A cognitive phenotype for a polymorphism in the nicotinic receptor gene CHRNA4

Neuroscience and Biobehavioral Reviews

Volumn 36, Issue 4, 2012, Pages 1331-1341

  Greenwood, P M ^a   Parasuraman, Raja ^a   Espeseth, Thomas ^b,c,d  

^a GEORGE MASON UNIVERSITY   (United States)

^b CENTRE FOR ADVANCED STUDY   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF BERGEN   (Norway)

Author keywords

CHRNA4; Cognition; NAChR; Nicotinic; Phenotype; Polymorphism; Visuospatial attention

Indexed keywords

NICOTINIC RECEPTOR ALPHA4BETA2;

ALLELE; ATTENTION; BEHAVIOR; BRAIN FUNCTION; CHOLINERGIC SYSTEM; COGNITION; ELECTROPHYSIOLOGY; HUMAN; IMAGING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR GENE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; VISUOSPATIAL ATTENTION;

ATTENTION; BRAIN; COGNITION; GENETIC VARIATION; GENOTYPE; HUMANS; PHENOTYPE; PSYCHOMOTOR PERFORMANCE; RECEPTORS, NICOTINIC; VISUAL PERCEPTION;

EID: 84857928575     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2012.02.010     Document Type: Review

References (104)

