Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR

European Journal of Medicinal Chemistry

Volumn 118, Issue , 2016, Pages 250-258

  Abdelall, Eman K A ^a   Kamel, Gehan M ^b  

^a Beni Suef University   (Egypt)

^b Cairo University   (Egypt)

Author keywords

15 Lipoxygenase inhibitors; Anti inflammatory; Celecoxib analogues; Cyclooxygenase inhibitors; DMFDMA; Ethyl trifloroacetate; SO2NH2 pharmacophores

Indexed keywords

1 [1 (4 METHYL 2 PHENYLTHIAZOL 5 YL)ETHYLIDENE] 2 (4 METHYLSULFONYL)PHENYL) HYDRAZINE; 1 [1 (4 METHYL 2 PHENYLTHIAZOL 5 YL)ETHYLIDENE] 2 (4 SULFAMOYL-PHENYL) HYDRAZINE; 4,5 DIHYDRO 5 (4 METHOXYPHENYL) 3 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 [4 (METHYLSULFONYL)PHENYL] 1H PYRAZOLE; 4,5 DIHYDRO 5 (4 METHOXYPHENYL) 3 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 [4 (SULFAMOYL)PHENYL] 1H PYRAZOLE; 5 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 [4 (METHYLSULFONYL) PHENYL] 1H PYRAZOLE; 5 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 [4 (N,N DIMETHYLFORMAMIDINE SULFAM OYL) PHENYL] 1H PYRAZOLE; 5 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 [4 (SULFAMOYL)PHENYL] 1H PYRAZOLE; 5 (TRIFLUOROMETHYL) 3 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 (4 METHYL SULFONYL) PHENYL) 1H PYRAZOLE; 5 (TRIFLUOROMETHYL) 3 (4 METHYL 2 PHENYLTHIAZOL 5 YL) 1 (4 SULFAMOYL-PHENYL) 1H PYRAZOLE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; MECLOFENAMATE SODIUM; OXYGENASE INHIBITOR; PYRAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; ARACHIDONATE 15 LIPOXYGENASE; CYCLOOXYGENASE 2; LIPOXYGENASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PYRAZOLE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLIZATION; DRUG DETERMINATION; DRUG DOSE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; IC50; IN VITRO STUDY; IN VIVO STUDY; MALE; MELTING POINT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PAW EDEMA; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM MECHANICS; RAT; THIN LAYER CHROMATOGRAPHY; ULCERATION INDEX; ANIMAL; BOVINE; CHEMICALLY INDUCED; CHEMISTRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM; SYNTHESIS; ULCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 15-LIPOXYGENASE; CATTLE; CELECOXIB; CHEMISTRY TECHNIQUES, SYNTHETIC; CYCLIZATION; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PYRAZOLES; RATS; STEREOISOMERISM; THIAZOLES; ULCER;

EID: 84964789953     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.04.049     Document Type: Article

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