메뉴 건너뛰기




Volumn 2, Issue 1, 2014, Pages

Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS

Author keywords

2 photon imaging; Experimental autoimmune encephalomyelitis; Regulatory T cells

Indexed keywords

CYTOKINE; INTERLEUKIN 2;

EID: 84964697162     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/s40478-014-0163-1     Document Type: Review
Times cited : (101)

References (32)
  • 1
    • 84859416933 scopus 로고    scopus 로고
    • Regulatory T cells: Mechanisms of differentiation and function
    • Josefowicz SZ, Lu LF, Rudensky AY: Regulatory T cells: Mechanisms of differentiation and function. Annu Rev Immunol 2012, 30: 531-564. doi:10.1146/annurev.immunol.25.022106.141623 10.1146/annurev.immunol.25.022106.141623
    • (2012) Annu Rev Immunol , vol.30 , pp. 531-564
    • Josefowicz, S.Z.1    Lu, L.F.2    Rudensky, A.Y.3
  • 4
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells
    • Fontenot JD, Gavin MA, Rudensky AY: Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat Immunol 2003, 4: 330-336. doi:10.1038/ni904 10.1038/ni904
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 5
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim JM, Rasmussen JP, Rudensky AY: Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007, 8: 277-284. doi:10.1038/ni1428 10.1038/ni1437
    • (2007) Nat Immunol , vol.8 , pp. 277-284
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 7
    • 35448969346 scopus 로고    scopus 로고
    • Experimental models of spontaneous autoimmune disease in the central nervous system
    • Krishnamoorthy G, Holz A, Wekerle H: Experimental models of spontaneous autoimmune disease in the central nervous system. J Mol Med 2007, 85: 1161-1173. doi:10.1007/s00109-007-0218-x 10.1007/s00109-007-0218-x
    • (2007) J Mol Med , vol.85 , pp. 1161-1173
    • Krishnamoorthy, G.1    Holz, A.2    Wekerle, H.3
  • 9
    • 23844478869 scopus 로고    scopus 로고
    • Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4 + CD25 + regulatory cells within the central nervous system
    • McGeachy MJ, Stephens LA, Anderton SM: Natural recovery and protection from autoimmune encephalomyelitis: Contribution of CD4 + CD25 + regulatory cells within the central nervous system. J Immunol 2005, 175: 3025-3032. 10.4049/jimmunol.175.5.3025
    • (2005) J Immunol , vol.175 , pp. 3025-3032
    • McGeachy, M.J.1    Stephens, L.A.2    Anderton, S.M.3
  • 10
    • 34548734314 scopus 로고    scopus 로고
    • The inflamed central nervous system drives the activation and rapid proliferation of Foxp3 + regulatory T cells
    • O'Connor RA, Malpass KH, Anderton SM: The inflamed central nervous system drives the activation and rapid proliferation of Foxp3 + regulatory T cells. J Immunol 2007, 179: 958-966. 10.4049/jimmunol.179.2.958
    • (2007) J Immunol , vol.179 , pp. 958-966
    • O'Connor, R.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 11
    • 0036838536 scopus 로고    scopus 로고
    • Cutting edge: CD4 + CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis
    • Kohm AP, Carpentier PA, Anger HA, Miller SD: Cutting edge: CD4 + CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol 2002, 169: 4712-4716. 10.4049/jimmunol.169.9.4712
    • (2002) J Immunol , vol.169 , pp. 4712-4716
    • Kohm, A.P.1    Carpentier, P.A.2    Anger, H.A.3    Miller, S.D.4
  • 12
    • 23844550915 scopus 로고    scopus 로고
    • IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4 + CD25 + T lymphocytes
    • Mekala DJ, Alli RS, Geiger TL: IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4 + CD25 + T lymphocytes. Proc Natl Acad Sci U S A 2005, 102: 11817-11822. 10.1073/pnas.0505445102
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 11817-11822