1. Alkondon M., Pereira E.F., Eisenberg H.M., Albuquerque E.X. Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks. J. Neurosci. 2000, 20(1):66-75.
2. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., et al. Gene ontology: tool for the unification of biology The Gene Ontology Consortium. Nat. Genet. 2000, 25(1):25-29.
3. Bayes A., van de Lagemaat L.N., Collins M.O., Croning M.D., Whittle I.R., Choudhary J.S., et al. Characterization of the proteome, diseases and evolution of the human postsynaptic density. Nat. Neurosci. 2010, 14(1):19-21.
4. Beauchamp M.S., Lee K.E., Haxby J.V., Martin A. Parallel visual motion processing streams for manipulable objects and human movements. Neuron 2001, 34(1):149-159.
5. Bilder R.M., Sabb F.W., Parker D.S., Kalar D., Chu W.W., Fox J., et al. Cognitive ontologies for neuropsychiatric phenomics research. Cogn. Neuropsychiatry 2009, 14(4-5):419-450.
6. Breitling L.P., Dahmen N., Mittelstrass K., Rujescu D., Gallinat J., Fehr C., et al. Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. Pharmacogenomics J. 2009, 9(4):219-224.
7. Brody A.L., Mandelkern M.A., Costello M.R., Abrams A.L., Scheibal D., Farahi J., et al. Brain nicotinic acetylcholine receptor occupancy: effect of smoking a denicotinized cigarette. Int. J. Neuropsychopharmacol. 2009, 12(3):305-316.
8. Buisson B., Bertrand D. Chronic exposure to nicotine upregulates the human (alpha)4((beta)2 nicotinic acetylcholine receptor function. J. Neurosci. 2001, 21(6):1819-1829.
9. Bundesen C. A theory of visual attention. Psychol. Rev. 1990, 97(4):523-547.
10. Castiello U., Umilta C. Size of the attentional focus and efficiency of processing. Acta Psychol. (Amst.) 1990, 73:195-209.
11. Cavanagh P., Alvarez G.A. Tracking multiple targets with multifocal attention. Trends Cogn. Sci. 2005, 9(7):349-354.
12. Constantinidis C., Steinmetz M.A. Neuronal responses in area 7a to multiple stimulus displays: II. Responses are suppressed at the cued location. Cereb. Cortex 2001, 11(7):592-597.
13. Corbetta M., Patel G., Shulman G.L. The reorienting system of the human brain: from environment to theory of mind. Neuron 2008, 58(3):306-324.
14. Corder E.H., Saunders A.M., Strittmatter W.J., Schmechel D.E., Gaskell P.C., Small G.W., et al. Gene dose of Apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993, 261:921-923.
15. Cosgrove K.P., Batis J., Bois F., Maciejewski P.K., Esterlis I., Kloczynski T., et al. beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch. Gen. Psychiatry 2009, 66(6):666-676.
16. Culham J.C., Cavanagh P., Kanwisher N.G. Attention response functions: characterizing brain areas using fMRI activation during parametric variations of attentional load. Neuron 2001, 32(4):737-745.
17. Darsow T., Booker T.K., Pina-Crespo J.C., Heinemann S.F. Exocytic trafficking is required for nicotine-induced up-regulation of alpha 4 beta 2 nicotinic acetylcholine receptors. J. Biol. Chem. 2005, 280(18):18311-18320.
18. Davidson M.C., Marrocco R.T. Local infusion of scopolamine into intraparietal cortex slows covert orienting in rhesus monkeys. J. Neurophysiol. 2000, 83(3):1536-1549.
19. Davies G., Tenesa A., Payton A., Yang J., Harris S.E., Liewald D., et al. Genome-wide association studies establish that human intelligence is highly heritable and polygenic. Mol. Psychiatry 2011, 1-10.
20. Donnai D., Karmiloff-Smith A. Williams syndrome: from genotype through to the cognitive phenotype. Am. J. Med. Genet. 2000, 97(2):164-171.
21. Downing C.J. Expectancy and visual-spatial attention: effects on perceptual quality. J. Exp. Psychol. Hum. Percept. Perform. 1988, 14:188-202.
22. Driver J., Spence C. Cross-modal links in spatial attention. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 1998, 353(1373):1319-1331.
23. Egan M.F., Goldberg T.E., Kolachana B.S., Callicott J.H., Mazzanti C.M., Straub R.E., et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 2001, 98(12):6917-6922.
24. Eriksen C.W., St James J.D. Visual attention within and around the field of focal attention: a zoom lens model. Percept. Psychophys. 1986, 40(4):225-240.
25. Espeseth T., Endestad T., Rootwelt H., Reinvang I. Nicotine receptor gene CHRNA4 modulates early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience 2007, 147(4):974-985.
26. Espeseth T., Greenwood P.M., Reinvang I., Fjell A.M., Walhovd K.B., Westlye L.T., et al. Interactive effects of APOE and CHRNA4 on attention and white matter volume in healthy middle-aged and older adults. Cogn. Affect. Behav. Neurosci. 2006, 6(1):31-43.
27. Espeseth T., Sneve M.H., Rootwelt H., Laeng B. Nicotinic receptor gene CHRNA4 interacts with processing load in attention. PLoS ONE 2010, 5(12):e14407.
