Calcium-dependent antigen binding as a novel modality for antibody recycling by endosomal antigen dissociation

mAbs

Volumn 8, Issue 1, 2016, Pages 65-73

  Hironiwa, N ^a   Ishii, S ^a   Kadono, S ^a   Iwayanagi, Y ^a   Mimoto, F ^a   Habu, K ^a   Igawa, Tomoyuki ^a   Hattori, K ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Antibody engineering; Antigen clearance; Antigen dissociation; Calcium ion; Recycling antibody

Indexed keywords

ANTIGEN; CALCIUM ION; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERLEUKIN 6 RECEPTOR ANTIBODY; RECOMBINANT ANTIBODY; RECYCLING ANTIBODY; UNCLASSIFIED DRUG; CALCIUM; COMPLEMENTARITY DETERMINING REGION; IL6R PROTEIN, HUMAN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL CELL; ANTIBODY DISSOCIATION; ANTIBODY LIBRARY; ANTIBODY RECYCLING; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CALCIUM DEPENDENT ANTIGEN BINDING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOCIATION CONSTANT; ENDOSOME; ENZYME LINKED IMMUNOSORBENT ASSAY; MOUSE; NONHUMAN; PH; PHAGE DISPLAY; SURFACE PLASMON RESONANCE; THERMODYNAMICS; THERMOSTABILITY; CELL LINE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; HUMAN; METABOLISM;

ANTIGENS; CALCIUM; CELL LINE; COMPLEMENTARITY DETERMINING REGIONS; ENDOSOMES; HUMANS; HYDROGEN-ION CONCENTRATION; RECEPTORS, INTERLEUKIN-6; SINGLE-CHAIN ANTIBODIES;

EID: 84964413709     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2015.1110660     Document Type: Article

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