메뉴 건너뛰기




Volumn 145, Issue , 2015, Pages

PCSK9 inhibitors

Author keywords

Cardiometabolic disease; Cardiovascular prevention; Lipids; Pharmacological therapies

Indexed keywords

ANTILIPEMIC AGENT; BOCOCIZUMAB; EVOLOCUMAB; EZETIMIBE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; PLACEBO; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9 INHIBITOR; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ALIROCUMAB; MONOCLONAL ANTIBODY; PCSK9 PROTEIN, HUMAN; SERINE PROTEINASE;

EID: 84929208446     PISSN: 14247860     EISSN: 14243997     Source Type: Journal    
DOI: 10.4414/smw.2015.14094     Document Type: Review
Times cited : (27)

References (30)
  • 1
    • 84862176457 scopus 로고    scopus 로고
    • PCSK9 inhibition: The next statin?
    • Vogel RA. PCSK9 inhibition: the next statin? J Am Coll Cardiol. 2012;59(25):2354-5.
    • (2012) J Am Coll Cardiol. , vol.59 , Issue.25 , pp. 2354-2355
    • Vogel, R.A.1
  • 3
    • 84885447918 scopus 로고    scopus 로고
    • Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis
    • Urban D, Poss J, Bohm M, Laufs U. Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis. J Am Coll Cardiol. 2013;62(16):1401-8.
    • (2013) J Am Coll Cardiol. , vol.62 , Issue.16 , pp. 1401-1408
    • Urban, D.1    Poss, J.2    Bohm, M.3    Laufs, U.4
  • 4
    • 84925351969 scopus 로고    scopus 로고
    • Lipid lowering with PCSK9 inhibitors
    • Dadu RT, Ballantyne CM. Lipid lowering with PCSK9 inhibitors. Nat Rev Cardiol. 2014;11(10):563-75.
    • (2014) Nat Rev Cardiol. , vol.11 , Issue.10 , pp. 563-575
    • Dadu, R.T.1    Ballantyne, C.M.2
  • 5
    • 84880095092 scopus 로고    scopus 로고
    • PCSK9 inhibitors
    • Farnier M. PCSK9 inhibitors. Curr Opin Lipidol. 2013;24(3):251-8.
    • (2013) Curr Opin Lipidol. , vol.24 , Issue.3 , pp. 251-258
    • Farnier, M.1
  • 6
    • 84926250913 scopus 로고    scopus 로고
    • PCSK9 inhibition in LDL cholesterol reduction: Genetics and therapeutic implications of very low plasma lipoprotein levels
    • Marais AD, Kim JB, Wasserman SM, Lambert G. PCSK9 inhibition in LDL cholesterol reduction: Genetics and therapeutic implications of very low plasma lipoprotein levels. Pharmacology & Therapeutics 2014.
    • (2014) Pharmacology & Therapeutics
    • Marais, A.D.1    Kim, J.B.2    Wasserman, S.M.3    Lambert, G.4
  • 7
    • 84895075938 scopus 로고    scopus 로고
    • PCSK9: From discovery to therapeutic applications
    • Farnier M. PCSK9: From discovery to therapeutic applications. Arch Cardiovasc Dis. 2014;107(1):58-66.
    • (2014) Arch Cardiovasc Dis. , vol.107 , Issue.1 , pp. 58-66
    • Farnier, M.1
  • 8
    • 84882927131 scopus 로고    scopus 로고
    • New LDL-cholesterol lowering therapies: Pharmacology, clinical trials, and relevance to acute coronary syndromes
    • Sahebkar A, Watts GF. New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes. Clinical therapeutics. 2013;35(8):1082-98.
    • (2013) Clinical Therapeutics. , vol.35 , Issue.8 , pp. 1082-1098
    • Sahebkar, A.1    Watts, G.F.2
  • 10
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nature genetics. 2005;37(2):161-5.
    • (2005) Nature Genetics. , vol.37 , Issue.2 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 11
    • 84890461947 scopus 로고    scopus 로고
    • Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus statement of the European Atherosclerosis Society
    • Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society. Eur Heart J. 2013;34(45):3478-90a.
    • (2013) Eur Heart J. , vol.34 , Issue.45 , pp. 3478-90a
    • Nordestgaard, B.G.1    Chapman, M.J.2    Humphries, S.E.3    Ginsberg, H.N.4    Masana, L.5    Descamps, O.S.6
  • 12
    • 79960539641 scopus 로고    scopus 로고
    • ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS)
    • Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J. 2011;32(14):1769-818.
    • (2011) Eur Heart J. , vol.32 , Issue.14 , pp. 1769-1818
    • Reiner, Z.1    Catapano, A.L.2    De Backer, G.3    Graham, I.4    Taskinen, M.R.5    Wiklund, O.6
  • 14
    • 84897889156 scopus 로고    scopus 로고
    • PCSK9: A key modulator of cardiovascular health
    • Seidah NG, Awan Z, Chretien M, Mbikay M. PCSK9: a key modulator of cardiovascular health. Circ Res. 2014;114(6):1022-36.
    • (2014) Circ Res. , vol.114 , Issue.6 , pp. 1022-1036
    • Seidah, N.G.1    Awan, Z.2    Chretien, M.3    Mbikay, M.4
  • 16
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • Cohen JC, Boerwinkle E, Mosley TH, Jr., Hobbs HH. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med. 2006;354(12):1264-72.
    • (2006) N Engl J Med. , vol.354 , Issue.12 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley, T.H.3    Hobbs, H.H.4
  • 17
    • 84868206496 scopus 로고    scopus 로고
    • Effects of AMG 145 on low-density lipoprotein cholesterol levels: Results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins
