Identification of nondiabetic heart failure-associated genes by bioinformatics approaches in patients with dilated ischemic cardiomyopathy

Experimental and Therapeutic Medicine

Volumn 11, Issue 6, 2016, Pages 2602-2608

  Yu, Anzhong ^a   Zhang, Jingyao ^b   Liu, Haiyan ^c   Liu, Bing ^a   Meng, Lingdong ^a  

^a Jinan Frist People's Hospital   (China)

^b JINAN INFECTIOUS DISEASE HOSPITAL   (China)

^c Jinan Minzu Hospital   (China)

Author keywords

Differentially expressed genes; Gene ontology; Heart failure; Pathway; Protein protein interaction network

Indexed keywords

ARTICLE; BIOINFORMATICS; BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE ONTOLOGY; HUMAN; HUMAN TISSUE; ISCHEMIC CARDIOMYOPATHY; MALE; PATHOGENESIS; PROTEIN PROTEIN INTERACTION; UPREGULATION;

EID: 84964047147     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2016.3252     Document Type: Article

References (38)

1. Van Diepen S, Hellkamp AS, Patel MR, Becker RC, Breithardt G, Hacke W, Halperin JL, Hankey GJ, Nessel CC, Singer DE, et al: Efficacy and safety of rivaroxaban in patients with heart failure and nonvalvular atrial fibrillation: Insights from ROCKET AF. Circ Heart Fail 6: 740-747, 2013.
2. Carr HJ, McDermott A, Tadbiri H, Uebbing A-M and Londrigan M: The effectiveness of computer-based learning in hospitalized adults with heart failure on knowledge, re-admission, self-care, quality of life and patient satisfaction: A systematic review protocol. The JBI Database of Systematic Reviews and Implementation Reports 11: 129-145, 2013.
3. Suskin N, McKelvie RS, Burns RJ, Latini R, Pericak D, Probstfield J, Rouleau JL, Sigouin C, Solymoss CB, Tsuyuki R, et al: Glucose and insulin abnormalities relate to functional capacity in patients with congestive heart failure. Eur Heart J 21: 1368-1375, 2000.
4. Diercks G, Van Boven A, Hillege H, Janssen W, Kors J, De Jong P, Grobbee D, Crijns H and Van Gilst W: Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study. Eur Heart J 21: 1922-1927, 2000.
5. Klamann A, Sarfert P, Launhardt V, Schulte G, Schmiegel WH and Nauck MA: Myocardial infarction in diabetic vs non-diabetic subjects. Survival and infarct size following therapy with sulfonylureas (glibenclamide). Eur Heart J 21: 220-229, 2000.
6. Anker SD, Egerer KR, Volk H-D, Kox WJ, Poole-Wilson PA and Coats AJ: Elevated soluble CD14 receptors and altered cytokines in chronic heart failure. Am J Cardiol 79: 1426-1430, 1997.
7. Krishnan E: Hyperuricemia and incident heart failure. Circ Heart Fail 2: 556-562, 2009.
8. Harutyunyan M, Christiansen M, Johansen JS, Køber L, Torp-Petersen C and Kastrup J: The inflammatory biomarker YKL-40 as a new prognostic marker for all-cause mortality in patients with heart failure. Immunobiology 217: 652-656, 2012.
9. Kusumoto A, Miyata M, Kubozono T, Ikeda Y, Shinsato T, Kuwahata S, Fujita S, Takasaki K, Yuasa T and Hamasaki S: Highly sensitive cardiac troponin T in heart failure: Comparison with echocardiographic parameters and natriuretic peptides. J Cardiol 59: 202-208, 2012.
10. Troughton RW, Frampton CM, Yandle TG, Espiner EA, Nicholls MG and Richards AM: Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. The Lancet 355: 1126-1130, 2000.
11. Greco S, Fasanaro P, Castelvecchio S, D'Alessandra Y, Arcelli D, Di Donato M, Malavazos A, Capogrossi MC, Menicanti L and Martelli F: MicroRNA dysregulation in diabetic ischemic heart failure patients. Diabetes 61: 1633-1641, 2012.
12. Kapoun AM, Liang F, O'Young G, Damm DL, Quon D, White RT, Munson K, Lam A, Schreiner GF and Protter AA: B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-beta in primary human cardiac fibroblasts: Fibrosis, myofibroblast conversion, proliferation and inflammation. Circ Res 94: 453-461, 2004.
13. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics 4: 249-264, 2003.
14. Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. Journal of the Royal Statistical Society. Series B (Methodological) 289-300, 1995.
15. Von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P and Snel B: STRING: A database of predicted functional associations between proteins. Nucleic Acids Res 31: 258-261, 2003.
16. Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics 27: 431-432, 2011.
