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Volumn 27, Issue 4, 2016, Pages 375-381

Identifying familial hypercholesterolemia in acute coronary syndrome

Author keywords

acute coronary syndrome; cardiovascular prevention; familial hypercholesterolemia; lipids; proprotein convertase subtilisin kexin type 9

Indexed keywords

ANTILIPEMIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PCSK9 INHIBITOR; UNCLASSIFIED DRUG; PCSK9 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 9;

EID: 84964378012     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0000000000000311     Document Type: Review
Times cited : (22)

References (46)
  • 1
    • 84890461947 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus statement of the European Atherosclerosis Society
    • Nordestgaard BG, Chapman MJ, Humphries SE, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J 2013; 34:3478-3490a.
    • (2013) Eur Heart J , vol.34 , pp. 3478-3490a
    • Nordestgaard, B.G.1    Chapman, M.J.2    Humphries, S.E.3
  • 2
    • 84934965790 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia in children and adolescents: Gaining decades of life by optimizing detection and treatment
    • Wiegman A, Gidding SS, Watts GF, et al. Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. Eur Heart J 2015; 36:2425-2437.
    • (2015) Eur Heart J , vol.36 , pp. 2425-2437
    • Wiegman, A.1    Gidding, S.S.2    Watts, G.F.3
  • 3
    • 84868628467 scopus 로고    scopus 로고
    • Familial hypercholesterolemia in the danish general population: Prevalence, coronary artery disease, and cholesterol-lowering medication
    • Benn M, Watts GF, Tybjaerg-Hansen A, Nordestgaard BG. Familial hypercholesterolemia in the danish general population: prevalence, coronary artery disease, and cholesterol-lowering medication. J Clin Endocrinol Metab 2012; 97:3956-3964.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 3956-3964
    • Benn, M.1    Watts, G.F.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 4
    • 79959728614 scopus 로고    scopus 로고
    • Effect of lipid-lowering treatment on natural history of heterozygous familial hypercholesterolemia in past three decades
    • Elis A, Zhou R, Stein EA. Effect of lipid-lowering treatment on natural history of heterozygous familial hypercholesterolemia in past three decades. Am J CardiolS 2011; 108:223-226.
    • (2011) Am J CardiolS , vol.108 , pp. 223-226
    • Elis, A.1    Zhou, R.2    Stein, E.A.3
  • 5
    • 79959332777 scopus 로고    scopus 로고
    • Efficacy of statins in familial hypercholesterolaemia: A long term cohort study
    • Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: A long term cohort study. BMJ 2008; 337:a2423.
    • (2008) BMJ , vol.337 , pp. a2423
    • Versmissen, J.1    Oosterveer, D.M.2    Yazdanpanah, M.3
  • 7
    • 84893939616 scopus 로고    scopus 로고
    • Familial hypercholesterolemia: An under-recognized but significant concern in cardiology practice
    • Foody JM. Familial hypercholesterolemia: An under-recognized but significant concern in cardiology practice. Clin Cardiol 2014; 37:119-125.
    • (2014) Clin Cardiol , vol.37 , pp. 119-125
    • Foody, J.M.1
  • 8
    • 55749088063 scopus 로고    scopus 로고
    • Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: A prospective registry study
    • Neil A, Cooper J, Betteridge J, et al. Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: A prospective registry study. Eur Heart J 2008; 29:2625-2633.
    • (2008) Eur Heart J , vol.29 , pp. 2625-2633
    • Neil, A.1    Cooper, J.2    Betteridge, J.3
  • 9
    • 84942092305 scopus 로고    scopus 로고
    • Prevalence and management of familial hypercholesterolaemia in patients with acute coronary syndromes
    • Nanchen D, Gencer B, Auer R, et al. Prevalence and management of familial hypercholesterolaemia in patients with acute coronary syndromes. Eur Heart J 2015; 36:2438-2445.
