Pharmacological targeting of β-Catenin in normal karyotype acute myeloid leukemia blasts

Haematologica

Volumn 100, Issue 2, 2015, Pages e49-e52

  Griffiths, Elizabeth A ^a   Golding, Michelle C ^a   Srivastava, Pragya ^a   Povinelli, Benjamin J ^a   James, Smitha R ^a   Ford, Laurie A ^a   Wetzler, Meir ^a   Wang, Eunice S ^a   Nemeth, Michael J ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Acute myeloid leukemia; WNT inhibitors; WNT signaling; catenin

Indexed keywords

BETA CATENIN; MOLECULAR LIBRARY; WNT PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ANTAGONISTS AND INHIBITORS; ARTICLE; BLAST CRISIS; CANCER CELL CULTURE; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; DRUG THERAPY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IN VITRO STUDY; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; METABOLISM; MIDDLE AGED; MOLECULAR LIBRARY; PATHOLOGY; PHARMACOLOGY; QUANTITATIVE ANALYSIS; SAMPLING; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTAGONISTS AND INHIBITORS; BETA CATENIN; BLAST CRISIS; CASE-CONTROL STUDIES; CELLS, CULTURED; DRUG EFFECTS; DRUG THERAPY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, LEUKEMIC; HUMANS; KARYOTYPING; LEUKEMIA, MYELOID, ACUTE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHARMACOLOGY; SMALL MOLECULE LIBRARIES;

EID: 84964308486     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2014.113118     Document Type: Article

References (15)

1. Howlader N, Noone AM, Krapcho M, (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, USA. April 2014. Available from: http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER.
2. Wang Y, Krivtsov AV, Sinha AU, et al. The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML. Science. 2010;327(5973):1650-1653.
3. Yeung J, Esposito MT, Gandillet A, et al. β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells. Cancer Cell. 2010;18(6):606-618.
4. Luis TC, Ichii M, Brugman MH, Kincade P, Staal FJT. Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia. 2012;26(3):414-421.
5. Ysebaert L, Chicanne G, Demur C, et al. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia. 2006;20(7):1211-1216.
6. Xu J, Suzuki M, Niwa Y, et al. Clinical significance of nuclear non-phosphorylated beta-catenin in acute myeloid leukaemia and myelodysplastic syndrome. Br J Haematol. 2008;140(4):394-401.
7. Gandillet A, Park S, Lassailly F, et al. Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation. Leukemia. 2011;25(5):770–780.
8. Kim Y, Thanendrarajan S, Schmidt-Wolf IGH. Wnt/β-Catenin: A New Therapeutic Approach to Acute Myeloid Leukemia. Leuk Res Treatment. 2011;2011(3):1-4.
9. Maguire O, Collins C, O'Loughlin K, Miecznikowski J, Minderman H. Quantifying nuclear p65 as a parameter for NF-kB activation: Correlation between ImageStream cytometry, microscopy, and Western blot. Cytometry A. 2011;79(6):461-469.
10. Siapati EK, Papadaki M, Kozaou Z, et al. Proliferation and bone marrow engraftment of AML blasts is dependent on β-catenin signalling. Br J Haematol. 2011;152(2):164-174.
11. Simon M, Grandage V, Linch D, Khwaja A. Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia. Oncogene. 2005;24(14):2410-2420.
12. Gonsalves FC, Klein K, Carson BB, et al. An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. Proc Natl Acad Sci USA. 2011;108(15):5954-5963.
13. Klco JM, Spencer DH, Lamprecht TL, et al. Genomic impact of transient low-dose decitabine treatment on primary AML cells. Blood. 2013;121(9):1633-1643.
14. Huang S-MA, Mishina YM, Liu S, et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009; 461(7264):614-620.
15. Proffitt KD, Madan B, Ke Z, et al. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Res. 2013; 73(2):502-507.