Safety and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs

Immunology Letters

Volumn 174, Issue , 2016, Pages 63-71

  Lei, Jian Lin ^a,b   Xia, Shui Li ^a   Wang, Yimin ^a   Du, Mingliang ^a   Xiang, Guang Tao ^a   Cong, Xin ^a   Luo, Yuzi ^a   Li, Lian Feng ^a   Zhang, Lingkai ^a   Yu, Jiahui ^a   Hu, Yonghao ^b   Qiu, Hua Ji ^a   Sun, Yuan ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b GANSU AGRICULTURAL UNIVERSITY   (China)

Author keywords

Bivalent vaccine; Classical swine fever; Immunogenicity; Pseudorabies virus variant; Safety

Indexed keywords

CLASSICAL SWINE FEVER VIRUS NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY; PSEUDORABIES VIRUS NEUTRALIZING ANTIBODY; RECOMBINANT PSEUDORABIES VIRUS TJ STRAIN DELGE GI THYMIDINE KINASE VACCINE; UNCLASSIFIED DRUG; VIRUS RNA; VIRUS VACCINE; GLYCOPROTEIN E2, CLASSICAL SWINE FEVER VIRUS; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; GENETIC STABILITY; HISTOPATHOLOGY; HUMORAL IMMUNITY; IMMUNIZATION; IMMUNOGENICITY; IMMUNOPROPHYLAXIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NOSE SMEAR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDORABIES; RECTAL SWAB; SMEAR; SURVIVAL RATE; SYMPTOM; TIME SERIES ANALYSIS; VIRUS ISOLATION; VIRUS SHEDDING; VIRUS STRAIN; ANIMAL; BLOOD; CELL LINE; GENE DELETION; GENE EXPRESSION; GENE ORDER; GENE VECTOR; GENETICS; IMMUNOLOGY; MORTALITY; PIG; PSEUDORABIES VIRUS; VIROLOGY; VIRUS GENE;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; CLASSICAL SWINE FEVER; CLASSICAL SWINE FEVER VIRUS; GENE DELETION; GENE EXPRESSION; GENE ORDER; GENES, VIRAL; GENETIC VECTORS; HERPESVIRUS 1, SUID; IMMUNIZATION; SWINE; VIRAL ENVELOPE PROTEINS; VIRAL VACCINES;

EID: 84964514111     PISSN: 01652478     EISSN: 18790542     Source Type: Journal    
DOI: 10.1016/j.imlet.2016.04.014     Document Type: Article

References (34)

