-
1
-
-
83455250287
-
Cirrhosis: Diagnosis, management, and prevention
-
Starr, S. P. & Raines, D. Cirrhosis: diagnosis, management, and prevention. Am Fam Physician 84, 1353-1359 (2011).
-
(2011)
Am Fam Physician
, vol.84
, pp. 1353-1359
-
-
Starr, S.P.1
Raines, D.2
-
2
-
-
80054872790
-
Alcoholic liver disease: Pathogenesis and new therapeutic targets
-
Gao, B. & Bataller, R. Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets. Gastroenterology 141, 1572-1585, doi: 10.1053/j.gastro.2011.09.002 (2011).
-
(2011)
Gastroenterology
, vol.141
, pp. 1572-1585
-
-
Gao, B.1
Bataller, R.2
-
3
-
-
66149115196
-
Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines
-
Shen, Z. et al. Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am J Physiol-Gastr L 296, G1047-G1053, doi: 10.1152/ajpgi.00016.2009 (2009).
-
(2009)
Am J Physiol-Gastr L
, vol.296
, pp. G1047-G1053
-
-
Shen, Z.1
-
4
-
-
84864216017
-
Inflammation in alcoholic liver disease
-
Wang, H. J., Gao, B., Zakhari, S. & Nagy, L. E. Inflammation in Alcoholic Liver Disease. Annu Rev Nutr, Vol 32 32, 343-368, doi: 10.1146/annurev-nutr-072610-145138 (2012).
-
(2012)
Annu Rev Nutr
, vol.32
, pp. 343-368
-
-
Wang, H.J.1
Gao, B.2
Zakhari, S.3
Nagy, L.E.4
-
5
-
-
0035907302
-
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through toll-like receptor 4
-
Lee, J. Y., Sohn, K. H., Rhee, S. H. & Hwang, D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 276, 16683-16689, doi: 10.1074/jbc.M011695200 (2001).
-
(2001)
J Biol Chem
, vol.276
, pp. 16683-16689
-
-
Lee, J.Y.1
Sohn, K.H.2
Rhee, S.H.3
Hwang, D.4
-
6
-
-
0031436304
-
Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells
-
Lakshminarayanan, V., Beno, D. W. & Costa, R. H. & Roebuck, K. A. Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells. J Biol Chem 272, 32910-32918, doi: 10.1074/jbc.272.52.32910 (1997).
-
(1997)
J Biol Chem
, vol.272
, pp. 32910-32918
-
-
Lakshminarayanan, V.1
Beno, D.W.2
Costa, R.H.3
Roebuck, K.A.4
-
7
-
-
54449092214
-
The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
-
Hritz, I. et al. The critical role of Toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 48, 1224-1231, doi: 10.1002/Hep.22470 (2008).
-
(2008)
Hepatology
, vol.48
, pp. 1224-1231
-
-
Hritz, I.1
-
8
-
-
77249094005
-
Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice
-
Shen, Z., Liang, X., Rogers, C. Q., Rideout, D. & You, M. Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. Am J Physiol Gastrointest Liver Physiol 298, G364-374, doi: 10.1152/ajpgi.00456.2009 (2010).
-
(2010)
Am J Physiol Gastrointest Liver Physiol
, vol.298
, pp. G364-G374
-
-
Shen, Z.1
Liang, X.2
Rogers, C.Q.3
Rideout, D.4
You, M.5
-
9
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity
-
Canto, C. et al. AMPK regulates energy expenditure by modulating NAD(+) metabolism and SIRT1 activity. Nature 458, 1056-1060, doi: 10.1038/Nature07813 (2009).
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
-
10
-
-
64549127790
-
PGC-1 alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
-
Canto, C. & Auwerx, J. PGC-1 alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure. Curr Opin Lipidol 20, 98-105, doi: 10.1097/Mol.0b013e328328d0a4 (2009).
