Cholinergic modulation of auditory P3 event-related potentials as indexed by CHRNA4 and CHRNA7 genotype variation in healthy volunteers

Neuroscience Letters

Volumn 623, Issue , 2016, Pages 36-41

  Hyde, Molly ^a   Choueiry, Joëlle ^a   Smith, Dylan ^a   de la Salle, Sara ^a   Nelson, Renee ^a   Impey, Danielle ^a   Baddeley, Ashley ^a   Aidelbaum, Robert ^b   Millar, Anne ^a   Knott, Verner ^a,b  

^a UNIVERSITY OF OTTAWA   (Canada)

^b CARLETON UNIVERSITY   (Canada)

Author keywords

Alpha 4 nicotinic acetylcholine receptor ( 4 nAChR); Alpha 7 nicotinic acetylcholine receptor ( 7 nAChR); Attention; Choline transporter; P300; Schizophrenia

Indexed keywords

ADULT; ARTICLE; ATTENTION; AUDITORY EVOKED POTENTIAL; CAUCASIAN; CHOLINERGIC STIMULATION; CHRNA 4 GENE; CHRNA 7 GENE; GENE; GENE FUNCTION; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SLC 5 A 7 GENE; ADOLESCENT; EVENT RELATED POTENTIAL; EXPLORATORY BEHAVIOR; GENETIC POLYMORPHISM; GENETICS; PILOT STUDY; YOUNG ADULT;

BUNGAROTOXIN RECEPTOR; CHRNA7 PROTEIN, HUMAN; COTRANSPORTER; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4 SUBUNIT; NICOTINIC RECEPTOR; SLC5A7 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR; ATTENTION; EVENT-RELATED POTENTIALS, P300; EVOKED POTENTIALS, AUDITORY; EXPLORATORY BEHAVIOR; GENOTYPE; HUMANS; MALE; PILOT PROJECTS; POLYMORPHISM, GENETIC; RECEPTORS, NICOTINIC; SYMPORTERS; YOUNG ADULT;

EID: 84964904347     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.04.040     Document Type: Article

References (36)

