Time Course of Coagulation and Fibrinolytic Parameters in Patients with Traumatic Brain Injury

Journal of Neurotrauma

Volumn 33, Issue 7, 2016, Pages 688-695

  Nakae, Ryuta ^a   Takayama, Yasuhiro ^b   Kuwamoto, Kentaro ^b   Naoe, Yasutaka ^a   Sato, Hidetaka ^b   Yokota, Hiroyuki ^b  

^a Kawaguchi Municipal Medical Center   (Japan)

^b NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

coagulopathy; D dimer; fibrinolysis; prognosis; traumatic brain injury

Indexed keywords

D DIMER; FIBRINOGEN; BIOLOGICAL MARKER; FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

ABBREVIATED INJURY SCORE; ADULT; AGE; AGED; ARTICLE; BLOOD CLOTTING DISORDER; BLOOD SAMPLING; BRAIN INJURY ASSESSMENT; FEMALE; FIBRINOGEN BLOOD LEVEL; FIBRINOLYSIS; GLASGOW COMA SCALE; HOSPITAL ADMISSION; HUMAN; IMMUNOASSAY ANALYZER; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; RETROSPECTIVE STUDY; THROMBOCYTE COUNT; TRAUMATIC BRAIN INJURY; AREA UNDER THE CURVE; BLOOD; BLOOD CLOTTING; BLOOD COAGULATION DISORDERS; COMPLICATION; MIDDLE AGED; PHYSIOLOGY; PROGNOSIS; RECEIVER OPERATING CHARACTERISTIC; TIME FACTOR;

ADULT; AGED; AREA UNDER CURVE; BIOMARKERS; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; BRAIN INJURIES, TRAUMATIC; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; FIBRINOLYSIS; HUMANS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PLATELET COUNT; PROGNOSIS; PROTHROMBIN TIME; RETROSPECTIVE STUDIES; ROC CURVE; TIME FACTORS;

EID: 84964757104     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2015.4039     Document Type: Article

References (61)

