Inhibition of glutathione S-transferases (GSTs) from parasitic nematodes by extracts from traditional Nigerian medicinal plants

Phytotherapy Research

Volumn 14, Issue 8, 2000, Pages 630-634

  Fakae, B B ^a   Campbell, A M ^b   Barrett, J ^b   Scott, I M ^b   Teesdale Spittle, P H ^b   Liebau, E ^c   Brophy, P M ^b  

^a UNIVERSITY OF NIGERIA   (Nigeria)

^b ABERYSTWYTH UNIVERSITY   (United Kingdom)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

Anthelmintic; Glutathione S transferase; Nematode; Piliostigma thonningii; Proanthrocyanidin

Indexed keywords

ALSTONIA BOONEI EXTRACT; ANTHELMINTIC AGENT; GLUTATHIONE TRANSFERASE; NAUCLEA LATIFOLIA EXTRACT; OCIMUM GRATISSIMUM EXTRACT; PILIOSTIGMA THONNINGII EXTRACT; PIPERAZINE; PLANT EXTRACT; PROANTHOCYANIDIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTEMIA; ARTICLE; BIOASSAY; DRUG EFFICACY; ENZYME INHIBITION; HAEMONCHUS; HERBAL MEDICINE; HUMAN; LD 50; NEMATODE; NIGERIA; NONHUMAN; PARASITOSIS; THERMOSTABILITY; TRADITIONAL MEDICINE;

ANIMALS; ANTHOCYANINS; ANTIOXIDANTS; ARTEMIA; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE TRANSFERASE; HUMANS; LEAST-SQUARES ANALYSIS; LINEAR MODELS; MEDICINE, AFRICAN TRADITIONAL; NEMATODA; NIGERIA; PLACENTA; PLANT EXTRACTS; PLANTS, MEDICINAL; PROANTHOCYANIDINS;

ALSTONIA; ALSTONIA BOONEI; ANIMALIA; ANOSTRACA; ASCARIS; DECAPODA (CRUSTACEA); HAEMONCHUS; NAUCLEA; NAUCLEA LATIFOLIA; NEMATODA; OCIMUM; OCIMUM GRATISSIMUM; ONCHOCERCA; PILIOSTIGMA; PILIOSTIGMA THONNINGII; VERMES;

EID: 0033675480     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1573(200012)14:8<630::AID-PTR773>3.0.CO;2-5     Document Type: Article

References (24)

1. The in vitro acute toxicity of Piliostigma thonningii bark ethanolic extract on selected strongyle larvae of cattle
2. Anthelmintic activity of the ethanolic extract of Piliostigma thonningii bark in Ascaridia galli infected chickens
3. Glutathione transferases in the tapeworm Moniezia expansa
4. Detoxification reaction of Fasciola hepatica cystolic glutathione transferases
5. Glutathione transferase in helminths
6. Parasitic helminth glutathione S-transferases: An update on their potentials as targets for immuno- and chemotherapy
7. Glutathione-S-transferases from gastrointestinal tract nematode Heligmosomoides polygrus and mammalian liver compared
8. Antifungal effects of cocoa tannin on the witches' broom pathogen Crinipellis perniciosa
9. Vanillin assay for proanthocyanidins (condensed tannins): Modification of solvent estimation of the degree of polymerization
10. Effect of dietary tannin and protein level on the susceptibility of sheep to parasitic infection
11. Epidemiology of helminthosis of small ruminants under the traditional husbandry system in eastern Nigeria
12. Designer drugs: Pipe-dreams or realities?
13. Structural and functional analysis of a glutathione S-transferase from the nematode Ascaris suum
14. The 24 kDa glutathione S-transferase from Onchocerca volvulus: Biochemical analysis, localisation and gene structure
15. Target sites of anthelmintics
16. The use of biological assays to evaluate botanicals
17. The anthelmintic activities of Pleicocarpa bicarpellata leaf aqueous extract
18. Oleanolic acid, a bioactive component of the leaves of Ocimum gratissimum (Lamiaceae)
19. Glutathione transferase in the free-living nematode Panagrellus redivivus
20. Anthelmintic resistance: Past, present and future
21. Sense or nonsense? Traditional methods of animal parasite control
22. Medicinal plants and the control of parasites. Novel anthelmintic compounds and molluscides from medicinal plants