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Volumn 9, Issue 2, 2016, Pages 260-267

Safety concerns about intravenous iron therapy in patients with chronic kidney disease

Author keywords

anaphylaxis; atherosclerosis; chronic kidney disease; iron; safety

Indexed keywords

ANTIANEMIC AGENT; FERRIC CARBOXYMALTOSE; FERRIC GLUCONATE; FERRITIN; FERUMOXYTOL; IRON; IRON SACCHARATE;

EID: 84963938772     PISSN: 20488505     EISSN: 20488513     Source Type: Journal    
DOI: 10.1093/ckj/sfv142     Document Type: Review
Times cited : (47)

References (86)
  • 1
    • 70949108082 scopus 로고    scopus 로고
    • A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
    • Pfeffer MA, Burdmann EA, Chen CY, et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009; 361: 2019-2032
    • (2009) N Engl J Med , vol.361 , pp. 2019-2032
    • Pfeffer, M.A.1    Burdmann, E.A.2    Chen, C.Y.3
  • 2
    • 77749282884 scopus 로고    scopus 로고
    • Can the response to iron therapy be predicted in anemic nondialysis patients with chronic kidney disease?
    • Stancu S, Barsan L, Stanciu A, et al. Can the response to iron therapy be predicted in anemic nondialysis patients with chronic kidney disease?. Clin J Am Soc Nephrol 2010; 5: 409-416
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 409-416
    • Stancu, S.1    Barsan, L.2    Stanciu, A.3
  • 3
    • 77949559450 scopus 로고    scopus 로고
    • Bone marrow iron, iron indices, and the response to intravenous iron in patients with non-dialysis-dependent CKD
    • Stancu S, Stanciu A, Zugravu A, et al. Bone marrow iron, iron indices, and the response to intravenous iron in patients with non-dialysis-dependent CKD. Am J Kidney Dis 2010; 55: 639-647
    • (2010) Am J Kidney Dis , vol.55 , pp. 639-647
    • Stancu, S.1    Stanciu, A.2    Zugravu, A.3
  • 4
    • 84916928192 scopus 로고    scopus 로고
    • FIND-CKD: A randomized trial of intravenous ferric carboxymaltose versus oral iron in patients with chronic kidney disease and iron deficiency anaemia
    • Macdougall IC, Bock AH, Carrera F, et al. FIND-CKD: a randomized trial of intravenous ferric carboxymaltose versus oral iron in patients with chronic kidney disease and iron deficiency anaemia. Nephrol Dial Transplant 2014; 29: 2075-2084
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 2075-2084
    • Macdougall, I.C.1    Bock, A.H.2    Carrera, F.3
  • 5
    • 84884333035 scopus 로고    scopus 로고
    • KDIGO clinical practice guideline for anemia in chronic kidney disease
    • Kidney Disease Improving Global Outcomes Anemia Work Group
    • Kidney Disease: Improving Global Outcomes Anemia Work Group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney Int Suppl 2012; 2: 279-335
    • (2012) Kidney Int Suppl , vol.2 , pp. 279-335
  • 6
    • 84879836673 scopus 로고    scopus 로고
    • Kidney disease: Improving global outcomes guidelines on anaemia management in chronic kidney disease: A european renal best practice position statement
    • Locatelli F, Bárány P, Covic A, et al. Kidney Disease: Improving Global Outcomes guidelines on anaemia management in chronic kidney disease: a European Renal Best Practice position statement. Nephrol Dial Transplant 2013; 28: 1346-1359
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 1346-1359
    • Locatelli, F.1    Bárány, P.2    Covic, A.3
  • 7
    • 84886727039 scopus 로고    scopus 로고
    • Kdoqi us commentary on the 2012 kdigo clinical practice guideline for anemia in ckd
    • Kliger AS, Foley RN, Goldfarb DS, et al. KDOQI US commentary on the 2012 KDIGO Clinical Practice Guideline for Anemia in CKD. Am J Kidney Dis 2013; 62: 849-859
    • (2013) Am J Kidney Dis , Issue.62 , pp. 849-859
    • Kliger, A.S.1    Foley, R.N.2    Goldfarb, D.S.3
  • 8
    • 84886718491 scopus 로고    scopus 로고
    • Canadian society of nephrology commentary on the 2012 kdigo clinical practice guideline for anemia in ckd
    • Moist LM, Troyanov S, White CT, et al. Canadian Society of Nephrology commentary on the 2012 KDIGO Clinical Practice Guideline for Anemia in CKD. Am J Kidney Dis 2013; 62: 860-873
    • (2013) Am J Kidney Dis , Issue.62 , pp. 860-873