    • Dias CS, Shaywitz AJ, Wasserman SM, Smith BP, Gao B, Stolman DS, et al. Effects of AMG 145 on low-density lipoprotein cholesterol levels: results from 2 randomized, double-blind, placebo-controlled, ascending-dose phase 1 studies in healthy volunteers and hypercholesterolemic subjects on statins. J Am Coll Cardiol. 2012;60(19):1888-98.
    • (2012) J Am Coll Cardiol. , vol.60 , Issue.19 , pp. 1888-1898
    • Dias, C.S.1    Shaywitz, A.J.2    Wasserman, S.M.3    Smith, B.P.4    Gao, B.5    Stolman, D.S.6
  • 18
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS randomized trial
    • Sullivan D, Olsson AG, Scott R, Kim JB, Xue A, Gebski V, et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA. 2012;308(23):2497-506.
    • (2012) JAMA , vol.308 , Issue.23 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3    Kim, J.B.4    Xue, A.5    Gebski, V.6
  • 19
    • 84870478439 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): A randomised, placebo-controlled, dose-ranging, phase 2 study
    • Giugliano RP, Desai NR, Kohli P, Rogers WJ, Somaratne R, Huang F, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 in combination with a statin in patients with hypercholesterolaemia (LAPLACE-TIMI 57): a randomised, placebo-controlled, dose-ranging, phase 2 study. Lancet. 2012;380(9858):2007-17.
    • (2012) Lancet. , vol.380 , Issue.9858 , pp. 2007-2017
    • Giugliano, R.P.1    Desai, N.R.2    Kohli, P.3    Rogers, W.J.4    Somaratne, R.5    Huang, F.6
  • 20
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, double-blind, placebo-controlled, phase 2 study
    • Koren MJ, Scott R, Kim JB, Knusel B, Liu T, Lei L, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2012;380(9858):1995-2006.
    • (2012) Lancet. , vol.380 , Issue.9858 , pp. 1995-2006
    • Koren, M.J.1    Scott, R.2    Kim, J.B.3    Knusel, B.4    Liu, T.5    Lei, L.6
  • 21
    • 84869220345 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial
    • Raal F, Scott R, Somaratne R, Bridges I, Li G, Wasserman SM, et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation. 2012;126(20):2408-17.
    • (2012) Circulation. , vol.126 , Issue.20 , pp. 2408-2417
    • Raal, F.1    Scott, R.2    Somaratne, R.3    Bridges, I.4    Li, G.5    Wasserman, S.M.6
  • 24
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
    • Stein EA, Gipe D, Bergeron J, Gaudet D, Weiss R, Dufour R, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet. 2012;380(9836):29-36.
    • (2012) Lancet. , vol.380 , Issue.9836 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3    Gaudet, D.4    Weiss, R.5    Dufour, R.6
  • 25
    • 84868689211 scopus 로고    scopus 로고
    • Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    • Roth EM, McKenney JM, Hanotin C, Asset G, Stein EA. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med. 2012;367(20):1891-900.
    • (2012) N Engl J Med. , vol.367 , Issue.20 , pp. 1891-1900
    • Roth, E.M.1    McKenney, J.M.2    Hanotin, C.3    Asset, G.4    Stein, E.A.5
  • 26
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol. 2012;59(25):2344-53.
    • (2012) J Am Coll Cardiol. , vol.59 , Issue.25 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3    Hanotin, C.4    Ferrand, A.C.5    Stein, E.A.6
  • 27
    • 84892590856 scopus 로고    scopus 로고
    • Antibodies to watch in 2014
    • Reichert JM. Antibodies to watch in 2014. mAbs 2014;6(1):5-14.
    • (2014) mAbs , vol.6 , Issue.1 , pp. 5-14
    • Reichert, J.M.1
  • 28
    • 84902096056 scopus 로고    scopus 로고
    • Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia, irrespective of low-density lipoprotein receptor defects
    • Lambert G, Petrides F, Chatelais M, Blom DJ, Choque B, Tabet F, et al. Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia, irrespective of low-density lipoprotein receptor defects. J Am Coll Cardiol. 2014;63(22):2365-73.
    • (2014) J Am Coll Cardiol. , vol.63 , Issue.22 , pp. 2365-2373
    • Lambert, G.1    Petrides, F.2    Chatelais, M.3    Blom, D.J.4    Choque, B.5    Tabet, F.6
  • 29
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
    • Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376(9753):1670-81.
    • (2010) Lancet. , vol.376 , Issue.9753 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4    Reith, C.5    Bhala, N.6
  • 30
    • 84870941622 scopus 로고    scopus 로고
    • Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction
    • Martin SS, Gosch K, Kulkarni KR, Spertus JA, Mathews R, Ho PM, et al. Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction. Am Heart J. 2013;165(1):26-33 e3.
    • (2013) Am Heart J , vol.165 , Issue.1 , pp. 26-33e3
    • Martin, S.S.1    Gosch, K.2    Kulkarni, K.R.3    Spertus, J.A.4    Mathews, R.5    Ho, P.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.