28. Espeseth T., Sneve M.H., Rootwelt H., Laeng B. Nicotinic receptor gene CHRNA4 interacts with processing load in attention. Paper Presented at the Nicotinic Acetylcholine Receptors 2011. Wellcome Trust Conference 2011.
29. Feng Y., Niu T., Xing H., Xu X., Chen C., Peng S., et al. A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am. J. Hum. Genet. 2004, 75(1):112-121.
30. Freimer N., Sabatti C. The human phenome project. Nat. Genet. 2003, 34(1):15-21.
31. Gießing C., Fink G.R., Rosler F., Thiel C.M. fMRI data predict individual differences of behavioral effects of nicotine: a partial least square analysis. J. Cogn. Neurosci. 2007, 19(4):658-670.
32. Gießing C., Neber T., Thiel C.M. Genetic variation in nicotinic receptors affects brain networks involved in reorienting attention. Neuroimage 2011, 59(1):831-839.
33. Gießing C., Thiel C.M., Rosler F., Fink G.R. The modulatory effects of nicotine on parietal cortex activity in a cued target detection task depend on cue reliability. Neuroscience 2006, 137(3):853-864.
34. Gil Z., Connors B.W., Amitai Y. Differential regulation of neocortical synapses by neuromodulators and activity. Neuron 1997, 19(3):679-686.
35. Gioanni Y., Rougeot C., Clarke P.B., Lepouse C., Thierry A.M., Vidal C. Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission. Eur. J. Neurosci. 1999, 11(1):18-30.
36. Goldberg T.E., Weinberger D.R. Genes and the parsing of cognitive processes. Trends Cogn. Sci. 2004, 8(7):325-335.
37. Green A.E., Munafo M.R., DeYoung C.G., Fossella J.A., Fan J., Gray J.R. Using genetic data in cognitive neuroscience: from growing pains to genuine insights. Nat. Rev. Neurosci. 2008, 9(9):710-720.
38. Green C.S., Bavelier D. Action video game modifies visual selective attention. Nature 2003, 423(6939):534-537.
39. Green C.S., Bavelier D. Effect of action video games on the spatial distribution of visuospatial attention. J. Exp. Psychol. Hum. Percept. Perform. 2006, 32(6):1465-1478.
40. Green C.S., Bavelier D. Enumeration versus multiple object tracking: the case of action video game players. Cognition 2006, 101(1):217-245.
41. Green C.S., Bavelier D. Action-video-game experience alters the spatial resolution of vision. Psychol. Sci. 2007, 18(1):88-94.
42. Greenwood P.M., Fossella J.A., Parasuraman R. Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention. J. Cogn. Neurosci. 2005, 17(10):1611-1620.
43. Greenwood P.M., Lambert C., Sunderland T., Parasuraman R. Effects of apolipoprotein E genotype on spatial attention, working memory, and their interaction in healthy, middle-aged adults: results From the National Institute of Mental Health's BIOCARD study. Neuropsychology 2005, 19(2):199-211.
44. Greenwood P.M., Lin M.-K., Sundararajan R., Fryxell K.J., Parasuraman R. Gene-gene interactions between COMT and BDNF are exerted broadly on cognition. Paper Presented at the Society for Neuroscience 2008.
45. Greenwood P.M., Lin M.K., Sundararajan R., Fryxell K.J., Parasuraman R. Synergistic effects of genetic variation in nicotinic and muscarinic receptors on visual attention but not working memory. Proc. Natl. Acad. Sci. U.S.A. 2009, 106(9):3633-3638.
46. Greenwood P.M., Parasuraman R. Scale of attentional focus in visual search. Percept. Psychophys. 1999, 61:837-859.
47. Greenwood P.M, Parasuraman R. Normal genetic variation, cognition, and aging. Behav. Cogn. Neurosci. Rev. 2003, 2(4):278-306.
48. Greenwood P.M., Parasuraman R. The scaling of spatial attention in visual search and its modification in healthy aging. Percept. Psychophys. 2004, 66:3-22.
49. Greenwood P.M., Sundararajan R., Lin M.K., Kumar R., Fryxell K.J., Parasuraman R. Both a nicotinic single nucleotide polymorphism (SNP) and a noradrenergic SNP modulate working memory performance when attention is manipulated. J. Cogn. Neurosci. 2009, 21(11):2139-2153.
50. Hampshire A., Duncan J., Owen A.M. Selective tuning of the blood oxygenation level-dependent response during simple target detection dissociates human frontoparietal subregions. J. Neurosci. 2007, 27(23):6219-6223.
51. Harkness P.C., Millar N.S. Changes in conformation and subcellular distribution of alpha4beta2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. J. Neurosci. 2002, 22(23):10172-10181.
52. Hasselmo M.E., McGaughy J. High acetylcholine levels set circuit dynamics for attention and encoding and low acetylcholine levels set dynamics for consolidation. Prog. Brain Res. 2004, 145:207-231.
53. Havik B., Le Hellard S., Rietschel M., Lybaek H., Djurovic S., Mattheisen M., et al. The complement control-related genes CSMD1 and CSMD2 associate to schizophrenia. Biol. Psychiatry 2011, 70(1):35-42.
