메뉴 건너뛰기




Volumn 2, Issue 1, 2014, Pages

Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy

Author keywords

COQ2; Mitochondrial fission; Multiple system atrophy; Nucleus; P25 Tubulin polymerization promoting protein (TPPP); synuclein

Indexed keywords

ANTIBODY; NERVE PROTEIN; P25 PROTEIN, HUMAN; UBIQUINONE; UBIQUINONE Q2;

EID: 84964698725     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/s40478-014-0136-4     Document Type: Review
Times cited : (36)

References (42)
  • 1
    • 0025769484 scopus 로고
    • A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions
    • Takahashi M, Tomizawa K, Ishiguro K, Sato K, Omori A, Sato S, Shiratsuchi A, Uchida T, Imahori K: A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions. FEBS Lett 1991, 289: 37-43. 10.1016/0014-5793(91)80903-G
    • (1991) FEBS Lett , vol.289 , pp. 37-43
    • Takahashi, M.1    Tomizawa, K.2    Ishiguro, K.3    Sato, K.4    Omori, A.5    Sato, S.6    Shiratsuchi, A.7    Uchida, T.8    Imahori, K.9
  • 2
    • 0037047003 scopus 로고    scopus 로고
    • Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations
    • Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF, Ovadi J: Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. Biochemistry 2002, 41: 8657-8664. 10.1021/bi020140g
    • (2002) Biochemistry , vol.41 , pp. 8657-8664
    • Hlavanda, E.1    Kovacs, J.2    Olah, J.3    Orosz, F.4    Medzihradszky, K.F.5    Ovadi, J.6
  • 3
    • 33748689004 scopus 로고    scopus 로고
    • P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain
    • Skjoerringe T, Lundvig DM, Jensen PH, Moos T: P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain. J Neurochem 2006, 99: 333-342. 10.1111/j.1471-4159.2006.04073.x
    • (2006) J Neurochem , vol.99 , pp. 333-342
    • Skjoerringe, T.1    Lundvig, D.M.2    Jensen, P.H.3    Moos, T.4
  • 4
    • 73149109270 scopus 로고    scopus 로고
    • Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
    • Lehotzky A, Lau P, Tokesi N, Muja N, Hudson LD, Ovadi J: Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. Glia 2010, 58: 157-168. 10.1002/glia.20909
    • (2010) Glia , vol.58 , pp. 157-168
    • Lehotzky, A.1    Lau, P.2    Tokesi, N.3    Muja, N.4    Hudson, L.D.5    Ovadi, J.6
  • 6
    • 67650175319 scopus 로고    scopus 로고
    • An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration
    • Ovadi J, Orosz F: An unstructured protein with destructive potential: TPPP/p25 in neurodegeneration. Bioessays 2009, 31: 676-686. 10.1002/bies.200900008
    • (2009) Bioessays , vol.31 , pp. 676-686
    • Ovadi, J.1    Orosz, F.2
  • 9
    • 80155138574 scopus 로고    scopus 로고
    • Zn(2) + -induced rearrangement of the disordered TPPP/p25 affects its microtubule assembly and GTPase activity
    • Zotter A, Olah J, Hlavanda E, Bodor A, Perczel A, Szigeti K, Fidy J, Ovadi J: Zn(2) + -induced rearrangement of the disordered TPPP/p25 affects its microtubule assembly and GTPase activity. Biochemistry 2011, 50: 9568-9578. 10.1021/bi201447w
    • (2011) Biochemistry , vol.50 , pp. 9568-9578
    • Zotter, A.1    Olah, J.2    Hlavanda, E.3    Bodor, A.4    Perczel, A.5    Szigeti, K.6    Fidy, J.7    Ovadi, J.8
  • 13
    • 0024843373 scopus 로고
    • Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome)
    • Papp MI, Kahn JE, Lantos PL: Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome). J Neurol Sci 1989, 94: 79-100. 10.1016/0022-510X(89)90219-0
    • (1989) J Neurol Sci , vol.94 , pp. 79-100
    • Papp, M.I.1    Kahn, J.E.2    Lantos, P.L.3
  • 15
    • 0031715398 scopus 로고    scopus 로고
    • NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
    • Arima K, Ueda K, Sunohara N, Arakawa K, Hirai S, Nakamura M, Tonozuka-Uehara H, Kawai M: NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 1998, 96: 439-444. 10.1007/s004010050917
    • (1998) Acta Neuropathol , vol.96 , pp. 439-444
    • Arima, K.1    Ueda, K.2    Sunohara, N.3    Arakawa, K.4    Hirai, S.5    Nakamura, M.6    Tonozuka-Uehara, H.7    Kawai, M.8
  • 16
    • 0032529707 scopus 로고    scopus 로고
    • Multiple-system atrophy: a new alpha-synuclein disease?
    • Gai WP, Power JH, Blumbergs PC, Blessing WW: Multiple-system atrophy: a new alpha-synuclein disease? Lancet 1998, 352: 547-548. 10.1016/S0140-6736(05)79256-4