    • Moist, L.M.1    Troyanov, S.2    White, C.T.3
  • 9
    • 84963987009 scopus 로고    scopus 로고
    • 9 December date last accessed
    • http://www.nice.org.uk/guidance/ng8 (9 December 2015, date last accessed
    • (2015)
  • 10
    • 84963987003 scopus 로고    scopus 로고
    • 26 January date last accessed
    • http://www.ema.europa.eu/ema/index.jsp?curl=pages/news-and-events/news/2013/06/news-detail-001833.jsp&mid=WC0b01ac058004d5c1 (26 January 2015, date last accessed
    • (2015)
  • 11
    • 0036191165 scopus 로고    scopus 로고
    • Iron administration and clinical outcomes in hemodialysis patients
    • Feldman HI, Santanna J, Guo W, et al. Iron administration and clinical outcomes in hemodialysis patients. J Am Soc Nephrol 2002; 13: 734-744
    • (2002) J Am Soc Nephrol , vol.13 , pp. 734-744
    • Feldman, H.I.1    Santanna, J.2    Guo, W.3
  • 12
    • 2542429341 scopus 로고    scopus 로고
    • Administration of parenteral iron and mortality among hemodialysis patients
    • Feldman HI, Joffe M, Robinson B, et al. Administration of parenteral iron and mortality among hemodialysis patients. Am Soc Nephrol 2004; 15: 1623-1632
    • (2004) Am Soc Nephrol , vol.15 , pp. 1623-1632
    • Feldman, H.I.1    Joffe, M.2    Robinson, B.3
  • 13
    • 84926225569 scopus 로고    scopus 로고
    • Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients
    • Kuragano T, Matsumura O, Matsuda A, et al. Association between hemoglobin variability, serum ferritin levels, and adverse events/mortality in maintenance hemodialysis patients. Kidney Int 2014; 86: 845-854
    • (2014) Kidney Int , vol.86 , pp. 845-854
    • Kuragano, T.1    Matsumura, O.2    Matsuda, A.3
  • 14
    • 84920107364 scopus 로고    scopus 로고
    • Data fromthe dialysis outcomes and practice patterns study validate an association between high intravenous iron doses and mortality
    • Bailie GR, Larkina M, Goodkin DA, et al. Data fromthe Dialysis Outcomes and Practice Patterns Study validate an association between high intravenous iron doses and mortality. Kidney Int 2015; 87: 162-168
    • (2015) Kidney Int , vol.87 , pp. 162-168
    • Bailie, G.R.1    Larkina, M.2    Goodkin, D.A.3
  • 15
    • 33644824809 scopus 로고    scopus 로고
    • Timedependent associations between iron and mortality in hemodialysis patients
    • Kalantar-Zadeh K, Regidor DL, McAllister CJ, et al. Timedependent associations between iron and mortality in hemodialysis patients. J Am Soc Nephrol 2005; 16: 3070-3080
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3070-3080
    • Kalantar-Zadeh, K.1    Regidor, D.L.2    McAllister, C.J.3
  • 16
    • 84926442768 scopus 로고    scopus 로고
    • Intravenous iron exposure and mortality in patients on hemodialysis
    • Miskulin DC, Tangri N, Bandeen-Roche K, et al. Intravenous iron exposure and mortality in patients on hemodialysis. Clin J Am Soc Nephrol 2014; 9: 1930-1939
    • (2014) Clin J Am Soc Nephrol , vol.9 , pp. 1930-1939
    • Miskulin, D.C.1    Tangri, N.2    Bandeen-Roche, K.3
  • 17
    • 77649193846 scopus 로고    scopus 로고
    • Comparative mortality risk of anemia management practices in incident hemodialysis patients
    • Brookhart MA, Schneeweiss S, Avorn J, et al. Comparative mortality risk of anemia management practices in incident hemodialysis patients. JAMA 2010; 303: 857-864
    • (2010) JAMA , vol.303 , pp. 857-864
    • Brookhart, M.A.1    Schneeweiss, S.2    Avorn, J.3
  • 18
    • 84893662996 scopus 로고    scopus 로고
    • Efficacy and safety of intravenous iron therapy for functional iron deficiency anemia in hemodialysis patients: A meta-Analysis
    • Susantitaphong P, Alqahtani F, Jaber BL. Efficacy and safety of intravenous iron therapy for functional iron deficiency anemia in hemodialysis patients: a meta-Analysis. Am J Nephrol 2014; 39: 130-141
    • (2014) Am J Nephrol , vol.39 , pp. 130-141
    • Susantitaphong, P.1    Alqahtani, F.2    Jaber, B.L.3
  • 19
    • 84963988231 scopus 로고    scopus 로고
    • 15 April date last accessed
    • https://www.clinicaltrialsregister.eu/ctr-search/trial/2013-002267-25/GB#F (15 April 2015, date last accessed
    • (2015)
  • 20
