Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat

Obesity

Volumn 22, Issue 3, 2014, Pages 673-680

  McLaughlin, T ^a   Lamendola, C ^a   Coghlan, N ^a   Liu, T C ^a   Lerner, K ^a   Sherman, A ^b   Cushman, S W ^b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

ADULT; ARTICLE; BODY FAT; BODY FAT DISTRIBUTION; BODY MASS; CELL SIZE; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; OBESITY; SEX DIFFERENCE; STEADY STATE; SUBCUTANEOUS FAT;

ADIPOCYTES; ADIPOGENESIS; ADULT; BIOPSY; BLOOD GLUCOSE; BODY MASS INDEX; CELL SIZE; FEMALE; HEALTHY VOLUNTEERS; HUMANS; INSULIN; INSULIN RESISTANCE; LINEAR MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OBESITY; OVERWEIGHT; SUBCUTANEOUS FAT; TRIGLYCERIDES;

EID: 84895795817     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20209     Document Type: Article

References (40)

1. Reaven GM,. Obesity, insulin resistance, and cardiovascular disease. Recent Prog Horm Res 2004; 59: 207-223.
2. McLaughlin T, Allison G, Abbasi F, Lamendola C, Reaven G,. Prevalence of insulin resistance and associated cardiovascular disease risk factors among normal weight, overweight, and obese individuals. Metabolism 2004; 53: 495-499.
3. McLaughlin T, Abbasi F, Kim HS, Lamendola C, Schaaf P, Reaven G,. Relationship between insulin resistance, weight loss and coronary heart disease risk in obese healthy women. Metabolism 2001; 50: 795-800.
4. Salans LB, Cushman SW, Weismann RE,. Studies of human adipose tissue. J Clin Invest 1973; 52: 929-941.
5. Sjostrom L, Smith U, Krotkiewski M, Pjorntorp P,. Cellularity in different regions of adipose tissue in young men and women. Metabolism 1972; 21: 1143-1153.
6. Spalding KL, Arner E, Westermark PO, et al. Dynamics of fat cell turnover in humans. Nature 2008; 453: 783-787.
7. Kashiwagi A, Mott D, Bogardus C, Lillioja S, Reaven GM, Foley JE,. The effects of short-term overfeeding on adipocyte metabolism in Pima Indians. Metabolism 1985; 34: 364-370.
8. Salans LB, Horton ES, Sims EH,. Experimental obesity in man: cellular character of the adipose tissue. J Clin Invest 1971; 50: 1005-1011.
9. Tchoukalova YD, Votruba SB, Tchkonia T, Giorgadze N, Kirkland JL, Jensen MD,. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci USA 2010; 107: 18226-18231.
10. Krotkiewski M, Pjorntorp P, Sjostrom L, Smith U,. Impact of obesity on metabolism in men and women. J Clin Invest 1983; 72: 1150-1162.
11. Faust IM, Johnson PR, Stern JS, Hirsch J,. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol 1978; 4: E279-E286.
12. Bjorntorp P, Sjostrom L,. The number and size of adipose tissue fat cells in relation to metabolism in human obesity. Metabolism 1971; 20: 703.
13. Bjorntorp P, Gustafson A, Tibblin G,. Relationships between adipose tissue cellularity and carbohydrate and lipid metabolism in a randomly selected population. In:, Jones RJ, ed. Atherosclerosis: Proceedings of the Second International Symposium. Berlin: Springer-Verlag; 1970. p 374.
14. Bjorntorp P, Berchtold P, Tibblin G,. Insulin secretion in relation to adipose tissue in men. Diabetes 1971; 20: 65.
15. Czech MP,. Cellular basis of insulin insensitivity in large rat adipocytes. J Clin Invest 1976; 57: 1523-1532.
16. Kissebah AH, Vydelingum N, Murray R, et al. Relation of body fat distribution to metabolic complications of obesity. J Clin Endocrinol Metab 1982; 54: 254-260.
17. Arner E, Westermark PO, Spalding KL, et al. Adipocyte turnover: relevance to human adipose tissue morphology. Diabetes 2010; 59: 105-109.
18. Lundgren M, Svensson M, Lindmark S, Renstrom F, Ruge T, Eriksson JW,. Fat cell inlargement is an independent marker of insulin resistance and hyperleeptinaemia. Diabetologia 2007; 50: 625-633.