    • (1998) Lancet , vol.352 , pp. 547-548
    • Gai, W.P.1    Power, J.H.2    Blumbergs, P.C.3    Blessing, W.W.4
  • 17
    • 0032584686 scopus 로고    scopus 로고
    • Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, Crowther RA, Jakes R, Cairns NJ, Lantos PL, Goedert M: Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies. Neurosci Lett 1998, 251: 205-208. 10.1016/S0304-3940(98)00504-7
    • (1998) Neurosci Lett , vol.251 , pp. 205-208
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Cairns, N.J.4    Lantos, P.L.5    Goedert, M.6
  • 18
  • 19
    • 0032546895 scopus 로고    scopus 로고
    • Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
    • Wakabayashi K, Yoshimoto M, Tsuji S, Takahashi H: Alpha-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy. Neurosci Lett 1998, 249: 180-182. 10.1016/S0304-3940(98)00407-8
    • (1998) Neurosci Lett , vol.249 , pp. 180-182
    • Wakabayashi, K.1    Yoshimoto, M.2    Tsuji, S.3    Takahashi, H.4
  • 21
    • 79952316801 scopus 로고    scopus 로고
    • Disordered TPPP/p25 binds GTP and displays Mg2 + -dependent GTPase activity
    • Zotter A, Bodor A, Olah J, Hlavanda E, Orosz F, Perczel A, Ovadi J: Disordered TPPP/p25 binds GTP and displays Mg2 + -dependent GTPase activity. FEBS Lett 2011, 585: 803-808. 10.1016/j.febslet.2011.02.006
    • (2011) FEBS Lett , vol.585 , pp. 803-808
    • Zotter, A.1    Bodor, A.2    Olah, J.3    Hlavanda, E.4    Orosz, F.5    Perczel, A.6    Ovadi, J.7
  • 23
    • 84880440278 scopus 로고    scopus 로고
    • Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy
    • The Multiple-System Atrophy Research C: Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy. N Engl J Med 2013, 369: 233-244. 10.1056/NEJMoa1212115
    • (2013) N Engl J Med , vol.369 , pp. 233-244
    • The Multiple-System Atrophy Research, C.1
  • 26
    • 67649845784 scopus 로고    scopus 로고
    • Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs
    • Kosugi S, Hasebe M, Tomita M, Yanagawa H: Systematic identification of cell cycle-dependent yeast nucleocytoplasmic shuttling proteins by prediction of composite motifs. Proc Natl Acad Sci U S A 2009, 106: 10171-10176. 10.1073/pnas.0900604106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 10171-10176
    • Kosugi, S.1    Hasebe, M.2    Tomita, M.3    Yanagawa, H.4
  • 28
    • 34250183465 scopus 로고    scopus 로고
    • TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells
    • Preusser M, Lehotzky A, Budka H, Ovadi J, Kovacs GG: TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells. Acta Neuropathol 2007, 113: 213-215. 10.1007/s00401-006-0173-6
    • (2007) Acta Neuropathol , vol.113 , pp. 213-215
    • Preusser, M.1    Lehotzky, A.2    Budka, H.3    Ovadi, J.4    Kovacs, G.G.5
  • 29
    • 84889242417 scopus 로고    scopus 로고
    • Mitochondrial Dynamics - Mitochondrial Fission and Fusion in Human Diseases
    • Longo DL, Archer SL: Mitochondrial Dynamics - Mitochondrial Fission and Fusion in Human Diseases. N Engl J Med 2013, 369: 2236-2251. 10.1056/NEJMra1215233
    • (2013) N Engl J Med , vol.369 , pp. 2236-2251
    • Longo, D.L.1    Archer, S.L.2
  • 30
    • 0029328619 scopus 로고
    • Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody Rip
    • Butt AM, Ibrahim M, Ruge FM, Berry M: Biochemical subtypes of oligodendrocyte in the anterior medullary velum of the rat as revealed by the monoclonal antibody Rip. Glia 1995, 14: 185-197. 10.1002/glia.440140304
    • (1995) Glia , vol.14 , pp. 185-197
    • Butt, A.M.1    Ibrahim, M.2    Ruge, F.M.3    Berry, M.4
  • 31
    • 0035827319 scopus 로고    scopus 로고
    • Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import
    • Stewart M, Baker RP, Bayliss R, Clayton L, Grant RP, Littlewood T, Matsuura Y: Molecular mechanism of translocation through nuclear pore complexes during nuclear protein import. FEBS Lett 2001, 498: 145-149. 10.1016/S0014-5793(01)02489-9
    • (2001) FEBS Lett , vol.498 , pp. 145-149
    • Stewart, M.1    Baker, R.P.2    Bayliss, R.3    Clayton, L.4    Grant, R.P.5    Littlewood, T.6    Matsuura, Y.7
  • 32
    • 34247135913 scopus 로고    scopus 로고
    • Classical nuclear localization signals: definition, function, and interaction with importin alpha
