Low aneuploidy rate in early pregnancy loss abortuses from patients with polycystic ovary syndrome

Reproductive BioMedicine Online

Volumn 33, Issue 1, 2016, Pages 85-92

  Wang, Qiong ^a,b   Luo, Lu ^a,b   Lei, Qiong ^c   Lin, Ming Mei ^a,b,d   Huang, Xuan ^a   Chen, Ming Hui ^a,b   Zeng, Yan hong ^a,b   Zhou, Can quan ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes   (China)

^c Guangdong Women and Children Hospital ^*  (China)

^d PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

aneuploidy; chromosome; early miscarriage; embryo; IVF; polycystic ovary syndrome

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DISOMY; EMBRYO TRANSFER; ENDOMETRIAL DISEASE; FEMALE; FIRST TRIMESTER PREGNANCY; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC ANALYSIS; HUMAN; KARYOTYPING; MAJOR CLINICAL STUDY; MATERNAL AGE; MONOSOMY; MOSAICISM; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; OBSERVATIONAL STUDY; OVARY POLYCYSTIC DISEASE; PROSPECTIVE STUDY; SPONTANEOUS ABORTION; TRIPLOIDY; TRISOMY; CHORION VILLUS; CHROMOSOME; COMPLICATION; FETUS DEATH; GENETICS; IN VITRO FERTILIZATION; INSULIN RESISTANCE; METABOLISM; PREGNANCY; RISK; ULTRASTRUCTURE;

PROGESTERONE;

ABORTED FETUS; ABORTION, SPONTANEOUS; ADULT; ANEUPLOIDY; CHORIONIC VILLI; CHROMOSOMES; COMPARATIVE GENOMIC HYBRIDIZATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INSULIN RESISTANCE; KARYOTYPING; MATERNAL AGE; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PROGESTERONE; PROSPECTIVE STUDIES; RISK;

EID: 84964913976     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2016.04.006     Document Type: Article

References (41)