    • Mekala, D.J.1    Alli, R.S.2    Geiger, T.L.3
  • 13
    • 65449122461 scopus 로고    scopus 로고
    • Curing CNS autoimmune disease with myelin-reactive Foxp3(+) Treg
    • Stephens LA, Malpass KH, Anderton SM: Curing CNS autoimmune disease with myelin-reactive Foxp3(+) Treg. Eur J Immunol 2009, 39: 1108-1117. 10.1002/eji.200839073
    • (2009) Eur J Immunol , vol.39 , pp. 1108-1117
    • Stephens, L.A.1    Malpass, K.H.2    Anderton, S.M.3
  • 14
    • 33244469494 scopus 로고    scopus 로고
    • CD25 regulatory T cells determine secondary but not primary remission in EAE: Impact on long-term disease progression
    • Gärtner D, Hoff H, Gimsa U, Burmester GR, Brunner-Weinzierl MC: CD25 regulatory T cells determine secondary but not primary remission in EAE: Impact on long-term disease progression. J Neuroimmunol 2006, 172: 73-84. 10.1016/j.jneuroim.2005.11.003
    • (2006) J Neuroimmunol , vol.172 , pp. 73-84
    • Gärtner, D.1    Hoff, H.2    Gimsa, U.3    Burmester, G.R.4    Brunner-Weinzierl, M.C.5
  • 15
    • 3242740010 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by CD4 +, CD25 + and CD8 + T cells: analysis using depleting antibodies
    • Montero E, Nussbaum G, Kaye JF, Perez R, Lage A, Ben-Nun A, Cohen IR: Regulation of experimental autoimmune encephalomyelitis by CD4 +, CD25 + and CD8 + T cells: analysis using depleting antibodies. J Autoimmun 2004, 23: 1-7. 10.1016/j.jaut.2004.05.001
    • (2004) J Autoimmun , vol.23 , pp. 1-7
    • Montero, E.1    Nussbaum, G.2    Kaye, J.F.3    Perez, R.4    Lage, A.5    Ben-Nun, A.6    Cohen, I.R.7
  • 16
    • 1042269477 scopus 로고    scopus 로고
    • IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25 + CD4+ regulatory T cells
    • Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL: IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25 + CD4+ regulatory T cells. Int Immunol 2004, 16: 249-256. 10.1093/intimm/dxh029
    • (2004) Int Immunol , vol.16 , pp. 249-256
    • Zhang, X.1    Koldzic, D.N.2    Izikson, L.3    Reddy, J.4    Nazareno, R.F.5    Sakaguchi, S.6    Kuchroo, V.K.7    Weiner, H.L.8
  • 17
    • 0037062420 scopus 로고    scopus 로고
    • Specificity requirements for selection and effector functions of CD25 + 4 + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice
    • Hori S, Haury M, Coutinho A, Demengeot J: Specificity requirements for selection and effector functions of CD25 + 4 + regulatory T cells in anti-myelin basic protein T cell receptor transgenic mice. Proc Natl Acad Sci U S A 2002, 99: 8213-8218. 10.1073/pnas.122224799
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8213-8218
    • Hori, S.1    Haury, M.2    Coutinho, A.3    Demengeot, J.4
  • 18
    • 0032538918 scopus 로고    scopus 로고
    • Regulatory CD4 + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
    • Olivares-Villagómez D, Wang Y, Lafaille JJ: Regulatory CD4 + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 1998, 188: 1883-1894. 10.1084/jem.188.10.1883
    • (1998) J Exp Med , vol.188 , pp. 1883-1894
    • Olivares-Villagómez, D.1    Wang, Y.2    Lafaille, J.J.3
  • 19
    • 84885476681 scopus 로고    scopus 로고
    • Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response
    • Lowther DE, Chong DL, Ascough S, Ettorre A, Ingram RJ, Boyton RJ, Altmann DM: Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response. Acta Neuropathol 2013, 126: 501-515. doi:10.1007/s00401-013-1159-9 10.1007/s00401-013-1159-9
    • (2013) Acta Neuropathol , vol.126 , pp. 501-515
    • Lowther, D.E.1    Chong, D.L.2    Ascough, S.3    Ettorre, A.4    Ingram, R.J.5    Boyton, R.J.6    Altmann, D.M.7
  • 24
    • 48249103057 scopus 로고    scopus 로고