    • Lange A, Mills RE, Lange CJ, Stewart M, Devine SE, Corbett AH: Classical nuclear localization signals: definition, function, and interaction with importin alpha. J Biol Chem 2007, 282: 5101-5105. 10.1074/jbc.R600026200
    • (2007) J Biol Chem , vol.282 , pp. 5101-5105
    • Lange, A.1    Mills, R.E.2    Lange, C.J.3    Stewart, M.4    Devine, S.E.5    Corbett, A.H.6
  • 33
    • 84864019723 scopus 로고    scopus 로고
    • Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation
    • Niu J, Mei F, Wang L, Liu S, Tian Y, Mo W, Li H, Lu QR, Xiao L: Phosphorylated olig1 localizes to the cytosol of oligodendrocytes and promotes membrane expansion and maturation. Glia 2012, 60: 1427-1436. 10.1002/glia.22364
    • (2012) Glia , vol.60 , pp. 1427-1436
    • Niu, J.1    Mei, F.2    Wang, L.3    Liu, S.4    Tian, Y.5    Mo, W.6    Li, H.7    Lu, Q.R.8    Xiao, L.9
  • 35
    • 33846558382 scopus 로고    scopus 로고
    • The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
    • Kovacs GG, Gelpi E, Lehotzky A, Hoftberger R, Erdei A, Budka H, Ovadi J: The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases. Acta Neuropathol 2007, 113: 153-161. 10.1007/s00401-006-0167-4
    • (2007) Acta Neuropathol , vol.113 , pp. 153-161
    • Kovacs, G.G.1    Gelpi, E.2    Lehotzky, A.3    Hoftberger, R.4    Erdei, A.5    Budka, H.6    Ovadi, J.7
  • 36
    • 0033774686 scopus 로고    scopus 로고
    • alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes
    • Richter-Landsberg C, Gorath M, Trojanowski JQ, Lee VM: alpha-synuclein is developmentally expressed in cultured rat brain oligodendrocytes. J Neurosci Res 2000, 62: 9-14. 10.1002/1097-4547(20001001)62:1<9::AID-JNR2>3.0.CO;2-U
    • (2000) J Neurosci Res , vol.62 , pp. 9-14
    • Richter-Landsberg, C.1    Gorath, M.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 37
    • 78649634791 scopus 로고    scopus 로고
    • Role of TPPP/p25 on alpha-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy
    • Hasegawa T, Baba T, Kobayashi M, Konno M, Sugeno N, Kikuchi A, Itoyama Y, Takeda A: Role of TPPP/p25 on alpha-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy. Neurochem Int 2010, 57: 857-866. 10.1016/j.neuint.2010.09.002
    • (2010) Neurochem Int , vol.57 , pp. 857-866
    • Hasegawa, T.1    Baba, T.2    Kobayashi, M.3    Konno, M.4    Sugeno, N.5    Kikuchi, A.6    Itoyama, Y.7    Takeda, A.8
  • 38
    • 84864915936 scopus 로고    scopus 로고
    • Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
    • Konno M, Hasegawa T, Baba T, Miura E, Sugeno N, Kikuchi A, Fiesel FC, Sasaki T, Aoki M, Itoyama Y, Takeda A: Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy. Mol Neurodegener 2012, 7: 38. 10.1186/1750-1326-7-38
    • (2012) Mol Neurodegener , vol.7 , pp. 38
    • Konno, M.1    Hasegawa, T.2    Baba, T.3    Miura, E.4    Sugeno, N.5    Kikuchi, A.6    Fiesel, F.C.7    Sasaki, T.8    Aoki, M.9    Itoyama, Y.10    Takeda, A.11
  • 40
    • 84887879281 scopus 로고    scopus 로고
    • Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins
    • Birsa N, Norkett R, Higgs N, Lopez-Domenech G, Kittler JT: Mitochondrial trafficking in neurons and the role of the Miro family of GTPase proteins. Biochem Soc Trans 2013, 41: 1525-1531.
    • (2013) Biochem Soc Trans , vol.41 , pp. 1525-1531
    • Birsa, N.1    Norkett, R.2    Higgs, N.3    Lopez-Domenech, G.4    Kittler, J.T.5
  • 41
    • 84872833228 scopus 로고    scopus 로고
    • Mitochondrial dynamics in neurodegeneration
    • Itoh K, Nakamura K, Iijima M, Sesaki H: Mitochondrial dynamics in neurodegeneration. Trends Cell Biol 2013, 23: 64-71. 10.1016/j.tcb.2012.10.006
    • (2013) Trends Cell Biol , vol.23 , pp. 64-71
    • Itoh, K.1    Nakamura, K.2    Iijima, M.3    Sesaki, H.4
  • 42
    • 18844422710 scopus 로고    scopus 로고
    • SUMO-1 marks subdomains within glial cytoplasmic inclusions of multiple system atrophy
    • Pountney DL, Chegini F, Shen X, Blumbergs PC, Gai WP: SUMO-1 marks subdomains within glial cytoplasmic inclusions of multiple system atrophy. Neurosci Lett 2005, 381: 74-79. 10.1016/j.neulet.2005.02.013
    • (2005) Neurosci Lett , vol.381 , pp. 74-79
    • Pountney, D.L.1    Chegini, F.2    Shen, X.3    Blumbergs, P.C.4    Gai, W.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.