The Link Between Adverse Childhood Experiences and Diabetes

Current Diabetes Reports

Volumn 16, Issue 6, 2016, Pages

  Huffhines, Lindsay ^a,b   Noser, Amy ^a,b   Patton, Susana R ^b,c  

^a UNIVERSITY OF KANSAS   (United States)

^b Center for Children's Healthy Lifestyles and Nutrition   (United States)

^c UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Adverse childhood experiences; Diabetes; Maltreatment; PTSD

Indexed keywords

CHILD ABUSE; CHILDHOOD ADVERSITY; DIABETES MELLITUS; DISEASE ASSOCIATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LIFE EVENT; NON INSULIN DEPENDENT DIABETES MELLITUS; POSTTRAUMATIC STRESS DISORDER; REVIEW; RISK FACTOR; CHILD; COMORBIDITY;

CHILD; CHILD ABUSE; COMORBIDITY; DIABETES MELLITUS; HUMANS; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84964555704     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-016-0740-8     Document Type: Review

References (59)

1. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) Study. Am J Prev Med. 1998;14(4):245–58.
2. Kim‐Spoon J, Cicchetti D, Rogosch FA. A longitudinal study of emotion regulation, emotion lability‐negativity, and internalizing symptomatology in maltreated and nonmaltreated children. Child Dev. 2013;84(2):512–27.
3. Ayoub CC, O’Connor E, Rappolt-Schlichtmann G, Fischer KW, Rogosch FA, Toth SL, et al. Cognitive and emotional differences in young maltreated children: a translational application of dynamic skill theory. Dev Psychopathol. 2006;18(03):679–706.
4. Miller GE, Chen E, Parker KJ. Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull. 2011;137(6):959–97.
5. Gary-Webb TL, Suglia SF, Tehranifar P. Social epidemiology of diabetes and associated conditions. Curr Diabetes Rep. 2013;13(6):850–9.
6. Turner HA, Ormond R, Hamby SL. Violence, crime, and abuse exposure in a national sample of children and youth: an update. JAMA Pediatr. 2013;167(7):614–21.
7. US Department of Health and Family Services. Child maltreatment. 2012; retrieved from http://www.acf.hhs.gov/sites/default/files/cb/cm2012.pdf.
8. Burke NJ, Hellman JL, Scott BG, Weems CF, Carrion VG. The impact of adverse childhood experiences on an urban pediatric population. Child Abuse Negl. 2011;35(6):408–13.
9. Barnard KD, Skinner TC, Peveler R. The prevalence of co‐morbid depression in adults with Type 1 diabetes: systematic literature review. Diabet Med. 2006;23(4):445–8.
10. Lawrence JM, Standiford DA, Loots B, Klingensmith GJ, Williams DE, Ruggiero A, et al. SEARCH for diabetes in youth study. Pediatrics. 2006;117(4):1348–58.
11. Cooper MN, O’Connell SM, Davis EA, Jones TW. A population-based study of risk factors for severe hypoglycaemia in a contemporary cohort of childhood-onset type 1 diabetes. Diabetologia. 2013;56(10):2164–70.
12. Valenzuela JM, Seid M, Waitzfelder B, Anderson AM, Beavers DP, Dabelea DM. SEARCH for Diabetes in Youth Study Group. Prevalence of and disparities in barriers to care experienced by youth with type 1 diabetes. J Pediatr. 2014;164(6):1369–75.
13. Bellis MA, Hughes K, Leckenby N, Hardcastle KA, Perkins C, Lowey H. Measuring mortality and the burden of adult disease associated with adverse childhood experiences in England: a national survey. Journal of public health. 2014; 1–10. This paper has an important impact because it demonstrated a threshold effect for ACES and diabetes; the odds of diabetes were higher with at least 4 ACEs, and there was no dose-response relation.
14. Almuneef M, Qayad M, Aleissa M, Albuhairan F. Adverse childhood experiences, chronic diseases, and risky health behaviors in Saudi Arabian adults: a pilot study. Child Abuse Negl. 2014;38(11):1787–93.
15. Scott KM, Von Korff M, Angermeyer MC, Benjet C, Bruffaerts R, De Girolamo G, et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Arch Gen Psychiatry. 2011;68(8):838–44.
16. Gilbert LK, Breiding MJ, Merrick MT, Thompson WW, Ford DC, Dhingra SS, et al. Childhood adversity and adult chronic disease: an update from ten states and the District of Columbia. Am J Prev Med. 2015;48(3):345–9. This paper is of importance because it demonstrated that 1–3 or 4–6 ACEs, but not 7–9 ACEs, increased the odds of diabetes, which is contrary to previous ACE studies.
