C-Aryl 5a-carba-β-d-glucopyranosides as novel sodium glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 13, 2012, Pages 4117-4127

  Ohtake, Yoshihito ^a   Sato, Tsutomu ^a   Matsuoka, Hiroharu ^a   Kobayashi, Takamitsu ^a   Nishimoto, Masahiro ^a   Taka, Naoki ^a   Takano, Koji ^a   Yamamoto, Keisuke ^a   Ohmori, Masayuki ^a   Higuchi, Takashi ^a   Murakata, Masatoshi ^a   Morikawa, Kazumi ^a   Shimma, Nobuo ^a   Suzuki, Masayuki ^a   Hagita, Hitoshi ^a   Ozawa, Kazuharu ^a   Yamaguchi, Koji ^a   Kato, Motohiro ^a   Ikeda, Sachiya ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

5a Carba d glucopyranose; Carbasugar; SGLT2 inhibitor; Type 2 diabetes

Indexed keywords

1 [2 ETHOXY 5 (4 ETHYLBENZYL)PHENYL] 5 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3,4 TETRAOL; 1 [3 (4 ETHYLBENZYL) 4 METHOXYPHENYL] 5 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3,4 TETRAOL; 1 [5 (4 ETHYLBENZYL) 2 METHYLPHENYL] 5 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3,4 TETRAOL; 1 [5 (4 ETHYLBENZYL) 2,4 DIMETHOXYPHENYL] 5 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3,4 TETRAOL; 1 [5 (4 ETHYLBENZYL) 4 METHOXYPHENYL] 5 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3,4 TETRAOL; 4 [2 ETHOXY 5 (4 ETHYLBENZYL)PHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 [3 (4 CYCLOPROPYLBENZYL)PHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 [3 (4 ETHYLBENZYL) 4 METHOXYPHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 [3 (4 ETHYLBENZYL)PHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 [5 (4 ETHYLBENZYL) 2 METHOXYPHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 [5 (4 ETHYLBENZYL) 2 METHYLPHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 [5 (4 ETHYLBENZYL) 2,4 DIMETHOXYPHENYL] 6 (HYDROXYMETHYL)CYCLOHEXANE 1,2,3 TRIOL; 4 HYDROXYMETHYL 6 [3 (4 METHOXYBENZYL)PHENYL]CYCLOHEXANE 1,2,3 TRIOL; 5A CARBA BETA DEXTRO GLUCOPYRANOSIDE DERIVATIVE; ANTIDIABETIC AGENT; CYTOCHROME P450 3A4; GLUCOPYRANOSIDE; O CARBASUGAR COMPOUND; SERGLIFLOZIN ETABONATE; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIDIABETIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MALE; MOLECULAR MODEL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BLOOD GLUCOSE; CYCLOHEXANOLS; DIABETES MELLITUS, TYPE 2; GLUCOSE; HYPOGLYCEMIC AGENTS; MICE; MICE, OBESE; SODIUM-GLUCOSE TRANSPORTER 2; STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 84862156420     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.04.053     Document Type: Article

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