54. Hillmer A.T., Wooten D.W., Moirano J.M., Slesarev M., Barnhart T.E., Engle J.W., et al. Specific alpha4beta2 nicotinic acetylcholine receptor binding of [F-18]nifene in the rhesus monkey. Synapse 2011, 65(12):1309-1318.
55. Hogg R.C., Raggenbass M., Bertrand D. Nicotinic acetylcholine receptors: from structure to brain function. Rev. Physiol. Biochem. Pharmacol. 2003, 147:1-46.
56. Horovitz S.G., Skudlarski P., Gore J.C. Correlations and dissociations between BOLD signal and P300 amplitude in an auditory oddball task: a parametric approach to combining fMRI and ERP. Magn. Reson. Imaging 2002, 20(4):319-325.
57. Hughes C., Plumet M.H., Leboyer M. Towards a cognitive phenotype for autism: increased prevalence of executive dysfunction and superior spatial span amongst siblings of children with autism. J. Child Psychol. Psychiatry 1999, 40(5):705-718.
58. Jovicich J., Peters R.J., Koch C., Braun J., Chang L., Ernst T. Brain areas specific for attentional load in a motion-tracking task. J. Cogn. Neurosci. 2001, 13(8):1048-1058.
59. Kaufmann W.E., Abrams M.T., Chen W., Reiss A.L. Genotype, molecular phenotype, and cognitive phenotype: correlations in fragile X syndrome. Am. J. Med. Genet. 1999, 83(4):286-295.
60. Kim-Cohen J., Caspi A., Taylor A., Williams B., Newcombe R., Craig I.W., et al. MAOA, maltreatment, and gene-environment interaction predicting children's mental health: new evidence and a meta-analysis. Mol. Psychiatry 2006, 11(10):903-913.
61. Kuryatov A., Luo J., Cooper J., Lindstrom J. Nicotine acts as a pharmacological chaperone to up-regulate human alpha4beta2 acetylcholine receptors. Mol. Pharmacol. 2005, 68(6):1839-1851.
62. LaBerge D., Brown V., Carter M., Bash D., Hartley A. Reducing the effects of adjacent distractors by narrowing attention. J. Exp. Psychol. Hum. Percept. Perform. 1991, 17(1):65-76.
63. Lavie N. Perceptual load as a necessary condition for selective attention. J. Exp. Psychol. Hum. Percept. Perform. 1995, 21(3):451-468.
64. Markett S., Montag C., Walter N.T., Reuter M. Evidence for the modality independence of the genetic epistasis between the dopaminergic and cholinergic system on working memory capacity. Eur. Neuropsychopharmacol. 2009, 21(2):216-220.
65. Meinke A., Thiel C.M., Fink G.R. Effects of nicotine on visuo-spatial selective attention as indexed by event-related potentials. Neuroscience 2006, 141(1):201-212.
66. Mier D., Kirsch P., Meyer-Lindenberg A. Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Mol. Psychiatry 2010, 15(9):918-927.
67. Muller N.G., Bartelt O.A., Donner T.H., Villringer A., Brandt S.A. A physiological correlate of the " Zoom Lens" of visual attention. J. Neurosci. 2003, 23(9):3561-3565.
68. Murphy F.C., Klein R.M. The effects of nicotine on spatial and non-spatial expectancies in a covert orienting task. Neuropsychologia 1998, 36(11):1103-1114.
69. Nelson C.L., Sarter M., Bruno J.P. Prefrontal cortical modulation of acetylcholine release in posterior parietal cortex. Neuroscience 2005, 132(2):347-359.
70. Ozaki T.J. Frontal-to-parietal top-down causal streams along the dorsal attention network exclusively mediate voluntary orienting of attention. PLoS ONE 2011, 6(5):e20079.
71. Parasuraman R., Greenwood P.M., Haxby J.V., Grady C.L. Visuospatial attention in dementia of the Alzheimer type. Brain 1992, 115:711-733.
72. Parasuraman R., Greenwood P.M., Kumar R., Fossella J. Beyond heritability: neurotransmitter genes differentially modulate visuospatial attention and working memory. Psychol. Sci. 2005, 16(3):200-207.
73. Parasuraman R., Mouloua M. Interaction of signal discriminability and task type in vigilance decrement. Percept. Psychophys. 1987, 41(1):17-22.
74. Parikh V., Kozak R., Martinez V., Sarter M. Prefrontal acetylcholine release controls cue detection on multiple timescales. Neuron 2007, 56(1):141-154.
75. Phillips J.M., McAlonan K., Robb W.G., Brown V.J. Cholinergic neurotransmission influences covert orientation of visuospatial attention in the rat. Psychopharmacology (Berl.) 2000, 150(1):112-116.
76. Posner M.I. Orienting of attention. Q. J. Exp. Psychol. 1980, 32:3-25.
77. Posner M.I., Petersen S.E. The attention system of the human brain. Annu. Rev. Neurosci. 1990, 13:25-42.
78. Posner M.I., Rothbart M.K., Sheese B.E. Attention genes. Dev. Sci. 2007, 10(1):24-29.
79. Posner M.I., Walker J.A., Friedrich F.J., Rafal R.D. Effects of parietal injury on covert orienting of attention. J. Neurosci. 1984, 4(7):1863-1874.
80. Powell K.D., Goldberg M.E. Response of neurons in the lateral intraparietal area to a distractor flashed during the delay period of a memory-guided saccade. J. Neurophysiol. 2000, 84(1):301-310.