    • 84888325289 scopus 로고    scopus 로고
    • The DOPPS practice monitor for US dialysis care: Update on trends in anemia management 2 years into the bundle
    • Fuller DS, Pisoni RL, Bieber BA, et al. The DOPPS practice monitor for US dialysis care: update on trends in anemia management 2 years into the bundle. Am J Kidney Dis 2013; 62: 1213-1216
    • (2013) Am J Kidney Dis , vol.62 , pp. 1213-1216
    • Fuller, D.S.1    Pisoni, R.L.2    Bieber, B.A.3
  • 21
    • 84943786773 scopus 로고    scopus 로고
    • Understanding the recent increase in ferritin levels in United States dialysis patients: Potential impact of changes in intravenous iron and erythropoiesis-stimulating agent dosing
    • Karaboyas A, Zee J, Morgenstern H, et al. Understanding the recent increase in ferritin levels in United States dialysis patients: potential impact of changes in intravenous iron and erythropoiesis-stimulating agent dosing. Clin J Am Soc Nephrol 2015; 10: 1814-1821
    • (2015) Clin J Am Soc Nephrol , vol.10 , pp. 1814-1821
    • Karaboyas, A.1    Zee, J.2    Morgenstern, H.3
  • 22
    • 84965143715 scopus 로고    scopus 로고
    • Trends in haemoglobin, erythropoietin-stimulating agents and iron use in Swedish chronic kidney disease patients between 2008 and 2013
    • Evans M, Suttorp MM, Bellocco R, et al. Trends in haemoglobin, erythropoietin-stimulating agents and iron use in Swedish chronic kidney disease patients between 2008 and 2013. Nephrol Dial Transplant 2015; doi: 10.1093/ndt/gfv298
    • (2015) Nephrol Dial Transplant
    • Evans, M.1    Suttorp, M.M.2    Bellocco, R.3
  • 23
    • 66849126016 scopus 로고    scopus 로고
    • Association of markers of iron stores with outcomes in patients with nondialysis-dependent chronic kidney disease
    • Kovesdy CP, Estrada W, Ahmadzadeh S, et al. Association of markers of iron stores with outcomes in patients with nondialysis-dependent chronic kidney disease. Clin J Am Soc Nephrol 2009; 4: 435-441
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 435-441
    • Kovesdy, C.P.1    Estrada, W.2    Ahmadzadeh, S.3
  • 24
    • 84890012992 scopus 로고    scopus 로고
    • Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease
    • Hatamizadeh P, Ravel V, Lukowsky LR, et al. Iron indices and survival in maintenance hemodialysis patients with and without polycystic kidney disease. Nephrol Dial Transplant 2013; 28: 2889-2898
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 2889-2898
    • Hatamizadeh, P.1    Ravel, V.2    Lukowsky, L.R.3
  • 25
    • 33947212276 scopus 로고    scopus 로고
    • Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: Results of the dialysis patients? Response to IV iron with elevated ferritin (drIVe) study
    • Coyne DW, Kapoian T, Suki W, et al. Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients? Response to IV Iron with Elevated Ferritin (DRIVE) Study. J Am Soc Nephrol 2007; 18: 975-984
    • (2007) J Am Soc Nephrol , vol.18 , pp. 975-984
    • Coyne, D.W.1    Kapoian, T.2    Suki, W.3
  • 26
    • 0020058810 scopus 로고
    • Failure of serum ferritin levels to predict bone-marrow iron content after intravenous iron-dextran therapy
    • Ali M, Rigolosi R, Fayemi AO, et al. Failure of serum ferritin levels to predict bone-marrow iron content after intravenous iron-dextran therapy. Lancet 1982; 1: 652-655
    • (1982) Lancet , vol.1 , pp. 652-655
    • Ali, M.1    Rigolosi, R.2    Fayemi, A.O.3
  • 27
    • 77949774448 scopus 로고    scopus 로고
    • Molecular mechanisms of hepcidin regulation: Implications for the anemia of CKD
    • Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. AmJ Kidney Dis 2010; 55: 726-741
    • (2010) AmJ Kidney Dis , vol.55 , pp. 726-741
    • Babitt, J.L.1    Lin, H.Y.2
  • 29
    • 84857373097 scopus 로고    scopus 로고
    • Non-Transferrin bound iron: A key role in iron overload and iron toxicity
    • Brissot P, Ropert M, Le Lan C, et al. Non-Transferrin bound iron: a key role in iron overload and iron toxicity. Biochim Biophys Acta 2012; 1820: 403-410
    • (2012) Biochim Biophys Acta , vol.1820 , pp. 403-410
    • Brissot, P.1    Ropert, M.2    Le Lan, C.3
  • 30