-
(2009)
Curr Opin Lipidol
, vol.20
, pp. 98-105
-
-
Canto, C.1
Auwerx, J.2
-
11
-
-
84868701222
-
Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia
-
Quiroga, A. D. et al. Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. Hepatology 56, 2188-2198, doi: 10.1002/hep.25961 (2012).
-
(2012)
Hepatology
, vol.56
, pp. 2188-2198
-
-
Quiroga, A.D.1
-
12
-
-
84899493129
-
Hepatic carboxylesterase 1 is essential for both normal and farnesoid X-receptor-controlled lipid homeostasis
-
Xu, J. et al. Hepatic carboxylesterase 1 is essential for both normal and farnesoid X-receptor-controlled lipid homeostasis. Hepatology 59, 1761-1771, doi: 10.1002/hep.26714 (2014).
-
(2014)
Hepatology
, vol.59
, pp. 1761-1771
-
-
Xu, J.1
-
13
-
-
0242322491
-
Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase
-
Ghosh, S., St Clair, R. W. & Rudel, L. L. Mobilization of cytoplasmic CE droplets by overexpression of human macrophage cholesteryl ester hydrolase. J Lipid Res 44, 1833-1840, doi: 10.1194/jlr.M300162-JLR200 (2003).
-
(2003)
J Lipid Res
, vol.44
, pp. 1833-1840
-
-
Ghosh, S.1
St Clair, R.W.2
Rudel, L.L.3
-
14
-
-
84907688712
-
Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels
-
Xu, J. et al. Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels. PloS One 9, e109663, doi: 10.1371/journal.pone.0109663 (2014).
-
(2014)
PloS One
, vol.9
, pp. e109663
-
-
Xu, J.1
-
15
-
-
33846272136
-
Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages
-
Zhao, B., Song, J., St Clair, R. W. & Ghosh, S. Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages. Am J Physiol Cell Physiol 292, C405-412, doi: 10.1152/ajpcell.00306.2006 (2007).
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, pp. C405-C412
-
-
Zhao, B.1
Song, J.2
St Clair, R.W.3
Ghosh, S.4
-
16
-
-
0035141324
-
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
-
Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M. & Gonzalez, F. J. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21, 1393-1403, doi: 10.1128/MCB.21.4.1393-1403.2001 (2001).
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1393-1403
-
-
Hayhurst, G.P.1
Lee, Y.H.2
Lambert, G.3
Ward, J.M.4
Gonzalez, F.J.5
-
17
-
-
79551483835
-
Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis
-
Yin, L., Ma, H., Ge, X., Edwards, P. A. & Zhang, Y. Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis. Arterioscler Thromb Vasc Biol 31, 328-336, doi: 10.1161/ATVBAHA.110.217828 (2011).
-
(2011)
Arterioscler Thromb Vasc Biol
, vol.31
, pp. 328-336
-
-
Yin, L.1
Ma, H.2
Ge, X.3
Edwards, P.A.4
Zhang, Y.5
-
18
-
-
84875160269
-
Mouse model of chronic and binge ethanol feeding (the NIAAA model)
-
Bertola, A., Mathews, S., Ki, S. H., Wang, H. & Gao, B. Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nat Protoc 8, 627-637, doi: 10.1038/nprot.2013.032 (2013).
-
(2013)
Nat Protoc
, vol.8
, pp. 627-637
-
-
Bertola, A.1
Mathews, S.2
Ki, S.H.3
Wang, H.4
Gao, B.5
-
19
-
-
71349084365
-
Acetaldehyde-induced mitochondrial dysfunction sensitizes hepatocytes to oxidative damage
-
Labonne, B. E. F. et al. Acetaldehyde-induced mitochondrial dysfunction sensitizes hepatocytes to oxidative damage. Cell Biol Toxicol 25, 599-609, doi: 10.1007/s10565-008-9115-5 (2009).
-
(2009)
Cell Biol Toxicol
, vol.25
, pp. 599-609
-
-
Labonne, B.E.F.1
-
20
-
-
79952184583
-
Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS)
-
Bulua, A. C. et al. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 208, 519-533, doi: 10.1084/jem.20102049 (2011).