1. Asunción, M., Calvo, R.M., San-Millán, J.L., Sancho, J., Avila, S., Escobar-Morreale, H.F., A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J. Clin. Endocrinol. Metab 8 (2000), 2434–2438.
2. Azziz, R., Woods, K.S., Reyna, R., Key, T.J., Knochenhauer, E.S., Yildiz, B.O., The prevalence and features of the polycystic ovary syndrome in an unselected population. J. Clin. Endocrinol. Metab 89 (2004), 2745–2749.
3. Balen, A.H., Tan, S.L., MacDougall, J., Jacobs, H.S., Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum. Reprod 8 (1993), 959–964.
4. Bellver, J., Ayllón, Y., Ferrando, M., Melo, M., Goyri, E., Pellicer, A., Remohí, J., Meseguer, M., Female obesity impairs in vitro fertilization outcome without affecting embryo quality. Fertil. Steril 93 (2010), 447–454.
5. Berker, B., Kaya, C., Aytac, R., Satiroglu, H., Homocysteine concentrations in follicular fluid are associated with poor oocyte and embryo qualities in polycystic ovary syndrome patients undergoing assisted reproduction. Hum. Reprod 24 (2009), 2293–2302.
6. Beydoun, H.A., Stadtmauer, L., Beydoun, M.A., Russell, H., Zhao, Y., Oehninger, S., Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies. Reprod. Biomed. Online 18 (2009), 856–863.
7. Bruno, D.L., Burgess, T., Ren, H., Nouri, S., Pertile, M.D., Francis, D.I., Norris, F., High-throughput analysis of chromosome abnormality in spontaneous miscarriage using an MLPA subtelomere assay with an an cillary FISH test for polyploidy. Am. J. Med. Genet. A 15 (2006), 2786–2793.
8. Cardozo, E., Pavone, M.E., Jennifer, E., Hirshfeld, C., Metabolic syndrome and oocyte quality. Trends Endocrinol. Metab 22 (2011), 103–109.
9. Cocksedge, K.A., Saravelos, S.H., Wang, Q., Tuckerman, E., Laird, S.M., Li, T.C., Does free androgen index predict subsequent pregnancy outcome in women with recurrent miscarriage?. Hum. Reprod 23 (2008), 797–802.
10. Doldi, N., Gessi, A., Destefani, A., Calzi, F., Ferrari, A., Polycystic ovary syndrome: anomalies in progesterone production. Hum. Reprod 13 (1998), 290–293.
11. Dosiou, C., Giudice, L.C., Natural killer cells in pregnancy and recurrent pregnancy loss: endocrine and immunologic perspectives. Endocr. Rev 26 (2005), 44–62.
12. Dumesic, D.A., Oocyte quality in adult polycystic ovary syndrome. Semin. Reprod. Med 26 (2008), 196–203.
13. Eng, G.S., Sheridan, R.A., Wyman, A., Chi, M.M., Bibee, K.P., Jungheim, E.S., AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations. Diabetes 56 (2007), 2228–2234.
14. Harris, S.E., Maruthini, D., Tang, T., Balen, A.H., Picton, H.M., Metabolism and karyotype analysis of oocytes from patients with polycystic ovary syndrome. Hum. Reprod 25 (2010), 2305–2315.
15. Homburg, R., Armar, N.A., Eshel, A., Adams, J., Jacobs, H.S., Influence of serum luteinizing hormone concentrations on ovulation, conception and early pregnancy loss in polycystic ovarian syndrome. BMJ 297 (1988), 1024–1026.
16. Irwin, J.C., de las Fuentes, L., Dsupin, B.A., Giudice, L.C., Insulin-like growth factor regulation of human endometrial stromal cell function: coordinate effects on insulin-like growth factor binding protein-1, cell proliferation and prolactin secretion. Regul. Pept 48 (1993), 165–177.
17. Kennerknecht, I., Baur-Aubele, S., Grab, D., Terinde, R., First trimester amniocentesis between the seventh and 13th weeks: evaluation of the earliest possible genetic diagnosis. Prenat. Diagn 12 (1992), 595–601.
18. Koolen, D.A., Nillesen, W.M., Versteeg, M.H., Merkx, G.F., Knoers, N.V., Kets, M., Vermeer, S., van Ravenswaaij, C.M., de Kovel, C.G., Brunner, H.G., Smeets, D., de Vries, B.B., Sistermans, E.A., Screening for subtelomeric rearrangements in 210 patients with unexplained mental retardation using multiplex ligation dependent probe amplification (MLPA). J. Med. Genet 41 (2004), 892–899.
19. Kushnir, V.A., Frattarelli, J.L., Aneuploidy in abortuses following IVF and ICSI. J. Assist. Reprod. Genet 26 (2009), 93–97.
20. Landres, I.V., Milki, A.A., Lathi, R.B., Karyotype of miscarriages in relation to maternal weight. Hum. Reprod 25 (2010), 1123–1126.
