Translational Research on Caregiving: Missing Links in the Translation Process

Family Caregiving in the New Normal

Volumn , Issue , 2015, Pages 193-209

  Wethington, Elaine ^a   Burgio, Louis D ^b  

^a Department of Obstetrics Gynecology   (United States)

^b Burgio Geriatric Consulting   (United States)

Author keywords

Aging in place; Alzheimer's disease; Dementia; Evidence based programs (EBPs); Multiple chronic conditions (MCC); Translational research

Indexed keywords

EID: 84963982411     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-417046-9.00011-8     Document Type: Chapter

References (56)

1. Acton G.J., Kang J. Interventions to reduce the burden of caregiving for an adult with dementia: A meta-analysis. Research in Nursing and Health 2001, 24:349-360.
2. Administration on Aging (2012). Translating innovation to impact: Evidence-based interventions to support people with Alzheimer's disease and their caregivers at home and in the community. Retrieved from:<>. http://www.aoa.gov/AoA_Programs/HPW/Alz_Grants/docs/TranslatingInnova-tiontoImpactAlzheimersDisease.pdf.
3. Amirall D., Compton S.N., Gunlicks-Stoessel M., Duan N., Murphy S.A. Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy. Statistical Medicine 2012, 31:1887-1902.
4. Belle S., Burgio L., the REACH Investigators Enhancing the quality of life of Hispanic/Latino, Black/African American, and White/Caucasian dementia caregivers: The REACH II randomized controlled trial. Annals of Internal Medicine 2006, 145(9):727-738.
5. Belle S.H., Czaja S.J., Schulz R., Zhang S., Burgio L., Gitlin L., et al. Using a new taxonomy to combine the uncombinable: Integrating results across diverse caregiving interventions. Psychology and Aging 2003, 18(3):396-405.
6. Berry D.A. Bayesian clinical trials. National Review of Drug Discovery 2006, 5:27-36.
7. Brodaty H., Green A., Koschera A. Meta-analysis of psychosocial interventions for people with dementia. Journal of the American Geriatrics Society 2003, 51:657-664.
8. Brown S.L., Lin I.-F. The gray divorce revolution: Rising divorce among middle-aged and older adults, 1990-2010. Journals of Gerontology Series B: Psychological Sciences and Social Sciences 2012, 67(6):731-741.
9. Burgio L.D. Disentangling the translational sciences: A social science perspective. Research and Theory for Nursing Practice: An International Journal 2010, 24(1):56-63.
10. Cohen D.J., Crabtree B.F., Etz R.S., Balasubramanian B.L., Donahue K.E., Leviton L.C., et al. Fidelity versus flexibility: Translating evidence-based research into practice. American Journal of Preventive Medicine 2008, 35(5S):S381-S389.
11. Collins F.S. Reengineering translational science: The time is right. Science Translational Medicine 2011, 3(90):90cm17. .
12. Collins L.M., Murphy S.A., Nair V., Strecher V. A strategy for optimizing and evaluating behavioral interventions. Annals of Behavioral Medicine 2005, 30:65-73.
13. Committee on the Quality of Health Care in America, Institute of Medicine Crossing the quality chasm: A new health system for the 21st century 2001, National Academies Press, Washington, DC.
14. Covinsky K.E., Johnston C.B. Envisioning better approaches for dementia care. Annals of Internal Medicine 2006, 145(10):780-781.
15. Cresswell, J., Klassen, A., Plano Clark, V., & Smith, C. (2011). Best practices for mixed methods research in the health sciences. Retrieved from:<>. http://obssr.od.nih.gov/mixed_methods_research.
16. Crist T.B., Schafer A.I., Walsh R.A. Translating basic discoveries into better health care: The APM's recommendations for improving translational research. The American Journal of Medicine 2004, 116:431-434.
17. Davidoff F. Improvement interventions are social treatments, not pills. Annals of Internal Medicine 2014, 161(7):526-527.