    • (2015) Eur Heart J , vol.36 , pp. 2438-2445
    • Nanchen, D.1    Gencer, B.2    Auer, R.3
  • 10
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • European Association for Cardiovascular Prevention & Rehabilitation
    • European Association for Cardiovascular Prevention & Rehabilitation. Catapano AL, De Backer G, Reiner Z, et al. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011; 32:1769-1818.
    • (2011) Eur Heart J , vol.32 , pp. 1769-1818
    • Catapano, A.L.1    De Backer, G.2    Reiner, Z.3
  • 11
    • 79956278397 scopus 로고    scopus 로고
    • Familial hypercholesterolemias: Prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia
    • Hopkins PN, Toth PP, Ballantyne CM, et al. Familial hypercholesterolemias: prevalence, genetics, diagnosis and screening recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Clin Lipidol 2011; 5:S9-17.
    • (2011) J Clin Lipidol , vol.5 , pp. S9-17
    • Hopkins, P.N.1    Toth, P.P.2    Ballantyne, C.M.3
  • 12
    • 84893647246 scopus 로고    scopus 로고
    • Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation
    • Watts GF, Gidding S, Wierzbicki AS, et al. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. Int J Cardiol 2014; 171:309-325.
    • (2014) Int J Cardiol , vol.171 , pp. 309-325
    • Watts, G.F.1    Gidding, S.2    Wierzbicki, A.S.3
  • 13
    • 0025944056 scopus 로고
    • Risk of fatal coronary heart disease in familial hypercholesterolaemia
    • Scientific Steering Committee on behalf of the Simon Broome Register Group
    • Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group. BMJ 1991; 303:893-896.
    • (1991) BMJ , vol.303 , pp. 893-896
  • 14
    • 51249096285 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia: Summary of NICE guidance
    • Wierzbicki AS, Humphries SE, Minhas R. Familial hypercholesterolaemia: summary of NICE guidance. BMJ 2008; 337:a1095.
    • (2008) BMJ , vol.337 , pp. a1095
    • Wierzbicki, A.S.1    Humphries, S.E.2    Minhas, R.3
  • 15
    • 84949321606 scopus 로고    scopus 로고
    • The agenda for familial hypercholesterolemia: A scientific statement from the American Heart Association
    • Gidding SS, Ann Champagne M, de Ferranti SD, et al. The agenda for familial hypercholesterolemia: A scientific statement from the American Heart Association. Circulation 2015; 132:2167-2192
    • (2015) Circulation , vol.132 , pp. 2167-2192
    • Gidding, S.S.1    Ann Champagne, M.2    De Ferranti, S.D.3
  • 16
    • 84876167878 scopus 로고    scopus 로고
    • Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: A case-control study
    • Talmud PJ, Shah S, Whittall R, et al. Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: A case-control study. Lancet 2013; 381:1293-1301.
    • (2013) Lancet , vol.381 , pp. 1293-1301
    • Talmud, P.J.1    Shah, S.2    Whittall, R.3
  • 17
    • 84924273749 scopus 로고    scopus 로고
    • Prevalence of DNA-confirmed familial hypercholesterolaemia in young patients with myocardial infarction
    • Wald DS, Bangash FA, Bestwick JP. Prevalence of DNA-confirmed familial hypercholesterolaemia in young patients with myocardial infarction. Eur J Int Med 2015; 26:127-130.
    • (2015) Eur J Int Med , vol.26 , pp. 127-130
    • Wald, D.S.1    Bangash, F.A.2    Bestwick, J.P.3
  • 18
    • 54549111350 scopus 로고    scopus 로고
    • Comparison of genetic versus clinical diagnosis in familial hypercholesterolemia
    • Civeira F, Ros E, Jarauta E, et al. Comparison of genetic versus clinical diagnosis in familial hypercholesterolemia. Am J Cardiol 2008; 102:1187-1193.
