Plasminogen is a critical regulator of cutaneous wound healing

Thrombosis and Haemostasis

Volumn 115, Issue 5, 2016, Pages 1001-1009

  Sulniute, Rima ^a   Shen, Yue ^a   Guo, Yong Zhi ^a   Fallah, Mahsa ^a   Ahlskog, Nina ^a   Ny, Lina ^a   Rakhimova, Olena ^a   Broden, Jessica ^a   Boija, Hege ^a   Moghaddam, Aliyeh ^a   Li, Jinan ^a   Wilczynska, Malgorzata ^a   Ny, Tor ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Inflammation; Plasminogen; Wound healing

Indexed keywords

FIBRINOGEN; PLASMINOGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BURN; CELL MIGRATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INCISION; INFLAMMATORY INFILTRATE; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DEFICIENCY; FUNCTIONS OF THE SKIN AND ITS APPENDAGES; GENETICS; HUMAN; INJURIES; KNOCKOUT MOUSE; METABOLISM; NEUTROPHIL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SKIN;

ANIMALS; BURNS; FIBRINOGEN; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NEUTROPHILS; PLASMINOGEN; SKIN; SKIN PHYSIOLOGICAL PHENOMENA; WOUND HEALING;

EID: 84964826142     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-08-0653     Document Type: Article

References (39)

1. Bratton DL, Henson PM. Neutrophil clearance: when the party is over, clean-up begins. Trends Immunol 2011; 32: 350-357.
2. Mocsai A. Diverse novel functions of neutrophils in immunity, inflammation, and beyond. J Experimental Med 2013; 210: 1283-1299.
3. Koh TJ, DiPietro LA. Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med 2011; 13: e23.
4. Weber CE, Li NY, Wai PY, et al. Epithelial-mesenchymal transition, TGF-beta, and osteopontin in wound healing and tissue remodeling after injury. J Burn Care Res 2012; 33: 311-318.
5. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007; 127: 514-525.
6. Lund LR, Romer J, Bugge TH, et al. Functional overlap between two classes of matrix-degrading proteases in wound healing. EMBO J 1999; 18: 4645-4656.
7. Romer J, Bugge TH, Pyke C, et al. Plasminogen and wound healing. Nature Med 1996; 2: 725.
8. Ra HJ, Parks WC. Control of matrix metalloproteinase catalytic activity. Matrix Biol 2007; 26: 587-596.
9. Blasi F. Proteolysis, cell adhesion, chemotaxis, and invasiveness are regulated by the u-PA-u-PAR-PAI-1 system. Thromb Haemost 1999; 82: 298-304.
10. Mignatti P, Rifkin DB. Biology and biochemistry of proteinases in tumor invasion. Physiol Rev 1993; 73: 161-195.
11. Romer J, Bugge TH, Pyke C, et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med 1996; 2: 287-292.
12. Rovee DTMH. The epidermis in wound healing. Dermatology: clinical and basics science series, CRC Press. 2004.
13. Busuttil SJ, Ploplis VA, Castellino FJ, et al. A central role for plasminogen in the inflammatory response to biomaterials. J Thromb Haemost 2004; 2: 1798-1805.
14. Schaiff WT, Eisenberg PR. Direct induction of complement activation by pharmacologic activation of plasminogen. Coronary Artery Dis 1997; 8: 9-18.
15. Syrovets T, Lunov O, Simmet T. Plasmin as a proinflammatory cell activator. J Leukocyte Biol 2012; 92: 509-519.
16. Eriksson PO, Li J, Ny T, et al. Spontaneous development of otitis media in plasminogen-deficient mice. Intern J Med Microbiol 2006; 296: 501-509.
17. Shen Y, Guo Y, Mikus P, et al. Plasminogen is a key proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Blood 2012; 119: 5879-5887.
18. Ploplis VA, Carmeliet P, Vazirzadeh S, et al. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Circulation 1995; 92: 2585-2593.
19. Ny A, Leonardsson G, Hagglund AC, et al. Ovulation in plasminogen-deficient mice. Endocrinology 1999; 140: 5030-5035.
20. Li J, Eriksson PO, Hansson A, et al. Plasmin/plasminogen is essential for the healing of tympanic membrane perforations. Thromb Haemost 2006; 96: 512-519.
21. Church D, Elsayed S, Reid O, et al. Burn wound infections. Clin Microbiol Rev 2006; 19: 403-434.
22. Lund LR, Green KA, Stoop AA, et al. Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice. EMBO J 2006; 25: 2686-2697.
23. Jogi A, Rono B, Lund IK, et al. Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice. PloS one 2010; 5: e12746.
24. Green KA, Almholt K, Ploug M, et al. Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogen. J Invest Dermatol 2008; 128: 2092-2101.
25. Guo Y, Li J, Hagstrom E, et al. Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis. Arthritis Rheumatism 2008; 58: 764-772.
26. Drew AF, Tucker HL, Kombrinck KW, et al. Plasminogen is a critical determinant of vascular remodeling in mice. Circulation Res 2000; 87: 133-139.
27. Sulniute R, Lindh T, Wilczynska M, et al. Plasmin is essential in preventing periodontitis in mice. Am J Pathol 2011; 179: 819-828.
28. Bezerra JA, Bugge TH, Melin-Aldana H, et al. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver. Proc Natl Acad Sci USA 1999; 96: 15143-15148.
29. Pohl JF, Melin-Aldana H, Sabla G, et al. Plasminogen deficiency leads to impaired lobular reorganisation and matrix accumulation after chronic liver injury. Am J Pathol 2001; 159: 2179-2186.
30. Ng VL, Sabla GE, Melin-Aldana H, et al. Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury. J Hepatol 2001; 35: 781-789.
31. Kawao N, Nagai N, Tamura Y, et al. Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo. Thromb Haemost 2012; 107: 749-759.
32. Rosenwald M, Koppe U, Keppeler H, et al. Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance. J Immunol 2012; 189: 5722-5728.
33. Das R, Ganapathy S, Mahabeleshwar GH, et al. Macrophage gene expression and foam cell formation are regulated by plasminogen. Circulation 2013; 127: 1209-1218, e1-16.
34. Guo Y, Li J, Hagstrom E, et al. Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice. PloS one 2011; 6: e24774.
35. Hepburn L, Prajsnar TK, Klapholz C, et al. Innate immunity. A Spaetzle-like role for nerve growth factor beta in vertebrate immunity to Staphylococcus aureus. Science 2014; 346: 641-646.
36. Kawamoto K, Matsuda H. Nerve growth factor and wound healing. Prog Brain Res 2004; 146: 369-384.
37. Sulniute R, Lindh T, Wilczynska M, et al. Plasmin is essential in preventing periodontitis in mice. Am J Pathol 2012; 179: 819-828.
38. Miles LA, Parmer RJ. Plasminogen receptors: the first quarter century. Semin Thromb Hemost 2013; 39: 329-337.
39. Deryugina EI, Quigley JP. Cell surface remodelling by plasmin: a new function for an old enzyme. J Biomed Biotechnol 2012; 2012: 564259.