17. He X and Zhang J: Why do hubs tend to be essential in protein networks? PLoS Genet 2: e88, 2006.
18. Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics 4: 2, 2003.
19. Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res 28: 27-30, 2000.
20. Alvord WG, Roayaei J, Stephens R, Baseler MW, Lane HC, Lempicki RA, Huang DW, Sherman BT, Tan Q and Collins JR: The DAVID Gene Functional Classification Tool: A novel biological module-centric algorithm to functionally analyze large gene lists. Genome Biol 8: R183, 2007.
21. Bottomley PA, Panjrath GS, Lai S, Hirsch GA, Wu K, Najjar SS, Steinberg A, Gerstenblith G and Weiss RG: Metabolic rates of ATP transfer through creatine kinase (CK Flux) predict clinical heart failure events and death. Sci Transl Med 5: 215re3, 2013.
22. Burchell AE, Sobotka PA, Hart EC, Nightingale AK and Dunlap ME: Chemohypersensitivity and autonomic modulation of venous capacitance in the pathophysiology of acute decompensated heart failure. Curr Heart Fail Rep 10: 139-146, 2013.
23. Tulassay T, Seri I and Rascher W: Atrial natriuretic peptide and extracellular volume contraction after birth. Acta Paediatr Scand 76: 444-446, 1987.
24. Samson WK: Atrial natriuretic factor inhibits dehydration and hemorrhage-induced vasopressin release. Neuroendocrinology 40: 277-279, 1985.
25. Ren X, Xu C, Zhan C, Yang Y, Shi L, Wang F, Wang C, Xia Y, Yang B, Wu G, et al: Identification of NPPA variants associated with atrial fibrillation in a Chinese GeneID population. Clin Chim Acta 411: 481-485, 2010.
26. Maeda K, Tsutamoto T, Wada A, Hisanaga T and Kinoshita M: Plasma brain natriuretic peptide as a biochemical marker of high left ventricular end-diastolic pressure in patients with symptomatic left ventricular dysfunction. Am Heart J 135: 825-832, 1998.
27. Seronde MF, Gayat E, Logeart D, Lassus J, Laribi S, Boukef R, Sibellas F, Launay JM, Manivet P, Sadoune M, et al: Comparison of the diagnostic and prognostic values of B-type and atrial-type natriuretic peptides in acute heart failure. Int J cardiol 168: 3404-3411, 2013.
28. Potocki M, Breidthardt T, Reichlin T, Hartwiger S, Morgenthaler NG, Bergmann A, Noveanu M, Freidank H, Taegtmeyer AB, Wetzel K, et al: Comparison of midregional pro-atrial natriuretic peptide with N-terminal pro-B-type natriuretic peptide in the diagnosis of heart failure. J Intern Med 267: 119-129, 2010.
29. Lip GY and Gibbs CR: Does heart failure confer a hypercoagulable state? Virchow's triad revisited. J Am Coll Cardiol 33: 1424-1426, 1999.
30. Rengo G, Pagano G, Squizzato A, Moja L, Femminella GD, de Lucia C, Komici K, Parisi V, Savarese G, Ferrara N, et al: Oral anticoagulation therapy in heart failure patients in sinus rhythm: A systematic review and meta-analysis. PLoS One 8: e52952, 2013.
31. Camp NP, Jones SD, Liebeschuetz JW, et al: Serine protease inhibitors. Journal 2005.
32. Askari AT, Brennan ML, Zhou X, Drinko J, Morehead A, Thomas JD, Topol EJ, Hazen SL and Penn MS: Myeloperoxidase and plasminogen activator inhibitor 1 play a central role in ventricular remodeling after myocardial infarction. J Exp Med 197: 615-624, 2003.
33. Xu Z, Castellino FJ and Ploplis VA: Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood 115: 2038-2047, 2010.
34. Spiroski I, Kedev S, Antov S, Trajkov D, Petlichkovski A, Dzhekova-Stojkova S, Kostovska S and Spiroski M: Investigation of SERPINE1 genetic polymorphism in Macedonian patients with occlusive artery disease and deep vein thrombosis. Kardiol Pol 67: 1088-1094, 2009.
35. Iwanaga Y, Aoyama T, Kihara Y, Onozawa Y, Yoneda T and Sasayama S: Excessive activation of matrix metalloproteinases coincides with left ventricular remodeling during transition from hypertrophy to heart failure in hypertensive rats. J Am Coll Cardiol 39: 1384-1391, 2002.
36. Janicki JS and Brower GL: The role of myocardial fibrillar collagen in ventricular remodeling and function. J Card Fail 8: (Suppl 6) S319-S325, 2002.
37. Zheng J, Chen Y, Pat B, Dell'italia LA, Tillson M, Dillon AR, Powell PC, Shi K, Shah N, Denney T, et al: Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog. Circulation 119: 2086-2095, 2009.
38. Chatila K, Ren G, Xia Y, Huebener P, Bujak M and Frangogiannis NG: The role of the thrombospondins in healing myocardial infarcts. Cardiovasc Hematol Agents Med Chem 5: 21-27, 2007.