    • Foxp3 + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
    • Onishi Y, Fehérvári Z, Yamaguchi T, Sakaguchi AY: Foxp3 + natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci U S A 2008, 105: 10113-10118. 10.1073/pnas.0711106105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 10113-10118
    • Onishi, Y.1    Fehérvári, Z.2    Yamaguchi, T.3    Sakaguchi, A.Y.4
  • 25
    • 33745978399 scopus 로고    scopus 로고
    • Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation
    • Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH: Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation. Immunity 2006, 25: 129-141. http://dx.doi.org/10.1016/j.immuni.2006.04.015 10.1016/j.immuni.2006.04.015
    • (2006) Immunity , vol.25 , pp. 129-141
    • Mempel, T.R.1    Pittet, M.J.2    Khazaie, K.3    Weninger, W.4    Weissleder, R.5    von Boehmer, H.6    von Andrian, U.H.7
  • 26
    • 78649752513 scopus 로고    scopus 로고
    • Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis
    • Domingues HS, Mues M, Lassmann H, Wekerle H, Krishnamoorthy G (2010) Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. PLoS One 5:e15531. doi:10.1371/journal.pone.0015531
    • (2010) PLoS One , vol.5
    • Domingues, H.S.1    Mues, M.2    Lassmann, H.3    Wekerle, H.4    Krishnamoorthy, G.5
  • 27
    • 81855167104 scopus 로고    scopus 로고
    • Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
    • Berer K, Mues M, Koutroulos M, Al Rasbi Z, Boziki M, Johner C, Wekerle H, Krishnamoorthy G: Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination. Nature 2011, 479: 538-541. doi:10.1038/nature10554 10.1038/nature10554
    • (2011) Nature , vol.479 , pp. 538-541
    • Berer, K.1    Mues, M.2    Koutroulos, M.3    Al Rasbi, Z.4    Boziki, M.5    Johner, C.6    Wekerle, H.7    Krishnamoorthy, G.8
  • 28
    • 84880301113 scopus 로고    scopus 로고
    • Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator
    • Mues M, Bartholomaus I, Thestrup T, Griesbeck O, Wekerle H, Kawakami N, Krishnamoorthy G: Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator. Nat Med 2013, 19: 778-783. doi:10.1038/nm.3180 10.1038/nm.3180
    • (2013) Nat Med , vol.19 , pp. 778-783
    • Mues, M.1    Bartholomaus, I.2    Thestrup, T.3    Griesbeck, O.4    Wekerle, H.5    Kawakami, N.6    Krishnamoorthy, G.7
  • 30
    • 0026043866 scopus 로고
    • Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in the sf thymic environment: Potential model for thymic education
    • Godfrey VL, Wilkinson JE, Rinchik EM, Russell LB: Fatal lymphoreticular disease in the scurfy (sf) mouse requires T cells that mature in the sf thymic environment: Potential model for thymic education. Proc Natl Acad Sci U S A 1991, 88: 5528-5532. 10.1073/pnas.88.13.5528
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 5528-5532
    • Godfrey, V.L.1    Wilkinson, J.E.2    Rinchik, E.M.3    Russell, L.B.4
  • 31
    • 36248976097 scopus 로고    scopus 로고
    • CD4 + CD25 + Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan P, Zheng L, Ishihara S, Reed J, Lenardo MJ: CD4 + CD25 + Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007, 8: 1353-1362. doi:10.1038/ni1536 10.1038/ni1536
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 32
    • 38949198691 scopus 로고    scopus 로고
    • Regulation of T-cell migration and effector functions: insights from in vivo imaging studies
    • Pittet MJ, Mempel TR: Regulation of T-cell migration and effector functions: insights from in vivo imaging studies. Immunol Rev 2008, 221: 107-129. 10.1111/j.1600-065X.2008.00584.x
    • (2008) Immunol Rev , vol.221 , pp. 107-129
    • Pittet, M.J.1    Mempel, T.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.