1. Epstein, D.S., Mitra, B., O'Reilly, G., Rosenfeld, J.V., and Cameron, P.A. (2014). Acute traumatic coagulopathy in the setting of isolated traumatic brain injury: a systematic review and meta-analysis. Injury 45, 819-824.
2. Harhangi, B.S., Kompanje, E.J., Leebeek, F.W., and Maas, A.I. (2008). Coagulation disorders after traumatic brain injury. Acta Neurochir. (Wien) 150, 165-175.
3. Wafaisade, A., Lefering, R., Tjardes, T., Wutzler, S., Simanski, C., Paffrath, T., Fischer, P., Bouillon, B., and Maegele, M. (2010). Acute coagulopathy in isolated blunt traumatic brain injury. Neurocrit. Care 12, 211-219.
4. Laroche, M., Kutcher, M.E., Huang, M.C., Cohen, M.J., and Manley, G.T. (2012). Coagulopathy after traumatic brain injury. Neurosurgery 70, 1334-1345.
5. Maegele, M. (2013). Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options. Transfusion (Paris). 53 Suppl 1, S28-S37.
6. Stein, S.C., and Smith, D.H. (2004). Coagulopathy in traumatic brain injury. Neurocrit. Care 1, 479-488.
7. Allard, C.B., Scarpelini, S., Rhind, S.G., Baker, A.J., Shek, P.N., Tien, H., Fernando, M., Tremblay, L., Morrison, L.J., Pinto, R., and Rizoli, S.B. (2009). Abnormal coagulation tests are associated with progression of traumatic intracranial hemorrhage. J. Trauma 67, 959-967.
8. Kurland, D., Hong, C., Aarabi, B., Gerzanich, V., and Simard, J.M. (2012). Hemorrhagic progression of a contusion after traumatic brain injury: a review. J. Neurotrauma 29, 19-31.
9. Stein, S.C., Spettell, C., Young, G., and Ross, S.E. (1993). Delayed and progressive brain injury in closed-head trauma: radiological demonstration. Neurosurgery 32, 25-31.
10. Astrup, T. (1965). Assay and content of tissue thromboplastin in different organs. Thromb. Diath. Haemorrh. 14, 401-416.
11. Goodnight, S.H., Kenoyer, G., Rapaport, S.I., Patch, M.J., Lee, J.A., and Kurze, T. (1974). Defibrination after brain-tissue destruction: A serious complication of head injury. N. Engl. J. Med. 290, 1043-1047.
12. Keimowitz, R.M., and Annis, B.L. (1973). Disseminated intravascular coagulation associated with massive brain injury. J. Neurosurg. 39, 178-180.
13. Takahashi, H., Urano, T., Takada, Y., Nagai, N., and Takada, A. (1997). Fibrinolytic parameters as an admission prognostic marker of head injury in patients who talk and deteriorate. J. Neurosurg. 86, 768-772.
14. Van Beek, J.G., Mushkudiani, N.A., Steyerberg, E.W., Butcher, I., McHugh, G.S., Lu, J., Marmarou, A., Murray, G.D., and Maas, A.I. (2007). Prognostic value of admission laboratory parameters in traumatic brain injury: results from the IMPACT study. J. Neurotrauma 24, 315-328.
15. Crone, K.R., Lee, K.S., and Kelly, D.L., Jr. (1987). Correlation of admission fibrin degradation products with outcome and respiratory failure in patients with severe head injury. Neurosurgery 21, 532-536.
16. Juratli, T.A., Zang, B., Litz, R.J., Sitoci, K.H., Aschenbrenner, U., Gottschlich, B., Daubner, D., Schackert, G., and Sobottka, S.B. (2014). Early hemorrhagic progression of traumatic brain contusions: frequency, correlation with coagulation disorders, and patient outcome: a prospective study. J. Neurotrauma 31, 1521-1527.
17. Olson, J.D., Kaufman, H.H., Moake, J., O'Gorman, T.W., Hoots, K., Wagner, K., Brown, C.K., and Gildenberg, P.L. (1989). The incidence and significance of hemostatic abnormalities in patients with head injuries. Neurosurgery 24, 825-832.
18. Greuters, S., van den Berg, A., Franschman, G., Viersen, V.A., Beishuizen, A., Peerdeman, S.M., and Boer, C. (2011). Acute and delayed mild coagulopathy are related to outcome in patients with isolated traumatic brain injury. Crit Care 15, R2.
19. Alberico, A.M., Ward, J.D., Choi, S.C., Marmarou, A., and Young, H.F. (1987). Outcome after severe head injury. Relationship to mass lesions, diffuse injury, and ICP course in pediatric and adult patients. J. Neurosurg. 67, 648-656.
20. Becker, D.P., Miller, J.D., Ward, J.D., Greenberg, R.P., Young, H.F., and Sakalas, R. (1977). The outcome from severe head injury with early diagnosis and intensive management. J. Neurosurg. 47, 491-502.
21. Kushimoto, S., Yamamoto, Y., Shibata, Y., Sato, H., and Koido, Y. (2001). Implications of excessive fibrinolysis and alpha(2)-plasmin inhibitor deficiency in patients with severe head injury. Neurosurgery 49, 1084-1090.
