Circadian misalignment affects sleep and medication use before and during spaceflight

npj Microgravity

Volumn 2, Issue , 2016, Pages

  Flynn Evans, Erin E ^a,b,c   Barger, Laura K ^a,b   Kubey, Alan A ^a   Sullivan, Jason P ^a   Czeisler, Charles A ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c NASA AMES RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALIGNMENT; COMPUTER SOFTWARE; MANNED SPACE FLIGHT; ORBITS; PATIENT MONITORING; PHOTOMETRY; REGRESSION ANALYSIS; SPACE STATIONS;

DATA COLLECTION; INTERNATIONAL SPACE STATIONS; LONG DURATION; LOW EARTH ORBITS; PERFORMANCE SIMULATION; REGRESSION MODEL; REPEATED MEASURES; SUBJECTIVE RATING;

SLEEP RESEARCH;

EID: 84964201819     PISSN: None     EISSN: 23738065     Source Type: Journal    
DOI: 10.1038/npjmgrav.2015.19     Document Type: Article

References (53)

1. Barger, L. K. et al. Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study. Lancet Neurol. 13, 904–912 (2014).
2. Dijk, D. J. et al. Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1647–R1664 (2001).
3. Gundel, A., Polyakov, V. V. & Zulley, J. The alteration of human sleep and circadian rhythms during spaceflight. J. Sleep Res. 6, 1–8 (1997).
4. Monk, T. H., Buysse, D. J., Billy, B. D., Kennedy, K. S. & Willrich, L. M. Sleep and circadian rhythms in four orbiting astronauts. J. Biol. Rhythms 13, 188–201 (1998).
5. Santy, P. A., Kapanka, H., Davis, J. R. & Stewart, D. F. Analysis of sleep on Shuttle missions. Aviat. Space Environ. Med. 59, 1094–1097 (1988).
6. Czeisler, C. A. et al. Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 248, 2177–2181 (1999).
7. Santhi, N., Horowitz, T. S., Duffy, J. F. & Czeisler, C. A. Acute sleep deprivation and circadian misalignment associated with transition onto the first night of work impairs visual selective attention. PLoS ONE 2, e1233 (2007).
8. Flynn-Evans E. E., Gregory K., Arsintescu L., Whitmire A., Leveton L. B. Risk of performance decrements and adverse health outcomes resulting from sleep loss, circadian desynchronization, and work overload in human health and performance risks of space exploration missions NASA human research roadmap (http://humanresearchroadmap.nasa.gov/evidence/reports/sleep.pdf) (2015).
9. Hooke, L. R., Radtke, M., Garshnek, V., Teeter, R. & Rowe, J. E. NASA Contractor Report USSR Space Life Sciences Digest 1986; 3822(08), Washington, DC.
10. Chang, A. M., Aeschbach, D., Duffy, J. F. & Czeisler, C. A. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proc. Natl Acad. Sci. USA 112, 1232–1237 (2015).
11. Monk, T. H., Kennedy, K. S., Rose, L. R. & Linenger, J. M. Decreased human circadian pacemaker influence after 100 days in space: a case study. Psychosom. Med. 63, 881–885 (2001).
12. Czeisler, C. A., Chiasera, A. J. & Duffy, J. F. Research on sleep, circadian rhythms and aging: applications to manned spaceflight. Exp. Gerontol. 26, 217–232 (1991).
13. McMenamin, T. M. A time to work: recent trends in shift work and flexible schedules. Bureau of Labor Statistics 2007; Washington, DC.
14. Czeisler, C. A. Duration, timing and quality of sleep are each vital for health, performance and safety. Sleep Health 1, 5–8 (2015).
15. Buxton, O. M. et al. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci. Transl. Med. 4, 129ra143 (2012).
16. Tenkanen, L., Sjoblom, T., Kalimo, R., Alikoski, T. & Harma, M. Shift work, occupation and coronary heart disease over 6 years of follow-up in the Helsinki Heart Study. Scand. J. Work Environ. Health 23, 257–265 (1997).
17. Stevens, R. G. et al. Considerations of circadian impact for defining 'shift work' in cancer studies: IARC Working Group Report. Occup. Environ. Med. 68, 154–162 (2011).
18. Flynn-Evans, E. E., Mucci, L., Stevens, R. G. & Lockley, S. W. Shiftwork and prostate-specific antigen in the National Health and Nutrition Examination Survey. J. Natl Cancer Inst. 105, 1292–1297 (2013).
19. Lockley, S. W. et al. Effect of reducing interns' weekly work hours on sleep and attentional failures. N. Engl. J. Med. 351, 1829–1837 (2004).
20. Landrigan, C. P. et al. Effect of reducing interns' work hours on serious medical errors in intensive care units. N. Engl. J. Med. 351, 1838–1848 (2004).
21. Barger, L. K. et al. Extended work shifts and the risk of motor vehicle crashes among interns. N. Engl. J. Med. 352, 125–134 (2005).
22. Lindbeck S., Adasiak A., Richter C. K., Spivey P. SPILL The wreck of the Exxon Valdez. Alaska Oil Spill Commission, 1990.
23. Report of the Presidential Commission on the Space Shuttle Challenger Accident II. Appendix G. (http://history.nasa.gov/rogersrep/v1comm.htm#staff) US Government Printing Office, Washington, DC, 1986.
24. Arthur, C. Mir crash `arose from Russian spending cuts. (http://www.independent. co.uk/news/mir-crash-arose-from-russian-spending-cuts-cuts-caused-mir-crash-with-1182424.html) London, UK (1998).