17. Husarewycz MN, El-Gabalawy R, Logsetty S, Sareen J. The association between number and type of traumatic life experiences and physical conditions in a nationally representative sample. Gen Hosp Psychiatry. 2014;36(1):26–32. This paper is important given that it was one of the few that adjusted for numerous covariates, included a large number of adverse events, and found that both adversity type and exposure to cumulative events resulted in greater odds of diabetes.
18. Karavanaki K, Tsoka E, Liacopoulou M, Karayianni C, Petrou V, Pippidou E, et al. Psychological stress as a factor potentially contributing to the pathogenesis of type 1 diabetes mellitus. J Endocrinol Investig. 2008;31(5):406–15.
19. Roy A, Janal MN, Roy M. Childhood trauma and prevalence of cardiovascular disease in patients with type 1 diabetes. Psychosom Med. 2010;72(8):833–8.
20. Lynch L, Waite R, Davey MP. Adverse childhood experiences and diabetes in adulthood: support for a collaborative approach to primary care. Contemp Fam Ther. 2013;35(4):639–55. This paper was significant for the field given that it was one of the first to establish a relation between ACEs and T2DM. Specifically, with every 1 point increase in ACE score, patients had 11% greater likelihood of T2DM.
21. Danese A, Tan M. Childhood maltreatment and obesity: systematic review and meta-analysis. Mol Psychiatry. 2014;19(5):544–54.
22. Kendall-Tackett KA, Marshall R. Victimization and diabetes: an exploratory study. Child Abuse Negl. 1999;23(6):593–6.
23. Widom CS, Czaja SJ, Bentley T, Johnson MS. A prospective investigation of physical health outcomes in abused and neglected children: new findings from a 30-year follow-up. Am J Public Health. 2012;102(6):1135–44.
24. Goodwin RD, Weisberg SP. Childhood abuse and diabetes in the community. Diabetes Care. 2002;25(4):801–2.
25. Zung A, Blumenfeld O, Shehadeh N, Dally Gottfried O, Tenenbaum Rakover Y, Hershkovitz E, et al. Increase in the incidence of type 1 diabetes in Israeli children following the Second Lebanon War. Pediatr Diabetes. 2012;13(4):326–33.
26. Vlajinac H, Šipetić S, Marinković J, Bjekić M, Kocev N, Sajić S. The Belgrade childhood diabetes study–comparison of children with type 1 diabetes with their siblings. Paediatr Perinat Epidemiol. 2006;20(3):238–43.
27. Sipetic S, Vlajinac H, Marinkovi J, Kocev N, Milan B, Ratkov I, et al. Stressful life events and psychological dysfunctions before the onset of type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2007;20(4):527–34.
28. Goodwin RD, Stein MB. Association between childhood trauma and physical disorders among adults in the United States. Psychol Med. 2004;34(03):509–20.
29. Shaw BA, Krause N. Exposure to physical violence during childhood, aging, and health. J Aging Health. 2002;14(4):467–94.
30. Thomas C, Hyppönen E. Power C Obesity and type 2 diabetes risk in midadult life: the role of childhood adversity. Pediatrics. 2008;121(5):e1240–9.
31. Norman SB, Means‐Christensen AJ, Craske MG, Sherbourne CD, Roy‐Byrne PP, Stein MB. Associations between psychological trauma and physical illness in primary care. J Trauma Stress. 2006;19(4):461–70.
32. Romans S, Belaise C, Martin J, Morris E, Raffi A. Childhood abuse and later medical disorders in women. Psychother Psychosom. 2002;71(3):141–50.
33. Rich-Edwards JW, Spiegelman D, Hibert ENL, Jun HJ, Todd TJ, Kawachi I, et al. Abuse in childhood and adolescence as a predictor of type 2 diabetes in adult women. Am J Prev Med. 2010;39(6):529–36.
34. Duncan AE, Auslander WF, Bucholz KK, et al. Relationship between abuse and neglect in childhood and diabetes in adulthood: differential effects by sex, National Longitudinal Study of Adolescent Health. Prev Chron Dis. 2015;12(E70):1–14. This paper was important in providing evidence for a threshold effect, given that greater odds of diabetes were only evident for men who were sexually abused three or more times.
35. Brewin CR, Andrews B. Valentine JD Meta-analysis of risk factors for posttraumatic stress disorder in trauma-exposed adults. J Consult Clin Psychol. 2000;68:748–66.
36. Ozer EJ, Best SR, Lipsey TL, Weiss DS. Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis. Psychol Bull. 2003;129:52–73.
37. Dedert EA, Calhoun PS, Watkins LL, Sherwood A, Beckham JC. Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence. Ann Behav Med. 2010;39:61–78.
38. Pacella ML, Hruska B, Delahanty DL. The physical health consequences of PTSD and PTSD symptoms: a meta-analytic review. J Anxiety Disord. 2013;27:33–46.
