A systematic review and meta-analysis examining pneumonia-associated mortality in dementia

Dementia and Geriatric Cognitive Disorders

Volumn 39, Issue , 2015, Pages 52-67

  Foley, Norine C ^a,b,f   Affoo, Rebecca H ^g   Martin, Ruth E ^a,c,d,e  

^a Elborn College   (Canada)

^b Physical Medicine and Rehabilitation   (Canada)

^c Physiology and Pharmacology   (Canada)

^d Departments of Otolaryngology   (Canada)

^e WESTERN UNIVERSITY   (Canada)

^f BRESCIA UNIVERSITY COLLEGE   (Canada)

^g Graduate Program of Health and Rehabilitation Sciences   (Canada)

Author keywords

Alzheimer's disease; Cause of death; Epidemiology

Indexed keywords

ALZHEIMER DISEASE; CAUSE OF DEATH; COMPARATIVE STUDY; COMPLICATION; DEMENTIA; HUMAN; META ANALYSIS; MORTALITY; PNEUMONIA; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; SYSTEMATIC REVIEW;

ALZHEIMER DISEASE; CAUSE OF DEATH; COMPLICATIONS; HUMANS; MORTALITY; PNEUMONIA; RISK FACTORS;

EID: 84963955197     PISSN: 14208008     EISSN: 14219824     Source Type: Journal    
DOI: 10.1159/000367783     Document Type: Review

References (53)