    • 1342301446 scopus 로고    scopus 로고
    • Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients
    • Canavese C, Bergamo D, Ciccone G, et al. Validation of serum ferritin values by magnetic susceptometry in predicting iron overload in dialysis patients. Kidney Int 2004; 65: 1091-1098
    • (2004) Kidney Int , vol.65 , pp. 1091-1098
    • Canavese, C.1    Bergamo, D.2    Ciccone, G.3
  • 31
    • 84864286737 scopus 로고    scopus 로고
    • Hemodialysisassociated hemosiderosis in the era of erythropoiesisstimulating agents: A MRI study
    • Rostoker G, Griuncelli M, Loridon C, et al. Hemodialysisassociated hemosiderosis in the era of erythropoiesisstimulating agents: a MRI study. Am J Med 2012; 125: 991-999
    • (2012) Am J Med , vol.125 , pp. 991-999
    • Rostoker, G.1    Griuncelli, M.2    Loridon, C.3
  • 32
    • 84862558474 scopus 로고    scopus 로고
    • Evidence for tissue iron overload in long-Term hemodialysis patients and the impact of withdrawing parenteral iron
    • Ghoti H, Rachmilewitz EA, Simon-Lopez R, et al. Evidence for tissue iron overload in long-Term hemodialysis patients and the impact of withdrawing parenteral iron. Eur J Haematol 2012; 89: 87-93
    • (2012) Eur J Haematol , vol.89 , pp. 87-93
    • Ghoti, H.1    Rachmilewitz, E.A.2    Simon-Lopez, R.3
  • 33
    • 84941313009 scopus 로고    scopus 로고
    • Reassessment of iron biomarkers for prediction of dialysis iron overload: An MRI study
    • Rostoker G, Griuncelli M, Loridon C, et al. Reassessment of iron biomarkers for prediction of dialysis iron overload: an MRI study. PLoS One 2015; 10: e0132006
    • (2015) PLoS One , vol.10 , pp. e0132006
    • Rostoker, G.1    Griuncelli, M.2    Loridon, C.3
  • 34
    • 84889675405 scopus 로고    scopus 로고
    • At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death
    • Masuda Y, Ichii H, Vaziri ND. At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death. Am J Transl Res 2013; 6: 64-70
    • (2013) Am J Transl Res , vol.6 , pp. 64-70
    • Masuda, Y.1    Ichii, H.2    Vaziri, N.D.3
  • 35
    • 84907424942 scopus 로고    scopus 로고
    • Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload
    • Alnahal AA, Tahan M, Fathy A, et al. Effect of deferoxamine therapy on insulin resistance in end-stage renal disease patients with iron overload. Saudi J Kidney Dis Transpl 2014; 25: 808-813
    • (2014) Saudi J Kidney Dis Transpl , vol.25 , pp. 808-813
    • Alnahal, A.A.1    Tahan, M.2    Fathy, A.3
  • 36
    • 4644260549 scopus 로고    scopus 로고
    • Hepatic iron in hemodialysis patients
    • Fishbane S, Miyawaki N, Masani N. Hepatic iron in hemodialysis patients. Kidney Int 2004; 66: 1714-1715
    • (2004) Kidney Int , vol.66 , pp. 1714-1715
    • Fishbane, S.1    Miyawaki, N.2    Masani, N.3
  • 37
    • 84892159757 scopus 로고    scopus 로고
    • Iron and infection in hemodialysis patients
    • Ishida JH, Johansen KL. Iron and infection in hemodialysis patients. Semin Dial 2014; 27: 26-36
    • (2014) Semin Dial , vol.27 , pp. 26-36
    • Ishida, J.H.1    Johansen, K.L.2
  • 38
    • 84897423286 scopus 로고    scopus 로고
    • Distinct immunologic effects of different intravenous iron preparations on monocytes
    • Fell LH, Zawada AM, Rogacev KS, et al. Distinct immunologic effects of different intravenous iron preparations on monocytes. Nephrol Dial Transplant 2014; 29: 809-822
    • (2014) Nephrol Dial Transplant , vol.29 , pp. 809-822
    • Fell, L.H.1    Zawada, A.M.2    Rogacev, K.S.3
  • 39
    • 84862491003 scopus 로고    scopus 로고
    • Iron sucrose impairs phagocytic function and promotes apoptosis in polymorphonuclear leukocytes
    • Ichii H, Masuda Y, Hassanzadeh T, et al. Iron sucrose impairs phagocytic function and promotes apoptosis in polymorphonuclear leukocytes. Am J Nephrol 2012; 36: 50-57
    • (2012) Am J Nephrol , vol.36 , pp. 50-57
    • Ichii, H.1    Masuda, Y.2    Hassanzadeh, T.3
  • 40
    • 2342578904 scopus 로고    scopus 로고
    • Iron storage indices: Novel predictors of bacteriemia in hemodialysis patients initiating intravenous iron therapy