21. Lei, Q., Wang, Q., Zhou, C.Q., Chen, B.J., Chen, Z., Zeng, Y.H., Analysis of chromosome mosaicism in spontaneously aborted chorionic villus using an MLPA subtelomere assay with an ancillary FISH test. Chin. J. Birth Health Hered 16 (2008), 49–51.
22. Lei, Q., Wang, Q., Zhou, C.Q., Chen, B.J., Chen, Z., Xu, Y.W., Genetic analysis of chorionic villi specimen in spontaneous abortion using various methods. Zhong Hua Fu Chan Ke Za Zhi 44 (2009), 253–256.
23. Li, Y., Yang, D., Zhang, Q., Impact of overweight and underweight on IVF treatment in Chinese women. Gynecol. Endocrinol 26 (2010), 416–422.
24. Ludwig, M., Finas, D.F., al-Hasani, S., Diedrich, K., Ortmann, O., Oocyte quality and treatment outcome in intracytoplasmic sperm injection cycles of polycystic ovarian syndrome patients. Hum. Reprod 14 (1999), 354–358.
25. Martínez, M.C., Méndez, C., Ferro, J., Nicolás, M., Serra, V., Landeras, J., Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment. Fertil. Steril 93 (2010), 289–292.
26. Nafiye, Y., Sevtap, K., Muammer, D., Emre, O., Senol, K., Leyla, M., The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, non hyper androgenemic polycystic ovary syndrome patients on in vitro fertilization outcome. Fertil. Steril 93 (2010), 1864–1869.
27. Okon, M.A., Laird, S.M., Tuckerman, E.M., Li, T.C., Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function. Fertil. Steril 69 (1998), 682–690.
28. Patel, S.S., Carr, B.R., Abbott, D.H., Implications of polycystic ovary syndrome on oocyte development. Semin. Reprod. Med 26 (2008), 53–61.
29. Regan, L., Owen, E.J., Jacobs, H.S., Hypersecretion of luteinizing hormone, infertility and miscarriage. Lancet 336 (1990), 1141–1144.
30. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum. Reprod 19 (2004), 41–47.
31. Schaeffer, A.J., Chung, J., Heretis, K., Wong, A., Ledbetter, D.H., Lese Martin, C., Comparative genomic hybridization-array analysis enhances the detection of aneuploidies and submicroscopic imbalances in spontaneous miscarriages. Am. J. Hum. Genet 74 (2004), 1168–1174.
32. Schouten, J.P., McElgunn, C.J., Waaijer, R., Zwijnenburg, D., Diepvens, F., Pals, G., Relative quantification of 40nucleic acid sequences by multiplex ligation-dependent probe amplification. Nucleic Acids Res, 30, 2002, e57.
33. Sengoku, K., Tamate, K., Takuma, N., Yoshida, T., Goishi, K., Ishikawa, M., The chromosomal normality of unfertilized oocytes from patients with polycystic ovarian syndrome. Hum. Reprod 12 (1997), 474–477.
34. Shaffer, L.G., McGowan-Jordan, J., Schmid, M., An International System for Human Cytogenetic Nomenclature (2013) ISCN 2013. Report of the Standing Committee on Human Cytogenetic Nomenclature, 2013, Karger, Basel.
35. Simoni, G., Tibiletti, M.G., Dalprà, L., Ferrari, M., Brambati, B., Routine chromosome analysis on fetal blood micro aliquots obtained at fetoscopy. Prenat. Diagn 3 (1983), 203–208.
36. Viaggi, C.D., Cavani, S., Malacarne, M., Floriddia, F., Zerega, G., Baldo, C., Mogni, M., Castagnetta, M., Piombo, G., Coviello, D.A., Camandona, F., Lijoi, D., Insegno, W., Traversa, M., Pierluigi, M., First-trimester euploid miscarriages analysed by array-CGH. J. Appl. Genet 54 (2013), 353–359.
37. Vieira, R.C., Barcelos, I.D., Ferreira, E.M., Martins, W.P., Ferriani, R.A., Navarro, P.A., Spindle and chromosome configurations of in vitro-matured oocytes from polycystic ovary syndrome and ovulatory infertile women: a pilot study. J. Assist. Reprod. Genet 28 (2011), 15–21.
38. Warren, J.E., Silver, R.M., Genetics of pregnancy loss. Clin. Obstet. Gynecol 51 (2008), 84–95.
39. Weghofer, A., Munne, S., Chen, S., Barad, D., Gleicher, N., Lack of association between polycystic ovary syndrome and embryonic aneuploidy. Fertil. Steril 88 (2007), 900–905.
40. Wolstenholme, J., Confined placental mosaicism for trisomies2, 3, 7, 8, 9, 16, and 22: their incidence, likely origins, and mechanisms for cell lineage compartmentalization. Prenat. Diagn 16 (1996), 511–524.
41. Wood, J.R., Dumesic, D.A., Abbott, D.H., Strauss, J.F., Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. Clin. Endocrinol. Metab 92 (2007), 705–713.