Effects of feeding a diet containing Gymnema sylvestre extract: Attenuating progression of obesity in C57BL/6J mice

Asian Pacific Journal of Tropical Medicine

Volumn 9, Issue 5, 2016, Pages 437-444

  Kim, Hyeon Jeong ^a   Hong, Seong Ho ^a   Chang, Seung Hee ^a   Kim, Sanghwa ^a   Lee, Ah Young ^a   Jang, Yoonjeong ^a   Davaadamdin, Orkhonselenge ^a   Yu, Kyeong Nam ^a   Kim, Ji Eun ^a   Cho, Myung Haing ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Adipocyte; Body weight gain; Gymnema sylvestre extract; High fat diet; Liver injury; Obesity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; EOSIN; FAT DROPLET; GLUCOSE; GYMNEMA SYLVESTRE EXTRACT; GYMNEMIC ACID; HEMATOXYLIN; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METHANOL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ABDOMINAL FAT; ADIPOCYTE; ADIPOSE TISSUE; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ANTIOBESITY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; EPIDIDYMIS FAT; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE TEST; GYMNEMA SYLVESTRE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; INTRAPERITONEAL GLUCOSE TOLERANCE TEST; LIPID BLOOD LEVEL; LIVER INJURY; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 84964690994     PISSN: 19957645     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apjtm.2016.03.037     Document Type: Article

References (30)

