble MA (2004) A review of neuroprotective agents. Curr Med Chem 11:2383-2397
11. Singh HK, Dhawan BN (1992) Drugs affecting learning and memory. In: Tandon PN, Bijiani V, Wadhwa S (eds) Lectures in neurobiology, vol 1. Wiley Eastern, New Delhi
12. 3-a triterpenoid saponins from Bacopa monnieri. Phytochemistry 36:133-137
13. Singh HK, Rastogi RP, Srimal RC, Dhawan BN (1988) Effect of bacosides A and B on avoidance responses in rats. Phytother Res 2:70-75
14. Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J (2002) Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology 27:279-281
15. Kishore K, Singh M (2005) Effect of bacosides, alcoholic extract of Bacopa monniera Linn. (brahmi), on experimental amnesia in mice. Indian J Exp Biol 43:640-645
16. Anbarasi K, Vani G, Balakrishna K, Devi CS (2006) Effect of bacoside A on brain antioxidant status in cigarette smoke exposed rats. Life Sci 78:1378-1384
17. Anbarasi K, Sabitha KE, Devi CS (2005) Lactate dehydrogenase isoenzyme patterns upon chronic exposure to cigarette smoke: protective effect of bacoside A. Environ Toxicol Pharmacol 20:345-350
18. Halliwell B, Gutteridge JM (1985) The importance of free radicals and catalytic metal ions in human diseases. Mol Aspects Med 8:89-193
19. Vohora D, Pal SN, Pillai KK (2000) Protection from phenytoin-induced cognitive deficit by Bacopa monniera, a reputed Indian nootropic plant. J Ethnopharmacol 71:383-390
20. Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ (2001) The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 156:481-484
21. Shukia B, KhannaNK, Godhwani JL (1987) Effect of Brahmi Rasayan on the central nervous system. J Ethnopharmacol 21:65-74
22. Sheikh N, Ahmad A, Siripurapu KB, Kuchibhotla VK, Singh S, Palit G (2007) Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. J Ethnopharmacol 111:671-676
23. Mathew J, Peeyush Kumar T, Khan RS, Paulose CS (2010) Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A. Epilepsy Behav 17:441-447
24. Hota SK, Barhwal K, Baitharu I, Prasad D, Singh SB, Ilavazhagan G (2009) Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment. Neurobiol Dis 34:23-39
25. Jyoti A, Sethi P, Sharma D (2007) Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain. J Ethnopharmacol 111:56-62
26. Holcomb LA, Dhanasekaran M, Hitt AR, Young KA, Riggs M, Manyam BV (2006) Bacopa monniera extract reduces amyloid levels in PSAPP mice. J Alzheimers Dis 9:243-251
27. Singh M, Murthy V, Ramassamy C (2010) Modulation of hydrogen peroxide and acrolein-induced oxidative stress, mitochondrial dysfunctions and redox regulated pathways by the Bacopa monniera extract: potent implication in Alzheimer’s disease. J Alzheimers Dis 21:219-247
28. Vijayan V, Helen A (2007) Protective activity of Bacopa monniera Linn. on nicotine-induced toxicity in mice. Phytother Res 21:378-381
29. Chowdhuri DK, Parmar D, Kakkar P, Shukla R, Seth PK, Srimal RC (2002) Antistress effects of bacosides of Bacopa monnieri: modulation of Hsp70 expression, superoxide dismutase and cytochrome P450 activity in rat brain. Phytother Res 16:639-645
30. Das A, Shanker G, Nath C, Pal R, Singh S, Singh H (2002) A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba. Pharmacol Biochem Behav 73:893-900
31. Sumathy T, Subramanian S, Govindasamy S, Balakrishna K, Veluchamy G (2001) Protective role of Bacopa monniera on morphine induced hepatotoxicity in rats. Phytother Res 15:643-645.
