Pharmacokinetics of clarithromycin in bronchial epithelial lining fluid

Respirology

Volumn 13, Issue 2, 2008, Pages 221-226

  Kikuchi, Eiki ^a   Yamazaki, Koichi ^a   Kikuchi, Junko ^a   Hasegawa, Naoki ^b   Hashimoto, Satoru ^c   Ishizaka, Akitoshi ^b   Nishimura, Masaharu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Anti infective agent; BAL; Bronchoscopy; Clarithromycin; Extracellular fluid; pharmacokinetics

Indexed keywords

14 HYDROXYCLARITHROMYCIN; CLARITHROMYCIN; DRUG METABOLITE;

ADULT; ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; BRONCHOSCOPIC MICROSAMPLING; BRONCHOSCOPY; BRONCHUS MUCOSA; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ADMINISTRATION, ORAL; ADULT; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CLARITHROMYCIN; FEMALE; HUMANS; MALE; RESPIRATORY MUCOSA;

EID: 40749140314     PISSN: 13237799     EISSN: 14401843     Source Type: Journal    
DOI: 10.1111/j.1440-1843.2007.01208.x     Document Type: Article

References (30)

1. Wilson R, Dowling RB, Jackson AD. The biology of bacterial colonization and invasion of the respiratory mucosa. Eur. Respir. J. 1996 9 : 1523 30.
2. Boselli E, Breilh D, Rimmelé T, Djabarouti S, Saux MC et al. Pharmacokinetics and intrapulmonary diffusion of levofloxacin in critically ill patients with severe community-acquired pneumonia. Crit. Care Med. 2005 33 : 104 9.
3. Hers JF, Mulder J. The mucosal epithelium of the respiratory tract in muco-purulent bronchitis caused by Haemophilus influenzae. J. Pathol. Bacteriol. 1953 66 : 103 8.
4. Marlin GE, Burgess J, Burgoyne J, Funnell GR, Guiness MD. Penetration of piperacillin into bronchial mucosa and sputum. Thorax 1981 36 : 774 80.
5. Ren Q, Conte JE Jr, Zurlinden E, Lin ET. A high-performance liquid chromatographic-tandem mass spectrometric method for the determination of cethromycin (ABT-773) in human plasma, bronchoalveolar lavage fluid, and alveolar cells. J. Chromatogr. Sci. 2003 41 : 494 9.
6. Baldwin DR, Honeybourne D, Wise R. Pulmonary disposition of antimicrobial agents: methodological considerations. Antimicrob. Agents Chemother. 1992 36 : 1171 5.
7. Tsang KW, Roberts P, Read RC, Kees F, Wilson R et al. The concentrations of clarithromycin and its 14-hydroxy metabolite in sputum of patients with bronchiectasis following single dose oral administration. J. Antimicrob. Chemother. 1994 33 : 289 97.
8. Ishizaka A, Watanabe M, Yamashita T, Ogawa Y, Koh H et al. New bronchoscopic microsample probe to measure the biochemical constituents in epithelial lining fluid of patients with acute respiratory distress syndrome. Crit. Care Med. 2001 29 : 896 8.
9. Yamazaki K, Ogura S, Ishizaka A, Oh-hara T, Nishimura M. Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid. Am. J. Respir. Crit. Care Med. 2003 168 : 1304 7.
10. Kikuchi J, Yamazaki K, Kikuchi E, Ishizaka A, Nishimura M. Pharmacokinetics of gatifloxacin after a single oral dose in healthy young adult subjects and adult patients with chronic bronchitis, with a comparison of drug concentrations obtained by bronchoscopic microsampling and bronchoalveolar lavage. Clin. Ther. 2007 29 : 123 30.
11. Kikuchi J, Yamazaki K, Kikuchi E, Ishizaka A, Nishimura M. Pharmacokinetics of telithromycin using bronchoscopic microsampling after single and multiple oral doses. Pulm. Pharmacol. Ther. 2007 20 : 549 55.
12. Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S et al. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am. J. Physiol. Lung Cell. Mol. Physiol. 2004 286 : L1088 94.