    • (2008) Am J Cardiol , vol.102 , pp. 1187-1193
    • Civeira, F.1    Ros, E.2    Jarauta, E.3
  • 19
    • 84929413403 scopus 로고    scopus 로고
    • Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology
    • De Backer G, Besseling J, Chapman J, et al. Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology. Atherosclerosis 2015; 241:169-175
    • (2015) Atherosclerosis , vol.241 , pp. 169-175
    • De Backer, G.1    Besseling, J.2    Chapman, J.3
  • 20
    • 84941343041 scopus 로고    scopus 로고
    • Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit
    • Pang J, Poulter EB, Bell DA, et al. Frequency of familial hypercholesterolemia in patients with early-onset coronary artery disease admitted to a coronary care unit. Journal of clinical lipidology 2015; 9:703-708.
    • (2015) Journal of Clinical Lipidology , vol.9 , pp. 703-708
    • Pang, J.1    Poulter, E.B.2    Bell, D.A.3
  • 21
    • 84858264853 scopus 로고    scopus 로고
    • Suboptimal consideration and management of potential familial hypercholesterolaemia in patients with suspected premature coronary artery disease
    • Yudi M, Omera L, McCubbery N, et al. Suboptimal consideration and management of potential familial hypercholesterolaemia in patients with suspected premature coronary artery disease. Singapore Med J 2012; 53:174-178.
    • (2012) Singapore Med J , vol.53 , pp. 174-178
    • Yudi, M.1    Omera, L.2    McCubbery, N.3
  • 22
    • 84962156856 scopus 로고    scopus 로고
    • Prognostic value of PCSK9 levels in patients with acute coronary syndromes
    • Gencer B, Montecucco F, Nanchen D, et al. Prognostic value of PCSK9 levels in patients with acute coronary syndromes. Eur Heart J 2016; 37:546-553.
    • (2016) Eur Heart J , vol.37 , pp. 546-553
    • Gencer, B.1    Montecucco, F.2    Nanchen, D.3
  • 23
    • 84955383209 scopus 로고    scopus 로고
    • Acute coronary syndromes: Low prognostic utility of measuring PCSK9 levels in ACS. Nature reviews
    • Lim GB. Acute coronary syndromes: low prognostic utility of measuring PCSK9 levels in ACS. Nature reviews. Cardiology 2016; 13:62-63.
    • (2016) Cardiology , vol.13 , pp. 62-63
    • Lim, G.B.1
  • 24
    • 84930619624 scopus 로고    scopus 로고
    • Low statin use in adults hospitalized with acute coronary syndrome
    • Selby K, Nanchen D, Auer R, et al. Low statin use in adults hospitalized with acute coronary syndrome. Preventive Med 2015; 77:131-136.
    • (2015) Preventive Med , vol.77 , pp. 131-136
    • Selby, K.1    Nanchen, D.2    Auer, R.3
  • 25
    • 84897970506 scopus 로고    scopus 로고
    • 2013ACC/AHAguideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
    • Stone NJ, Robinson JG, LichtensteinAH, et al. 2013ACC/AHAguideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014; 129:S1-S45.
    • (2014) Circulation , vol.129 , pp. S1-S45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3
  • 26
    • 84933673677 scopus 로고    scopus 로고
    • Efficacy and safety of LDL-lowering therapy among men and women: Meta-analysis of individual data from 174000 participants in 27 randomised trials
    • Fulcher J, O'Connell R, Voysey M, et al. Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174000 participants in 27 randomised trials. Lancet 2015; 385:1397-1405.
    • (2015) Lancet , vol.385 , pp. 1397-1405
    • Fulcher, J.1    O'Connell, R.2    Voysey, M.3
  • 27
    • 84899816195 scopus 로고    scopus 로고
    • Quality of care after acute coronary syndromes in a prospective cohort with reasons for nonprescription of recommended medications
    • Auer R, Gencer B, Raber L, et al. Quality of care after acute coronary syndromes in a prospective cohort with reasons for nonprescription of recommended medications. PloS One 2014; 9:e93147.
    • (2014) PloS One , vol.9 , pp. e93147
    • Auer, R.1    Gencer, B.2    Raber, L.3
  • 28
    • 84927742065 scopus 로고    scopus 로고
    • Statin-associated muscle symptoms: Impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management
    • Stroes ES, Thompson PD, Corsini A, et al. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J 2015; 36:1012-1022.
