Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019

International Journal of Cancer

Volumn 136, Issue 6, 2015, Pages 1445-1457

  Vecchio, Donatella ^a   Daga, Antonio ^a   Carra, Elisa ^a   Marubbi, Daniela ^a,b   Raso, Alessandro ^c   Mascelli, Samantha ^c   Nozza, Paolo ^c   Garrè, Maria Luisa ^c   Pitto, Francesca ^a   Ravetti, Jean Louis ^a   Vagge, Stefano ^a   Corvò, Renzo ^a   Profumo, Aldo ^a   Baio, Gabriella ^a,d   Marcello, Diana ^a   Frosina, Guido ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Anaplastic astrocytoma; Ataxia telangiectasia mutated; Glioblastoma; Inhibition; Pediatric; Pharmacodynamics; Pharmacokinetics; Radiotherapy; Sensitization

Indexed keywords

2 (2, 6 DIMETHYLMORPHOLIN 4 YL) N [5 (6 MORPHOLIN 4 YL 4 OXO 4H PYRAN 2 YL) 9H THIOXANTHEN 2 YL]ACETAMIDE; ATM PROTEIN; METHYLENE BLUE; PROTEIN P53; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATM GENE; BLOOD BRAIN BARRIER; CANCER RADIOTHERAPY; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CHILD; CONTROLLED STUDY; CONVECTION ENHANCED DELIVERY; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG SAFETY; DRUG STABILITY; DRUG TISSUE LEVEL; GLIOBLASTOMA CELL LINE; GLIOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; OSMOTIC PUMP; PHARMACODYNAMICS; PI3K GENE; RADIOSENSITIZATION; SCHOOL CHILD; TUMOR SUPPRESSOR GENE;

EID: 84963948871     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29121     Document Type: Article

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