Simultaneous assessment of the pharmacokinetics of a pleuromutilin, lefamulin, in plasma, soft tissues and pulmonary epithelial lining fluid

Journal of Antimicrobial Chemotherapy

Volumn 71, Issue 4, 2016, Pages 1022-1026

  Zeitlinger, M ^a   Schwameis, R ^a   Burian, A ^a   Burian, B ^a   Matzneller, P ^a   Muller M ^a   Wicha, W W ^b   Strickmann, D B ^b   Prince, W ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Nabriva Therapeutics Inc   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; LEFAMULIN; PLEUROMUTILIN ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; DITERPENE; PLEUROMUTILIN;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHILL; DIARRHEA; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXPOSURE; DRUG HALF LIFE; DRUG PENETRATION; DRUG TISSUE LEVEL; DRUG TOLERABILITY; EPITHELIAL LINING FLUID; FLU LIKE SYNDROME; HEADACHE; HUMAN; HUMAN EXPERIMENT; INJECTION SITE PAIN; LEUKOCYTOSIS; LUNG ALVEOLUS EPITHELIUM; LUNG LAVAGE; MALAISE; MALE; MICRODIALYSIS; NORMAL HUMAN; PHARMACOKINETIC PARAMETERS; PHASE 1 CLINICAL TRIAL; PLASMA CONCENTRATION-TIME CURVE; SIDE EFFECT; SINGLE DRUG DOSE; SKELETAL MUSCLE; SOFT TISSUE; SUBCUTANEOUS FAT; VOLUME OF DISTRIBUTION; CLINICAL TRIAL; TISSUE DISTRIBUTION; YOUNG ADULT;

ADULT; ANTI-INFECTIVE AGENTS; DITERPENES; HEALTHY VOLUNTEERS; HUMANS; MALE; MICRODIALYSIS; TISSUE DISTRIBUTION; YOUNG ADULT;

EID: 84964344237     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkv442     Document Type: Article

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