Acinetobacter baumannii OxPhos inhibitors as selective anti-infective agents

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 2, 2015, Pages 378-383

  Rubin, Harvey ^a   Selwood, Trevor ^a   Yano, Takahiro ^a   Weaver, Damian G ^b   Loughran, H Marie ^b   Costanzo, Michael J ^b   Scott, Richard W ^b   Wrobel, Jay E ^b   Freeman, Katie B ^b   Reitz, Allen B ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Fox Chase Chemical Diversity Center Inc ^*  (United States)

Author keywords

2 Iminobenzimidazole; Acinetobacter baumannii; Anti infective; Oxidative phosphorylation

Indexed keywords

2 IMINOBENZIMIDAZOLE; ANTIINFECTIVE AGENT; BENZIMIDAZOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MOLECULAR LIBRARY; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ACINETOBACTER BAUMANNII; ARTICLE; CYTOTOXICITY; DRUG DEVELOPMENT; HEPG2 CELL LINE; MINIMUM INHIBITORY CONCENTRATION; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; 3T3 CELL LINE; ACINETOBACTER INFECTIONS; ANIMAL; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; LIVER NEOPLASMS; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOLECULAR LIBRARY; MOUSE; PATHOLOGY; PHARMACOLOGY;

ACINETOBACTER; ACINETOBACTER BAUMANNII; MAMMALIA; NEGIBACTERIA;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; CELL PROLIFERATION; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NIH 3T3 CELLS; OXIDATIVE PHOSPHORYLATION; QUINONE REDUCTASES; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84964313613     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.11.020     Document Type: Article

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