32. Singh A, Singh SK (2009) Evaluation of antifertility potential of Brahmi in male mouse. Contraception 79:71-79
33. Sivaramakrishna C, Rao CV, Trimurtulu G, Vanisree M, Subbaraju GV (2005) Triterpenoid glycosides from Bacopa monnieri. Phytochemistry 66:2719-2728
34. Deepak M, Amit A (2004) The need for establishing the identities of ‘bacoside A and B’, the putative major bioactive saponins of Indian medicinal plant Bacopa monnieri. Phytomedicine 11:264-268
35. Basu N, Rastogi RP, Dhar ML (1967) Chemical examination of Bacopa monnieri Wettst: Part III-Bacoside B. Ind J Chem 5:84-86
36. Garai S, Mahato SB, Ohtani K, Yamasaki K (1996) Dammarane-type triterpenoid saponins from Bacopa monniera. Phytochemistry 42:815-820
37. Chakravarty AK, Sarkar T, Masuda K, Shiojima K, Nakane T, Kawahara N (2001) Bacopaside I and II: two pseudojujubogenin glycosides from Bacopa monniera. Phytochemistry 58:553-556
38. Chakravarty AK, Garai S, Masuda K, Nakane T, Kawahara N (2003) Bacopasides III-V: three new triterpenoid glycosides from Bacopa monniera. Chem Pharm Bull, Tokyo 51:215-217.
39. Hostettmann K, Marston A (1995) Saponins. Cambridge University Press, Cambridge
40. Croteau R, Kutchan TM, Lewis NG (2000) Natural products (secondary metabolites). In: Buchanan B, Gruissem W, Jones R (eds) Biochemistry & molecular biology of plants. American Society of Plant Physiologists, Rockville
41. James JT, Dubery IA (2009) Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) urban. Molecules 14:3922-3941
42. Pawar R, Gopalakrishnan C, Bhutani KK (2001) Dammarane triterpene saponin from Bacopa monniera as the superoxide inhibitor in polymorphonuclear cells. Planta Med 67:752-754
43. Bafna PA, Balaraman R (2005) Antioxidant activity of DHC-1, an herbal formulation, in experimentally-induced cardiac and renal damage. Phytother Res 19:216-221
44. Sairam K, Rao CV, Babu MD, Goel RK (2001) Prophylactic and curative effects of Bacopa monniera in gastric ulcer models. Phytomedicine 8:423-430
45. Goel RK, Sairam K, Babu MD, Tavares IA, Raman A (2003) In vitro evaluation of Bacopa monniera on anti-Helicobacter pylori activity and accumulation of prostaglandins. Phytomedicine 10:523-527
46. Kar A, Panda S, Bharti S (2002) Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. J Ethnopharmacol 81:281-285
47. Russo A, Borrelli F, Campisi A, Acquaviva R, Raciti G, Vanella A (2003) Nitric oxide-related toxicity in cultured astrocytes: effect of Bacopa monniera. Life Sci 73:1517-1526
48. Russo A, Izzo AA, Borrelli F, Renis M, Vanella A (2003) Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage. Phytother Res 17:870-875
49. Sharma R, Chaturvedi C, Tewari PV (1987) Efficacy of Bacopa monnieri in revitalizing intellectual functions in children. J Res Edu Ind Med 1:1-12
50. Gohil KJ, Patel JA (2010) A review on Bacopa monniera: current research and future prospects. Int J Green Pharm 4:1-9
51. Sukumar E, Gopal RH, Rao RB, Kundu AB, Viswanathan S, Thirugnanasambandam P, Gopalakrishnan C (1991) Pharmacological investigations on Pristimera grahamii leaves. Fitoterapia 62:429-433
52. Dar A, Channa S (1999) Calcium antagonistic activity of Bacopa monniera on vascular and intestinal smooth muscles of rabbit and guinea-pig. J Ethnopharmacol 66:167-174
53. Sahoo PK, Pradhan D, Behera P (2010) Neuroprotective effect of Bacopa monnieri leaf extract targeted at adenosine receptor in diabetic neuropathic pain. J Pharm Res 3:1806-1809
54. Bhattacharya SK, Ghosal S (1998) Anxiolytic activity of a standardized extract of Bacopa monniera: an experimental study. Phytomedicine 5:77-82
55. Singh RH, Singh L (1980) Studies on the anti-anxiety effect of the Medyha Rasayana drug, Brahmi (Bacopa monniera Wettst.)-Part 1. J Res Ayur Siddha 1:133-148
56. Saraf MK, Prabhakar S, Khanduja KL, Anand A (2011) Bacopa monniera attenuates scopolamine-induced impairment of spatial memory in mice. Evid Based Complement Alternat Med. doi:10.1093/ecam/neq038
57. Majumdar S, Garai S, Jha S (2011) Genetic transformation of Bacopa monnieri by wild type strains of Agrobacterium rhizogenes stimulates production of bacopa saponins in transformed calli and plants. Plant Cell Rep. doi:10.1007/s00299-011-1035-9