19. Arner P, Arner E, Hammarstedt A, Smith U,. Genetic predisposition for type 2 diabetes, but not for overweight/obesity is associated with a restricted adipogenesis. PloS One 2011; 6: 1-5.
20. Weyer C, Foley JE, Bogardus C, Tataranni PA, Pratley RE,. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance. Diabetologia 2000; 43: 1298-1506.
21. Julien P, Despres JP, Angel A,. Scanning electron microscopy of very small fat cells and mature fat cells in human obesity. J Lipid Res 1989; 30: 293-299.
22. Jernas M, Palming J, Sjoholm K, et al. Separation of human adipocytes by size: hypertrophic fat cells display distinct gene expression. FASEB J 2006; 20: E832-E839.
23. McLaughlin T, Sherman A, Tsao P, et al. Enhanced proportion of small adipose cells in insulin-resistant vs insulin-sensitive obese individuals implicates impaired adipogenesis. Diabetologia 2007; 50: 1707-1715.
24. Smith SR, Baghian S, Needham A, McNeil M, Bogacha I, Bray GA,. Pioglitazone changes the distribution of adipocyte size in type 2 diabetics. Adipocytes 2006; 1: 11-22.
25. Pei D, Jones CNO, Bhargava R, Chen Y-DI, Reaven GM,. Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test. Diabetologia 1994; 37: 843-845.
26. Shen S-W, Reaven GM, Farquhar JW,. Comparison of impedance to insulin mediated glucose uptake in normal and diabetic subjects. J Clin Invest 1970; 49: 2151-2160.
27. Greenfield MS, Doberne L, Kraemer FB, Tobey TA, Reaven GM,. Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp. Diabetes 1981; 30: 387-392.
28. Carantoni M, Abbasi F, Chu L, et al. Adherence of mononuclear cells to endothelium in vitro is increased in patients with NIDDM. Diabetes Care 1997; 20: 1462-1465.
29. Deurenberg P, Westrate J, Seidell JC,. Body mass index as a measure of body fatness: age- and sex- specific prediction formulas. Br J Nutr 1991; 65: 105-114.
30. Hirsch J, Knittel JL,. Cellularity of obese and non-obese human adipose tissue. Fed Proc 1970; 29: 1516-1521.
31. Jo J, Gavrilova O, Pack S, et al. Hypertrophy and/or hyperplasia: dynamics of adipose tissue growth. PLoS Comput Biol 2009; 5: 1-11.
32. Yang J, Eliasson B, Smith U, Cushman SW, Sherman A,. The size of large adipose cells is a predictor of insulin resistance in first-degree relatives of type 2 diabetic patients. Obesity 2012; 20: 932-938.
33. McLaughlin T, Deng A, Yee G, et al. Inflammation in subcutaneous adipose tissue: relationship to adipose cell size. Diabetologia 2010; 53: 369-377.
34. Pasarica M, Xie H, Hymel D, et al. Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes. Diabetes Care 2009; 32: 900-902.
35. McLaughlin T, Liu T, Yee G, et al. Pioglitazone increases the proportion of small cells in human subcutaneous adipose tissue. Obesity 2010; 18: 926-931.
36. Yang X, Jansson PS, Nagaev I, et al. Evidence of impaired adipogenesis in insulin resistance. Biochem Biophys Res Commun 2004; 317: 1045-1051.
37. Krotkiewski M, Bjorntop P, Sjostrom L, Smith U,. Impact of obesity on metabolism in men and women: importance of regional adipose tissue distribution. J Clin Invest 1983; 72: 1150-1162.
38. Salans LB, Knittle JL, Hirsch J,. Role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity. J Clin Invest 1968; 47: 152-165.
39. Stern JS, Batchelor BR, Hollander N, Cohn CK, Hirsch J,. Adipose cell size and immunoreactive insulin levels in obese and normal weight adults. Lancet 1972; 2: 948-951.
40. Liu A, Sonmez A, Yee G, et al. Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats. Diab Vasc Dis Res 2010; 7: 311-318.