Associations of metabolic, inflammatory and oxidative stress markers with total morbidity and multi-morbidity in a large cohort of older German adults

Age and Ageing

Volumn 45, Issue 1, 2016, Pages 127-135

  Schöttker, Ben ^a,b   Saum, Kai Uwe ^a   Jansen, Eugéne H J M ^c   Holleczek, Bernd ^d   Brenner, Hermann ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d SAARLAND CANCER REGISTRY   (Germany)

Author keywords

Ageing; Co morbidity; Inflammation; Multi morbidity; Older people; Oxidative stress

Indexed keywords

C REACTIVE PROTEIN; REACTIVE OXYGEN METABOLITE; THIOL; AUTACOID; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CUMULATIVE ILLNESS RATING SCALE GERIATRIC VERSION; DIABETES MELLITUS; DISEASE ASSESSMENT; DYSLIPIDEMIA; FEMALE; GERMANY; HOMEOSTASIS; HUMAN; HYPERTENSION; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; METABOLIC DISORDER; MIDDLE AGED; MORBIDITY; OBESITY; OXIDATIVE STRESS; POPULATION RESEARCH; PRIORITY JOURNAL; AGE; AGING; BLOOD; COMORBIDITY; CROSS-SECTIONAL STUDY; GERIATRIC ASSESSMENT; METABOLIC DISEASES; OXIDATION REDUCTION REACTION; RISK FACTOR; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BIOMARKERS; COMORBIDITY; CROSS-SECTIONAL STUDIES; FEMALE; GERIATRIC ASSESSMENT; GERMANY; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; METABOLIC DISEASES; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; RISK FACTORS;

EID: 84964579690     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afv159     Document Type: Article

References (29)

1. Barzilai N, Huffman DM, Muzumdar RH, Bartke A. The critical role of metabolic pathways in aging. Diabetes 2012; 61: 1315-22.
2. Chung HY, Cesari M, Anton S et al. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev 2009; 8: 18-30.
3. Salminen A, Ojala J, Kaarniranta K, Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci 2012; 69: 2999-3013.
4. Pandey KB, Rizvi SI. Markers of oxidative stress in erythrocytes and plasma during aging in humans. Oxid Med Cell Longev 2010; 3: 2-12.
5. Salmon AB, Richardson A, Perez VI. Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging? Free Radic Biol Med 2010; 48: 642-55.
6. Shawi M, Autexier C. Telomerase, senescence and ageing. Mech Ageing Dev 2008; 129: 3-10.
7. Starr JM, Shiels PG, Harris SE et al. Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. Mech Ageing Dev 2008; 129: 745-51.
8. Tracy RP. Emerging relationships of inflammation, cardiovascular disease and chronic diseases of aging. Int J Obes Relat Metab Disord 2003; 27(Suppl. 3): S29-34.
9. Manabe I. Chronic inflammation links cardiovascular, metabolic and renal diseases. Circ J 2011; 75: 2739-48.
10. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 2005; 28: 1769-78.
11. Schöttker B, Haug U, Schomburg L et al. Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study. Am J Clin Nutr 2013; 97: 782-93.
12. Stephens JW, Khanolkar MP, Bain SC. The biological relevance and measurement of plasma markers of oxidative stress in diabetes and cardiovascular disease. Atherosclerosis 2009; 202: 321-9.
13. Kotani K, Sakane N. C-reactive protein and reactive oxygen metabolites in subjects with metabolic syndrome. J Int Med Res 2012; 40: 1074-81.
14. Jansen E, Beekhof P, Cremers J, Viezeliene D, Muzakova V, Skalicky J. Short-term stability of biomarkers of oxidative stress and antioxidant status in human serum. ISRN Biomarkers 2013; (Article ID 316528); 2013: 1-5.
15. Schöttker B, Saum KU, Jansen EH et al. Oxidative stress markers and all-cause mortality at older age: a populationbased cohort study. J Gerontol A Biol Sci Med Sci 2015; 70: 518-24.
16. Saum KU, Dieffenbach AK, Jansen EH et al. Association between oxidative stress and frailty in an elderly German population: results from the ESTHER cohort study. Gerontology 2015; 61: 407-15.
17. Voorrips LE, Ravelli AC, Dongelmans PC, Deurenberg P, van Staveren WA. A physical activity questionnaire for the elderly. Med Sci Sports Exerc 1991; 23: 974-9.
18. NHLBI Obesity Education Initiative Expert Panel on the Identification, Evaluation, and Treatment of Obesity in Adults (US). Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults - the evidence report. Report No. 98-4083. Bethesda, MD: National Heart, Lung, and Blood Insitute; National Institutes of Health, 1998.
19. American Diabetes Association. Standards of medical care in diabetes-2012. Diabetes Care 2012; 35(Suppl. 1): S11-63.
20. Chobanian AV, Bakris GL, Black HR et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003; 42: 1206-52.
21. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detec-tion, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486-97 .
22. Pan WH, Yeh WT, Chen HJ et al. The U-shaped relationship between BMI and all-cause mortality contrasts with a progressive increase in medical expenditure: a prospective cohort study. Asia Pac J Clin Nutr 2012; 21: 577-87.
23. Upmeier E, Lavonius S, Lehtonen A, Viitanen M, Isoaho H, Arve S. Serum lipids and their association with mortality in the elderly: a prospective cohort study. Aging Clin Exp Res 2009; 21: 424-30.
24. Gutierrez-Misis A, Sanchez-Santos MT, Banegas JR et al. Association between blood pressure and mortality in a Spanish cohort of persons aged 65 years or over: a dynamic model. Rev Esp Cardiol 2013; 66: 464-71.
25. Miller MD, Paradis CF, Houck PR et al. Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale. Psychiatry Res 1992; 41: 237-48.
26. Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004; 59: 255-63.
27. Zhang Y, Hu G, Yuan Z, Chen L. Glycosylated hemoglobin in relationship to cardiovascular outcomes and death in patients with type 2 diabetes: a systematic review and meta-analysis. PLoS ONE 2012; 7: e42551.
28. Hoehn KL, Salmon AB, Hohnen-Behrens C et al. Insulin resistance is a cellular antioxidant defense mechanism. Proc Natl Acad Sci USA 2009; 106: 17787-92.
29. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996; 271: 665-8.