    • Teehan GS, Bahdouch D, Ruthazer R, et al. Iron storage indices: novel predictors of bacteriemia in hemodialysis patients initiating intravenous iron therapy. Clin Infect Dis 2004; 38: 1090-1094
    • (2004) Clin Infect Dis , vol.38 , pp. 1090-1094
    • Teehan, G.S.1    Bahdouch, D.2    Ruthazer, R.3
  • 41
    • 84879979126 scopus 로고    scopus 로고
    • Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients
    • Brookhart MA, Freburger JK, Ellis AR, et al. Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients. J Am Soc Nephrol 2013; 24: 1151-1158
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1151-1158
    • Brookhart, M.A.1    Freburger, J.K.2    Ellis, A.R.3
  • 42
    • 20144376979 scopus 로고    scopus 로고
    • Effect of intravenous iron on hemodialysis catheter microbial colonization and blood-borne infection
    • Brewster UC, Coca SG, Reilly RF, et al. Effect of intravenous iron on hemodialysis catheter microbial colonization and blood-borne infection. Nephrology (Carlton) 2005; 10: 124-128
    • (2005) Nephrology (Carlton , vol.10 , pp. 124-128
    • Brewster, U.C.1    Coca, S.G.2    Reilly, R.F.3
  • 43
    • 33746354586 scopus 로고    scopus 로고
    • Non-Transferrin-bound iron is associated with enhanced Staphylococcus aureus growth in hemodialysis patients receiving intravenous iron sucrose
    • Barton Pai A, Pai J, Depczynski CR, Mercier, RC. Non-Transferrin-bound iron is associated with enhanced Staphylococcus aureus growth in hemodialysis patients receiving intravenous iron sucrose. Am J Nephrol 2006; 26: 304-309
    • (2006) Am J Nephrol , vol.26 , pp. 304-309
    • Barton Pai, A.1    Pai, J.2    Depczynski, C.R.3    Mercier, R.C.4
  • 44
    • 2342578904 scopus 로고    scopus 로고
    • Iron storage indices: Novel predictors of bacteriemia in hemodialysis patients initiating intravenous iron therapy
    • Teehan GS, Bahdouch D, Ruthazer R, et al. Iron storage indices: novel predictors of bacteriemia in hemodialysis patients initiating intravenous iron therapy. Clin Infect Dis 2004; 38: 1090-1094
    • (2004) Clin Infect Dis , vol.38 , pp. 1090-1094
    • Teehan, G.S.1    Bahdouch, D.2    Ruthazer, R.3
  • 45
    • 84879979126 scopus 로고    scopus 로고
    • Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients
    • Brookhart MA, Freburger JK, Ellis AR, et al. Infection risk with bolus versus maintenance iron supplementation in hemodialysis patients. J Am Soc Nephrol 2013; 24: 1151-1158
    • (2013) J Am Soc Nephrol , vol.24 , pp. 1151-1158
    • Brookhart, M.A.1    Freburger, J.K.2    Ellis, A.R.3
  • 46
    • 84883779160 scopus 로고    scopus 로고
    • Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: Systematic review and meta-Analysis of randomised clinical trials
    • Litton E, Xiao J, Ho KM. Safety and efficacy of intravenous iron therapy in reducing requirement for allogeneic blood transfusion: systematic review and meta-Analysis of randomised clinical trials. BMJ 2013; 347: f4822
    • (2013) BMJ , vol.347 , pp. f4822
    • Litton, E.1    Xiao, J.2    Ho, K.M.3
  • 47
    • 0035985424 scopus 로고    scopus 로고
    • Intravenous iron administration does not significantly increase the risk of bacteriemia in chronic hamodialysis patients
    • Hoen B, Paul-Dauphin A, Kessler M. Intravenous iron administration does not significantly increase the risk of bacteriemia in chronic hamodialysis patients. Clin Nephrol 2002; 57: 457-461
    • (2002) Clin Nephrol , vol.57 , pp. 457-461
    • Hoen, B.1    Paul-Dauphin, A.2    Kessler, M.3
  • 48
    • 61649124758 scopus 로고    scopus 로고
    • Lipid peroxidation products formation with various intravenous iron preparations in chronic kidney disease
    • Ganguli A, Kohli HS, Khullar M, et al. Lipid peroxidation products formation with various intravenous iron preparations in chronic kidney disease. Ren Fail 2009; 31: 106-110
    • (2009) Ren Fail , vol.31 , pp. 106-110
    • Ganguli, A.1    Kohli, H.S.2    Khullar, M.3
  • 49
    • 0021351203 scopus 로고
    • Oxygen toxicity, oxygen radicals, transition metals and disease
    • Halliwell B, Gutteridge JM. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J 1984; 219: 1-14
    • (1984) Biochem J , vol.219 , pp. 1-14