22. Halpern, C.H., Reilly, P.M., Turtz, A.R., and Stein, S.C. (2008). Traumatic coagulopathy: the effect of brain injury. J. Neurotrauma 25, 997-1001.
23. Lustenberger, T., Talving, P., Kobayashi, L., Inaba, K., Lam, L., Plurad, D., and Demetriades, D. (2010). Time course of coagulopathy in isolated severe traumatic brain injury. Injury 41, 924-928.
24. Talving, P., Benfield, R., Hadjizacharia, P., Inaba, K., Chan, L.S., and Demetriades, D. (2009). Coagulopathy in severe traumatic brain injury: a prospective study. J. Trauma 66, 55-62.
25. Hukkelhoven, C.W., Steyerberg, E.W., Rampen, A.J., Farace, E., Habbema, J.D., Marshall, L.F., Murray, G.D., and Maas, A.I. (2003). Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. J. Neurosurg. 99, 666-673.
26. Murray, G.D., Butcher, I., McHugh, G.S., Lu, J., Mushkudiani, N.A., Maas, A.I., Marmarou, A., and Steyerberg, E.W. (2007). Multivariable prognostic analysis in traumatic brain injury: results from the IMPACT study. J. Neurotrauma 24, 329-337.
27. Vollmer, D.G., Torner, J.C., Jane, J.A., Sadovnic, B., Charlebois, D., Eisenberg, H.M., Foulkes, M.A., Marmarou, A., and Marshall, L.F. (1991). Age and outcome following traumatic coma: why do older patients fare worse? J. Neurosurg. 75, S37-S49.
28. Association for the Advancement of Automotive Medicine. (1998). The Abbreviated Injury Scale (AIS) 1998 Revision. Association for the Advancement of Automotive Medicine: Des Plaines, IL.
29. Shigemori, M., Abe, T., Aruga, T., Ogawa, T., Okudera, H., Ono, J., Onuma, T., Katayama, Y., Kawai, N., Kawamata, T., Kohmura, E., Sakaki, T., Sakamoto, T., Sasaki, T., Sato, A., Shiogai, T., Shima, K., Sugiura, K., Takasato, Y., Tokutomi, T., Tomita, H., Toyoda, I., Nagao, S., Nakamura, H., Park, Y.S., Matsumae, M., Miki, T., Miyake, Y., Murai, H., Murakami, S., Yamaura, A., Yamaki, T., Yamada, K., Yoshimine, T., and Guidelines Committee on the Management of Severe Head Injury, the Japan Society of Neurotraumatology. (2012). Guidelines for the Management of Severe Head Injury. 2nd Edition guidelines from the Guidelines Committee on the Management of Severe Head Injury, the Japan Society of Neurotraumatology. Neurol. Med. Chir. (Tokyo). 52, 1-30.
30. Jennett, B., Snoek, J., Bond, M.R., and Brooks, N. (1981). Disability after severe head injury: observations on the use of the Glasgow Outcome Scale. J. Neurol. Neurosurg. Psychiatry 44, 285-293.
31. Carrick, M.M., Tyroch, A.H., Youens, C.A., and Handley, T. (2005). Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination. J. Trauma 58, 725-730.
32. Gando, S., Nanzaki, S., and Kemmotsu, O. (1999). Coagulofibrinolytic changes after isolated head injury are not different from those in trauma patients without head injury. J. Trauma 46, 1070-1077.
33. Kuo, J.R., Chou, T.J., and Chio, C.C. (2004). Coagulopathy as a parameter to predict the outcome in head injury patients-analysis of 61 cases. J. Clin. Neurosci. 11, 710-714.
34. Kushimoto, S., Shibata, Y., and Yamamoto, Y. (2003). Implications of fibrinogenolysis in patients with closed head injury. J. Neurotrauma 20, 357-363.
35. Yokota, H., Naoe, Y., Nakabayashi, M., Unemoto, K., Kushimoto, S., Kurokawa, A., Node, Y., and Yamamoto, Y. (2002). Cerebral endothelial injury in severe head injury: the significance of measurements of serum thrombomodulin and the von Willebrand factor. J. Neurotrauma 19, 1007-1015.
36. Jamjoom, A. (1992). The influence of concomitant intradural pathology on the presentation and outcome of patients with acute traumatic extradural haematoma. Acta Neurochir. (Wien). 115, 86-89.
37. Lobato, R.D., Rivas, J.J., Cordobes, F., Alted, E., Perez, C., Sarabia, R., Cabrera, A., Diez, I., Gomez, P., and Lamas, E. (1988). Acute epidural hematoma: an analysis of factors influencing the outcome of patients undergoing surgery in coma. J. Neurosurg. 68, 48-57.
38. Phonprasert, C., Suwanwela, C., Hongsaprabhas, C., Prichayudh, P., and O'Charoen, S. (1980). Extradural hematoma: analysis of 138 cases. J. Trauma 20, 679-683.
39. Lobato, R.D., Rivas, J.J., Gomez, P.A., Castaneda, M., Canizal, J.M., Sarabia, R., Cabrera, A., and Munoz, M.J. (1991). Head-injured patients who talk and deteriorate into coma. Analysis of 211 cases studied with computerized tomography. J. Neurosurg. 75, 256-261.
40. Marshall, L.F., Toole, B.M., and Bowers, S.A. (1983). The National Traumatic Coma Data Bank. Part 2: Patients who talk and deteriorate: implications for treatment. J. Neurosurg. 59, 285-288.