1. Michaud CM, McKenna MT, Begg S, Tomijima N, Majmudar M, Bulzacchelli MT, Ebrahim S, Ezzati M, Salomon JA, Kreiser JG, Hogan M, Murray CJ: The burden of disease and injury in the United States 1996. Popul Health Metr 2006; 4: 11.
2. Murray CJ, Lopez AD: Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997; 349: 1498-1504.
3. Ganguli M, Dodge HH, Shen C, Pandav RS, DeKosky ST: Alzheimer disease and mortality: a 15-year epidemiological study. Arch Neurol 2005; 62: 779-784.
4. Todd S, Barr S, Passmore AP: Cause of death in Alzheimers disease: a cohort study. QJM 2013; 106: 747-753.
5. Marengoni A, Corrao S, Nobili A, Tettamanti M, Pasina L, Salerno F, Iorio A, Marcucci M, Bonometti F, Mannucci PM: In-hospital death according to dementia diagnosis in acutely ill elderly patients: the REPOSI study. Int J Geriatr Psychiatry 2011; 26: 930-936.
6. Brunnström HR, Englund EM: Cause of death in patients with dementia disorders. Eur J Neurol 2009; 16: 488-492.
7. Burns A, Jacoby R, Luthert P, Levy R: Cause of death in Alzheimers disease. Age Ageing 1990; 19: 341-344.
8. Keene J, Hope T, Fairburn CG, Jacoby R: Death and dementia. Int J Geriatr Psychiatry 2001; 16: 969-974.
9. Natalwala A, Potluri R, Uppal H, Heun R: Reasons for hospital admissions in dementia patients in Birmingham, UK, during 2002-2007. Dement Geriatr Cogn Disord 2008; 26: 499-505.
10. Fu C, Chute DJ, Farag ES, Garakian J, Cummings JL, Vinters HV: Comorbidity in dementia: an autopsy study. Arch Pathol Lab Med 2004; 128: 32-38.
11. Andersen K, Lolk A, Martinussen T, Kragh-Srensen P: Very mild to severe dementia and mortality: a 14-year follow-up - The Odense Study. Dement Geriatr Cogn Disord 2010; 29: 61-67.
12. Kammoun S, Gold G, Bouras C, Giannakopoulos P, McGee W, Herrmann F, Michel JP: Immediate causes of death of demented and non-demented elderly. Acta Neurol Scand Suppl 2000; 176: 96-99.
13. Attems J, König C, Huber M, Lintner F, Jellinger KA: Cause of death in demented and non-demented elderly inpatients; an autopsy study of 308 cases. J Alzheimers Dis 2005; 8: 57-62.
14. Laditka JN, Laditka SB, Cornman CB: Evaluating hospital care for individuals with Alzheimers disease using inpatient quality indicators. Am J Alzheimers Dis Other Demen 2005; 20: 27-36.
15. Magaki S, Boon-Unge K, Su K, Yong W, Khanlou N, Vinters H: Comorbidity in dementia: an update of an autopsy study (poster). 89th Annu Meet Am Assoc Neuropathol, Charleston, 2013, p 580.
16. Beard CM, Kokmen E, Sigler C, Smith GE, Petterson T, OBrien PC: Cause of death in Alzheimers disease. Ann Epidemiol 1996; 6: 195-200.
17. Tschanz JT, Corcoran C, Skoog I, Khachaturian AS, Herrick J, Hayden KM, Welsh-Bohmer KA, Calvert T, Norton MC, Zandi P, Breitner JC: Dementia: the leading predictor of death in a defined elderly population: the Cache County Study. Neurology 2004; 62: 1156-1162.
18. Chamandy N, Wolfson C: Underlying cause of death in demented and non-demented elderly Canadians. Neuroepidemiology 2005; 25: 75-84.
19. Morgan K, Clarke D: To what extent is dementia underreported on British death certificates? Int J Geriatr Psychiatry 1995; 10: 987-990.
20. Kukull WA, Brenner DE, Speck CE, Nochlin D, Bowen J, McCormick W, Teri L, Pfanschmidt ML, Larson EB: Causes of death associated with Alzheimer disease: variation by level of cognitive impairment before death. J Am Geriatr Soc 1994; 42: 723-726.
21. Zhao Y, Kuo TC, Weir S, Kramer MS, Ash AS: Healthcare costs and utilization for Medicare beneficiaries with Alzheimers. BMC Health Serv Res 2008; 8: 108.
22. Phelan EA, Borson S, Grothaus L, Balch S, Larson EB: Association of incident dementia with hospitalizations. JAMA 2012; 307: 165-172.
23. Zuliani G, Galvani M, Sioulis F, Bonetti F, Prandini S, Boari B, Guerzoni F, Gallerani M: Discharge diagnosis and comorbidity profile in hospitalized older patients with dementia. Int J Geriatr Psychiatry 2012; 27: 313-320.
24. Nourhashemi F, Andrieu S, Sastres N, Ducasse JL, Lauque D, Sinclair AJ, Albarede JL, Vellas BJ: Descriptive analysis of emergency hospital admissions of patients with Alzheimer disease. Alzheimer Dis Assoc Disord 2001; 15: 21-25.
25. Bynum JP, Rabins PV, Weller W, Niefeld M, Anderson GF, Wu AW: The relationship between a dementia diagnosis, chronic illness, Medicare expenditures, and hospital use. J Am Geriatr Soc 2004; 52: 187-194.
26. Rudolph JL, Zanin NM, Jones RN, Marcantonio ER, Fong TG, Yang FM, Yap L, Inouye SK: Hospitalization in community-dwelling persons with Alzheimers disease: frequency and causes. J Am Geriatr Soc 2010; 58: 1542-1548.
27. Draper B, Karmel R, Gibson D, Peut A, Anderson P: The Hospital Dementia Services Project: age differences in hospital stays for older people with and without dementia. Int Psychogeriatr 2011; 23: 1649-1658.
