Pre-formulation studies of resveratrol

Drug Development and Industrial Pharmacy

Volumn 41, Issue 9, 2015, Pages 1464-1469

  Robinson, Keila ^a   Mock, Charlotta ^a   Liang, Dong ^a  

^a TEXAS SOUTHERN UNIVERSITY   (United States)

Author keywords

Natural compound; Physiochemical evaluation; Plasma protein binding; Polyphenol; Solubility; Stability

Indexed keywords

MACROGOL 400; PLASMA PROTEIN; RESVERATROL; SOLVENT; WATER; ANTINEOPLASTIC AGENT; PROTEIN BINDING; SOLUTION AND SOLUBILITY; STILBENE DERIVATIVE;

ARTICLE; DRUG BLOOD LEVEL; DRUG DEGRADATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; NONHUMAN; PH; PLASMA PROTEIN BINDING; PREFORMULATION; RAT; ULTRACENTRIFUGATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; HALF LIFE TIME; MALE; MEDICINAL CHEMISTRY; METABOLISM; PROCEDURES; SOLUBILITY; SOLUTION AND SOLUBILITY; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; VALIDATION STUDY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIOLOGICAL AVAILABILITY; BLOOD PROTEINS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HALF-LIFE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; PHARMACEUTICAL SOLUTIONS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS; SPECIES SPECIFICITY; STILBENES;

EID: 84964240216     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2014.958753     Document Type: Article

References (18)

1. Das S, Lin HS, Ho PC, Ng KY. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm Res 2008; 25: 2594-600.
2. Gescher AJ, Steward WP. Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: A conundrum. Cancer Epidemiol Biomarkers Prev 2003; 12: 953-7.
3. He H, Chen X, Wang G, et al. High-performanc liquid chromatography spectrometric analysis of trans-resveratrol in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci 2006; 832: 177-80.
4. Juan ME, Lamuela-Raventós RM, de la Torre-Boronat MC, Planas JM. Determination of trans-resveratrol in plasma by HPLC. Anal Chem 1999; 71: 747-50.
5. Delmas D, Lancon A, Colin D, et al. Resveratrol as a chemopreventive agent: A promising molecule for fighting cancer. Curr Drug Targets 2006; 7: 423-42.
6. López-Nicolás JM, García-Carmona F. Aggregation state and pKa values of (E)-resveratrol as determined by fluorescence spectroscopy and UV-visible absorption. J Agric Food Chem 2008; 56: 7600-5.
7. Resveratrol Compound Summary. PubChem [Online]. Available from: Http: //pubchem.ncbi.nlm.nih.gov/summary/summary.cgi? cid=445154& loc=ec-rcs [last accessed 21 Oct 2013].
8. Jensen JS, Wertz CF, O'Neill VA. Preformulation stability of transresveratrol and trans-resveratrol glucoside (Piceid). J Agric Food Chem 2010; 58: 1658-90.
9. Walle T, Hsieh F, DeLegge MH, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004; 32: 1377-82.
10. Boocock DJ, Faust GE, Patel KR, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 2007; 16: 1246-52.
11. Katsagonis A, Atta-Politou J, Koupparis MA. HPLC method with UV detection for the determination of trans-Resveratrol in Plasma. J Liq Chromatogr 2005; 28: 1393-405.
12. Neves AR, Lũcio M, Martins S, et al. Novel resveratrol nanodelivery systems based on lipid nanoparticles to enhance its oral bioavailability. Int J Nanomed 2013; 8: 177-87.
13. Delmas D, Aires V, Limagne E, et al. Transport, stability, and biological activity of resveratrol. Ann NYAcad Sci 2011; 215: 48-59.
14. The United States Pharmacopeial Convention. General Notices and Requirements [Online] 2011: 1-14. Available from: Http: //www. usp.org/sites/default/files/usp-pdf/EN/USPNF/USP34-NF29General %20Notices.pdf [last accessed 21 Oct 2013].
15. Nayak AK, Panigrahi PP. Solubility enhancement of etoricoxib by cosolvency approach. ISRN Phys Chem 2012: 1-5.
16. Weber M, Weber M. Phenols. In: Pilato L, ed. Phenolic resins: A century of progress. Berlin, Heidelberg: Springer-Verlag; 2010: 9-23. DOI 10.1007/978-3-642-04714-5-2.
17. Figueiras TS, Neves-Petersen MT, Petersen SB. Activation energy of light induced isomerization of resveratrol. J Fluoresc 2011; 5: 1897-906.
18. Yi-Ping Q, Yu-Jun C, Gui-Juan F, et.al. Antioxidant-based lead discovery for cancer chemoprevention: The case of resveratrol. J Med Chem 2009; 52: 1963-74.