39. Friedman MJ, McEwen BS. Posttraumatic stress disorder, allostatic load, and medical illness. In: Schnurr PP, Green BL, editors. Trauma and health: physical health consequences of exposure to extreme stress. Washington: American Psychological Association; 2004. p. 157–88.
40. Boscarino JA. Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. Ann N Y Acad Sci. 2004;1032(1):141–53.
41. Boyko EJ, Seelig AD, Jacobson IG, Hooper TI, Smith B, Smith TC. Millennium Cohort Study Team. Sleep Characteristics, Mental Health, and Diabetes Risk A prospective study of US military service members in the Millennium Cohort Study. Diabetes Care. 2013;36(10):3154–61.
42. David D, Woodward C, Esquenazi J, Mellman TA. Comparison of comorbid physical illnesses among veterans with PTSD and veterans with alcohol dependence. Psychiatr Serv. 2004;55(1):82–5.
43. Trief PM, Ouimette P, Wade M, Shanahan P, Weinstock RS. Post-traumatic stress disorder and diabetes: co-morbidity and outcomes in a male veterans sample. J Behav Med. 2006;29(5):411–8.
44. Vaccarino V, Goldberg J, Magruder KM, Forsberg CW, Friedman MJ, Litz BT, et al. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014;56:158–64.
45. Boyko EJ, Jacobson IG, Smith B, Ryan MA, Hooper TI, Amoroso PJ. Millennium Cohort Study Team. Risk of diabetes in US military service members in relation to combat deployment and mental health. Diabetes Care. 2010;36:3154–61.
46. Lukaschek K, Baumert J, Kruse J, Emeny RT, Lacruz ME, Huth C, et al. Relationship between posttraumatic stress disorder and type 2 diabetes in a population-based cross-sectional study with 2970 participants. J Psychosom Res. 2013;74(4):340–5.
47. Rao MN, Chau A, Madden E, Inslicht S, Talbot L, Richards A, et al. Hyperinsulinemic response to oral glucose challenge in individuals with posttraumatic stress disorder. Psychoneuroendocrinology. 2014;49:171–81.
48. Goodwin RD, Davidson JR. Self-reported diabetes and posttraumatic stress disorder among adults in the community. Prev Med. 2005;40(5):570–4.
49. Miller-Archie SA, Jordan HT, Ruff RR, Chamany S, Cone JE, Brackbill RM, et al. Posttraumatic stress disorder and new-onset diabetes among adult survivors of the World Trade Center disaster. Prev Med. 2014;66:34–8.
50. Pietrzak RH, Goldstein RB, Southwick SM, Grant BF. Medical comorbidity of full and partial posttraumatic stress disorder in United States adults: results from wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions. Psychosom Med. 2011;73(8):697–707.
51. Weisberg RB, Bruce SE, Machan JT, Kessler RC, Culpepper L, Keller MB. Nonpsychiatric illness among primary care patients with trauma histories and posttraumatic stress disorder. Psychiatr Serv. 2014;53(7):848–54.
52. Miller SA, Mancuso CA, Boutin-Foster C, Michelen W, McLean-Long C, Foote B. Charlson ME associations between posttraumatic stress disorder and hemoglobin A1 C in low-income minority patients with diabetes. Gen Hosp Psychiatry. 2011;33:116–22.
53. Wagner J, Burke G, Kuoch T, Scully M, Armeli S, Rajan TV. Trauma, healthcare access, and health outcomes among Southeast Asian refugees in Connecticut. J Immigr Minor Health. 2013;15(6):1065–72.
54. Roberts AL, Agnew-Blais JC, Spiegelman D, Kubzansky LD, Mason SM, Galea S, et al. Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry. 2015;72(3):203–10.
55. Agyemang C, Goosen S, Anujuo K, Ogedegbe G. Relationship between post-traumatic stress disorder and diabetes among 105,180 asylum seekers in the Netherlands. Eur J Public Health. 2011;22(5):658–62.
56. Layne CM, Greeson JKP, Ostrowski SA, Kim S, Reading S, Vivrette RL, et al. Cumulative trauma exposure and high risk behavior in adolescence: findings from the National Child Traumatic Stress Network Core Data Set. Psychol Trauma Theory, Res, Pract, Policy. 2014;6:S40–9.
57. Jackson Y, Gabrielli J, Fleming K, Tunno AM, Makanui PK. Untangling the relative contribution of maltreatment severity and frequency to type of behavioral outcome in foster youth. Child Abuse Negl. 2014;38(7):1147–59.
58. Shenk CE, Putnam FW, Rausch JR, Peugh JL, Noll JG. A longitudinal study of several potential mediators of the relationship between child maltreatment and posttraumatic stress disorder symptoms. Dev Psychopathol. 2014;26(01):81–91.
59. Collishaw S, Pickles A, Messer J, Rutter M, Shearer C, Maughan B. Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample. Child Abuse Negl. 2007;31(3):211–29.