1. Moennig V., Floegel-Niesmann G., Greiser-Wilke I. Clinical signs and epidemiology of classical swine fever: a review of new knowledge. Vet. J. 2003, 165:11-20.
2. Peeters B., Bienkowska-Szewczyk K., Hulst M., Gielkens A., Kimman T. Biologically safe, non-transmissible pseudorabies virus vector vaccine protects pigs against both Aujeszky's disease and classical swine fever. J. Gen. Virol. 1997, 78:3311-3315. (Pt. 12).
3. Weiland E., Ahl R., Stark R., Weiland F., Thiel H.J. A second envelope glycoprotein mediates neutralization of a pestivirus, hog cholera virus. J. Virol. 1992, 66:3677-3682.
4. van Rijn P.A., Bossers A., Wensvoort G., Moormann R.J. Classical swine fever virus (CSFV) envelope glycoprotein E2 containing one structural antigenic unit protects pigs from lethal CSFV challenge. J. Gen. Virol. 1996, 77:2737-2745. (Pt. 11).
5. Bouma A., de Smit A.J., de Kluijver E.P., Terpstra C., Moormann R.J. Efficacy and stability of a subunit vaccine based on glycoprotein E2 of classical swine fever virus. Vet. Microbiol. 1999, 66:101-114.
6. Sun Y., Liu D.F., Wang Y.F., Liang B.B., Cheng D., Li N., Qi Q.F., Zhu Q.H., Qiu H.J. Generation and efficacy evaluation of a recombinant adenovirus expressing the E2 protein of classical swine fever virus. Res. Vet. Sci. 2010, 88:77-82.
7. Sun Y., Li H.Y., Tian D.Y., Han Q.Y., Zhang X., Li N., Qiu H.J. A novel alphavirus replicon-vectored vaccine delivered by adenovirus induces sterile immunity against classical swine fever. Vaccine 2011, 29:8364-8372.
8. Suradhat S., Damrongwatanapokin S. The influence of maternal immunity on the efficacy of a classical swine fever vaccine against classical swine fever virus, genogroup 2. 2, infection. Vet. Microbiol. 2003, 92:187-194.
9. Graham S.P., Everett H.E., Haines F.J., Johns H.L., Sosan O.A., Salguero F.J., Clifford D.J., Steinbach F., Drew T.W., Crooke H.R. Challenge of pigs with classical swine fever viruses after C-strain vaccination reveals remarkably rapid protection and insights into early immunity. PLoS One 2012, 7:e29310.
10. Klupp B.G., Hengartner C.J., Mettenleiter T.C., Enquist L.W. Complete, annotated sequence of the pseudorabies virus genome. J. Virol. 2004, 78:424-440.
11. Hooft van Iddekinge B.J., de Wind N., Wensvoort G., Kimman T.G., Gielkens A.L., Moormann R.J. Comparison of the protective efficacy of recombinant pseudorabies viruses against pseudorabies and classical swine fever in pigs; influence of different promoters on gene expression and on protection. Vaccine 1996, 14:6-12.
12. Kratchmarov R., Kramer T., Greco T.M., Taylor M.P., Ch'ng T.H., Cristea I.M., Enquist L.W. Glycoproteins gE and gI are required for efficient KIF1A-dependent anterograde axonal transport of alphaherpesvirus particles in neurons. J.Virol. 2013, 87:9431-9440.
13. Olsen L.M., Ch'ng T.H., Card J.P., Enquist L.W. Role of pseudorabies virus Us3 protein kinase during neuronal infection. J. Virol. 2006, 80:6387-6398.
14. Qian P., Li X.M., Jin M.L., Peng G.Q., Chen H.C. An approach to a FMD vaccine based on genetic engineered attenuated pseudorabies virus: one experiment using VP1 gene alone generates an antibody responds on FMD and pseudorabies in swine. Vaccine 2004, 22:2129-2136.
15. Qiu H.J., Tian Z.J., Tong G.Z., Zhou Y.J., Ni J.Q., Luo Y.Z., Cai X.H. Protective immunity induced by a recombinant pseudorabies virus expressing the GP5 of porcine reproductive and respiratory syndrome virus in piglets. Vet. Immunol. Immunopathol. 2005, 106:309-319.
16. Jiang Y., Fang L., Xiao S., Zhang H., Pan Y., Luo R., Li B., Chen H. Immunogenicity and protective efficacy of recombinant pseudorabies virus expressing the two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus. Vaccine 2007, 25:547-560.
17. An T.Q., Peng J.M., Tian Z.J., Zhao H.Y., Li N., Liu Y.M., Chen J.Z., Leng C.L., Sun Y., Chang D., Tong G.Z. Pseudorabies virus variant in Bartha-K61-vaccinated pigs China, 2012. Emerg. Infect. Dis. 2013, 19:1749-1755.