1. Mackowick K.M., Barr M.S., Wing V.C., Rabin R.a., Ouellet-Plamondon C., George T.P. Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2013, 52:79-85. 10.1016/j.pnpbp.2013.07.010.
2. Sepede G., Chiara Spano M., Lorusso M., De Berardis D., Salerno R.M., Di Giannantonio M., et al. Sustained attention in psychosis: neuroimaging findings. World J. Radiol. 2014, 6:261-273. 10.4329/wjr.v6.i6.261.
3. Cornblatt B.A., Keilp J.G. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr. Bull. 1994, 20:31-46. 10.1093/schbul/20.1.31.
4. Coull J.T. Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Prog. Neurobiol. 1998, 55:343-361. 10.1016/S0301-0082(98)00011-2.
5. Liu J., Kiehl K.A., Pearlson G., Perrone-Bizzozero N.I., Eichele T., Calhoun V.D. Genetic determinants of target and novelty-related event-related potentials in the auditory oddball response. Neuroimage 2009, 46:809-816. 10.1016/j.neuroimage.2009.02.045.
6. Heitland I., Kenemans J.L., Oosting R.S., Baas J.M.P., Böcker K.B.E. Auditory event-related potentials (P3a, P3b) and genetic variants within the dopamine and serotonin system in healthy females. Behav. Brain Res. 2013, 249:55-64. 10.1016/j.bbr.2013.04.013.
7. Polich J., Criado J.R. Neuropsychology and neuropharmacology of P3a and P3b. Int. J. Psychophysiol. 2006, 60:172-185. 10.1016/j.ijpsycho.2005.12.012.
8. Knott V.J., Scherling C.S., Blais C.M., Camarda J., Fisher D.J., Millar A., et al. Acute nicotine fails to alter event-related potential or behavioral performance indices of auditory distraction in cigarette smokers. Nicotine Tob. Res. 2006, 8:263-273. 10.1080/14622200600576669.
9. Pritchard W., Sokhadze E., Houlihan M. Effects of nicotine and smoking on event-related potentials: a review. Nicotine Tob. Res. 2004, 6:961-984. 10.1080/14622200412331324848.
10. Knott V., Choueiry J., Dort H., Smith D., Impey D., de la Salle S., et al. Baseline-dependent modulating effects of nicotine on voluntary and involuntary attention measured with brain event-related P3 potentials. Pharmacol. Biochem. Behav. 2014, 122C:107-117. 10.1016/j.pbb.2014.03.020.
11. Liu X., Hong X., Chan R.C.K., Kong F., Peng Z., Wan X., et al. Association study of polymorphisms in the alpha 7 nicotinic acetylcholine receptor subunit and catechol-o-methyl transferase genes with sensory gating in first-episode schizophrenia. Psychiatry Res. 2013, 209:431-438. 10.1016/j.psychres.2013.03.027.
12. Meda S.A., Jagannathan K., Gelernter J., Calhoun V.D., Liu J., Stevens M.C., et al. A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. Neuroimage 2010, 53:1007-1015. 10.1016/j.neuroimage.2009.11.052.
13. Handjaras G., Ricciardi E., Szczepanik J., Pietrini P., Furey M.L. Cholinergic enhancement differentially modulates neural response to encoding during face identity and face location working memory tasks. Exp. Biol. Med. 2013, 238:999-1008. 10.1177/1535370213497326.
14. Jones K.a., Porjesz B., Almasy L., Bierut L., Goate A., Wang J.C., et al. Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition. Int. J. Psychophysiol. 2004, 53:75-90. 10.1016/j.ijpsycho.2004.02.004.
15. Dierks T., Frolich L., Ihl R., Maurer K. Event-related potentials anc' psychopharmacology cholinergic modulation of P300. Pharmacopsychiatry 1994, 27:72-74.
16. Stormer V.S., Passow S., Biesenack J., Li S.C. Dopaminergic and cholinergic modulations of visual-spatial attention and working memory insight from molecular genetic research and implications for adult cognitve development.pdf. Dev. Psychol. 2012, 48:875-889. 10.1037/a0026198.
17. Katada E., Sato K., Sawaki A., Dohi Y., Ueda R., Ojika K. Long-term effects of donepezil on P300 auditory ERP in patients with alzheimer's disease. J. Geriatr. Psychiatry Neurol. 2003, 16:39-43. 10.1177/08919887022500561.
18. Thomas A., Iacono D., Bonanni L., D'Andreamatteo G., Onofrj M. Donepezil, rivastigmine, and vitamin E in Alzheimer disease: a combined P300 event-related potentials/neuropsychologic evaluation over 6 months. Clin. Neuropharmacol. 2001, 24:31-42. 10.1097/00002826-200101000-00007.
19. Young J.W., Geyer M.A. Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia. Biochem. Pharmacol. 2013, 86:1122-1132. 10.1016/j.bcp.2013.06.031.
20. Gratton G., Coles M.G.H., Donchin E. A new method for off-line removal of ocular artifact. Electroencephalogr. Clin. Neurophysiol. 1983, 55:468-484. 10.1016/0013-4694(83)90135-9.
21. Sarter M., Hasselmo M.E., Bruno J.P., Givens B. Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. Brain Res. Rev. 2005, 48:98-111. 10.1016/j.brainresrev.2004.08.006.
22. Joos K., Gilles A., Van de Heyning P., De Ridder D., Vanneste S. From sensation to percept: the neural signature of auditory event-related potentials. Neurosci. Biobehav. Rev. 2014, 42:148-156. 10.1016/j.neubiorev.2014.02.009.
23. Polich J., Criado J.R. Neuropsychology and neuropharmacology of P3a and P3b. Int. J. Psychophysiol. 2006, 60:172-185. 10.1016/j.ijpsycho.2005.12.012.
24. Greenwood P.M., Parasuraman R., Espeseth T. A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4. Neurosci. Biobehav. Rev. 2012, 36:1331-1341. 10.1016/j.neubiorev.2012.02.010.
25. Breckel T.P.K., Giessing C., Gieseler A., Querbach S., Reuter M., Thiel C.M. Nicotinergic modulation of attention-related neural activity differentiates polymorphisms of DRD2 and CHRNA4 receptor genes. PLoS One 2015, 10:e0126460. 10.1371/journal.pone.0126460.
26. Reinvang I., Lundervold A.J., Rootwelt H., Wehling E., Espeseth T. Individual variation in a cholinergic receptor gene modulates attention. Neurosci. Lett. 2009, 453:131-134. 10.1016/j.neulet.2009.02.029.
27. Schneider K.K., Schote A.B., Meyer J., Markett S., Reuter M., Frings C. Individual response speed is modulated by variants of the gene encoding the alpha 4 sub-unit of the nicotinic acetylcholine receptor (CHRNA4). Behav. Brain Res. 2015, 284:11-18. 10.1016/j.bbr.2015.01.041.
28. Winterer G., Musso F., Konrad A., Vucurevic G., Stoeter P., Sander T., et al. Association of attentional network function with exon 5 variations of the CHRNA4 gene. Hum. Mol. Genet. 2007, 16:2165-2174. 10.1093/hmg/ddm168.
29. Bellgrove M.A., Mattingley J.B. Molecular genetics of attention. Ann. N. Y. Acad. Sci. 2008, 1129:200-212. 10.1196/annals.1417.013.
30. Winterer G., Gallinat J., Brinkmeyer J., Musso F., Kornhuber J., Thuerauf N., et al. Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: a proof-of-mechanism study. Neuropharmacology 2013, 64:197-204. 10.1016/j.neuropharm.2012.06.040.
31. Greenwood T.A., Lazzeroni L.C., Murray S.S., Cadenhead K.S., Calkins M.E., Dobie D.J., et al. Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the consortium on the genetics of schizophrenia. Am. J. Psychiatry 2011, 168:930-946. 10.1176/appi.ajp.2011.10050723.
32. Proulx E., Piva M., Tian M.K., Bailey C.D.C., Lambe E.K. Nicotinic acetylcholine receptors in attention circuitry: the role of layer VI neurons of prefrontal cortex. Cell. Mol. Life Sci. 2014, 71:1225-1244. 10.1007/s00018-013-1481-3.
33. Bentley P., Driver J., Dolan R.J. Cholinergic modulation of cognition: insights from human pharmacological functional neuroimaging. Prog. Neurobiol. 2011, 94:360-388. 10.1016/j.pneurobio.2011.06.002.
34. Berry A.S., Blakely R.D., Sarter M., Lustig C. Cholinergic capacity mediates prefrontal engagement during challenges to attention: evidence from imaging genetics. Neuroimage 2015, 108:386-395. 10.1016/j.neuroimage.2014.12.036.
35. Berry A.S., Demeter E., Sabhapathy S., English B.A., Blakely R.D., Sarter M., et al. Disposed to distraction: genetic variation in the cholinergic system influences distractibility but not time-on-task effects. J. Cogn. Neurosci. 2013, 26:1981-1991. 10.1162/jocn.
36. First M.B., Spitzer R.L., Gibbon M., Williams J.B. Structured Clinical Interview For DSM-IV Axis I Disorders-patient Edition (SCID-I/P, Version 2.0) 1995, 722. Biometrics Research Department, New York State Psychiatric Institute, New York.