Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression

Journal of Biological Chemistry

Volumn 291, Issue 13, 2016, Pages 7017-7028

  Okazaki, Fumiyasu ^a,b   Matsunaga, Naoya ^b   Okazaki, Hiroyuki ^c   Azuma, Hiroki ^b   Hamamura, Kengo ^c   Tsuruta, Akito ^b   Tsurudome, Yuya ^b   Ogino, Takashi ^b   Hara, Yukinori ^b   Suzuki, Takuya ^d   Hyodo, Kenji ^d   Ishihara, Hiroshi ^d   Kikuchi, Hiroshi ^e   To, Hideto ^a   Aramaki, Hironori ^c   Koyanagi, Satoru ^b   Ohdo, Shigehiro ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c DAIICHI UNIVERSITY OF PHARMACY   (Japan)

^d Pharmaceutical Science and Technology Core Function Unit   (Japan)

^e EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CLOCKS; CYTOLOGY; IRON; MAMMALS; PROTEINS; TRANSCRIPTION;

BIOLOGICAL CATALYSTS; CIRCADIAN ORGANIZATION; CIRCADIAN VARIATION; IRON REGULATORY PROTEINS; PROLIFERATION RATE; TIME DEPENDENT VARIATIONS; TRANSFERRIN RECEPTOR 1; TUMOR PROGRESSIONS;

TUMORS;

CD71 ANTIGEN; IRON; IRON REGULATORY PROTEIN 2; MESSENGER RNA; TRANSCRIPTION FACTOR ARNTL; TRANSCRIPTION FACTOR CLOCK; ARNTL PROTEIN, MOUSE; CATION TRANSPORT PROTEIN; CIRCADIAN RHYTHM SIGNALING PROTEIN; CLOCK PROTEIN, MOUSE; IRON REGULATORY PROTEIN 1; PER2 PROTEIN, MOUSE; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; TFRC PROTEIN, MOUSE; TRANSFERRIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BMAL1 GENE; CELL PROLIFERATION; CIRCADIAN RHYTHM; CLOCK GENE; COLON TUMOR; CONTROLLED STUDY; DOWN REGULATION; IRON METABOLISM; IRON RESPONSIVE ELEMENT; IRP2 GENE; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN RNA BINDING; RNA STABILITY; RNA TRANSCRIPTION; TRANSCRIPTION REGULATION; TUMOR GROWTH; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; COLON; DEFICIENCY; DNA RESPONSIVE ELEMENT; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANIMALS; ARNTL TRANSCRIPTION FACTORS; CATION TRANSPORT PROTEINS; CELL LINE, TUMOR; CIRCADIAN CLOCKS; CLOCK PROTEINS; COLON; COLONIC NEOPLASMS; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; MALE; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; PERIOD CIRCADIAN PROTEINS; PROTEIN MULTIMERIZATION; RECEPTORS, TRANSFERRIN; RESPONSE ELEMENTS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84964789144     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.713412     Document Type: Article

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