81. Purcell S.M., Wray N.R., Stone J.L., Visscher P.M., O'Donovan M.C., Sullivan P.F., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009, 460(7256):748-752.
82. Rubboli F., Court J.A., Sala C., Morris C., Perry E., Clementi F. Distribution of neuronal nicotinic receptor subunits in human brain. Neurochem. Int. 1994, 25(1):69-71.
83. Sallette J., Pons S., Devillers-Thiery A., Soudant M., Prado de Carvalho L., Changeux J.P., et al. Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron 2005, 46(4):595-607.
84. Sarter M., Gehring W.J., Kozak R. More attention must be paid: the neurobiology of attentional effort. Brain Res. Rev. 2006, 51(2):145-160.
85. Sears C.R., Pylyshyn Z.W. Multiple object tracking and attentional processing. Can. J. Exp. Psychol. 2000, 54(1):1-14.
86. Seshadri S., Fitzpatrick A.L., Ikram M.A., DeStefano A.L., Gudnason V., Boada M., et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 2010, 303(18):1832-1840.
87. Shirtcliff E.A., Marrocco R.T. Salivary cotinine levels in human tobacco smokers predict the attentional validity effect size during smoking abstinence. Psychopharmacology (Berl.) 2003, 166(1):11-18.
88. Shulman G.L., Astafiev S.V., Franke D., Pope D.L., Snyder A.Z., McAvoy M.P., et al. Interaction of stimulus-driven reorienting and expectation in ventral and dorsal frontoparietal and basal ganglia-cortical networks. J. Neurosci. 2009, 29(14):4392-4407.
89. Shulman G.L., McAvoy M.P., Cowan M.C., Astafiev S.V., Tansy A.P., d'Avossa G., et al. Quantitative analysis of attention and detection signals during visual search. J. Neurophysiol. 2003, 90(5):3384-3397.
90. Sridharan D., Levitin D.J., Menon V. A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. Proc. Natl. Acad. Sci. U.S.A. 2008, 105(34):12569-12574.
91. Steinlein O.K., Deckert J., Nothen M.M., Franke P., Maier W., Beckmann H., et al. Neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and panic disorder: an association study. Am. J. Med. Genet. 1997, 74(2):199-201.
92. Thiel C.M., Fink G.R. Visual and auditory alertness: modality-specific and supramodal neural mechanisms and their modulation by nicotine. J. Neurophysiol. 2007, 97(4):2758-2768.
93. Thiel C.M., Zilles K., Fink G.R. Nicotine modulates reorienting of visuospatial attention and neural activity in human parietal cortex. Neuropsychopharmacology 2005, 30(4):810-820.
94. Todd J.J., Fougnie D., Marois R. Visual short-term memory load suppresses temporo-parietal junction activity and induces inattentional blindness. Psychol. Sci. 2005, 16(12):965-972.
95. Vangkilde S., Bundesen C., Coull J.T. Prompt but inefficient: nicotine differentially modulates discrete components of attention. Psychopharmacology (Berl.) 2011, 667-680.
96. Vossel S., Thiel C.M., Fink G.R. Behavioral and neural effects of nicotine on visuospatial attentional reorienting in non-smoking subjects. Neuropsychopharmacology 2008, 33(4):731-738.
97. Voytko M.L., Olton D.S., Richardson R.T., Gorman L.K., Tobin J.R., Price D.L. Basal forebrain lesions in monkeys disrupt attention but not learning and memory. J. Neurosci. 1994, 14(1):167-186.
98. Wada E., Wada K., Boulter J., Deneris E., Heinemann S., Patrick J., et al. Distribution of alpha 2, alpha 3, alpha 4, and beta 2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J. Comp. Neurol. 1989, 284(2):314-335.
99. Weissman D.H., Roberts K.C., Visscher K.M., Woldorff M.G. The neural bases of momentary lapses in attention. Nat. Neurosci. 2006, 9(7):971-978.
100. Winterer G., Musso F., Konrad A., Vucurevic G., Stoeter P., Sander T., et al. Association of attentional network function with exon 5 variations of the CHRNA4 gene. Hum. Mol. Genet. 2007, 16(18):2165-2174.
101. Winterer G., Rujescu D., Maier W., Steinlein O.K., Bertrand D. CHRNA4 Exon 5 genotype affects nicotinic receptor sensitivity and is associated with clinically high-functioning schizophrenia rapid drug treatment-response and superior prefrontal function. Paper Presented at the Nicotinic Acetylcholine Receptors 2011.
102. Witte E.A., Davidson M.C., Marrocco R.T. Effects of altering brain cholinergic activity on covert orienting of attention: comparison of monkey and human performance. Psychopharmacology (Berl.) 1997, 132(4):324-334.
103. Wu J., Ishikawa M., Zhang J., Hashimoto K. Brain imaging of nicotinic receptors in Alzheimer's disease. Int. J. Alzheimers Dis. 2010, 2010:548913.
104. Yarkoni T., Poldrack R.A., Van Essen D.C., Wager T.D. Cognitive neuroscience 2.0: building a cumulative science of human brain function. Trends Cogn. Sci. 2010, 14(11):489-496.