-
(2011)
J Exp Med
, vol.208
, pp. 519-533
-
-
Bulua, A.C.1
-
21
-
-
79951642032
-
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
-
Nakahira, K. et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 12, 222-230, doi: 10.1038/ni.1980 (2011).
-
(2011)
Nat Immunol
, vol.12
, pp. 222-230
-
-
Nakahira, K.1
-
22
-
-
79952712223
-
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
-
Naik, E. & Dixit, V. M. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med 208, 417-420, doi: 10.1084/jem.20110367 (2011).
-
(2011)
J Exp Med
, vol.208
, pp. 417-420
-
-
Naik, E.1
Dixit, V.M.2
-
23
-
-
65849373277
-
Oxidative stress induces degradation of mitochondrial DNA
-
Shokolenko, I., Venediktova, N., Bochkareva, A., Wilson, G. L. & Alexeyev, M. F. Oxidative stress induces degradation of mitochondrial DNA. Nucleic Acids Res 37, 2539-2548, doi: 10.1093/nar/gkp100 (2009).
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 2539-2548
-
-
Shokolenko, I.1
Venediktova, N.2
Bochkareva, A.3
Wilson, G.L.4
Alexeyev, M.F.5
-
24
-
-
84919786525
-
The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
-
Merali, Z., Ross, S. & Pare, G. The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect. Drug Metabol Drug Interact 29, 143-151, doi: 10.1515/dmdi-2014-0009 (2014).
-
(2014)
Drug Metabol Drug Interact
, vol.29
, pp. 143-151
-
-
Merali, Z.1
Ross, S.2
Pare, G.3
-
25
-
-
0036478820
-
Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: Inhibition by cyclic AMP and COUP transcription factors
-
You, M., Fischer, M., Cho, W. K. & Crabb, D. Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. Arch Biochem Biophys 398, 79-86, doi: 10.1006/abbi.2001.2713 (2002).
-
(2002)
Arch Biochem Biophys
, vol.398
, pp. 79-86
-
-
You, M.1
Fischer, M.2
Cho, W.K.3
Crabb, D.4
-
26
-
-
84891780760
-
Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks
-
Babeu, J. P. & Boudreau, F. Hepatocyte nuclear factor 4-alpha involvement in liver and intestinal inflammatory networks. World J Gastroenterol 20, 22-30, doi: 10.3748/wjg.v20.i1.22 (2014).
-
(2014)
World J Gastroenterol
, vol.20
, pp. 22-30
-
-
Babeu, J.P.1
Boudreau, F.2
-
27
-
-
84935009342
-
A metabolic stress-inducible MIR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism
-
Xu, Y. et al. A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism. Nat. Commun. 6, 7466, doi: 10.1038/ncomms8466 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7466
-
-
Xu, Y.1
-
28
-
-
0020683526
-
Zinc deficiency in the alcoholic: A review
-
McClain, C. J. & Su, L. C. Zinc deficiency in the alcoholic: a review. Alcohol Clin Exp Res 7, 5-10, doi: 10.1111/j.1530-0277 (1983).
-
(1983)
Alcohol Clin Exp Res
, vol.7
, pp. 5-10
-
-
McClain, C.J.1
Su, L.C.2
-
29
-
-
70350070340
-
Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha
-
Kang, X. et al. Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha. Hepatology 50, 1241-1250, doi: 10.1002/hep.23090 (2009).
-
(2009)
Hepatology
, vol.50
, pp. 1241-1250
-
-
Kang, X.1
-
30
-
-
84868709755
-
Carboxylesterase1/Esterase-x regulates chylomicron production in mice
-
Quiroga, A. D., Lian, J. H. & Lehner, R. Carboxylesterase1/Esterase-x Regulates Chylomicron Production in Mice. PloS One 7, doi: 10.1371/journal.pone.0049515 (2012).
