New hypotheses derived from the structure of a flaviviral Xrn1-resistant RNA: Conservation, folding, and host adaptation

RNA Biology

Volumn 12, Issue 11, 2015, Pages 1169-1177

  Kieft, Jeffrey S ^a,b   Rabe, Jennifer L ^c   Chapman, Erich G ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c Nutrition Obesity Research Center at the University of Colorado   (United States)

Author keywords

Flaviviral RNA; RNA folding; RNA structure; SfRNA; Xrn1 resistance

Indexed keywords

EXONUCLEASE; EXONUCLEASE XRN1; GENOMIC RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA; 3' UNTRANSLATED REGION; EXORIBONUCLEASE; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADAPTATION; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS; FLAVIVIRUS INFECTION; HOST ADAPTATION; HUMAN; HUMAN CELL; MURRAY VALLEY ENCEPHALITIS VIRUS; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN TERTIARY STRUCTURE; RNA FOLDING; RNA STRUCTURE; SIGNAL TRANSDUCTION; VIRUS STRAIN; WEST NILE VIRUS; BIOLOGICAL MODEL; CHEMISTRY; CONFORMATION; FLAVIVIRUS; GENETICS; HOST PATHOGEN INTERACTION; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; RNA STABILITY; SEQUENCE ALIGNMENT; VIRUS GENOME;

3' UNTRANSLATED REGIONS; ADAPTATION, BIOLOGICAL; BASE SEQUENCE; EVOLUTION, MOLECULAR; EXORIBONUCLEASES; FLAVIVIRUS; GENOME, VIRAL; HOST-PATHOGEN INTERACTIONS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA FOLDING; RNA STABILITY; RNA, VIRAL; SEQUENCE ALIGNMENT;

EID: 84964056773     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.1080/15476286.2015.1094599     Document Type: Article

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