Adipose cell size and regional fat deposition as predictors of metabolic response to overfeeding in insulin-resistant and insulin-sensitive humans

Diabetes

Volumn 65, Issue 5, 2016, Pages 1245-1254

  McLaughlin, Tracey ^a   Craig, Colleen ^a   Liu, Li Fen ^a   Perelman, Dalia ^a   Allister, Candice ^a   Spielman, Daniel ^a   Cushman, Samuel W ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACC1 PROTEIN; ATGL PROTEIN; CARBOHYDRATE; CD36 ANTIGEN; FAT; FATP1 PROTEIN; FATTY ACID BINDING PROTEIN 4; GLUCOSE TRANSPORTER 4; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HSL PROTEIN; INSULIN; LPL PROTEIN; PEPCK PROTEIN; PROTEIN; SATURATED FATTY ACID; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT;

ADIPOSE TISSUE CELL; ADULT; ARTICLE; BODY WEIGHT; CARBOHYDRATE INTAKE; CELL ENLARGEMENT; CELL SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FATTY ACID BLOOD LEVEL; FEMALE; GENE EXPRESSION; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; INSULIN MEDIATED GLUCOSE UPTAKE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; INTRAHEPATIC LIPID; LIPID LIVER LEVEL; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; MALE; MIDDLE AGED; OBESITY; PREDICTION; PRIORITY JOURNAL; SYSTOLIC BLOOD PRESSURE; WAIST CIRCUMFERENCE; WEIGHT GAIN; BIOLOGICAL MODEL; BODY MASS; COHORT ANALYSIS; COMPARATIVE STUDY; DRUG EFFECTS; GENE EXPRESSION REGULATION; HYPERPHAGIA; LIVER; METABOLISM; OVERWEIGHT; PATHOLOGY; PATHOPHYSIOLOGY; SUBCUTANEOUS FAT;

ADIPOSITY; ADULT; BODY MASS INDEX; CELL SIZE; COHORT STUDIES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYPERPHAGIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LIPID METABOLISM; LIVER; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; OBESITY; OVERWEIGHT; SUBCUTANEOUS FAT; WEIGHT GAIN;

EID: 84964675021     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-1213     Document Type: Article

References (32)

1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012;307:491-497
2. Centers for Disease Control and Prevention (CDC). Increasing prevalence of diagnosed diabetes-United States and Puerto Rico, 1995-2010. MMWR Morb Mortal Wkly Rep 2012;61:918-921
3. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356-359
4. Bogardus C, Lillioja S, Mott DM, Hollenbeck C, Reaven GM. Relationship between degree of obesity and in vivo insulin action in man. Am J Physiol 1985;248:E286-E291
5. McLaughlin T, Schweitzer P, Carter S, et al. Persistence of improvement in insulin sensitivity following a dietary weight loss programme. Diabetes Obes Metab 2008;10:1186-1194
6. McLaughlin T, Allison G, Abbasi F, Lamendola C, Reaven G. Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism 2004;53:495-499
7. McLaughlin T, Sherman A, Tsao P, et al. Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia 2007;50:1707-1715
8. McLaughlin T, Lamendola C, Coghlan N, et al. Subcutaneous adipose cell size and distribution: relationship to insulin resistance and body fat. Obesity (Silver Spring) 2014;22:673-680
9. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature 2008;453:783-787
10. Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 2000;43:1498-1506
11. Gavrilova O, Marcus-Samuels B, Graham D, et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest 2000;105:271-278
12. Robbins DC, Horton ES, Tulp O, Sims EA. Familial partial lipodystrophy: complications of obesity in the non-obese? Metabolism 1982;31:445-452
13. de Souza CJ, Eckhardt M, Gagen K, et al. Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes 2001;50:1863-1871
14. McLaughlin TM, Liu T, Yee G, et al. Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue. Obesity (Silver Spring) 2010;18:926-931
15. Eliasson B, Smith U, Mullen S, Cushman SW, Sherman AS, Yang J. Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients. Adipocyte 2014;3:314-321
16. Yang X, Jansson PA, Nagaev I, et al. Evidence of impaired adipogenesis in insulin resistance. Biochem Biophys Res Commun 2004;317:1045-1051
17. Deurenberg P, Weststrate JA, Seidell JC. Body mass index as a measure of body fatness: age- and sex-specific prediction formulas. Br J Nutr 1991;65:105-114
18. Deurenberg P, Andreoli A, Borg P, et al. The validity of predicted body fat percentage from body mass index and from impedance in samples of five European populations. Eur J Clin Nutr 2001;55:973-979
19. Dubois SG, Heilbronn LK, Smith SR, Albu JB, Kelley DE, Ravussin E; Look AHEAD Adipose Research Group. Decreased expression of adipogenic genes in obese subjects with type 2 diabetes. Obesity (Silver Spring) 2006;14:1543-1552
20. Shen SW, Reaven GM, Farquhar JW. Comparison of impedance to insulinmediated glucose uptake in normal subjects and in subjects with latent diabetes. J Clin Invest 1970;49:2151-2160
21. Pei D, Jones CN, Bhargava R, Chen YD, Reaven GM. Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test. Diabetologia 1994;37:843-845
22. Greenfield MS, Doberne L, Kraemer F, Tobey T, Reaven G. Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp. Diabetes 1981;30:387-392
23. McLaughlin T, Yee G, Glassford A, Lamendola C, Reaven G. Use of a twostage insulin infusion study to assess the relationship between insulin suppression of lipolysis and insulin-mediated glucose uptake in overweight/obese, nondiabetic women. Metabolism 2011;60:1741-1747
24. McLaughlin T, Lamendola C, Liu A, Abbasi F. Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity. J Clin Endocrinol Metab 2011;96:E1756-E1760
25. Davé V, Yousefi P, Huen K, Volberg V, Holland N. Relationship between expression and methylation of obesity-related genes in children. Mutagenesis 2015;30:411-420
26. Harris JA, Benedict FG. A Biometric Study of Basal Metabolism in Man (Publication 279). Washington, DC, Carnegie Institute of Washington, 1919
27. Faust IM, Johnson PR, Stern JS, Hirsch J. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol 1978;235:E279-E286
28. Jo J, Guo J, Liu T, et al. Hypertrophy-driven adipocyte death overwhelms recruitment under prolonged weight gain. Biophys J 2010;99:3535-3544
29. Kashiwagi A, Mott D, Bogardus C, Lillioja S, Reaven GM, Foley JE. The effects of short-term overfeeding on adipocyte metabolism in Pima Indians. Metabolism 1985;34:364-370
30. Tchoukalova YD, Votruba SB, Tchkonia T, Giorgadze N, Kirkland JL, Jensen MD. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci U S A 2010;107:18226-18231
31. Johannsen DL, Tchoukalova Y, Tam CS, et al. Effect of 8 weeks of overfeeding on ectopic fat deposition and insulin sensitivity: testing the "adipose tissue expandability" hypothesis. Diabetes Care 2014;37:2789-2797
32. Fabbrini E, Yoshino J, Yoshino M, et al. Metabolically normal obese people are protected from adverse effects following weight gain. J Clin Invest 2015;125:787-795