    • Halliwell, B.1    Gutteridge, J.M.2
  • 50
    • 34748888895 scopus 로고    scopus 로고
    • Acute injury with intravenous iron and concerns regarding long-Term safety
    • Bishu K, Agarwal R. Acute injury with intravenous iron and concerns regarding long-Term safety. Clin J Am Soc Nephrol 2006; 1(Suppl 1): S19-S20
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. S19-S20
    • Bishu, K.1    Agarwal, R.2
  • 51
    • 84879199103 scopus 로고    scopus 로고
    • Oxidative effect of several intravenous iron complexes in the rat
    • Bailie GR, Schuler C, Leggett RE, et al. Oxidative effect of several intravenous iron complexes in the rat. Biometals 2013; 26: 473-478
    • (2013) Biometals , vol.26 , pp. 473-478
    • Bailie, G.R.1    Schuler, C.2    Leggett, R.E.3
  • 52
    • 84923950749 scopus 로고    scopus 로고
    • Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD
    • Kuo KL, Hung SC, Lee TS, et al. Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD. J Am Soc Nephrol 2014; 25: 2596-2606
    • (2014) J Am Soc Nephrol , vol.25 , pp. 2596-2606
    • Kuo, K.L.1    Hung, S.C.2    Lee, T.S.3
  • 53
    • 84929191990 scopus 로고    scopus 로고
    • Cardiovascular outcomes of intravenous iron in perspective of clinical trials and the use of different iron preparations
    • Toblli JE, Cao G, Angerosa M. Cardiovascular outcomes of intravenous iron in perspective of clinical trials and the use of different iron preparations. Int J Cardiol 2015; 187: 196-197
    • (2015) Int J Cardiol , vol.187 , pp. 196-197
    • Toblli, J.E.1    Cao, G.2    Angerosa, M.3
  • 54
    • 2442563696 scopus 로고    scopus 로고
    • Direct detection and quantification of transition metal ions in human atherosclerotic plaques: Evidence for the presence of elevated levels of iron and copper
    • Stadler N, Lindner RA, Davies MJ. Direct detection and quantification of transition metal ions in human atherosclerotic plaques: evidence for the presence of elevated levels of iron and copper. Arterioscler Thromb Vasc Biol 2004; 24: 949-954
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 949-954
    • Stadler, N.1    Lindner, R.A.2    Davies, M.J.3
  • 55
    • 84855346179 scopus 로고    scopus 로고
    • Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques
    • Finn AV, Nakano M, Polavarapu R, et al. Hemoglobin directs macrophage differentiation and prevents foam cell formation in human atherosclerotic plaques. J Am Coll Cardiol 2012; 59: 166-177
    • (2012) J Am Coll Cardiol , vol.59 , pp. 166-177
    • Finn, A.V.1    Nakano, M.2    Polavarapu, R.3
  • 56
    • 33646042548 scopus 로고    scopus 로고
    • Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions
    • Stanley N, Stadler N, Woods AA, et al. Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. Free Radic Biol Med 2006; 40: 1636-1643
    • (2006) Free Radic Biol Med , vol.40 , pp. 1636-1643
    • Stanley, N.1    Stadler, N.2    Woods, A.A.3
  • 57
    • 77449128328 scopus 로고    scopus 로고
    • Do hemochromatosis mutations protect against iron-mediated atherogenesis?
    • Sullivan JL. Do hemochromatosis mutations protect against iron-mediated atherogenesis?. Circ Cardiovasc Genet 2009; 2: 652-657
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 652-657
    • Sullivan, J.L.1
  • 58
    • 84862784185 scopus 로고    scopus 로고
    • Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis
    • Li JJ, Meng X, Si HP, et al. Hepcidin destabilizes atherosclerotic plaque via overactivating macrophages after erythrophagocytosis. Arterioscler Thromb Vasc Biol 2012; 32: 1158-1166
    • (2012) Arterioscler Thromb Vasc Biol , vol.32 , pp. 1158-1166
    • Li, J.J.1    Meng, X.2    Si, H.P.3
  • 59
    • 84890237720 scopus 로고    scopus 로고
    • Testing the iron hypothesis in a mouse model of atherosclerosis
    • Kautz L, Gabayan V, Wang X, et al. Testing the iron hypothesis in a mouse model of atherosclerosis. Cell Rep 2013; 5: 1436-1442
    • (2013) Cell Rep , vol.5 , pp. 1436-1442
    • Kautz, L.1    Gabayan, V.2    Wang, X.3
  • 60
    • 84866662687 scopus 로고    scopus 로고
    • Does iron inhibit calcification during atherosclerosis?