    • (2015) Eur Heart J , vol.36 , pp. 1012-1022
    • Stroes, E.S.1    Thompson, P.D.2    Corsini, A.3
  • 29
    • 84875727583 scopus 로고    scopus 로고
    • Discontinuation of statins in routine care settings: A cohort study
    • Zhang H, Plutzky J, Skentzos S, et al. Discontinuation of statins in routine care settings: A cohort study. Ann Int Med 2013; 158:526-534.
    • (2013) Ann Int Med , vol.158 , pp. 526-534
    • Zhang, H.1    Plutzky, J.2    Skentzos, S.3
  • 30
    • 84921613144 scopus 로고    scopus 로고
    • Reasons for discontinuation of recommended therapies according to the patients after acute coronary syndromes
    • Gencer B, Rodondi N, Auer R, et al. Reasons for discontinuation of recommended therapies according to the patients after acute coronary syndromes. Eur J Int Med 2015; 26:56-62.
    • (2015) Eur J Int Med , vol.26 , pp. 56-62
    • Gencer, B.1    Rodondi, N.2    Auer, R.3
  • 31
    • 84920894208 scopus 로고    scopus 로고
    • Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the recommended lipid target achievement after acute coronary syndromes
    • Gencer B, Auer R, Nanchen D, et al. Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the recommended lipid target achievement after acute coronary syndromes. Atherosclerosis 2015; 239:118-124.
    • (2015) Atherosclerosis , vol.239 , pp. 118-124
    • Gencer, B.1    Auer, R.2    Nanchen, D.3
  • 32
    • 84971619896 scopus 로고    scopus 로고
    • 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent STsegment elevation: Task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC)
    • Roffi M, Patrono C, Collet JP, et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent STsegment elevation: Task force for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2016; 37:267-315.
    • (2016) Eur Heart J , vol.37 , pp. 267-315
    • Roffi, M.1    Patrono, C.2    Collet, J.P.3
  • 33
    • 0032890205 scopus 로고    scopus 로고
    • Mortality in treated heterozygous familial hypercholesterolaemia: Implications for clinical management
    • Scientific Steering Committee on behalf of the Simon Broome Register Group. Scientific Steering Committee on behalf of the Simon Broome Register Group
    • Scientific Steering Committee on behalf of the Simon Broome Register Group. Mortality in treated heterozygous familial hypercholesterolaemia: implications for clinical management. Scientific Steering Committee on behalf of the Simon Broome Register Group. Atherosclerosis 1999; 142:105-112.
    • (1999) Atherosclerosis , vol.142 , pp. 105-112
  • 34
    • 84893873856 scopus 로고    scopus 로고
    • Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: A study of a cohort of 14 000 mutation carriers
    • Besseling J, Kindt I, Hof M, et al. Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: A study of a cohort of 14 000 mutation carriers. Atherosclerosis 2014; 233:219-223.
    • (2014) Atherosclerosis , vol.233 , pp. 219-223
    • Besseling, J.1    Kindt, I.2    Hof, M.3
  • 35
    • 84864602990 scopus 로고    scopus 로고
    • Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: A study among 29 365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants
    • Huijgen R, Kindt I, Defesche JC, Kastelein JJ. Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: A study among 29 365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants. Eur Heart J 2012; 33:2325-2330.
    • (2012) Eur Heart J , vol.33 , pp. 2325-2330
    • Huijgen, R.1    Kindt, I.2    Defesche, J.C.3    Kastelein, J.J.4
  • 36
    • 0842309234 scopus 로고    scopus 로고
    • Cardiovascular disease and mortality in statin-treated patients with familial hypercholesterolemia
    • Mohrschladt MF, Westendorp RG, Gevers Leuven JA, Smelt AH. Cardiovascular disease and mortality in statin-treated patients with familial hypercholesterolemia. Atherosclerosis 2004; 172:329-335.