1. [1] World Health Organization. Global status report on noncommunicable diseases. 2014 [Online]. Available from: http://www.who.int/nmh/publications/ncd-status-report-2014/en/ [Accessed on 10th October, 2015].
2. [2] Pothuraju, R., Sharma, R.K., Chagalamarri, J., Jangra, S., Kumar Kavadi, P., A systematic review of Gymnema sylvestre in obesity and diabetes management. J Sci Food Agric 94:5 (2013), 834–840.
3. [3] Kumar, V., Bhandari, U., Tripathi, C.D., Khanna, G., Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian J Pharmacol 44:5 (2012), 607–613.
4. [4] Xu, Y., Zhang, M., Wu, T., Dai, S., Xu, J., Zhou, Z., The anti-obesity effect of green tea polysaccharides, polyphenols and caffeine in rats fed with a high-fat diet. Food Funct 6:1 (2015), 296–303.
5. [5] Kim, J., Jang, J.Y., Cai, J., Kim, Y., Shin, K., Choi, E.K., et al. Ethanol extracts of unroasted Coffea canephora robusta beans suppress adipogenesis in preadipocytes and fat accumulation in rats fed a high-fat diet. Food Sci Biotechnol 23:6 (2014), 2029–2035.
6. [6] Gao, M., Ma, Y., Liu, D., High-fat diet-induced adiposity, adipose inflammation, hepatic steatosis and hyperinsulinemia in outbred CD-1 mice. PLoS One, 10(3), 2015, e0119784.
7. [7] Leach, M.J., Gymnema sylvestre for diabetes mellitus: a systematic review. J Altern Complement Med 13:9 (2007), 977–983.
8. [8] Tiwari, P., Mishra, B.N., Sangwan, N.S., Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int, 2014, 2014, 830285.
9. [9] Vermaak, I., Viljoen, A.M., Hamman, J.H., Natural products in anti-obesity therapy. Nat Prod Rep 28:9 (2011), 1493–1533.
10. [10] Kishore, L., Kaur, N., Singh, R., Role of Gymnema sylvestre as alternative medicine. J Homeop Ayurv Med 3:4 (2014), 172–180.
11. [11] Porchezhian, E., Dobriyal, R.M., An overview on the advances of Gymnema sylvestre: chemistry, pharmacology and patents. Pharmazie 58:1 (2003), 5–12.
12. [12] Bishayee, A., Chatterjee, M., Hypolipidaemic and antiatherosclerotic effects of oral Gymnema sylvestre R. Br. Leaf extract in albino rats fed on a high fat diet. Phytother Res 8:2 (1994), 118–120.
13. [13] Reddy, R.M., Lathan, P.B., Vijaya, T., Rao, D.S., The saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract reduces cafeteria and high-fat diet-induced obesity. Z Naturforsch C 67:1–2 (2012), 39–46.
14. [14] Shigematsu, N., Asano, R., Shimosakan, M., Okazaki, M., Effect of administration with the extract of Gymnema sylvestre R. Br leaves on lipid metabolism in rats. Biol Pharm Bull 24:6 (2001), 713–717.
15. [15] Kusum, D., Nimisha, J., A validated HPLC method for estimation of Gymnemic acids as Deacyl gymnemic acid in various extracts and formulations of Gymnema sylvestre. Int J Phytomed 6:2 (2014), 165–169.
16. [16] Kim, J.E., Lim, H.T., Minai-Tehrani, A., Kwon, J.T., Shin, J., Woo, C.G., et al. Toxicity and clearance of intratracheally administered multiwalled carbon nanotubes from murine lung. J Toxicol Env Health Part A 73:21–22 (2010), 1530–1543.
17. [17] Jung, T.S., Kim, S.K., Shin, H.J., Jeon, B.T., Hahm, J.R., Roh, G.S., α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats. Liver Int 32:10 (2012), 1565–1573.
18. [18] Giuliano Ide, C., Coutinho, M.S., Freitas, S.F., Pires, M.M., Zunino, J.N., Ribeiro, R.Q., Serum lipids in school kids and adolescents from Florianópolis, SC, Brazil–Healthy Floripa 2040 study. Arq Bras Cardiol 85:2 (2005), 85–91.
19. [19] Mopuri, R., Meriga, B., Anti-lipase and anti-obesity activities of Terminalia paniculata bark in high calorie diet-induced obese rats. Glob J Pharmacol 8:1 (2014), 114–119.
20. [20] Lee, M.R., Kim, B.C., Kim, R., Oh, H.I., Kim, H.K., Choi, K.J., et al. Anti-obesity effects of black ginseng extract in high fat diet-fed mice. J Ginseng Res 37:3 (2013), 308–314.
21. [21] Li, Q., Liu, Z., Huang, J., Luo, G., Liang, Q., Wang, D., et al. Anti-obesity and hypolipidemic effects of Fuzhuan brick tea water extract in high-fat diet-induced obese rats. J Sci Food Agric 93:6 (2013), 1310–1316.
22. [22] Jin, D., Xu, Y., Mei, X., Meng, Q., Gao, Y., Li, B., et al. Antiobesity and lipid lowering effects of theaflavins on high-fat diet induced obese rats. J Funct Food 5:3 (2013), 1142–1150.
23. [23] Gulab, S.T., Rohit, S., Bhagwan, S.S., Mukeshwar, P., GBKS, P., Prakash, S.B., Gymnema sylvestre: an alternative therapeutic agent for management of diabetes. J App Pharm Sci 2:12 (2012), 1–6.
24. [24] Choi, H.K., Won, E.K., Jang, Y.P., Choung, S.Y., Antiobesity effect of Codonopsis lanceolata in high-calorie/high-fat-diet-induced obese rats. Evid Based Complement Altern Med, 2013, 2013, 210297.
25. [25] Kang, Y., Lee, H.Y., Kim, J.H., Moon, D.I., Seo, M.Y., Park, S.H., et al. Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet. Lab Anim Res 28:1 (2012), 23–29.
26. [26] Yoon, Y.I., Chung, M., Hwang, J.S., Han, M., Goo, T.W., Yun, E.Y., Allomyrina dichotoma (Arthropoda: Insecta) Larvae confer resistance to obesity in mice fed a high-fat diet. Nutrients 7:3 (2015), 1978–1991.
27. [27] Ikewuch, C.J., Ikewuchi, C.C., Alteration of plasma lipid profiles and atherogenic indices by Stachytarpheta jamaicensis L. (Vahl). Biokemistri 21:2 (2009), 71–77.
28. [28] Yang, Z.H., Miyahara, H., Takeo, J., Katayama, M., Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice. Diabetol Metab Syndr 4:1 (2012), 32–46.
29. [29] Mohajeri, D., Sefidan, A.M., Inhibitory effects of Solanum lycopersicum L. on high fat diet-induced fatty liver disease in rats. AdvBiores 4:4 (2013), 33–39.
30. [30] Daisy, P., Eliza, J., Mohamed Farook, K.A., A novel dihydroxy gymnemic triacetate isolated from Gymnema sylvestre possessing normoglycemic and hypolipidemic activity on STZ-induced diabetic rats. J Ethnopharmacol 126:2 (2009), 339–344.