13. Watanabe M, Ishizaka A, Ikeda E, Ohashi A, Kobayashi K. Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma. Ann. Thorac. Surg. 2003 76 : 1668 72 discussion 1673.
14. Mandell LA, Bartlett JG, Dowell SF, File TM Jr, Musher DM et al. Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults. Clin. Infect. Dis. 2003 37 : 1405 33.
15. Patel KB, Xuan D, Tessier PR, Russomanno JH, Quintiliani R et al. Comparison of bronchopulmonary pharmacokinetics of clarithromycin and azithromycin. Antimicrob. Agents Chemother. 1996 40 : 2375 9.
16. Gotfried MH, Danziger LH, Rodvold KA. Steady-state plasma and bronchopulmonary characteristics of clarithromycin extended-release tablets in normal healthy adult subjects. J. Antimicrob. Chemother. 2003 52 : 450 6.
17. Conte JE Jr, Golden JA, Duncan S, McKenna E, Zurlinden E. Intrapulmonary pharmacokinetics of clarithromycin and of erythromycin. Antimicrob. Agents Chemother. 1995 39 : 334 8.
18. Honeybourne D, Kees F, Andrews JM, Baldwin D, Wise R. The levels of clarithromycin and its 14-hydroxy metabolite in the lung. Eur. Respir. J. 1994 7 : 1275 80.
19. Jiang Y, Wang J, Li H, Wang Y, Gu J. Determination of clarithromycin in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. J. Pharm. Biomed. Anal. 2007 43 : 1460 4.
20. Li W, Rettig J, Jiang X, Francisco DT, Naidong W. Liquid chromatographic-electrospray tandem mass spectrometric determination of clarithromycin in human plasma. Biomed. Chromatogr. 2006 20 : 1242 51.
21. Rennard SI, Basset G, Lecossier D, O'Donnell KM, Pinkston P et al. Estimation of volume of epithelial lining fluid recovered by lavage using urea as a marker of dilution. J. Appl. Physiol. 1986 60 : 532 8.
22. Baldwin DR, Wise R, Andrews JM, Ashby JP, Honeybourne D. Azithromycin levels at the sites of pulmonary infection. Eur. Respir. J. 1990 3 : 886 90.
23. Okubo T, Iyobe S, Fujiki Y, Sagai H. Antimicrobial activities of macrolides against recent clinical isolates, and analysis of resistant mechanisms. Jpn. J. Antibiot. 2003 56 : 163 70. (in Japanese, with English abstract)
24. Rodvold KA, Gotfried MH, Danziger LH, Servi RJ. Intrapulmonary steady-state concentrations of clarithromycin and azithromycin in healthy adult volunteers. Antimicrob. Agents Chemother. 1997 41 : 1399 402.
25. Fish DN, Gotfried MH, Danziger LH, Rodvold KA. Penetration of clarithromycin into lung tissues from patients undergoing lung resection. Antimicrob. Agents Chemother. 1994 38 : 876 8.
26. Wollmer P, Pride NB, Rhodes CG, Sanders A, Pike VW et al. Measurement of pulmonary erythromycin concentration in patients with lobar pneumonia by means of positron tomography. Lancet 1982 2 : 1361 4.
27. Hardy DJ, Swanson RN, Rode RA, Marsh K, Shipkowitz NL et al. Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its metabolite in humans. Antimicrob. Agents Chemother. 1990 34 : 1407 13.
28. Baldwin DR, Honeybourne D, Wise R. Pulmonary disposition of antimicrobial agents: in vivo observations and clinical relevance. Antimicrob. Agents Chemother. 1992 36 : 1176 80.
29. Hand WL, Boozer RM, King-Thompson NL. Antibiotic uptake by alveolar macrophages of smokers. Antimicrob. Agents Chemother. 1985 27 : 42 5.
30. Conte JE Jr, Golden JA, Kipps J, Lin ET, Zurlinden E. Effects of AIDS and gender on the steady-state plasma and intrapulmonary ethambutol concentrations. Antimicrob. Agents Chemother. 2001 45 : 2891 6.