    • Rajendran R, Minqin R, Ronald JA, et al. Does iron inhibit calcification during atherosclerosis?. Free Radic Biol Med 2012; 53: 1675-1679
    • (2012) Free Radic Biol Med , vol.53 , pp. 1675-1679
    • Rajendran, R.1    Minqin, R.2    Ronald, J.A.3
  • 61
    • 0037159304 scopus 로고    scopus 로고
    • Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease
    • Drüeke T, Witko-Sarsat V, Massy Z, et al. Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease. Circulation 2002; 106: 2212-2217
    • (2002) Circulation , vol.106 , pp. 2212-2217
    • Drüeke, T.1    Witko-Sarsat, V.2    Massy, Z.3
  • 62
    • 84890058899 scopus 로고    scopus 로고
    • Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients
    • van derWeerd NC, Grooteman MP, Bots ML, et al. Hepcidin-25 is related to cardiovascular events in chronic haemodialysis patients. Nephrol Dial Transplant 2013; 28: 3062-3071
    • (2013) Nephrol Dial Transplant , vol.28 , pp. 3062-3071
    • Van Der Weerd, N.C.1    Grooteman, M.P.2    Bots, M.L.3
  • 63
    • 84891434596 scopus 로고    scopus 로고
    • Intravenous iron supplementation practices and short-Term risk of cardiovascular events in hemodialysis patients
    • Kshirsagar AV, Freburger JK, Ellis AR, et al. Intravenous iron supplementation practices and short-Term risk of cardiovascular events in hemodialysis patients. PLoS One 2013; 8: e78930
    • (2013) PLoS One , vol.8 , pp. e78930
    • Kshirsagar, A.V.1    Freburger, J.K.2    Ellis, A.R.3
  • 64
    • 84963981400 scopus 로고    scopus 로고
    • 26 January date last accessed
    • http://www.ema.europa.eu/ema/index.jsp?curl=pages/news-and-events/news/2013/06/news-detail-001833.jsp&mid=WC0b01ac058004d5c1 (26 January 2015, date last accessed
    • (2015)
  • 66
    • 33646158450 scopus 로고    scopus 로고
    • Anaphylactoid reactions to dextran 40 and 70: Reports to the United States food and drug administration 1969 to 2004
    • Zinderman C, Landow L, Wise R. Anaphylactoid reactions to dextran 40 and 70: reports to the United States Food and Drug Administration, 1969 to 2004. J Vasc Surg 2006; 43: 1004-1009
    • (2006) J Vasc Surg , Issue.43 , pp. 1004-1009
    • Zinderman, C.1    Landow, L.2    Wise, R.3
  • 67
    • 0028271604 scopus 로고
    • Immunologic studies of anaphylaxis to iron dextran in patients on renal dialysis
    • Novey HS, Pahl M, Haydik I, et al. Immunologic studies of anaphylaxis to iron dextran in patients on renal dialysis. Ann Allergy 1994; 72: 224-228
    • (1994) Ann Allergy , vol.72 , pp. 224-228
    • Novey, H.S.1    Pahl, M.2    Haydik, I.3
  • 68
    • 84908459097 scopus 로고    scopus 로고
    • Hypersensitivity reactions to intravenous iron: Guidance for risk minimization and management
    • Rampton D, Folkersen J, Fishbane S, et al. Hypersensitivity reactions to intravenous iron: guidance for risk minimization and management. Haematologica 2014; 99: 1671-1676
    • (2014) Haematologica , vol.99 , pp. 1671-1676
    • Rampton, D.1    Folkersen, J.2    Fishbane, S.3
  • 69
    • 0018898174 scopus 로고
    • Intravenous iron dextran in clinical medicine
    • Hamstra RD, Block MH, Schock, et al. Intravenous iron dextran in clinical medicine. JAMA 1980; 243: 1726-1731
    • (1980) JAMA , vol.243 , pp. 1726-1731
    • Hamstra, R.D.1    Block, M.H.2    Schock3
  • 70
    • 0035057037 scopus 로고    scopus 로고
    • Suspected iron dextran-related adverse drug events in hemodialysis patients
    • Fletes R, Lazarus JM, Gage J, et al. Suspected iron dextran-related adverse drug events in hemodialysis patients. Am J Kidney Dis 2001; 37: 743-749
    • (2001) Am J Kidney Dis , vol.37 , pp. 743-749
    • Fletes, R.1    Lazarus, J.M.2    Gage, J.3
  • 71
    • 44049104314 scopus 로고    scopus 로고
    • High-molecular weight iron dextran a Wolf in sheep?s clothing?
    • Rodgers GM, Auerbach M, Cella D, et al. High-molecular weight iron dextran: a wolf in sheep?s clothing?. J Am Soc Nephrol 2008; 19: 833-834
    • (2008) J Am Soc Nephrol , vol.19 , pp. 833-834
    • Rodgers, G.M.1    Auerbach, M.2    Cella, D.3
  • 73
    • 39349083683 scopus 로고    scopus 로고
    • Tolerability and efficacy of parenteral iron therapy in haemodialysis patients: A comparison of preparations
    • Moniem KA, Bhandari S. Tolerability and efficacy of parenteral iron therapy in haemodialysis patients: a comparison of preparations. Transfus Altern Transfus Med 2007; 1: 1-7
    • (2007) Transfus Altern Transfus Med , vol.1 , pp. 1-7
    • Moniem, K.A.1    Bhandari, S.2
  • 74
    • 34248592639 scopus 로고    scopus 로고
    • Is there a difference between allergic potencies of the iron sucrose and low molecular weight iron dextran?