41. Ratanalert, S., Chompikul, J. and Hirunpat, S. (2002). Talked and deteriorated head injury patients: how many poor outcomes can be avoided? J. Clin. Neurosci. 9, 640-643.
42. Goldschlager, T., Rosenfeld, J.V., and Winter, C.D. (2007). 'Talk and die' patients presenting to a major trauma centre over a 10 year period: a critical review. J. Clin. Neurosci. 14, 618-624.
43. MacLeod, J.B., Lynn, M., McKenney, M.G., Cohn, S.M., and Murtha, M. (2003). Early coagulopathy predicts mortality in trauma. J. Trauma 55, 39-44.
44. Oertel, M., Kelly, D.F., McArthur, D., Boscardin, W.J., Glenn, T.C., Lee, J.H., Gravori, T., Obukhov, D., McBride, D.Q., and Martin, N.A. (2002). Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J. Neurosurg. 96, 109-116.
45. Schnuriger, B., Inaba, K., Abdelsayed, G.A., Lustenberger, T., Eberle, B.M., Barmparas, G., Talving, P., and Demetriades, D. (2010). The impact of platelets on the progression of traumatic intracranial hemorrhage. J. Trauma 68, 881-885.
46. Stein, S.C., Young, G.S., Talucci, R.C., Greenbaum, B.H., and Ross, S.E. (1992). Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery 30, 160-165.
47. Sun, Y., Wang, J., Wu, X., Xi, C., Gai, Y., Liu, H., Yuan, Q., Wang, E., Gao, L., Hu, J., and Zhou, L. (2011). Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury-analysis of 242 cases. Br. J. Neurosurg. 25, 363-368.
48. Kario, K., and Matsuo, T. (1993). Lipid-related hemostatic abnormalities in the elderly: imbalance between coagulation and fibrinolysis. Atherosclerosis 103, 131-138.
49. Kario, K., Matsuo, T., and Kobayashi, H. (1991). Which factors affect high D-dimer levels in the elderly? Thromb. Res. 62, 501-508.
50. MacCallum, P.K., Cooper, J.A., Martin, J., Howarth, D.J., Meade, T.W., and Miller, G.J. (2000). Haemostatic and lipid determinants of prothrombin fragment F1.2 and D-dimer in plasma. Thromb. Haemost. 83, 421-426.
51. Mari, D., Mannucci, P.M., Coppola, R., Bottasso, B., Bauer, K.A., and Rosenberg, R.D. (1995). Hypercoagulability in centenarians: the paradox of successful aging. Blood 85, 3144-3149.
52. May, A.K., Young, J.S., Butler, K., Bassam, D., and Brady, W. (1997). Coagulopathy in severe closed head injury: is empiric therapy warranted? Am. Surg. 63, 233-237.
53. Anglin, C.O., Spence, J.S., Warner, M.A., Paliotta, C., Harper, C., Moore, C., Sarode, R., Madden, C., and Diaz-Arrastia, R. (2013). Effects of platelet and plasma transfusion on outcome in traumatic brain injury patients with moderate bleeding diatheses. J. Neurosurg. 118, 676-686.
54. Winter, J.P., Plummer, D., Bottini, A., Rockswold, G.R., and Ray, D. (1989). Early fresh frozen plasma prophylaxis of abnormal coagulation parameters in the severely head-injured patient is not effective. Ann. Emerg. Med. 18, 553-555.
55. Morenski, J.D., Tobias, J.D., and Jimenez, D.F. (2003). Recombinant activated factor VII for cerebral injury-induced coagulopathy in pediatric patients. Report of three cases and review of the literature. J. Neurosurg. 98, 611-616.
56. Mayer, S.A., Brun, N.C., Begtrup, K., Broderick, J., Davis, S., Diringer, M.N., Skolnick, B.E., Steiner, T.; Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators. (2005). Recombinant activated factor VII for acute intracerebral hemorrhage. N. Engl. J. Med. 352, 777-785.
57. Perel, P., Roberts, I., Shakur, H., Thinkhamrop, B., Phuenpathom, N., and Yutthakasemsunt, S. (2010). Haemostatic drugs for traumatic brain injury. Cochrane Database Syst. Rev. CD007877.
58. Crash-Trial Collaborators, Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, El-Sayed H, Gogichaishvili T, Gupta S, Herrera J, Hunt B, Iribhogbe P, Izurieta M, Khamis H, Komolafe E, Marrero MA, Mejía-Mantilla J, Miranda J, Morales C, Olaomi O, Olldashi F, Perel P, Peto R, Ramana PV, Ravi RR, Yutthakasemsunt S. (2010). Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376, 23-32.
59. Crash-2 Trial Collaborators. (2011). Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study). BMJ 343, d3795.
60. Clinical Trials.gov. (n. d.). Prehospital tranexamic acid use for traumatic brain injury. Available at: https://clinicaltrials.gov/ct2/show/study/NCT01990768#contacts. Accessed: Aug. 25, 2015.
61. Dewan, Y., Komolafe, E.O., Mejia-Mantilla, J.H., Perel, P., Roberts, I., and Shakur, H. (2012). CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial. Trials 13, 87.