25. Board Meeting: Crash of Asiana Flight 214 Accident Report Summary. National Transportation and Safety Board (2014).
26. Kelly, S. M. et al. Flight controller alertness and performance during spaceflight shiftwork operations. Hum. Perf. Extrem. Environ. 3, 100–106 (1998).
27. Barger, L. K., Sullivan, J. P., Bollweg, L. J., Lockley, S. W. & Czeisler, C. A. Experimental trial of fatigue countermeasure program in operational flight controllers. Human Research Program Investigators' Workshop (Houston, TX, 2013).
28. Wright, K. P. Jr., Hull, J. T., Hughes, R. J., Ronda, J. M. & Czeisler, C. A. Sleep and wakefulness out of phase with internal biological time impairs learning in humans. J. Cogn. Neurosci. 18, 508–521 (2006).
29. Gronfier, C., Wright, K. P. Jr., Kronauer, R. E. & Czeisler, C. A. Entrainment of the human circadian pacemaker to longer-than-24-h days. Proc. Natl Acad. Sci. USA 104, 9081–9086 (2007).
30. Basner, M. et al. Mars 520-d mission simulation reveals protracted crew hypo-kinesis and alterations of sleep duration and timing. Proc. Natl Acad. Sci. USA 110, 2635–2640 (2013).
31. Wotring, V. E. Medication use by U.S. crewmembers on the International Space Station. FASEB J. 29, 4417–4423 (2015).
32. Czeisler, C. A., Moore-Ede, M. C. & Coleman, R. H. Rotating shift work schedules that disrupt sleep are improved by applying circadian principles. Science 217, 460–463 (1982).
33. Ursin, H., Endresen, I. M. & Ursin, G. Psychological factors and self-reports of muscle pain. Eur. J. Appl. Physiol. Occup. Physiol. 57, 282–290 (1988).
34. Czeisler, C. A. et al. Exposure to bright light and darkness to treat physiologic maladaptation to night work. N. Engl. J. Med. 322, 1253–1259 (1990).
35. Horowitz, T. S., Cade, B. E., Wolfe, J. M. & Czeisler, C. A. Efficacy of bright light and sleep/darkness scheduling in alleviating circadian maladaptation to night work. Am. J. Physiol. Endocrinol. Metab. 281, E384–E391 (2001).
36. Hanifin, J. P. & Brainard, G. C. Photoreception for circadian, neuroendocrine, and neurobehavioral regulation. J. Physiol. Anthropol. 26, 87–94 (2007).
37. Lockley, S. W. et al. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep 29, 161–168 (2006).
38. Rahman, S. A. et al. Diurnal spectral sensitivity of the acute alerting effects of light. Sleep 37, 271–281 (2014).
39. Whitson, P. A., Putcha, L., Chen, Y. M. & Baker, E. Melatonin and cortisol assessment of circadian shifts in astronauts before flight. J. Pineal Res. 18, 141–147 (1995).
40. Dijk, D. J. et al. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS ONE 7, e30037 (2012).
41. Viola, A. U., James, L. M., Schlangen, L. J. & Dijk, D. J. Blue-enriched white light in the workplace improves self-reported alertness, performance and sleep quality. Scand. J. Work. Environ. Health 34, 297–306 (2008).
42. Brainard, G. C. et al. Solid-state lighting for the International Space Station: tests of visual performance and melatonin regulation. Acta Astronautica 92(1): 21–28 (2013).
43. NASA ISS SSLA Specificiation, Revision C., Johnson Space Center; S684–13489 (2013).
44. Brigham and Women's Hospital BWH Bulletin. BWHers Win NASA Innovation Award for Space Station Lighting (http://www.brighamandwomens. org/about_bwh/publicaffairs/news/publications/DisplayBulletin.aspx?articleid=6528) (2015).
45. Jewett, M. E. & Kronauer, R. E. Interactive mathematical models of subjective alertness and cognitive throughput in humans. J. Biol. Rhythms 14, 588–597 (1999).
46. Strogatz, S. H., Kronauer, R. E. & Czeisler, C. A. Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia. Am. J. Physiol. 253, R172–R178 (1987).
47. Jewett, M. E., Forger, D. B. & Kronauer, R. E. Revised limit cycle oscillator model of human circadian pacemaker. J. Biol. Rhythms (1999); 14, 493–499.
48. Kronauer, R. E., Forger, D. B. & Jewett, M. E. Quantifying human circadian pacemaker response to brief, extended, and repeated light stimuli over the phototopic range. J. Biol. Rhythms (1999); 14, 500–515.
49. Jewett, M. E., Kronauer, R. E. & Czeisler, C. A. Phase-amplitude resetting of the human circadian pacemaker via bright light: a further analysis. J. Biol. Rhythms (1994); 9, 295–314.
50. Jewett, M. E. et al. Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Am. J. Physiol. (1997); 273, R1800–R1809.
51. Jewett, M. E. & Kronauer, R. E. Refinement of a limit cycle oscillator model of the effects of light on the human circadian pacemaker. J. Theor. Biol. (1998); 192, 455–465.
52. McKenna L. M. Sleep-wake actigraphy and light exposure during the Phoenix Mars Lander study. Master's Thesis, University College Dublin (2010).
53. Barger, L. K. et al. Learning to live on a Mars day: fatigue countermeasures during the Phoenix Mars Lander mission. Sleep 35, 1423–1435 (2012).