28. Albert SM, Costa R, Merchant C, Small S, Jenders RA, Stern Y: Hospitalization and Alzheimers disease: results from a community-based study. J Gerontol A Biol Sci Med Sci 1999; 54:M267-M271.
29. Bail K, Berry H, Grealish L, Draper B, Karmel R, Gibson D, Peut A: Potentially preventable complications of urinary tract infections, pressure areas, pneumonia, and delirium in hospitalised dementia patients: retrospective cohort study. BMJ Open 2013; 3:e002770.
30. Hu CJ, Liao CC, Chang CC, Wu CH, Chen TL: Postoperative adverse outcomes in surgical patients with dementia: a retrospective cohort study. World J Surg 2012; 36: 2051-2058.
31. Guijarro R, San Roman CM, Gomez-Huelgas R, Villalobos A, Martin M, Guil M, Martinez-Gonzalez MA, Toledo JB: Impact of dementia on hospitalization. Neuroepidemiology 2010; 35: 101-108.
32. Feinberg MJ, Ekberg O, Segall L, Tully J: Deglutition in elderly patients with dementia: findings of videofluorographic evaluation and impact on staging and management. Radiology 1992; 183: 811-814.
33. Horner J, Alberts MJ, Dawson DV, Cook GM: Swallowing in Alzheimers disease. Alzheimer Dis Assoc Disord 1994; 8: 177-189.
34. Sue EE: Dysphagia and aspiration pneumonia in older adults. J Am Acad Nurse Pract 2010; 22: 17-22.
35. van der Maarel-Wierink CD, Vanobbergen JN, Bronkhorst EM, Schols JM, de Baat C: Meta-analysis of dysphagia and aspiration pneumonia in frail elders. J Dent Res 2011; 90: 1398-1404.
36. Pace CC, McCullough GH: The association between oral microorgansims and aspiration pneumonia in the institutionalized elderly: review and recommendations. Dysphagia 2010; 25: 307-322.
37. Humbert IA, McLaren DG, Kosmatka K, Fitzgerald M, Johnson S, Porcaro E, Kays S, Umoh EO, Robbins J: Early deficits in cortical control of swallowing in Alzheimers disease. J Alzheimers Dis 2010; 19: 1185-1197.
38. Suzuki Y, Tamez S, Murakami A, et al: Survival of geriatric patients after percutaneous endoscopic gastrostomy in Japan. World J Gastroenterol 2010; 16: 5084-5091.
39. Finucane TE, Christmas C, Travis K: Tube feeding in patients with advanced dementia: a review of the evidence. JAMA 1999; 282: 1365-1370.
40. Chouinard J, Lavigne E, Villeneuve C: Weight loss, dysphagia, and outcome in advanced dementia. Dysphagia 1998; 13: 151-155.
41. Mitchell SL, Teno JM, Kiely DK, Shaffer ML, Jones RN, Prigerson HG, Volicer L, Givens JL, Hamel MB: The clinical course of advanced dementia. N Engl J Med 2009; 361: 1529-1538.
42. American Geriatrics Society Ethics Committee; Clinical Practice and Models of Care Committee: American Geriatrics Society feeding tubes in advanced dementia position statement. J Am Geriatr Soc 2014; 62: 1590-1593.
43. Shah FA, Pike F, Alvarez K, Angus D, Newman AB, Lopez O, Tate J, Kapur V, Wilsdon A, Krishnan JA, Hansel N, Au D, Avdalovic M, Fan VS, Barr RG, Yende S: Bidirectional relationship between cognitive function and pneumonia. Am J Respir Crit Care Med 2013; 188: 586-592.
44. Balzer KM: Drug-induced dysphagia. Int J MS Care 2000; 2: 40-50.
45. Bosch X, Formiga F, Cuerpo S, Torres B, Roson B, Lopez-Soto A: Aspiration pneumonia in old patients with dementia. Prognostic factors of mortality. Eur J Intern Med 2012; 23: 720-726.
46. Thomas BM, Starr JM, Whalley LJ: Death certification in treated cases of presenile Alzheimers disease and vascular dementia in Scotland. Age Ageing 1997; 26: 401-406.
47. Suh MK, Kim H, Na DL: Dysphagia in patients with dementia: Alzheimer versus vascular. Alzheimer Dis Assoc Disord 2009; 23: 178-184.
48. Yamamoto T, Kobayashi Y, Murata M: Risk of pneumonia onset and discontinuation of oral intake following videofluorography in patients with Lewy body disease. Parkinsonism Relat Disord 2010; 16: 503-506.
49. Shinagawa S, Adachi H, Toyota Y, Mori T, Matsumoto I, Fukuhara R, Ikeda M: Characteristics of eating and swallowing problems in patients who have dementia with Lewy bodies. Int Psychogeriatr 2009; 21: 520-525.
50. Bine JE, Frank EM, McDade HL: Dysphagia and dementia in subjects with Parkinsons disease. Dysphagia 1995; 10: 160-164.
51. Langmore SE, Olney RK, Lomen-Hoerth C, Miller BL: Dysphagia in patients with frontotemporal lobar dementia. Arch Neurol 2007; 64: 58-62.
52. Ikeda M, Brown J, Holland AJ, Fukuhara R, Hodges JR: Changes in appetite, food preference, and eating habits in frontotemporal dementia and Alzheimers disease. J Neurol Neurosurg Psychiatry 2002; 73: 371-376.
53. van der Steen JT, Ooms ME, Mehr DR, van der Wal G, Ribbe MW: Severe dementia and adverse outcomes of nursing home-acquired pneumonia: evidence for mediation by functional and pathophysiological decline. J Am Geriatr Soc 2002; 50: 439-448.