-
(2012)
PloS One
, vol.7
-
-
Quiroga, A.D.1
Lian, J.H.2
Lehner, R.3
-
31
-
-
80054113765
-
Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: A targeted lipidomic and gene expression study
-
Clugston, R. D. et al. Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study. J Lipid Res 52, 2021-2031, doi: 10.1194/jlr.M017368 (2011).
-
(2011)
J Lipid Res
, vol.52
, pp. 2021-2031
-
-
Clugston, R.D.1
-
32
-
-
23944503745
-
Structural insights into drug processing by human carboxylesterase 1: Tamoxifen, mevastatin, and inhibition by benzil
-
Fleming, C. D. et al. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol 352, 165-177, doi: 10.1016/j.jmb.2005.07.016 (2005).
-
(2005)
J Mol Biol
, vol.352
, pp. 165-177
-
-
Fleming, C.D.1
-
33
-
-
0034948044
-
Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans
-
Diczfalusy, M. A., Bjorkhem, I., Einarsson, C., Hillebrant, C. G. & Alexson, S. E. Characterization of enzymes involved in formation of ethyl esters of long-chain fatty acids in humans. J Lipid Res 42, 1025-1032 (2001).
-
(2001)
J Lipid Res
, vol.42
, pp. 1025-1032
-
-
Diczfalusy, M.A.1
Bjorkhem, I.2
Einarsson, C.3
Hillebrant, C.G.4
Alexson, S.E.5
-
34
-
-
84978224384
-
Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, ER stress and lipogenesis and is regulated by HNF4alpha
-
Li, Y. et al. Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, ER stress and lipogenesis and is regulated by HNF4alpha. Hepatology, doi: 10.1002/hep.28472 (2016).
-
(2016)
Hepatology
-
-
Li, Y.1
-
35
-
-
79960687149
-
Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis
-
Ge, X. M. et al. Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis. J Lipid Res 52, 1561-1568, doi: 10.1194/Jlr.M015859 (2011).
-
(2011)
J Lipid Res
, vol.52
, pp. 1561-1568
-
-
Ge, X.M.1
-
36
-
-
79955599893
-
Altered distribution of caveolin-1 in early liver steatosis
-
Mastrodonato, M. et al. Altered distribution of caveolin-1 in early liver steatosis. Eur J Clin Invest 41, 642-651, doi: 10.1111/j.1365-2362.2010.02459.x (2011).
-
(2011)
Eur J Clin Invest
, vol.41
, pp. 642-651
-
-
Mastrodonato, M.1
-
37
-
-
84882973364
-
Isolation of mouse hepatocytes
-
Edwards, M., Houseman, L., Phillips, I. R. & Shephard, E. A. Isolation of mouse hepatocytes. Methods Mol Biol 987, 283-293, doi: 10.1007/978-1-62703-321-3-24 (2013).
-
(2013)
Methods Mol Biol
, vol.987
, pp. 283-293
-
-
Edwards, M.1
Houseman, L.2
Phillips, I.R.3
Shephard, E.A.4
-
38
-
-
84857503074
-
An optimized method for the measurement of acetaldehyde by high-performance liquid chromatography
-
Guan, X., Rubin, E. & Anni, H. An optimized method for the measurement of acetaldehyde by high-performance liquid chromatography. Alcohol Clin Exp Res 36, 398-405, doi: 10.1111/j.1530-0277.2011.01612.x (2012).
-
(2012)
Alcohol Clin Exp Res
, vol.36
, pp. 398-405
-
-
Guan, X.1
Rubin, E.2
Anni, H.3
-
39
-
-
77952542916
-
Application of the amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes
-
Mishin, V., Gray, J. P., Heck, D. E., Laskin, D. L. & Laskin, J. D. Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med 48, 1485-1491, doi: 10.1016/j.freeradbiomed.2010.02.030 (2010).
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 1485-1491
-
-
Mishin, V.1
Gray, J.P.2
Heck, D.E.3
Laskin, D.L.4
Laskin, J.D.5
|