    • (2004) Atherosclerosis , vol.172 , pp. 329-335
    • Mohrschladt, M.F.1    Westendorp, R.G.2    Gevers Leuven, J.A.3    Smelt, A.H.4
  • 38
    • 84960464002 scopus 로고    scopus 로고
    • Use and role of monoclonal antibodies and other biologics in preventive cardiology
    • Gencer B, Laaksonen R, Buhayer A, Mach F. Use and role of monoclonal antibodies and other biologics in preventive cardiology. Swiss Med Wkly 2015; 145:w14179.
    • (2015) Swiss Med Wkly , vol.145 , pp. w14179
    • Gencer, B.1    Laaksonen, R.2    Buhayer, A.3    Mach, F.4
  • 39
    • 84944937913 scopus 로고    scopus 로고
    • Reducing LDL with PCSK9 Inhibitors: The clinical benefit of lipid drugs
    • Everett BM, Smith RJ, Hiatt WR. Reducing LDL with PCSK9 Inhibitors: The clinical benefit of lipid drugs. New Engl J Med 2015; 373:1588-1591.
    • (2015) New Engl J Med , vol.373 , pp. 1588-1591
    • Everett, B.M.1    Smith, R.J.2    Hiatt, W.R.3
  • 40
    • 84928823445 scopus 로고    scopus 로고
    • National lipid association recommendations for patient-centered management of dyslipidemia: Part 1: Full report
    • Jacobson TA, Ito MK, Maki KC, et al. National lipid association recommendations for patient-centered management of dyslipidemia: part 1: full report. Journal Clinical Lipidol 2015; 9:129-169.
    • (2015) Journal Clinical Lipidol , vol.9 , pp. 129-169
    • Jacobson, T.A.1    Ito, M.K.2    Maki, K.C.3
  • 41
    • 84931849550 scopus 로고    scopus 로고
    • Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: A systematic review and meta-analysis
    • Navarese EP, Kolodziejczak M, Schulze V, et al. Effects of proprotein convertase subtilisin/kexin type 9 antibodies in adults with hypercholesterolemia: A systematic review and meta-analysis. Ann Int Med 2015; 163:40-51.
    • (2015) Ann Int Med , vol.163 , pp. 40-51
    • Navarese, E.P.1    Kolodziejczak, M.2    Schulze, V.3
  • 42
    • 84926206074 scopus 로고    scopus 로고
    • Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015; 372:1500-1509.
    • (2015) N Engl J Med , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1    Giugliano, R.P.2    Wiviott, S.D.3
  • 43
    • 84926191670 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
    • Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. New Engl J Med 2015; 372:1489-1499.
    • (2015) New Engl J Med , vol.372 , pp. 1489-1499
    • Robinson, J.G.1    Farnier, M.2    Krempf, M.3
  • 44
    • 84929897016 scopus 로고    scopus 로고
    • Sweetless'n low LDL-C targets for PCSK9 treatment
    • Gencer B, Mach F. Sweetless'n low LDL-C targets for PCSK9 treatment. Eur Heart J 2015; 36:1146-1148.
    • (2015) Eur Heart J , vol.36 , pp. 1146-1148
    • Gencer, B.1    Mach, F.2
  • 45
    • 84921528143 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia: PCSK9 inhibitors are coming
    • Santos RD, Watts GF. Familial hypercholesterolaemia: PCSK9 inhibitors are coming. Lancet 2015; 385:307-310.
    • (2015) Lancet , vol.385 , pp. 307-310
    • Santos, R.D.1    Watts, G.F.2
  • 46
    • 84954521357 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for treatment of high cholesterol levels: Effectiveness and value
    • Tice JA, Kazi DS, Pearson SD. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for treatment of high cholesterol levels: effectiveness and value. JAMA Int Med 2016; 176:107-108.
    • (2016) JAMA Int Med , vol.176 , pp. 107-108
    • Tice, J.A.1    Kazi, D.S.2    Pearson, S.D.3


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