    • Sav T, Tokgoz B, Sipahioglu MH. Is there a difference between allergic potencies of the iron sucrose and low molecular weight iron dextran?. Ren Fail 2007; 29: 423-426
    • (2007) Ren Fail , vol.29 , pp. 423-426
    • Sav, T.1    Tokgoz, B.2    Sipahioglu, M.H.3
  • 75
    • 77956481295 scopus 로고    scopus 로고
    • Use of parenteral iron products and serious anaphylactic-Type reactions
    • Wysowski DK, Swartz L, Borders-Hemphill BV, et al. Use of parenteral iron products and serious anaphylactic-Type reactions. Am J Hematol 2010; 85: 650-654
    • (2010) Am J Hematol , vol.85 , pp. 650-654
    • Wysowski, D.K.1    Swartz, L.2    Borders-Hemphill, B.V.3
  • 76
    • 84963947304 scopus 로고    scopus 로고
    • 15 April date last accessed)
    • http://www.fda.gov/Drugs/DrugSafety/ucm440138.htm (15 April 2015, date last accessed
    • (2015)
  • 77
    • 26044476338 scopus 로고    scopus 로고
    • Hypersensitivity reactions and deaths associated with intravenous iron preparations
    • Bailie GR, Clark JA, Lane CE, et al. Hypersensitivity reactions and deaths associated with intravenous iron preparations. Nephrol Dial Transplant 2005; 20: 1443-1449
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 1443-1449
    • Bailie, G.R.1    Clark, J.A.2    Lane, C.E.3
  • 78
    • 84920439896 scopus 로고    scopus 로고
    • The safety of intravenous iron preparations: Systematic review and meta-Analysis
    • Avni T, Bieber A, Grossman A, et al. The safety of intravenous iron preparations: systematic review and meta-Analysis. Mayo Clin Proc 2015; 90: 12-23
    • (2015) Mayo Clin Proc , vol.90 , pp. 12-23
    • Avni, T.1    Bieber, A.2    Grossman, A.3
  • 79
    • 84947431101 scopus 로고    scopus 로고
    • Comparative risk of anaphylactic reactions associated with intravenous iron products
    • Wang C, Graham DJ, Kane RC, et al. Comparative risk of anaphylactic reactions associated with intravenous iron products. JAMA 2015; 314: 2062-2068
    • (2015) JAMA , vol.314 , pp. 2062-2068
    • Wang, C.1    Graham, D.J.2    Kane, R.C.3
  • 80
    • 84963992185 scopus 로고    scopus 로고
    • The Lombardy Section of Italian Society of Nephrology. Impact of European medicines agency recommendations for hypersensitivity reactions on intravenous iron prescription in haemodialysis centres of the Lombardy region
    • in press
    • Rivera R, Guido D, Del Vecchio L, et al. The Lombardy Section of Italian Society of Nephrology. Impact of European medicines agency recommendations for hypersensitivity reactions on intravenous iron prescription in haemodialysis centres of the Lombardy region. J Nephrol 2015; in press
    • (2015) J Nephrol
    • Rivera, R.1    Guido, D.2    Del Vecchio, L.3
  • 82
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3
  • 83
    • 84903609037 scopus 로고    scopus 로고
    • The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease
    • Mercadel L, Metzger M, Haymann JP, et al. The relation of hepcidin to iron disorders, inflammation and hemoglobin in chronic kidney disease. PLoS One 2014; 9: e99781
    • (2014) PLoS One , vol.9 , pp. e99781
    • Mercadel, L.1    Metzger, M.2    Haymann, J.P.3
  • 84
    • 84943594082 scopus 로고    scopus 로고
    • Bone marrowiron distribution, hepcidin, and ferroportin expression in renal anemia
    • Bârsan L, Stanciu A, Stancu S, et al. Bone marrowiron distribution, hepcidin, and ferroportin expression in renal anemia. Hematology 2015; 20: 543-552
    • (2015) Hematology , vol.20 , pp. 543-552
    • Bârsan, L.1    Stanciu, A.2    Stancu, S.3
  • 85
    • 70350521582 scopus 로고    scopus 로고
    • Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients
    • Costa E, Swinkels DW, Laarakkers CM, et al. Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients. Acta Haematol 2009; 122: 226-229
    • (2009) Acta Haematol , vol.122 , pp. 226-229
    • Costa, E.1    Swinkels, D.W.2    Laarakkers, C.M.3


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