18. Wu R., Bai C., Sun J., Chang S., Zhang X. Emergence of virulent pseudorabies virus infection in northern China. J. Vet. Sci. 2013, 14:363-365.
19. Wang C.H., Yuan J., Qin H.Y., Luo Y., Cong X., Li Y., Chen J., Li S., Sun Y., Qiu H.J. A novel gE-deleted pseudorabies virus (PRV) provides rapid and complete protection from lethal challenge with the PRV variant emerging in Bartha-K61-vaccinated swine population in China. Vaccine 2014, 32:3379-3385.
20. Luo Y., Li N., Cong X., Wang C.H., Du M., Li L., Zhao B., Yuan J., Liu D.D., Li S., Li Y., Sun Y., Qiu H.J. Pathogenicity and genomic characterization of a pseudorabies virus variant isolated from Bartha-K61-vaccinated swine population in China. Vet. Microbiol. 2014, 174:107-115.
21. Wang Y., Yuan J., Cong X., Qin H.Y., Wang C.H., Li Y., Li S., Luo Y., Sun Y., Qiu H.J. Generation and efficacy evaluation of a recombinant pseudorabies virus variant expressing the E2 protein of classical swine fever virus in pigs. Clin. Vaccine Immunol. 2015, 22:1121-1129.
22. Suradhat S., Intrakamhaeng M., Damrongwatanapokin S. The correlation of virus-specific interferon-gamma production and protection against classical swine fever virus infection. Vet. Immunol. Immunopathol. 2001, 83:177-189.
23. Xu G., Xu X., Li Z., He Q., Wu B., Sun S., Chen H. Construction of recombinant pseudorabies virus expressing NS1 protein of Japanese encephalitis (SA14-14-2) virus and its safety and immunogenicity. Vaccine 2004, 22:1846-1853.
24. Cong X., Lei J.L., Xia S.L., Wang Y., Li Y., Li S., Luo Y., Sun Y., Qiu H.J. Pathogenicity and immunogenicity of a gE/gI/TK gene-deleted pseudorabies virus variant in susceptible animals. Vet. Microbiol. 2016, 182:170-177.
25. Peng W.P., Hou Q., Xia Z.H., Chen D., Li N., Sun Y., Qiu H.J. Identification of a conserved linear B-cell epitope at the N-terminus of the E2 glycoprotein of Classical swine fever virus by phage-displayed random peptide library. Virus Res. 2008, 135:267-272.
26. Zhao J.J., Cheng D., Li N., Sun Y., Shi Z., Zhu Q.H., Tu C., Tong G.Z., Qiu H.J. Evaluation of a multiplex real-time RT-PCR for quantitative and differential detection of wild-type viruses and C-strain vaccine of classical swine fever virus. Vet. Microbiol. 2008, 126:1-10.
27. Souza A.P., Haut L., Reyes-Sandoval A., Pinto A.R. Recombinant viruses as vaccines against viral diseases. Braz. J. Med. Biol. Res. 2005, 38:509-522.
28. Hu R.M., Zhou Q., Song W.B., Sun E.C., Zhang M.M., He Q.G., Chen H.C., Wu B., Liu Z.F. Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge. Vaccine 2015, 43:5733-5740.
29. Weiland E., Stark R., Haas B., Rümenapf T., Meyers G., Thiel H.J. Pestivirus glycoprotein which induces neutralizing antibodies forms part of a disulfide-linked heterodimer. J.Virol 1990, 64:3563-3569.
30. Ganges L., Barrera M., Núñez J.I., Blanco I., Frias M.T., Rodríguez F., Sobrino F. A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge. Vaccine 2005, 23:3741-3752.
31. Tarradas J., Argilaguet J.M., Rosell R., Nofrarías M., Crisci E., Córdoba L., Pérez-Martín E., Díaz I., Rodríguez F., Domingo M., Montoya M., Ganges L. Interferon-gamma induction correlates with protection by DNA vaccine expressing E2 glycoprotein against classical swine fever virus infection in domestic pigs. Vet. Microbiol. 2010, 142:51-58.
32. Blome S., Aebischer A., Lange E., Hofmann M., Leifer I., Loeffen W., Koenen F., Beer M. Comparative evaluation of live marker vaccine candidates CP7_E2alf and flc11 along with C-strain Riems after oral vaccination. Vet. Microbiol. 2012, 158:42-59.
33. Moormann R.J., Bouma A., Kramps J.A., Terpstra C., De Smit H.J. Development of a classical swine fever subunit marker vaccine and companion diagnostic test. Vet. Microbiol. 2000, 73:209-219.
34. Tarradas J., Monsó M., Muñoz M., Rosell R., Fraile L., Frías M.T., Domingo M., Andreu D., Sobrino F., Ganges L. Partial protection against classical swine fever virus elicited by dendrimeric vaccine-candidate peptides in domestic pigs. Vaccine 2011, 29:4422-4429.