18. Department of Health and Human Services (2013). Dissemination and Implementation Research in Health (R01). PAR-13-055 Retrieved from:<>. Accessed 15.11.14. http://grants.nih.gov/grants/guide/pa-files/PAR-13-055.html.
19. Frank L., Basch E., Selby J.V., on behalf of the Patient-Centered Outcomes Research Institute Viewpoint: The PCORI perspective on patient-centered outcomes research. JAMA 2014, 312(15):1513-1514.
20. Gallagher-Thompson D., Coon D.W. Evidence-based psychological treatment for distress in family caregivers of older adults. Psychology and Aging 2007, 22(1):37-51.
21. Gitlin L.N. Introducing a new intervention: An overview of research phases and common challenges. American Journal of Occupational Therapy 2013, 67:177-184.
22. Gitlin L.N., Belle S.H., Burgio L.D., Czaja S.J., Mahoney D., Gallagher-Thompson D., et al. Effect of multicomponent interventions on caregiver burden and depression: The REACH multisite initiative at 6-month follow-up. Psychology and Aging 2013, 18(3):361-374.
23. Glasgow R.E., Emmons K.M. How can we increase translation of research into practice? Types of evidence needed. Annual Review of Public Health 2007, 28:413-433.
24. Goldman L.E., Sarkar U., Kessell E., Guzman D., Schneidermann M., Pierluissi E., et al. Support from hospital to home for elders. A randomized trial. Annals of Internal Medicine 2014, 161:472-481.
25. Green, L. (2012, January). Designing for dissemination: Making research more relevant and actionable for translation to other populations and settings. Paper presented at the Training Institute for Dissemination and Implementation Research in Health, July 9-10.
26. Hebert L.E., Weuve J., Scherr P.A., Evans D.A. Alzheimer disease in the United States (2010-2050) estimated using the 2010 census. Neurology 2013, 80:1778-1783.
27. Jack B.W., Chetty V.K., Anthony D., Greenwald J.L., Sanchez G.M., Johnson A.E., et al. A reengineered hospital discharge program to decrease rehospitalization: A randomized trial. Annals of Internal Medicine 2009, 150:178-187. <19189907>.
28. Jacobson N.S., Dobson K.S., Truaz P.A., Addis M.E., Koerner K., Gollan J.K., et al. A component analysis of cognitive-behavioral treatment for depression. Journal of Consulting and Clinical Psychology 1996, 64(2):295-304.
29. Katz D.L., Murimi M., Gonzalez A., Nijike V., Green L.W. From controlled trial to community adoption: The multisite translational community trial. American Journal of Public Health 2011, 101:e17. .
30. Kim Y., Schulz R. Family caregivers' strains: Comparative analysis of cancer caregiving with dementia, diabetes, and frail elderly caregiving. Journal of Aging and Health 2008, 20:483-503.
31. Luce B.R., Kramer J.M., Goodman S.N., Connor J.T., Tunis S., Whicher D., et al. Rethinking randomized clinical trials for comparative effectiveness research: The need for transformational change. Annals of Internal Medicine 2009, 151:206-209.
32. MacPherson H. Pragmatic clinical trials. Complementary Therapies in Medicine 2004, 12:136-140.
33. Milat A.J., King L., Bauman A., Redman S. Letter: Scaling up health promotion interventions: An emerging concept in implementation science. Health Promotion Journal of Australia 2011, 22:3.
34. Mittelman M.S., Bartels S.J. Translating research into practice: Case study of a community-based dementia caregiver intervention. Health Affairs 2014, 33(4):587-595.
35. National Institute on Aging (2014). Aging well in the 21st century: Strategic directions for research on aging. Retrieved from:<>Accessed 01.12.14. http://www.nih.gov/sites/default/files/draft-nia-strategic-directions-document-V2.pdf.
36. Parker D., Mills S., Abbey J. Effectiveness of interventions that assist caregivers to support people with dementia living in the community: A systematic review. International Journal of Evidence Based Healthcare 2008, 6:137-172.
