Proanthocyanidins inhibit Ascaris suum glutathione-S-transferase activity and increase susceptibility of larvae to levamisole in vitro

Parasitology International

Volumn 65, Issue 4, 2016, Pages 336-339

  Hansen, Tina V A ^a   Fryganas, Christos ^b   Acevedo, Nathalie ^c   Caraballo, Luis ^c   Thamsborg, Stig M ^a   Mueller Harvey, Irene ^b   Williams, Andrew R ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF READING   (United Kingdom)

^c UNIVERSIDAD DE CARTAGENA   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHELMINTIC AGENT; GLUTATHIONE TRANSFERASE; IVERMECTIN; LEVAMISOLE; PROANTHOCYANIDIN; RECOMBINANT ENZYME; XENOBIOTIC AGENT; HELMINTH PROTEIN; PLANT EXTRACT;

ANTHELMINTIC ACTIVITY; ARTICLE; ASCARIS SUUM; BARK; CELL MIGRATION ASSAY; CONTROLLED STUDY; DETOXIFICATION; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; IC50; IN VITRO STUDY; LARVA; NONHUMAN; PRIORITY JOURNAL; SCOTS PINE; ANIMAL; ANTAGONISTS AND INHIBITORS; ASCARIASIS; CHEMISTRY; CLOVER; CYTOLOGY; DRUG EFFECTS; FLOWER; ISOLATION AND PURIFICATION; METABOLISM; PARASITOLOGY;

ANIMALS; ANTHELMINTICS; ASCARIASIS; ASCARIS SUUM; DRUG SYNERGISM; FLOWERS; GLUTATHIONE TRANSFERASE; HELMINTH PROTEINS; IVERMECTIN; LARVA; LEVAMISOLE; PINUS SYLVESTRIS; PLANT BARK; PLANT EXTRACTS; PROANTHOCYANIDINS; TRIFOLIUM;

EID: 84963981978     PISSN: 13835769     EISSN: 18730329     Source Type: Journal    
DOI: 10.1016/j.parint.2016.04.001     Document Type: Article

References (19)

1. Sargison N.D. Pharmaceutical treatments of gastrointestinal nematode infections of sheep-future of anthelmintic drugs. Vet. Parasitol. 2012, 189:79-84.
2. Cotter J.L., Van Burgel A., Besier R.B. Anthelmintic resistance in nematodes of beef cattle in south-west Western Australia. Vet. Parasitol. 2015, 207:276-284.
3. Gerwert S., Failing K., Bauer C. Prevalence of levamisole and benzimidazole resistance in Oesophagostomum populations of pig-breeding farms in North Rhine-Westphalia, Germany. Parasitol. Res. 2002, 88:63-68.
4. Hoste H., Torres-Acosta J.F.J., Sandoval-Castro C.A., Mueller-Harvey I., Sotiraki S., Louvandini H., Thamsborg S.M., Terrill T.H. Tannin containing legumes as a model for nutraceuticals against digestive parasites in livestock. Vet. Parasitol. 2015, 212:5-17.
5. Ramírez-Restrepo C.A., Pernthaner A., Barry T.N., López-Villalobos N., Shaw R.J., Pomroy W.E., Hein W.R. Characterization of immune responses against gastrointestinal nematodes in weaned lambs grazing willow fodder blocks. Anim. Feed Sci. Technol. 2010, 155:99-110.
6. Brunet S., Fourquaux I., Hoste H. Ultrastructural changes in the third-stage, infective larvae of ruminant nematodes treated with sainfoin (Onobrychis viciifolia) extract. Parasitol. Int. 2011, 60:419-424.
7. Williams A.R., Fryganas C., Ramsay A., Mueller-Harvey I., Thamsborg S.M. Direct anthelmintic effects of condensed tannins from diverse plant sources against Ascaris suum. PLoS One 2014, 9.
8. Fakae B.B., Campbell A.M., Barrett J., Scott I.M., Teesdale-Spittle P.H., Liebau E., Brophy P.M. Inhibition of glutathione S-transferases (GSTs) from parasitic nematodes by extracts from traditional Nigerian medicinal plants. Phytother. Res. 2000, 14:630-634.
9. Goud G.N., Deumic V., Gupta R., Brelsford J., Zhan B., Gillespie P., Plieskatt J.L., Tsao E.I., Hotez P.J., Bottazzi M.E. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. Protein Expr. Purif. 2012, 83:145-151.
10. Whitney T.R., Wildeus S., Zajac A.M. The use of redberry juniper (Juniperus pinchoti) to reduce Haemonchus contortus fecal egg counts and increase ivermectin efficacy. Vet. Parasitol. 2013, 197:182-188.
11. Acevedo N., Mohr J., Zakzuk J., Samonig M., Briza P., Erler A., Pomés A., Huber C.G., Ferreira F., Caraballo L. Proteomic and immunochemical characterization of glutathione transferase as a new allergen of the nematode Ascaris lumbricoides. PLoS One 2013, 8.
12. Liebau E., Schönberger Ö.L., Walter R.D., Henkle-Dührsen K.J. Molecular cloning and expression of a cDNA encoding glutathione S-transferase from Ascaris suum. Mol. Biochem. Parasitol. 1994, 63:167-170.
13. Gea A., Stringano E., Brown R.H., Mueller-Harvey I. In situ analysis and structural elucidation of sainfoin (Onobrychis viciifolia) tannins for high-throughput germplasm screening. J. Agric. Food Chem. 2011, 59:495-503.
14. Klongsiriwet C., Quijada J., Williams A.R., Mueller-Harvey I., Williamson E.M., Hoste H. Synergistic inhibition of Haemonchus contortus exsheathment by flavonoid monomers and condensed tannins. Int. J. Parasitol. Drugs Drug Resist. 2015, 5:127-134.
15. Sarai R.S., Kopp S.R., Knox M.R., Coleman G.T., Kotze A.C. In vitro levamisole selection pressure on larval stages of Haemonchus contortus over nine generations gives rise to drug resistance and target site gene expression changes specific to the early larval stages only. Vet. Parasitol. 2015, 211:45-53.
16. Hibbs R.E., Gouaux E. Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature 2011, 474:54-60.
17. Martínez-Ortíz-de-Montellano C., Arroyo-López C., Fourquaux I., Torres-Acosta J.F.J., Sandoval-Castro C.A., Hoste H. Scanning electron microscopy of Haemonchus contortus exposed to tannin-rich plants under in vivo and in vitro conditions. Exp. Parasitol. 2013, 133:281-286.
18. Armstrong S.A., Klein D.R., Whitney T.R., Scott C.B., Muir J.P., Lambert B.D., Craig T.M. Effect of using redberry juniper (Juniperus pinchotii) to reduce Haemonchus contortus in vitro motility and increase ivermectin efficacy. Vet. Parasitol. 2013, 197:271-276.
19. Mueller-Harvey I. Unravelling the conundrum of tannins in animal nutrition and health. J. Sci. Food Agric. 2006, 86:2010-2037.