37. Peterson J.C., Czajkowski S., Charlson M.E., Link A.R., Wells M.T., Isen A.M., et al. Translating basic behavioral and social science research to clinical application: The EVOLVE mixed methods approach. Journal of Consulting and Clinical Psychology 2013, 81:217-230.
38. Pinquart M., Sorensen S. Helping caregivers of persons with dementia: Which interventions work and how large are their effects?. International Psychogeriatrics 2006, 18:577. .
39. Redfoot D., Feinberg L., Houser A. The aging of the baby boom and the growing care gap: A look at future declines in the availability of family caregivers: Insights on the Issues 2013, AARP Public Policy Institute, Washington, DC, 85(August): 1-12.
40. Reinhard S.C., Levine C., Samis S. Family caregivers providing complex chronic care 2012, AARP, Washington, DC.
41. Relton C., Torgerson D., O'Cathain A., Nicholl J. Rethinking pragmatic randomized controlled trials: Introducing the "cohort multiple randomized controlled trial" design. BMJ 2010, 340:c1066. .
42. Ryan L.H., Smith J., Antonucci T.C., Jackson J.S. Cohort differences in the availability of informal caregivers: Are the boomers at risk?. The Gerontologist 2012, 52(2):177-188.
43. Schneeweiss S., Seeger J.D., Jackson J.W., Smith S.R. Methods of comparative effectiveness research/patient-centered outcomes research: From efficacy to effectiveness. Journal of Clinical Epidemiology 2013, 66:S1-S4.
44. Schulz R., Sherwood P.R. Physical and mental health effects of family caregiving. American Journal of Nursing 2008, 108(Suppl. 9):23-27.
45. Sörensen S., Pinquart M., Duberstein P. How effective are interventions with caregivers? An updated meta-analysis. The Gerontologist 2002, 42(3):356-372.
46. Thompson C.A., Spilsbury K., Hall J., Birks Y., Barnes C., Adamson J. Systematic review of information and support interventions for caregivers of people with dementia. BMC Geriatrics 2007, 7:18. .
47. Van't Leven N., Prick A.J.C., Groenewoud J.G., Roelofs P.D.D.M., de Lange J., Pot A.M. Dyadic interventions for community-dwelling people with dementia and their family caregivers: A systematic review. International Psychogeriatrics 2013, 25(10):1581-1603.
48. Wallerstein N. Empowerment and health: The theory and practice of community change. Community Development Journal 1993, 28:218-227.
49. Westfall J.M., Mold J., Fagnan L. Practice-based research-blue highways on the NIH Roadmap. JAMA 2007, 297:403-406. .
50. Wethington E., Breckman R., Meador R., Lachs M.S., Reid M.C., Sabir M., et al. The CITRA pilot studies program: Mentoring translational research. The Gerontologist 2007, 47:845-850.
51. Wethington E., Herman H., Pillemer K. Introduction: Translational research in the social and behavioral sciences. Research for the public good: Applying the methods of translational research to improve human health and well-being 2012, 3-19. American Psychological Association Press, Washington, DC. E. Wethington, R.E. Dunifon (Eds.).
52. Wethington E., Pillemer K. Social isolation among older adults. Handbook of solitude: Psychological perspectives on social isolation, social withdrawal, and being alone 2014, 242-259. Wiley-Blackwell, Malden, MA. R.J. Copland, J. Bowker (Eds.).
53. Wethington E., Pillemer K., Meador R. Community-researcher partnerships in aging: The cornell institute for translational research on aging. Research for the public good: Applying the methods of translational research to improve human health and well-being 2012, 169-190. American Psychological Association Press, Washington, DC. E. Wethington, R.E. Dunifon (Eds.).
54. Zarit S., Femia E. Behavioral and psychosocial interventions for family caregivers. AJN 2008, 108(Suppl. 9):47-53.
55. Zarit S.H., Reamy A.M. Future directions in family and professional caregiving for the elderly. Gerontology 2012, 59(2):152-158.
56. Zerhouni E.A. The NIH Roadmap. Science 2003, October 3, 302:63-72.